Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR3127 Gene

Subcategory (RNA class) for MIR3127 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR3127 Gene

  • MicroRNA 3127 2 3 5
  • Hsa-Mir-3127 3
  • Mir-3127 3

External Ids for MIR3127 Gene

Previous GeneCards Identifiers for MIR3127 Gene

  • GC02U902172
  • GC02P097464

Summaries for MIR3127 Gene

Entrez Gene Summary for MIR3127 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3127 Gene

MIR3127 (MicroRNA 3127) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR3127 Gene

Genomics for MIR3127 Gene

Regulatory Elements for MIR3127 Gene

Enhancers for MIR3127 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F096800 1.2 Ensembl ENCODE 0.8 +2.9 2880 1.7 HDGF ELF3 ARID4B SIN3A YBX1 ZNF48 ZSCAN9 ZNF2 RAD21 GLIS2 LMAN2L CNNM4 SEMA4C MIR3127 PIR40637
GH02F096802 0.8 Ensembl ENCODE 0.8 +4.2 4173 0.6 HDGF CTCF ETS2 EGR1 POLR2A TSC22D4 FOXA1 LMAN2L CNNM4 MIR3127 PIR40637
GH02F096806 1.1 FANTOM5 Ensembl ENCODE 0.4 +8.6 8586 1.4 NRF1 ZBTB33 MLLT1 ZNF652 ZNF7 LMAN2L CNNM4 SNRNP200 ANKRD36 CNNM3 ARID5A KANSL3 PIR40637 MIR3127
GH02F096786 1.1 Ensembl ENCODE 0.4 -10.2 -10200 3.2 TBP PKNOX1 RFX5 ZNF121 ZNF366 RCOR1 FOS ZNF362 CEBPB NR2F2 ENSG00000278766 LMAN2L MIR3127 CNNM4
GH02F096772 1.1 Ensembl ENCODE 0.3 -24.6 -24578 2.2 HDGF CTCF IRF2 USF1 ZNF223 EBF1 RAD21 ZFHX2 EGR1 EED LMAN2L CIAO1 GPAT2P1 CNNM4 MIR3127
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR3127 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR3127 Gene

Chromosome:
2
Start:
96,798,278 bp from pter
End:
96,798,353 bp from pter
Size:
76 bases
Orientation:
Plus strand

Genomic View for MIR3127 Gene

Genes around MIR3127 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR3127 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3127 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3127 Gene

Proteins for MIR3127 Gene

Post-translational modifications for MIR3127 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR3127 Gene

Domains & Families for MIR3127 Gene

Gene Families for MIR3127 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR3127: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR3127 Gene

Function for MIR3127 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3127 Gene

Localization for MIR3127 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR3127 Gene

Pathways & Interactions for MIR3127 Gene

SuperPathways for MIR3127 Gene

No Data Available

Interacting Proteins for MIR3127 Gene

Gene Ontology (GO) - Biological Process for MIR3127 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR3127 Gene

Transcripts for MIR3127 Gene

mRNA/cDNA for MIR3127 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3127 Gene

No ASD Table

Relevant External Links for MIR3127 Gene

GeneLoc Exon Structure for
MIR3127
ECgene alternative splicing isoforms for
MIR3127

Expression for MIR3127 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR3127 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR3127 Gene:

MIR3127
genes like me logo Genes that share expression patterns with MIR3127: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR3127 Gene

Orthologs for MIR3127 Gene

Evolution for MIR3127 Gene

ENSEMBL:
Gene Tree for MIR3127 (if available)
TreeFam:
Gene Tree for MIR3127 (if available)

No data available for Orthologs for MIR3127 Gene

Paralogs for MIR3127 Gene

No data available for Paralogs for MIR3127 Gene

Variants for MIR3127 Gene

Sequence variations from dbSNP and Humsavar for MIR3127 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs111368952 -- 96,798,540(+) CTGCC(C/T)GCTCT intron-variant, downstream-variant-500B
rs112709649 -- 96,798,781(+) GAGGA(A/T)ACTGA intron-variant, downstream-variant-500B
rs114963520 -- 96,796,491(+) GCGTG(A/G)TGGCT intron-variant, upstream-variant-2KB
rs115256822 -- 96,798,831(+) CTTGC(A/G)GGAGC intron-variant, downstream-variant-500B
rs115538141 -- 96,797,291(+) CTGCA(C/G)TGGCC intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR3127 Gene

Variant ID Type Subtype PubMed ID
dgv607e201 CNV deletion 23290073
esv3425717 CNV duplication 20981092
esv5003 OTHER complex 18987735
nsv1135873 CNV deletion 24896259
nsv526313 CNV loss 19592680
nsv834307 CNV loss 17160897

Relevant External Links for MIR3127 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3127

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR3127 Gene

Disorders for MIR3127 Gene

Relevant External Links for MIR3127

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR3127

No disorders were found for MIR3127 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR3127 Gene

Publications for MIR3127 Gene

  1. MicroRNA-3127 promotes cell proliferation and tumorigenicity in hepatocellular carcinoma by disrupting of PI3K/AKT negative regulation. (PMID: 25849943) Jiang J. … Sun C. (Oncotarget 2015) 3 64
  2. Reduced miR-3127-5p expression promotes NSCLC proliferation/invasion and contributes to dasatinib sensitivity via the c-Abl/Ras/ERK pathway. (PMID: 25284075) Sun Y. … Gao W. (Sci Rep 2014) 3 64
  3. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  4. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  5. Characterization of the Melanoma miRNAome by Deep Sequencing. (PMID: 20300190) Stark M.S. … Hayward N.K. (PLoS ONE 2010) 3 64

Products for MIR3127 Gene

Sources for MIR3127 Gene

Content
Loading form....