Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR3191 Gene

Subcategory (RNA class) for MIR3191 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR3191 Gene

  • MicroRNA 3191 2 3
  • BBC3 4 5
  • P53 Up-Regulated Modulator Of Apoptosis 4
  • BCL2 Binding Component 3 5
  • Hsa-Mir-3191 3
  • Mir-3191 3
  • JFY-1 4
  • PUMA 4

External Ids for MIR3191 Gene

Previous GeneCards Identifiers for MIR3191 Gene

  • GC19U901414
  • GC19M047730

Summaries for MIR3191 Gene

Entrez Gene Summary for MIR3191 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3191 Gene

MIR3191 (MicroRNA 3191) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Activation of BH3-only proteins.

UniProtKB/Swiss-Prot for MIR3191 Gene

  • Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Isoform 3 fails to show any growth-inhibitory or apoptotic activity.

  • Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR3191 Gene

Genomics for MIR3191 Gene

Regulatory Elements for MIR3191 Gene

Enhancers for MIR3191 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F047209 1.4 Ensembl ENCODE 13.8 +22.4 22361 2.6 HDGF PKNOX1 MLX CREB3L1 ARID4B SIN3A ZNF143 KLF13 ZNF263 REST ZC3H4 GLTSCR2-AS1 GLTSCR1 ENSG00000268810 CCDC9 BBC3 MIR3191 SLC1A5 SAE1 TMEM160
GH19F047185 1.5 FANTOM5 Ensembl ENCODE 12.8 +44.1 44059 6.1 ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF143 FOS ZNF263 SP5 JUNB SAE1 BBC3 MIR3191 CCDC9 GLTSCR1 MIR3190 ZC3H4
GH19F047154 0.9 Ensembl ENCODE 12.7 +75.4 75364 5.6 ELF3 PKNOX1 TBL1XR1 THRB YY1 RARA ZNF121 FOS CREM THAP11 BBC3 MIR3191 CCDC9 SAE1 TMEM160 ZC3H4 MIR3190
GH19F047151 0.2 ENCODE 12.6 +80.0 80040 2.0 TAL1 ZBTB40 ZNF121 GATA3 CTBP1 NCOR1 SCRT2 FOSL2 FOS TCF7L2 MIR3191 BBC3 CCDC9 SAE1 ZC3H4 MIR3190
GH19F047225 0.4 ENCODE 0.8 +3.4 3385 8.2 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 ZC3H4 GLTSCR1 CCDC9 ENSG00000268810 GLTSCR2-AS1 ENSG00000269321 SLC1A5 PRKD2 SNORD23 ENSG00000268746
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR3191 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR3191 Gene

Chromosome:
19
Start:
47,220,822 bp from pter
End:
47,232,766 bp from pter
Size:
11,945 bases
Orientation:
Minus strand

Genomic View for MIR3191 Gene

Genes around MIR3191 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR3191 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3191 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3191 Gene

Proteins for MIR3191 Gene

  • Protein details for MIR3191 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PG8-BBC3B_HUMAN
    Recommended name:
    Bcl-2-binding component 3
    Protein Accession:
    Q96PG8

    Protein attributes for MIR3191 Gene

    Size:
    261 amino acids
    Molecular mass:
    26498 Da
    Quaternary structure:
    • Isoform 3 does not interact with BCL2.
    • Isoform 3 does not interact with BCL2.

    Alternative splice isoforms for MIR3191 Gene

    UniProtKB/Swiss-Prot:
  • Protein details for MIR3191 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXH1-BBC3_HUMAN
    Recommended name:
    Bcl-2-binding component 3
    Protein Accession:
    Q9BXH1
    Secondary Accessions:
    • B9EGI3
    • O00171
    • Q96PG9

    Protein attributes for MIR3191 Gene

    Size:
    193 amino acids
    Molecular mass:
    20532 Da
    Quaternary structure:
    • Interacts with MCL1 and BCL2A1 (By similarity). Interacts with BCL2 and BCL2L1/BCL-XL. Interacts (via BH3 domain) with NOL3 (via CARD domain); preventing the association of BBC3 with BCL2 and resulting in activation of CASP8 (By similarity).
    • Interacts with MCL1 and BCL2A1 (By similarity). Interacts with BCL2 and BCL2L1/BCL-XL. Interacts (via BH3 domain) with NOL3 (via CARD domain); preventing the association of BBC3 with BCL2 and resulting in activation of CASP8 (By similarity).

    Three dimensional structures from OCA and Proteopedia for MIR3191 Gene

    Alternative splice isoforms for MIR3191 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR3191 Gene

Post-translational modifications for MIR3191 Gene

Other Protein References for MIR3191 Gene

No data available for DME Specific Peptides for MIR3191 Gene

Domains & Families for MIR3191 Gene

Gene Families for MIR3191 Gene

Protein Domains for MIR3191 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9BXH1

UniProtKB/Swiss-Prot:

BBC3_HUMAN :
  • The BH3 motif is intrinsically disordered.
  • Belongs to the Bcl-2 family.
Domain:
  • The BH3 motif is intrinsically disordered.
Family:
  • Belongs to the Bcl-2 family.
genes like me logo Genes that share domains with MIR3191: view

No data available for Suggested Antigen Peptide Sequences for MIR3191 Gene

Function for MIR3191 Gene

Molecular function for MIR3191 Gene

UniProtKB/Swiss-Prot Function:
Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Isoform 3 fails to show any growth-inhibitory or apoptotic activity.
UniProtKB/Swiss-Prot Induction:
By DNA damage, glucocorticoid treatment, growth factor deprivation and p53/TP53.
UniProtKB/Swiss-Prot Function:
Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis.
UniProtKB/Swiss-Prot Induction:
By DNA damage, glucocorticoid treatment, growth factor deprivation and p53. By ER stress in a DDIT3/CHOP-dependent manner.

Gene Ontology (GO) - Molecular Function for MIR3191 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001948 glycoprotein binding IPI --
GO:0005515 protein binding IPI --
GO:0051117 ATPase binding IPI --
genes like me logo Genes that share ontologies with MIR3191: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3191 Gene

Localization for MIR3191 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR3191 Gene

Mitochondrion. Note=Localized to the mitochondria in order to induce cytochrome c release. Isoform 3 is not found in mitochondria.
Mitochondrion. Note=Localized to the mitochondria in order to induce cytochrome c release.

Gene Ontology (GO) - Cellular Components for MIR3191 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005741 mitochondrial outer membrane TAS --
GO:0005764 lysosome IDA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MIR3191: view

No data available for Subcellular locations from COMPARTMENTS for MIR3191 Gene

Pathways & Interactions for MIR3191 Gene

genes like me logo Genes that share pathways with MIR3191: view

Gene Ontology (GO) - Biological Process for MIR3191 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS --
GO:0006915 apoptotic process IEA --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA --
GO:0006974 cellular response to DNA damage stimulus ISS --
GO:0008340 determination of adult lifespan ISS --
genes like me logo Genes that share ontologies with MIR3191: view

No data available for SIGNOR curated interactions for MIR3191 Gene

Transcripts for MIR3191 Gene

mRNA/cDNA for MIR3191 Gene

(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3191 Gene

No ASD Table

Relevant External Links for MIR3191 Gene

GeneLoc Exon Structure for
MIR3191
ECgene alternative splicing isoforms for
MIR3191

Expression for MIR3191 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR3191 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR3191 Gene:

MIR3191

mRNA Expression by UniProt/SwissProt for MIR3191 Gene:

Q96PG8-BBC3B_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with MIR3191: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR3191 Gene

Orthologs for MIR3191 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for MIR3191 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BBC3 35
  • 98 (a)
OneToOne
Species where no ortholog for MIR3191 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR3191 Gene

ENSEMBL:
Gene Tree for MIR3191 (if available)
TreeFam:
Gene Tree for MIR3191 (if available)

Paralogs for MIR3191 Gene

No data available for Paralogs for MIR3191 Gene

Variants for MIR3191 Gene

Sequence variations from dbSNP and Humsavar for MIR3191 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10407441 -- 47,227,858(+) AGGAC(A/C)CAGAC intron-variant, upstream-variant-2KB
rs111696820 -- 47,227,321(+) CCCCC(A/C)CCCCC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs112701711 -- 47,227,324(+) CCCCC(A/C)CCCAC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs114978921 -- 47,227,574(+) GCCGG(A/C)AGGGA intron-variant, upstream-variant-2KB
rs116277200 -- 47,227,997(+) GTCTT(C/G)CTGCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR3191 Gene

Variant ID Type Subtype PubMed ID
nsv1067417 CNV gain 25217958
nsv833852 CNV loss 17160897

Relevant External Links for MIR3191 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3191

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR3191 Gene

Disorders for MIR3191 Gene

Relevant External Links for MIR3191

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR3191

No disorders were found for MIR3191 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR3191 Gene

Publications for MIR3191 Gene

  1. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  3. PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. (PMID: 23340338) Follis A.V. … Kriwacki R.W. (Nat. Chem. Biol. 2013) 4 64
  4. CHOP potentially co-operates with FOXO3a in neuronal cells to regulate PUMA and BIM expression in response to ER stress. (PMID: 22761832) Ghosh A.P. … Roth K.A. (PLoS ONE 2012) 4 64
  5. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64

Products for MIR3191 Gene

Sources for MIR3191 Gene

Content
Loading form....