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Aliases for MIR3189 Gene

Subcategory (RNA class) for MIR3189 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR3189 Gene

  • MicroRNA 3189 2 3 5
  • Hsa-Mir-3189 3
  • Mir-3189 3

External Ids for MIR3189 Gene

Previous GeneCards Identifiers for MIR3189 Gene

  • GC19U901396
  • GC19P018497

Summaries for MIR3189 Gene

Entrez Gene Summary for MIR3189 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3189 Gene

MIR3189 (MicroRNA 3189) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR3189 Gene

Genomics for MIR3189 Gene

Regulatory Elements for MIR3189 Gene

Enhancers for MIR3189 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F018390 0.5 ENCODE 0.8 +4.5 4484 0.2 ZFP3 POLR2A ZNF175 CEBPB MIR3189 GC19P019220
GH19F018391 0.6 ENCODE 0.8 +3.7 3654 0.2 SOX13 ZMYM3 UBTF RAD21 YY1 CHAMP1 GATA4 NCOR1 GATAD1 GATA2 GDF15 PGPEP1 GC19P019220 MIR3189
GH19F018394 0.6 ENCODE 0.8 +4.1 4084 0.5 ZMYM3 ZNF175 YY1 GATA4 NCOR1 GATAD1 POLR2A TRIM24 PAF1 SMARCA5 GC19P019220 MIR3189
GH19F018372 1.3 FANTOM5 Ensembl ENCODE 0.4 -5.5 -5462 18.0 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 ENSG00000268030 COLGALT1 UPF1 ENSG00000268938 MVB12A ENSG00000269191 KXD1 IFI30 GDF15 PGLS
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR3189 on UCSC Golden Path with GeneCards custom track

Promoters for MIR3189 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001418313 938 3001 HDGF ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for MIR3189 Gene

Chromosome:
19
Start:
18,386,562 bp from pter
End:
18,386,634 bp from pter
Size:
73 bases
Orientation:
Plus strand

Genomic View for MIR3189 Gene

Genes around MIR3189 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR3189 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3189 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3189 Gene

Proteins for MIR3189 Gene

Post-translational modifications for MIR3189 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR3189 Gene

Domains & Families for MIR3189 Gene

Gene Families for MIR3189 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR3189: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR3189 Gene

Function for MIR3189 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3189 Gene

Localization for MIR3189 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR3189 Gene

Pathways & Interactions for MIR3189 Gene

SuperPathways for MIR3189 Gene

No Data Available

Interacting Proteins for MIR3189 Gene

Gene Ontology (GO) - Biological Process for MIR3189 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR3189 Gene

Transcripts for MIR3189 Gene

mRNA/cDNA for MIR3189 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3189 Gene

No ASD Table

Relevant External Links for MIR3189 Gene

GeneLoc Exon Structure for
MIR3189
ECgene alternative splicing isoforms for
MIR3189

Expression for MIR3189 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR3189 Gene:

MIR3189
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR3189 Gene

Orthologs for MIR3189 Gene

Evolution for MIR3189 Gene

ENSEMBL:
Gene Tree for MIR3189 (if available)
TreeFam:
Gene Tree for MIR3189 (if available)

No data available for Orthologs for MIR3189 Gene

Paralogs for MIR3189 Gene

No data available for Paralogs for MIR3189 Gene

Variants for MIR3189 Gene

Sequence variations from dbSNP and Humsavar for MIR3189 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1059369 -- 18,386,331(-) TTCGG(A/T)GTGCA upstream-variant-2KB, reference, missense
rs1059519 -- 18,386,214(-) ATTCA(C/G)CGTCC upstream-variant-2KB, reference, missense
rs111589486 -- 18,385,987(+) AGCTT(C/T)ACTAG upstream-variant-2KB, utr-variant-5-prime
rs113971422 -- 18,386,781(+) GGCAT(A/G)GTCCC intron-variant, downstream-variant-500B
rs114127150 -- 18,386,840(+) CATGG(A/G)TAGAA intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR3189 Gene

Variant ID Type Subtype PubMed ID
nsv2430 CNV deletion 18451855
nsv952420 CNV deletion 24416366

Relevant External Links for MIR3189 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3189

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR3189 Gene

Disorders for MIR3189 Gene

Relevant External Links for MIR3189

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR3189

No disorders were found for MIR3189 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR3189 Gene

Publications for MIR3189 Gene

  1. Anti-tumoral effects of miR-3189-3p in glioblastoma. (PMID: 25645911) Jeansonne D. … Peruzzi F. (J. Biol. Chem. 2015) 3 64
  2. Growth differentiation factor-15 encodes a novel microRNA 3189 that functions as a potent regulator of cell death. (PMID: 25698447) Jones M.F. … Lal A. (Cell Death Differ. 2015) 3 64
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  4. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  5. Characterization of the Melanoma miRNAome by Deep Sequencing. (PMID: 20300190) Stark M.S. … Hayward N.K. (PLoS ONE 2010) 3 64

Products for MIR3189 Gene

Sources for MIR3189 Gene

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