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Aliases for MIR323B Gene

Subcategory (RNA class) for MIR323B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR323B Gene

  • MicroRNA 323b 2 3 5
  • MicroRNA 453 2 3
  • Hsa-Mir-323b 3
  • Hsa-Mir-453 3
  • Mir-323b 3
  • MIRN453 3
  • MIR453 3

External Ids for MIR323B Gene

ORGUL Members for MIR323B Gene

Previous HGNC Symbols for MIR323B Gene

  • MIR453
  • MIRN453

Previous GeneCards Identifiers for MIR323B Gene

  • GC14P101602
  • GC14P081705
  • GC14P101667
  • GC14P101702
  • GC14P101740
  • GC14P101779
  • GC14P101837
  • GC14P101977
  • GC14P102175
  • GC14P101268
  • GC14P101877
  • GC14P102200
  • GC14P102368
  • GC14P102538

Summaries for MIR323B Gene

Entrez Gene Summary for MIR323B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR323B Gene

MIR323B (MicroRNA 323b) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR323B Gene

Genomics for MIR323B Gene

Regulatory Elements for MIR323B Gene

Enhancers for MIR323B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G101096 1.1 FANTOM5 ENCODE 10.9 +42.1 42129 3.2 CTCF SUZ12 JUN ZIC2 RAD21 ZNF335 GLIS2 ZNF366 GATA2 POLR2A RTL1 LOC105370670 MEG9 MIR369 MIR409 MIR410 MIR412 MIR541 MIR656 MIR154
GH14G101004 0.8 Ensembl ENCODE 11 -51.1 -51135 1.9 GATA3 MNT MYC ZIC2 TCF7L2 MIR134 MIR487A MIR154 MIR323B MIR485 MIR377 MIR496 MIR376C MIR1185-1 MIR1185-2
GH14G101176 0.6 ENCODE 10.7 +121.1 121148 2.0 ZNF680 ZFP3 ZBTB33 REST FOXP2 ZNF507 MIR154 MIR377 MIR496 MIR134 MIR323B MIR485 MIR487A SNORD113-2 SNORD113-3 ENSG00000222185
GH14G101008 0.4 ENCODE 11 -47.5 -47521 0.2 ZNF263 KDM1A MIR487A MIR134 MIR323B MIR485 MIR154 MIR377 MIR496 MIR1185-1 MIR300 MIR376C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR323B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR323B Gene

Chromosome:
14
Start:
101,056,219 bp from pter
End:
101,056,300 bp from pter
Size:
82 bases
Orientation:
Plus strand

Genomic View for MIR323B Gene

Genes around MIR323B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR323B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR323B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR323B Gene

Proteins for MIR323B Gene

Post-translational modifications for MIR323B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR323B Gene

Domains & Families for MIR323B Gene

Gene Families for MIR323B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR323B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR323B Gene

Function for MIR323B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR323B Gene

Localization for MIR323B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR323B Gene

Pathways & Interactions for MIR323B Gene

SuperPathways for MIR323B Gene

No Data Available

Interacting Proteins for MIR323B Gene

Gene Ontology (GO) - Biological Process for MIR323B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR323B Gene

Transcripts for MIR323B Gene

mRNA/cDNA for MIR323B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR323B Gene

No ASD Table

Relevant External Links for MIR323B Gene

GeneLoc Exon Structure for
MIR323B
ECgene alternative splicing isoforms for
MIR323B

Expression for MIR323B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR323B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR323B Gene:

MIR323B
genes like me logo Genes that share expression patterns with MIR323B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR323B Gene

Orthologs for MIR323B Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR323B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 76 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 35
  • 59 (a)
OneToOne
Species where no ortholog for MIR323B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR323B Gene

ENSEMBL:
Gene Tree for MIR323B (if available)
TreeFam:
Gene Tree for MIR323B (if available)

Paralogs for MIR323B Gene

No data available for Paralogs for MIR323B Gene

Variants for MIR323B Gene

Sequence variations from dbSNP and Humsavar for MIR323B Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000537528 -- 101,056,105(+) GCATG(G/T)GTTTG upstream-variant-2KB
rs1002358672 -- 101,056,135(+) CCTCA(A/G)GGTCC upstream-variant-2KB
rs1003488050 -- 101,054,234(+) GGATG(A/G)TGGTT upstream-variant-2KB
rs1003864116 -- 101,054,505(+) TAGCT(G/T)TAAGT downstream-variant-500B, upstream-variant-2KB
rs1005576245 -- 101,055,284(+) CATGC(A/G)CTTAA nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR323B Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Relevant External Links for MIR323B Gene

Human Gene Mutation Database (HGMD)
MIR323B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR323B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR323B Gene

Disorders for MIR323B Gene

Relevant External Links for MIR323B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR323B

No disorders were found for MIR323B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR323B Gene

Publications for MIR323B Gene

  1. Association of a microRNA-323b polymorphism with the persistence of hepatitis B virus infection by the enhancement of viral replication. (PMID: 24341744) Yu S.J. … Kim Y.J. (J. Viral Hepat. 2013) 3 64
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  3. Characterization of the Melanoma miRNAome by Deep Sequencing. (PMID: 20300190) Stark M.S. … Hayward N.K. (PLoS ONE 2010) 3 64
  4. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3 64
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR323B Gene

Sources for MIR323B Gene

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