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Aliases for MIR3175 Gene

Subcategory (RNA class) for MIR3175 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR3175 Gene

  • MicroRNA 3175 2 3
  • Chromodomain Helicase DNA Binding Protein 2 5
  • ATP-Dependent Helicase CHD2 4
  • Hsa-Mir-3175 3
  • EC 3.6.4.12 4
  • Mir-3175 3
  • EC 3.6.1 61
  • CHD-2 4
  • CHD2 5

External Ids for MIR3175 Gene

Previous GeneCards Identifiers for MIR3175 Gene

  • GC15U901249
  • GC15P093447
  • GC15P092904
  • GC15P094457

Summaries for MIR3175 Gene

Entrez Gene Summary for MIR3175 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3175 Gene

MIR3175 (MicroRNA 3175) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR3175 include Epileptic Encephalopathy, Childhood-Onset. An important paralog of this gene is CHD1.

UniProtKB/Swiss-Prot for MIR3175 Gene

  • DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR3175 Gene

Genomics for MIR3175 Gene

Regulatory Elements for MIR3175 Gene

Enhancers for MIR3175 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F092898 0.4 ENCODE 0.4 +9.0 8981 20.4 CREB3L1 MLX FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 FAM174B ASB9P1 HMGN1P38 CHD2 MIR3175 LOC105370979
GH15F092924 0.2 ENCODE 0.3 +25.6 25605 1.6 ZNF121 GLIS1 CHD2 MIR3175 LOC105370979
GH15F092919 0.4 ENCODE 0.3 +21.6 21558 3.5 JUN BACH1 RFX5 ZNF664 ZNF316 SCRT2 NFE2 FOSL2 FOS MAFK FAM174B CHD2 MIR3175 LOC105370979
GH15F092929 1.1 ENCODE 0.3 +30.5 30503 2.0 GATA3 JUND PKNOX1 PBX2 FEZF1 FOS PRDM1 ZNF652 SP7 CHD2 MIR3175 LOC105370979
GH15F092933 0.6 ENCODE 0.3 +33.2 33217 0.2 GATA3 HLF DPF2 FOS MAFK RARA CHD2 FAM174B MIR3175 LOC105370979
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR3175 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR3175 Gene

Chromosome:
15
Start:
92,900,189 bp from pter
End:
93,028,005 bp from pter
Size:
127,817 bases
Orientation:
Plus strand

Genomic View for MIR3175 Gene

Genes around MIR3175 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR3175 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3175 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3175 Gene

Proteins for MIR3175 Gene

  • Protein details for MIR3175 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14647-CHD2_HUMAN
    Recommended name:
    Chromodomain-helicase-DNA-binding protein 2
    Protein Accession:
    O14647
    Secondary Accessions:
    • C6G482
    • Q96IP5

    Protein attributes for MIR3175 Gene

    Size:
    1828 amino acids
    Molecular mass:
    211344 Da
    Quaternary structure:
    • Interacts with MYOD1. Interacts with histone H3.3 (By similarity).
    • Interacts with MYOD1. Interacts with histone H3.3 (By similarity).

    Alternative splice isoforms for MIR3175 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR3175 Gene

Selected DME Specific Peptides for MIR3175 Gene

O14647:
  • VLIFSQMVR
  • DSDWNPQ
  • IFDSDWNP
  • FLLSTRA
  • DEMGLGKT
  • ERMRPVK
  • AGGLGINL
  • DEAHRLK
  • TGTPLQN
  • RVLIFSQM
  • RAHRIGQ
  • LLHFIMP
  • LSTRAGGLG
  • MGLGKTIQ

Post-translational modifications for MIR3175 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for MIR3175 Gene

Gene Families for MIR3175 Gene

Graphical View of Domain Structure for InterPro Entry

O14647

UniProtKB/Swiss-Prot:

CHD2_HUMAN :
  • Contains 2 chromo domains.
  • Belongs to the SNF2/RAD54 helicase family.
Domain:
  • Contains 2 chromo domains.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
Family:
  • Belongs to the SNF2/RAD54 helicase family.
genes like me logo Genes that share domains with MIR3175: view

No data available for Suggested Antigen Peptide Sequences for MIR3175 Gene

Function for MIR3175 Gene

Molecular function for MIR3175 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity).

Enzyme Numbers (IUBMB) for MIR3175 Gene

Gene Ontology (GO) - Molecular Function for MIR3175 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001046 core promoter sequence-specific DNA binding IEA --
GO:0003677 DNA binding IEA --
GO:0004003 ATP-dependent DNA helicase activity TAS --
GO:0004386 helicase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MIR3175: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3175 Gene

Localization for MIR3175 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR3175 Gene

Nucleus. Note=Binds to myogenic gene promoters. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for MIR3175 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
GO:0070062 extracellular exosome IDA --
genes like me logo Genes that share ontologies with MIR3175: view

No data available for Subcellular locations from COMPARTMENTS for MIR3175 Gene

Pathways & Interactions for MIR3175 Gene

SuperPathways for MIR3175 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MIR3175 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0007517 muscle organ development ISS --
genes like me logo Genes that share ontologies with MIR3175: view

No data available for Pathways by source and SIGNOR curated interactions for MIR3175 Gene

Transcripts for MIR3175 Gene

mRNA/cDNA for MIR3175 Gene

(30) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3175 Gene

No ASD Table

Relevant External Links for MIR3175 Gene

GeneLoc Exon Structure for
MIR3175
ECgene alternative splicing isoforms for
MIR3175

Expression for MIR3175 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR3175 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR3175 Gene:

MIR3175
genes like me logo Genes that share expression patterns with MIR3175: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR3175 Gene

Orthologs for MIR3175 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIR3175 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHD2 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHD2 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHD2 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chd2 35
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHD2 35
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHD2 35
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHD2 35
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHD2 35
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii chd2 35
  • 74 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Chd1 35
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea chd-1 35
  • 48 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CHD1 35
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 55 (a)
OneToMany
Species where no ortholog for MIR3175 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR3175 Gene

ENSEMBL:
Gene Tree for MIR3175 (if available)
TreeFam:
Gene Tree for MIR3175 (if available)

Paralogs for MIR3175 Gene

Paralogs for MIR3175 Gene

genes like me logo Genes that share paralogs with MIR3175: view

Variants for MIR3175 Gene

Sequence variations from dbSNP and Humsavar for MIR3175 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10852185 -- 92,904,085(+) TTCCC(A/C)CTCTC intron-variant, upstream-variant-2KB
rs111735136 -- 92,904,517(+) GTTGG(C/G)ACTTT intron-variant, downstream-variant-500B
rs111796093 -- 92,904,571(+) CTTGT(C/T)CGCCC intron-variant, downstream-variant-500B
rs111969873 -- 92,902,466(+) AAATA(A/G)TACAC intron-variant, upstream-variant-2KB
rs112453692 -- 92,904,057(+) GAAAT(C/G)TGAAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR3175 Gene

Variant ID Type Subtype PubMed ID
dgv2660n100 CNV gain 25217958

Relevant External Links for MIR3175 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3175

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR3175 Gene

Disorders for MIR3175 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR3175 Gene - From: GeneCards

Disorder Aliases PubMed IDs
epileptic encephalopathy, childhood-onset
  • childhood onset epileptic encephalopathy
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

CHD2_HUMAN
  • Epileptic encephalopathy, childhood-onset (EEOC) [MIM:615369]: A severe form of epilepsy characterized by onset of multiple seizure types in the first few years of life and associated with poor prognosis. Affected individuals have cognitive regression and intellectual disability. {ECO:0000269 PubMed:23708187}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MIR3175

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR3175
genes like me logo Genes that share disorders with MIR3175: view

No data available for Genatlas for MIR3175 Gene

Publications for MIR3175 Gene

  1. HOXB1 Is a Tumor Suppressor Gene Regulated by miR-3175 in Glioma. (PMID: 26565624) Han L. … Tian Y. (PLoS ONE 2015) 3 64
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  3. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  4. Targeted resequencing in epileptic encephalopathies identifies de novo mutations in CHD2 and SYNGAP1. (PMID: 23708187) Carvill G.L. … Mefford H.C. (Nat. Genet. 2013) 4 64
  5. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64

Products for MIR3175 Gene

Sources for MIR3175 Gene

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