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MIR3180-4 Gene(RNA Gene)

MicroRNA 3180-4

GCID:
GC16M015154
GIFtS:
20
Genes Participants
UDN Logo

Aliases for MIR3180-4 Gene

Subcategory (RNA class) for MIR3180-4 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR3180-4 Gene

  • MicroRNA 3180-4 2 3 5
  • Hsa-Mir-3180-4 3
  • Mir-3180-4 3

External Ids for MIR3180-4 Gene

ORGUL Members for MIR3180-4 Gene

Previous GeneCards Identifiers for MIR3180-4 Gene

  • GC16U901272
  • GC16P015249
  • GC16M015251

Summaries for MIR3180-4 Gene

Entrez Gene Summary for MIR3180-4 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3180-4 Gene

MIR3180-4 (MicroRNA 3180-4) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR3180-4 Gene

Genomics for MIR3180-4 Gene

Products:

  1. Regulatory Element

Regulatory Elements for MIR3180-4 Gene

Enhancers for MIR3180-4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G015707 1.2 FANTOM5 ENCODE dbSUPER 4.7 -553.3 -553299 0.6 JUN BHLHE40 MAX MNT NR2F2 POLR2A PBX2 NR2C1 FOS MAFK ENSG00000263335 MIR3180-4 ENSG00000280206 GC16P015721
GH16G015736 0.4 dbSUPER 5.3 -582.3 -582283 1.2 ZNF623 ENSG00000263335 MIR3180-4 PIR53197 GC16P015735 ENSG00000263065
GH16G015740 0.4 dbSUPER 4.2 -586.6 -586635 2.0 SCRT2 NR2F6 ENSG00000263335 NDE1 MPV17L NPIPA5 MIR3180-4 ENSG00000263065 GC16M015749
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR3180-4 on UCSC Golden Path with GeneCards custom track

Promoters for MIR3180-4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000083780 502 1801 ELF3 HDGF TBP ARID4B DMAP1 EGR1 ZNF366 ZNF143 IKZF2 EGR2

Genomic Location for MIR3180-4 Gene

Chromosome:
16
Start:
15,154,850 bp from pter
End:
15,155,002 bp from pter
Size:
153 bases
Orientation:
Minus strand

Genomic View for MIR3180-4 Gene

Genes around MIR3180-4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR3180-4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3180-4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR3180-4 Gene

ORGUL Member Location for MIR3180-4 Gene

ORGUL Member Location for MIR3180-4 gene

Proteins for MIR3180-4 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR3180-4 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR3180-4 Gene

Domains & Families for MIR3180-4 Gene

Gene Families for MIR3180-4 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR3180-4: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR3180-4 Gene

Function for MIR3180-4 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3180-4 Gene

Localization for MIR3180-4 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR3180-4 Gene

Pathways & Interactions for MIR3180-4 Gene

SuperPathways for MIR3180-4 Gene

PathCards logo More details on SuperPathways for MIR3180-4
No Data Available

Interacting Proteins for MIR3180-4 Gene

Gene Ontology (GO) - Biological Process for MIR3180-4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR3180-4 Gene

Drugs & Compounds for MIR3180-4 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR3180-4 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR3180-4 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3180-4 Gene

No ASD Table

Relevant External Links for MIR3180-4 Gene

GeneLoc Exon Structure for
MIR3180-4
ECgene alternative splicing isoforms for
MIR3180-4

Expression for MIR3180-4 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR3180-4 Gene

mRNA expression in normal human tissues for MIR3180-4 Gene
mRNA expression by GTEx for MIR3180-4 Gene

mRNA differential expression in normal tissues according to GTEx for MIR3180-4 Gene

This gene is overexpressed in Testis (x4.8).
genes like me logo Genes that share expression patterns with MIR3180-4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR3180-4 Gene

Orthologs for MIR3180-4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR3180-4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia -- 35
  • 49 (a)
 OneToMany
Species where no ortholog for MIR3180-4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR3180-4 Gene

ENSEMBL:
Gene Tree for MIR3180-4 (if available)
TreeFam:
Gene Tree for MIR3180-4 (if available)

Paralogs for MIR3180-4 Gene

No data available for Paralogs for MIR3180-4 Gene

Variants for MIR3180-4 Gene

Sequence variations from dbSNP and Humsavar for MIR3180-4 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000040074 -- 15,154,566(+) GCATC(A/G)TTAGG downstream-variant-500B
rs1002271242 -- 15,156,821(+) CCTAA(C/T)TTAGG upstream-variant-2KB
rs1002837255 -- 15,155,214(+) GGCAT(A/G)GATCC upstream-variant-2KB
rs1002937208 -- 15,155,333(+) CCTGG(C/T)TAAGA upstream-variant-2KB
rs1004734617 -- 15,155,350(+) CAGAA(A/G)GAGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR3180-4 Gene

Variant ID Type Subtype PubMed ID
dgv2755n100 CNV gain 25217958
dgv2765n100 CNV gain 25217958
esv21621 CNV loss 19812545
esv2671608 CNV deletion 23128226
esv2758632 CNV gain+loss 17122850
esv2762254 CNV gain+loss 21179565
esv3570354 CNV gain 25503493
esv3638024 CNV loss 21293372
esv3638025 CNV gain 21293372
nsv1036298 CNV gain 25217958
nsv1038955 CNV loss 25217958
nsv1050325 CNV loss 25217958
nsv1053467 CNV loss 25217958
nsv511045 OTHER complex 20534489
nsv7277 OTHER inversion 18451855
nsv9359 CNV gain+loss 18304495
nsv952934 CNV deletion 24416366
nsv977911 CNV duplication 23825009

Relevant External Links for MIR3180-4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3180-4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR3180-4 Gene

Disorders for MIR3180-4 Gene

Relevant External Links for MIR3180-4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR3180-4

No disorders were found for MIR3180-4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR3180-4 Gene

Publications for MIR3180-4 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  2. Discovery of novel microRNAs in female reproductive tract using next generation sequencing. (PMID: 20224791) Creighton C.J. … Gunaratne P.H. (PLoS ONE 2010) 3 64
  3. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR3180-4 Gene

Sources for MIR3180-4 Gene

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