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Aliases for MIR324 Gene

Subcategory (RNA class) for MIR324 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR324 Gene

  • MicroRNA 324 2 3 5
  • Hsa-Mir-324 3
  • Mir-324 3
  • MIRN324 3

External Ids for MIR324 Gene

Previous HGNC Symbols for MIR324 Gene

  • MIRN324

Previous GeneCards Identifiers for MIR324 Gene

  • GC17M007070
  • GC17M007126

Summaries for MIR324 Gene

Entrez Gene Summary for MIR324 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR324 Gene

MIR324 (MicroRNA 324) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR324 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR324

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR324 Gene

Genomics for MIR324 Gene

Regulatory Elements for MIR324 Gene

Enhancers for MIR324 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F008172 0.2 ENCODE 28.2 -951.6 -951588 5.2 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 DVL2 PFAS CTC1 SNORD10 CNTROB MIR6883 LOC105371523 SNORA48 RPL26 KCTD11
GH17F007233 0.4 ENCODE 27.3 -15.3 -15302 11.3 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF263 SP3 DVL2 CNTROB SNORD10 SNORA48 KIAA0753 ELP5 SENP3 MIR6883 NEURL4 ZBTB4
GH17F007571 0.7 ENCODE 27 -354.8 -354780 14.2 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF416 ZNF143 DVL2 SNORD10 SNORA48 PFAS LOC105371523 CTC1 CNTROB MIR6883 KCTD11 MIR324
GH17F007167 0.6 Ensembl ENCODE 21 +51.6 51629 8.0 ZNF133 NFXL1 YBX1 GLI4 RAD21 YY1 ZNF354C ZNF207 KLF7 ZNF548 DVL2 SNORD10 CNTROB SNORA48 MIR324 MIR6883 CYB5D1 SLC16A11 KCTD11 ACADVL
GH17F007306 0.5 ENCODE 19.9 -85.3 -85257 5.1 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 DVL2 SNORD10 SNORA48 PFAS KCTD11 EIF5A CTC1 MIR324 MIR6883 ENSG00000262067
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR324 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR324 Gene

Chromosome:
17
Start:
7,223,297 bp from pter
End:
7,223,379 bp from pter
Size:
83 bases
Orientation:
Minus strand

Genomic View for MIR324 Gene

Genes around MIR324 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR324 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR324 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR324 Gene

ORGUL Member Location for MIR324 Gene

ORGUL Member Location for MIR324 gene

Proteins for MIR324 Gene

Post-translational modifications for MIR324 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR324 Gene

Domains & Families for MIR324 Gene

Gene Families for MIR324 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR324: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR324 Gene

Function for MIR324 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR324 Gene

Localization for MIR324 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR324 Gene

Pathways & Interactions for MIR324 Gene

SuperPathways for MIR324 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR324: view

Pathways by source for MIR324 Gene

1 KEGG pathway for MIR324 Gene

Interacting Proteins for MIR324 Gene

Gene Ontology (GO) - Biological Process for MIR324 Gene

None

No data available for SIGNOR curated interactions for MIR324 Gene

Transcripts for MIR324 Gene

fRNAdb Secondary structures for MIR324 Gene

  • FR223933
  • hsa-mir-324_MI0000813_Homo_sapiens_miR-324_stem-loop_hairpin

mRNA/cDNA for MIR324 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR324 Gene

No ASD Table

Relevant External Links for MIR324 Gene

GeneLoc Exon Structure for
MIR324
ECgene alternative splicing isoforms for
MIR324

Expression for MIR324 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR324 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR324 Gene:

MIR324
genes like me logo Genes that share expression patterns with MIR324: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR324 Gene

Orthologs for MIR324 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR324 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-324 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-324 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-324 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir324 35
  • 92 (a)
OneToOne
Species where no ortholog for MIR324 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR324 Gene

ENSEMBL:
Gene Tree for MIR324 (if available)
TreeFam:
Gene Tree for MIR324 (if available)

Paralogs for MIR324 Gene

No data available for Paralogs for MIR324 Gene

Variants for MIR324 Gene

Sequence variations from dbSNP and Humsavar for MIR324 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs112406105 Pathogenic 7,223,152(+) TAATC(A/C/G)TACCC nc-transcript-variant, downstream-variant-500B, reference, missense
rs113994169 Pathogenic 7,223,687(+) AGCCA(C/G/T)GGACT nc-transcript-variant, upstream-variant-2KB, reference, missense
rs113994171 Pathogenic 7,224,636(+) CTACC(A/G)GACAG intron-variant, upstream-variant-2KB
rs118204014 Pathogenic 7,224,966(+) CAGCT(C/T)GGATC nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, reference, missense
rs118204015 Pathogenic 7,223,199(+) AGGAG(A/C)AGCTG nc-transcript-variant, downstream-variant-500B, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MIR324 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
esv2665200 CNV deletion 23128226
esv3639861 CNV loss 21293372
nsv1962 CNV insertion 18451855
nsv457659 CNV loss 19166990
nsv574322 CNV loss 21841781
nsv952118 CNV deletion 24416366

Relevant External Links for MIR324 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR324

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR324 Gene

Disorders for MIR324 Gene

Relevant External Links for MIR324

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR324

No disorders were found for MIR324 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR324 Gene

Publications for MIR324 Gene

  1. New human and mouse microRNA genes found by homology search. (PMID: 15634332) Weber M.J. (FEBS J. 2005) 1 3 64
  2. Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells. (PMID: 15800047) Cai X. … Cullen B.R. (Proc. Natl. Acad. Sci. U.S.A. 2005) 1 3 64
  3. Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. (PMID: 14691248) Kim J. … Ruvkun G. (Proc. Natl. Acad. Sci. U.S.A. 2004) 1 3 64
  4. Reducing Hepatocyte Injury and Necrosis in Response to Paracetamol Using Noncoding RNAs. (PMID: 27057006) Szkolnicka D. … Hay D.C. (Stem Cells Transl Med 2016) 3 64
  5. MiR-324-5p Suppresses Hepatocellular Carcinoma Cell Invasion by Counteracting ECM Degradation through Post-Transcriptionally Downregulating ETS1 and SP1. (PMID: 26177288) Cao L. … Shao Z. (PLoS ONE 2015) 3 64

Products for MIR324 Gene

Sources for MIR324 Gene

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