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Aliases for MIR31 Gene

Subcategory (RNA class) for MIR31 Gene


Quality Score for this RNA gene is


Aliases for MIR31 Gene

  • MicroRNA 31 2 3 5
  • Hsa-Mir-31 3
  • MiR-31 3
  • MIRN31 3

External Ids for MIR31 Gene

Previous HGNC Symbols for MIR31 Gene

  • MIRN31

Summaries for MIR31 Gene

Entrez Gene Summary for MIR31 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR31 Gene

MIR31 (MicroRNA 31) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR31 Gene

Genomics for MIR31 Gene

Regulatory Elements for MIR31 Gene

Enhancers for MIR31 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F021490 0.5 Ensembl 12.1 +22.0 21985 0.4 MIR31 MTAP IFNE GC09P021512
GH09F021542 1.1 Ensembl ENCODE 11.6 -31.2 -31179 1.5 MAFF TEAD4 MAFK MIR31 IFNE GC09M021524 MIR31HG
GH09F021547 0.9 Ensembl ENCODE 11 -42.8 -42799 14.6 PKNOX1 SIN3A FEZF1 ZNF2 ZNF121 GLIS2 ZNF302 FOS SP3 CBX8 MIR31 IFNE MIR31HG GC09M021524
GH09F021548 0.2 Ensembl 10.5 -35.1 -35116 0.2 FEZF1 MIR31 MIR31HG GC09M021524
GH09F021573 1.3 FANTOM5 Ensembl ENCODE 10.4 -71.7 -71731 20.1 PKNOX1 SIN3A FEZF1 GTF3C2 ZNF121 FOS DEK TSHZ1 MAFF ZNF610 FOCAD MIR31 IFNW1 IFNA1 IFNA6 MIR31HG ENSG00000227443
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR31 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR31 Gene

21,512,115 bp from pter
21,512,185 bp from pter
71 bases
Minus strand

Genomic View for MIR31 Gene

Genes around MIR31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR31 Gene

ORGUL Member Location for MIR31 Gene

ORGUL Member Location for MIR31 gene

Proteins for MIR31 Gene

Post-translational modifications for MIR31 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR31 Gene

Domains & Families for MIR31 Gene

Gene Families for MIR31 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR31: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR31 Gene

Function for MIR31 Gene

Animal Model Products

miRNA Products

Clone Products

  • Addgene plasmids for MIR31

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR31 Gene

Localization for MIR31 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR31 Gene

Pathways & Interactions for MIR31 Gene

SuperPathways for MIR31 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR31: view

Pathways by source for MIR31 Gene

1 KEGG pathway for MIR31 Gene

Interacting Proteins for MIR31 Gene

Gene Ontology (GO) - Biological Process for MIR31 Gene


No data available for SIGNOR curated interactions for MIR31 Gene

Transcripts for MIR31 Gene

mRNA/cDNA for MIR31 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

  • Addgene plasmids for MIR31

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR31 Gene

No ASD Table

Relevant External Links for MIR31 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR31 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR31 Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR31 Gene

Orthologs for MIR31 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR31 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-31 35
  • 100 (a)
(Canis familiaris)
Mammalia cfa-mir-31 35
  • 99 (a)
(Monodelphis domestica)
Mammalia mdo-mir-31 35
  • 78 (a)
(Bos Taurus)
Mammalia bta-mir-31 35
  • 72 (a)
(Mus musculus)
Mammalia Mir31 35
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-31 35
  • 45 (a)
(Gallus gallus)
Aves gga-mir-31 35
  • 67 (a)
(Anolis carolinensis)
Reptilia aca-mir-31 35
  • 60 (a)
(Danio rerio)
Actinopterygii dre-mir-31 35
  • 75 (a)
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-31 35
  • 49 (a)
Species where no ortholog for MIR31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR31 Gene

Gene Tree for MIR31 (if available)
Gene Tree for MIR31 (if available)

Paralogs for MIR31 Gene

No data available for Paralogs for MIR31 Gene

Variants for MIR31 Gene

Sequence variations from dbSNP and Humsavar for MIR31 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs112379215 -- 21,514,074(+) CCAGG(C/T)ATGGT intron-variant, upstream-variant-2KB
rs112868499 -- 21,511,648(+) ACTCT(A/G)AGGAT intron-variant, downstream-variant-500B
rs117131243 -- 21,513,784(+) TAAGG(A/G)TATTT intron-variant, upstream-variant-2KB
rs13283671 -- 21,511,741(+) AAATA(C/T)GTTTC intron-variant, downstream-variant-500B
rs139664097 -- 21,512,280(+) ATTAA(G/T)TGAAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR31 Gene

Variant ID Type Subtype PubMed ID
dgv7475n100 CNV loss 25217958
esv2759680 CNV loss 17122850
esv2764150 CNV gain+loss 21179565

Relevant External Links for MIR31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR31 Gene

Disorders for MIR31 Gene

Relevant External Links for MIR31

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR31 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR31 Gene

Publications for MIR31 Gene

  1. MicroRNA-31 initiates lung tumorigenesis and promotes mutant KRAS-driven lung cancer. (PMID: 26657862) Edmonds M.D. … Eischen C.M. (J. Clin. Invest. 2016) 3 64
  2. MiR-31 Functions as a Tumor Suppressor in Lung Adenocarcinoma Mainly by Targeting HuR. (PMID: 27215092) Xu H. … Xu S. (Clin. Lab. 2016) 3 64
  3. MicroRNA Expression Signatures Associated With BRAF-Mutated Versus KRAS-Mutated Colorectal Cancers. (PMID: 27082577) Choi Y.W. … Lee D. (Medicine (Baltimore) 2016) 3 64
  4. miR-31 and miR-17-5p levels change during transformation of follicular lymphoma. (PMID: 26997445) Thompson M.A. … Eischen C.M. (Hum. Pathol. 2016) 3 64
  5. Down-regulation of MicroRNA-31 in CD4+ T Cells Contributes to Immunosuppression in Human Sepsis by Promoting TH2 Skewing. (PMID: 26978146) van der Heide V. … Kreth S. (Anesthesiology 2016) 3 64

Products for MIR31 Gene

Sources for MIR31 Gene

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