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Aliases for MIR3189 Gene

Subcategory (RNA class) for MIR3189 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR3189 Gene

  • MicroRNA 3189 2 3 5
  • Hsa-Mir-3189 3
  • Mir-3189 3

External Ids for MIR3189 Gene

Previous GeneCards Identifiers for MIR3189 Gene

  • GC19U901396
  • GC19P018497

Summaries for MIR3189 Gene

Entrez Gene Summary for MIR3189 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3189 Gene

MIR3189 (MicroRNA 3189) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR3189 Gene

Genomics for MIR3189 Gene

Regulatory Elements for MIR3189 Gene

Enhancers for MIR3189 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G018372 2.1 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -5.5 -5462 18.0 MLX CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF548 ENSG00000268030 COLGALT1 UPF1 ENSG00000268938 MVB12A ENSG00000269191 KXD1 IFI30 GDF15 PGLS
GH19G018391 0.8 ENCODE 0.7 +3.7 3654 0.2 SOX13 ESRRA ZMYM3 UBTF RAD21 YY1 CHAMP1 GATA4 GATAD1 GATA2 GDF15 PGPEP1 GC19P019553 MIR3189
GH19G018393 0.8 ENCODE 0.7 +4.1 4084 0.5 ESRRA PTBP1 ZMYM3 ZNF175 CEBPG YY1 GATA4 GATAD1 NCOR1 POLR2A GC19P019553 MIR3189
GH19G018390 0.6 ENCODE 0.7 +4.5 4484 0.2 PTBP1 ZFP3 POLR2A CEBPB ZNF175 CEBPG RBFOX2 MIR3189 GC19P019553
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR3189 on UCSC Golden Path with GeneCards custom track

Promoters for MIR3189 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000108062 938 2601 MLX CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3

Genomic Location for MIR3189 Gene

Chromosome:
19
Start:
18,386,562 bp from pter
End:
18,386,634 bp from pter
Size:
73 bases
Orientation:
Plus strand

Genomic View for MIR3189 Gene

Genes around MIR3189 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR3189 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3189 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3189 Gene

Proteins for MIR3189 Gene

Post-translational modifications for MIR3189 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR3189 Gene

Domains & Families for MIR3189 Gene

Gene Families for MIR3189 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR3189: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR3189 Gene

Function for MIR3189 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3189 Gene

Localization for MIR3189 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR3189 Gene

Pathways & Interactions for MIR3189 Gene

SuperPathways for MIR3189 Gene

No Data Available

Interacting Proteins for MIR3189 Gene

Gene Ontology (GO) - Biological Process for MIR3189 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR3189 Gene

Transcripts for MIR3189 Gene

mRNA/cDNA for MIR3189 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3189 Gene

No ASD Table

Relevant External Links for MIR3189 Gene

GeneLoc Exon Structure for
MIR3189
ECgene alternative splicing isoforms for
MIR3189

Expression for MIR3189 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR3189 Gene:

MIR3189
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR3189 Gene

Orthologs for MIR3189 Gene

Evolution for MIR3189 Gene

ENSEMBL:
Gene Tree for MIR3189 (if available)
TreeFam:
Gene Tree for MIR3189 (if available)

No data available for Orthologs for MIR3189 Gene

Paralogs for MIR3189 Gene

No data available for Paralogs for MIR3189 Gene

Variants for MIR3189 Gene

Sequence variations from dbSNP and Humsavar for MIR3189 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000290705 -- 18,386,761(+) GGGGT(C/G)GGGCG intron-variant, downstream-variant-500B
rs1002465534 -- 18,384,767(+) CTCTG(C/T)GGGGT upstream-variant-2KB
rs1003080580 -- 18,385,151(+) TTGTA(C/T)ATTTA upstream-variant-2KB
rs1004319159 -- 18,384,576(+) TGATC(C/T)GCCCG upstream-variant-2KB
rs1006702471 -- 18,385,017(+) TCAGG(A/C)GGAAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR3189 Gene

Variant ID Type Subtype PubMed ID
nsv2430 CNV deletion 18451855
nsv952420 CNV deletion 24416366

Relevant External Links for MIR3189 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3189

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR3189 Gene

Disorders for MIR3189 Gene

Relevant External Links for MIR3189

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR3189

No disorders were found for MIR3189 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR3189 Gene

Publications for MIR3189 Gene

  1. Growth differentiation factor-15 encodes a novel microRNA 3189 that functions as a potent regulator of cell death. (PMID: 25698447) Jones M.F. … Lal A. (Cell Death Differ. 2015) 3 64
  2. Anti-tumoral effects of miR-3189-3p in glioblastoma. (PMID: 25645911) Jeansonne D. … Peruzzi F. (J. Biol. Chem. 2015) 3 64
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  4. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  5. Characterization of the Melanoma miRNAome by Deep Sequencing. (PMID: 20300190) Stark M.S. … Hayward N.K. (PLoS ONE 2010) 3 64

Products for MIR3189 Gene

Sources for MIR3189 Gene

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