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Aliases for MIR320A Gene

Subcategory (RNA class) for MIR320A Gene

miRNA

Quality Score for this RNA gene is

9.2

Aliases for MIR320A Gene

  • MicroRNA 320a 2 3 5
  • MicroRNA 320 2 3
  • Hsa-Mir-320a 3
  • Hsa-Mir-320 3
  • Mir-320a 3
  • MIRN320A 3
  • MIRN320 3

External Ids for MIR320A Gene

Previous HGNC Symbols for MIR320A Gene

  • MIRN320
  • MIRN320A

Previous GeneCards Identifiers for MIR320A Gene

  • GC08M022161
  • GC08M022102

Summaries for MIR320A Gene

Entrez Gene Summary for MIR320A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR320A Gene

MIR320A (MicroRNA 320a) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR320A Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR320A

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR320A Gene

Genomics for MIR320A Gene

Regulatory Elements for MIR320A Gene

Enhancers for MIR320A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F022286 1.2 Ensembl ENCODE 11.3 -42.4 -42397 1.3 PKNOX1 ATF1 ARID4B DMAP1 ZNF48 ZNF2 ZNF121 SLC30A9 ZNF143 SP5 PIWIL2 MIR320A POLR3D PHYHIP SLC39A14 SORBS3 ENSG00000251034
GH08F022202 1 ENCODE 11.6 +40.3 40294 3.8 HDGF CREB3L1 ARID4B SIN3A DMAP1 YBX1 ZNF48 YY1 ZNF121 FOS PHYHIP MIR320A POLR3D BMP1 SFTPC LGI3 NPM2 LOC105379319
GH08F022214 0.7 ENCODE 13.1 +29.0 29025 2.4 RFX1 L3MBTL2 ARID1B FOSL1 ZFHX2 NCOR1 SMARCA4 POLR2A KDM1A MYC PIWIL2 MIR320A POLR3D SFTPC LOC100507071 LGI3 PHYHIP LOC105379319
GH08F022312 0.8 ENCODE 10.8 -69.0 -69023 3.7 HDAC1 ATF1 TAL1 KLF17 ZNF121 ZFHX2 SCRT2 PATZ1 TRIM24 ZNF600 PIWIL2 SLC39A14 LOC100507071 POLR3D MIR320A PHYHIP PPP3CC RNU6-336P
GH08F022237 0.9 ENCODE 0.4 +7.6 7571 0.2 ELF3 ARID4B THRB ZNF48 ZNF2 RAD21 ZEB1 YY1 SCRT2 ZNF143 PHYHIP MIR320A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR320A on UCSC Golden Path with GeneCards custom track

Promoters for MIR320A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001387516 -157 2401 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for MIR320A Gene

Chromosome:
8
Start:
22,244,962 bp from pter
End:
22,245,043 bp from pter
Size:
82 bases
Orientation:
Minus strand

Genomic View for MIR320A Gene

Genes around MIR320A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR320A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR320A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR320A Gene

ORGUL Member Location for MIR320A Gene

ORGUL Member Location for MIR320A gene

Proteins for MIR320A Gene

Post-translational modifications for MIR320A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR320A Gene

Domains & Families for MIR320A Gene

Gene Families for MIR320A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR320A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR320A Gene

Function for MIR320A Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR320A Gene

Localization for MIR320A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR320A Gene

Pathways & Interactions for MIR320A Gene

SuperPathways for MIR320A Gene

No Data Available

Interacting Proteins for MIR320A Gene

Gene Ontology (GO) - Biological Process for MIR320A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR320A Gene

Transcripts for MIR320A Gene

fRNAdb Secondary structures for MIR320A Gene

  • FR207539
  • FR135411

mRNA/cDNA for MIR320A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR320A Gene

No ASD Table

Relevant External Links for MIR320A Gene

GeneLoc Exon Structure for
MIR320A
ECgene alternative splicing isoforms for
MIR320A

Expression for MIR320A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR320A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR320A Gene:

MIR320A
genes like me logo Genes that share expression patterns with MIR320A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR320A Gene

Orthologs for MIR320A Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR320A Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia cfa-mir-320 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-320a 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir320 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-320a-1 35
  • 83 (a)
OneToOne
Species where no ortholog for MIR320A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR320A Gene

ENSEMBL:
Gene Tree for MIR320A (if available)
TreeFam:
Gene Tree for MIR320A (if available)

Paralogs for MIR320A Gene

No data available for Paralogs for MIR320A Gene

Variants for MIR320A Gene

Sequence variations from dbSNP and Humsavar for MIR320A Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs112181807 -- 22,244,713(+) AACCC(A/G)CAGAC downstream-variant-500B, upstream-variant-2KB
rs112347265 -- 22,246,116(+) AAGCA(-/GGTTTT)GGTTT intron-variant, upstream-variant-2KB
rs112433431 -- 22,245,349(+) AGGGA(C/G)GCACC intron-variant, upstream-variant-2KB
rs113233791 -- 22,247,031(+) TCCAC(G/T)GCTAC intron-variant, upstream-variant-2KB
rs115213701 -- 22,245,288(+) CTCAC(C/T)TGGGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR320A Gene

Variant ID Type Subtype PubMed ID
nsv831265 CNV loss 17160897
nsv831264 CNV gain+loss 17160897
nsv470205 CNV loss 18288195
esv2759604 CNV loss 17122850
dgv12054n54 CNV loss 21841781

Relevant External Links for MIR320A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR320A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR320A Gene

Disorders for MIR320A Gene

Relevant External Links for MIR320A

Genetic Association Database (GAD)
MIR320A
Human Genome Epidemiology (HuGE) Navigator
MIR320A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR320A

No disorders were found for MIR320A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR320A Gene

Publications for MIR320A Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 46 64
  2. Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells. (PMID: 15325244) Kasashima K. … Kozu T. (Biochem. Biophys. Res. Commun. 2004) 1 3 64
  3. Reduced accumulation of specific microRNAs in colorectal neoplasia. (PMID: 14573789) Michael M.Z. … James R.J. (Mol. Cancer Res. 2003) 1 3 64
  4. NOD2 Is Regulated By Mir-320 in Physiological Conditions but this Control Is Altered in Inflamed Tissues of Patients with Inflammatory Bowel Disease. (PMID: 26752466) Pierdomenico M. … Stronati L. (Inflamm. Bowel Dis. 2016) 3 64
  5. MicroRNA-320a Regulates the Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells by Targeting HOXA10. (PMID: 26741129) Huang J. … Guo Y. (Cell. Physiol. Biochem. 2016) 3 64

Products for MIR320A Gene

Sources for MIR320A Gene

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