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Aliases for MIR3198-2 Gene

Subcategory (RNA class) for MIR3198-2 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR3198-2 Gene

  • MicroRNA 3198-2 2 3
  • CBX5 4 5
  • Heterochromatin Protein 1 Homolog Alpha 4
  • Hsa-Mir-3198-2 3
  • Antigen P25 4
  • Chromobox 5 5
  • Mir-3198-2 3
  • HP1 Alpha 4
  • HP1A 4

External Ids for MIR3198-2 Gene

Previous GeneCards Identifiers for MIR3198-2 Gene

  • GC12U901591
  • GC12M054653
  • GC12M054657
  • GC12M054670

Summaries for MIR3198-2 Gene

Entrez Gene Summary for MIR3198-2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3198-2 Gene

MIR3198-2 (MicroRNA 3198-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Factors involved in megakaryocyte development and platelet production and Response to elevated platelet cytosolic Ca2+. An important paralog of this gene is CBX3.

UniProtKB/Swiss-Prot for MIR3198-2 Gene

  • Component of heterochromatin that recognizes and binds histone H3 tails methylated at Lys-9 (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when Tyr-41 of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR3198-2 Gene

Genomics for MIR3198-2 Gene

Regulatory Elements for MIR3198-2 Gene

Enhancers for MIR3198-2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F053971 1.8 FANTOM5 Ensembl ENCODE 20.6 +289.9 289891 36.8 CREB3L1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 NFYC ZNF740 MAP3K12 SP1 ENSG00000258344 LOC100652999 HOXC8 HOXC5 PFDN5 HOTAIR IGFBP6
GH12F053320 1.2 ENCODE 22.9 +958.7 958746 2.3 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 AAAS ESPL1 PFDN5 MIR3198-2 IGFBP6 MAP3K12 SP1 ENSG00000258344 C12orf10 ENSG00000260470
GH12F054277 1.2 ENCODE 22.7 -0.9 -933 7.1 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 SP1 MIR3198-2 PFDN5 MAP3K12 ENSG00000260470 GPR84 COPZ1 RNU6-950P HOXC6 HOXC4
GH12F053386 1.2 Ensembl ENCODE 19.9 +891.0 890963 6.3 ZNF493 ZFP64 YY1 ZNF121 ZNF202 SP3 TSHZ1 REST ZNF623 ZNF518A ZNF740 AAAS SP1 ENSG00000258344 LOC100652999 MAP3K12 TARBP2 MIR3198-2 IGFBP6 PRR13
GH12F053824 1.1 ENCODE 20.9 +454.5 454534 1.7 PKNOX1 ARNT MLX ZFP64 ARID4B DMAP1 ZNF2 YY1 SLC30A9 ZNF143 MAP3K12 MIR3198-2 AAAS ZNF740 TARBP2 ENSG00000257596 ENSG00000250654 GC12P053834 RN7SKP289
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR3198-2 on UCSC Golden Path with GeneCards custom track

Promoters for MIR3198-2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000653664 -467 4801 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for MIR3198-2 Gene

Chromosome:
12
Start:
54,230,940 bp from pter
End:
54,280,133 bp from pter
Size:
49,194 bases
Orientation:
Minus strand

Genomic View for MIR3198-2 Gene

Genes around MIR3198-2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR3198-2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3198-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3198-2 Gene

Proteins for MIR3198-2 Gene

  • Protein details for MIR3198-2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P45973-CBX5_HUMAN
    Recommended name:
    Chromobox protein homolog 5
    Protein Accession:
    P45973
    Secondary Accessions:
    • B2R8T9

    Protein attributes for MIR3198-2 Gene

    Size:
    191 amino acids
    Molecular mass:
    22225 Da
    Quaternary structure:
    • Interacts with KMT5B and KMT5C (By similarity). Interacts with HP1BP3. Interacts directly with ATRX, CHAF1A, LBR, NIPBL, SP100, STAM2 and TRIM28 via the chromoshadow domain. Can interact directly with CBX3 via the chromoshadow domain. Interacts with histone H3 methylated at Lys-9. Interacts with BAHD1, MIS12 and DSN1. Interacts with POGZ; POGZ and PXVXL motif-containing proteins such as INCENP and TRIM28 compete for interaction with CBX5. Interacts with INCENP and TRIM24. Interacts with JC virus agnoprotein; this interaction induces the dissociation of CBX5 from LBR, resulting in destabilization of the nuclear envelope. Interacts with CHAMP1. Interacts with ASXL1.
    • Interacts with KMT5B and KMT5C (By similarity). Interacts with HP1BP3. Interacts directly with ATRX, CHAF1A, LBR, NIPBL, SP100, STAM2 and TRIM28 via the chromoshadow domain. Can interact directly with CBX3 via the chromoshadow domain. Interacts with histone H3 methylated at Lys-9. Interacts with BAHD1, MIS12 and DSN1. Interacts with POGZ; POGZ and PXVXL motif-containing proteins such as INCENP and TRIM28 compete for interaction with CBX5. Interacts with INCENP and TRIM24. Interacts with JC virus agnoprotein; this interaction induces the dissociation of CBX5 from LBR, resulting in destabilization of the nuclear envelope. Interacts with CHAMP1. Interacts with ASXL1.

    Three dimensional structures from OCA and Proteopedia for MIR3198-2 Gene

neXtProt entry for MIR3198-2 Gene

Post-translational modifications for MIR3198-2 Gene

  • Phosphorylation of HP1 and LBR may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle (By similarity). Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.
  • Ubiquitinated.
  • Ubiquitination at Lys 32, Lys 42, Lys 91, Lys 102, Lys 125, Lys 143, Lys 154, and Lys 159
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR3198-2 Gene

No data available for DME Specific Peptides for MIR3198-2 Gene

Domains & Families for MIR3198-2 Gene

Gene Families for MIR3198-2 Gene

Graphical View of Domain Structure for InterPro Entry

P45973

UniProtKB/Swiss-Prot:

CBX5_HUMAN :
  • Contains 2 chromo domains.
Domain:
  • Contains 2 chromo domains.
genes like me logo Genes that share domains with MIR3198-2: view

No data available for Suggested Antigen Peptide Sequences for MIR3198-2 Gene

Function for MIR3198-2 Gene

Molecular function for MIR3198-2 Gene

UniProtKB/Swiss-Prot Function:
Component of heterochromatin that recognizes and binds histone H3 tails methylated at Lys-9 (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when Tyr-41 of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.

Gene Ontology (GO) - Molecular Function for MIR3198-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI --
GO:0030674 protein binding, bridging ISS --
GO:0035064 methylated histone binding IDA --
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with MIR3198-2: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3198-2 Gene

Localization for MIR3198-2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR3198-2 Gene

Nucleus. Chromosome. Chromosome, centromere. Note=Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase.

Gene Ontology (GO) - Cellular Components for MIR3198-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 kinetochore IEA --
GO:0000784 nuclear chromosome, telomeric region IDA --
GO:0000792 heterochromatin IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MIR3198-2: view

No data available for Subcellular locations from COMPARTMENTS for MIR3198-2 Gene

Pathways & Interactions for MIR3198-2 Gene

genes like me logo Genes that share pathways with MIR3198-2: view

Pathways by source for MIR3198-2 Gene

Interacting Proteins for MIR3198-2 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000209875%0d%0a9606.ENSP00000253024%0d%0a9606.ENSP00000301280%0d%0a9606.ENSP00000355657%0d%0a9606.ENSP00000365877%0d%0a9606.ENSP00000336687%0d%0a
Selected Interacting proteins: P45973-CBX5_HUMAN ENSP00000209875 for MIR3198-2 Gene via IID STRING UniProtKB MINT

Symbol External ID(s) Details
HIST1H3J
CHAF1A
H3F3A
H3F3B
MIR4738

Gene Ontology (GO) - Biological Process for MIR3198-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007596 blood coagulation TAS --
GO:0016032 viral process IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA --
genes like me logo Genes that share ontologies with MIR3198-2: view

No data available for SIGNOR curated interactions for MIR3198-2 Gene

Transcripts for MIR3198-2 Gene

mRNA/cDNA for MIR3198-2 Gene

(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3198-2 Gene

No ASD Table

Relevant External Links for MIR3198-2 Gene

GeneLoc Exon Structure for
MIR3198-2
ECgene alternative splicing isoforms for
MIR3198-2

Expression for MIR3198-2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR3198-2 Gene

genes like me logo Genes that share expression patterns with MIR3198-2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR3198-2 Gene

Orthologs for MIR3198-2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR3198-2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CBX5 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CBX5 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CBX5 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cbx5 35
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 36 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 35
  • 89 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia CBX5 35
  • 91 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cbx5 35
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Su(var)205 35
  • 40 (a)
ManyToMany
HP6 35
  • 38 (a)
ManyToMany
HP1b 35
  • 36 (a)
ManyToMany
HP1e 35
  • 32 (a)
ManyToMany
HP1c 35
  • 27 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea hpl-1 35
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3133 35
  • 45 (a)
OneToMany
Species where no ortholog for MIR3198-2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR3198-2 Gene

ENSEMBL:
Gene Tree for MIR3198-2 (if available)
TreeFam:
Gene Tree for MIR3198-2 (if available)

Paralogs for MIR3198-2 Gene

Paralogs for MIR3198-2 Gene

Pseudogenes.org Pseudogenes for MIR3198-2 Gene

genes like me logo Genes that share paralogs with MIR3198-2: view

Variants for MIR3198-2 Gene

Sequence variations from dbSNP and Humsavar for MIR3198-2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1056010 -- 54,232,968(-) CCACC(A/G)CTGGG upstream-variant-2KB, utr-variant-3-prime
rs1056138 -- 54,231,097(-) TGTTC(A/C)CCTTT downstream-variant-500B, utr-variant-3-prime
rs1056162 -- 54,231,040(-) GACAT(C/T)TGATG downstream-variant-500B, utr-variant-3-prime
rs11542026 -- 54,232,176(-) GGCAC(C/T)TGGGA upstream-variant-2KB, utr-variant-3-prime
rs116944265 -- 54,231,734(+) AAGAG(A/G)TGACA upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MIR3198-2 Gene

Variant ID Type Subtype PubMed ID
nsv509467 CNV insertion 20534489
nsv832419 CNV loss 17160897
nsv832420 CNV loss 17160897
nsv976626 CNV duplication 23825009

Relevant External Links for MIR3198-2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3198-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR3198-2 Gene

Disorders for MIR3198-2 Gene

Relevant External Links for MIR3198-2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR3198-2

No disorders were found for MIR3198-2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR3198-2 Gene

Publications for MIR3198-2 Gene

  1. System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability. (PMID: 25755297) Xiao Z. … Vertegaal A.C. (Mol. Cell. Proteomics 2015) 4 64
  2. SUMO-2 orchestrates chromatin modifiers in response to DNA damage. (PMID: 25772364) Hendriks I.A. … Vertegaal A.C. (Cell Rep. 2015) 4 64
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  4. Uncovering global SUMOylation signaling networks in a site-specific manner. (PMID: 25218447) Hendriks I.A. … Vertegaal A.C. (Nat. Struct. Mol. Biol. 2014) 4 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for MIR3198-2 Gene

Sources for MIR3198-2 Gene

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