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Aliases for MIR30E Gene

Subcategory (RNA class) for MIR30E Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR30E Gene

  • MicroRNA 30e 2 3 5
  • Hsa-Mir-30e 3
  • Mir-30e 3
  • MIRN30E 3

External Ids for MIR30E Gene

ORGUL Members for MIR30E Gene

Previous HGNC Symbols for MIR30E Gene

  • MIRN30E

Previous GeneCards Identifiers for MIR30E Gene

  • GC01P040993
  • GC01P041220

Summaries for MIR30E Gene

Entrez Gene Summary for MIR30E Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR30E Gene

MIR30E (MicroRNA 30e) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNA targets in ECM and membrane receptors and MicroRNAs in cardiomyocyte hypertrophy.

Additional gene information for MIR30E Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR30E Gene

Genomics for MIR30E Gene

Regulatory Elements for MIR30E Gene

Enhancers for MIR30E Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H040708 1.7 FANTOM5 ENCODE dbSUPER 11.2 -43.1 -43117 6 PKNOX1 FOXA2 ARNT SIN3A ARID4B FEZF1 DMAP1 YY1 SLC30A9 ZNF143 EXO5 RLF RIMS3 LOC105378674 MIR30E MIR30C1 TRIT1 ZFP69 NFYC KCNQ4
GH01H040698 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -54.8 -54813 1 HDGF ATF1 ZBTB40 BATF ZNF121 FOS ATF7 RUNX3 CREM IKZF2 RIMS3 LOC105378674 MIR30E MIR30C1 NFYC ZNF684 KCNQ4 EXO5 CITED4 ZFP69
GH01H040801 1.5 Ensembl ENCODE dbSUPER 11.1 +48.3 48302 2 HDGF ATF1 ARNT GLIS2 ZNF207 ATF7 SP3 NCOA1 SMARCA4 RCOR2 MIR30C1 MIR30E NFYC KCNQ4 NFYC-AS1 GC01M040775
GH01H040690 1.4 ENCODE dbSUPER 11.1 -61.7 -61654 4 ZFP64 DMAP1 YY1 SLC30A9 SP3 NFYC MEF2D ZNF610 GLIS1 NBN ENSG00000259943 RIMS3 EXO5 NFYC-AS1 RLF LOC105378674 ZFP69 SLFNL1 TRIT1 MIR30C1
GH01H040948 1.4 Ensembl ENCODE dbSUPER 11 +194.5 194548 1 PKNOX1 ARNT DEAF1 SIN3A RAD21 ZNF143 FOS DEK THAP11 ZNF654 CITED4 ENSG00000229528 MIR30C1 MIR30E NFYC ENSG00000235358 GC01P040947 GC01M040907
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR30E on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR30E Gene

Chromosome:
1
Start:
40,754,355 bp from pter
End:
40,754,446 bp from pter
Size:
92 bases
Orientation:
Plus strand

Genomic View for MIR30E Gene

Genes around MIR30E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR30E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR30E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR30E Gene

Proteins for MIR30E Gene

Post-translational modifications for MIR30E Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR30E Gene

Domains & Families for MIR30E Gene

Gene Families for MIR30E Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR30E: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR30E Gene

Function for MIR30E Gene

Phenotypes From GWAS Catalog for MIR30E Gene

Gene Ontology (GO) - Molecular Function for MIR30E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 25950484
genes like me logo Genes that share ontologies with MIR30E: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MIR30E
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR30E Gene

Localization for MIR30E Gene

Gene Ontology (GO) - Cellular Components for MIR30E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR30E: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR30E Gene

Pathways & Interactions for MIR30E Gene

genes like me logo Genes that share pathways with MIR30E: view

Pathways by source for MIR30E Gene

Interacting Proteins for MIR30E Gene

Gene Ontology (GO) - Biological Process for MIR30E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010667 negative regulation of cardiac muscle cell apoptotic process ISS --
GO:0035195 gene silencing by miRNA IDA 25950484
GO:1901205 negative regulation of adrenergic receptor signaling pathway involved in heart process ISS --
genes like me logo Genes that share ontologies with MIR30E: view

No data available for SIGNOR curated interactions for MIR30E Gene

Drugs & Compounds for MIR30E Gene

No Compound Related Data Available

Transcripts for MIR30E Gene

mRNA/cDNA for MIR30E Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MIR30E
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR30E Gene

No ASD Table

Relevant External Links for MIR30E Gene

GeneLoc Exon Structure for
MIR30E
ECgene alternative splicing isoforms for
MIR30E

Expression for MIR30E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR30E Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR30E Gene:

MIR30E
genes like me logo Genes that share expression patterns with MIR30E: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR30E Gene

Orthologs for MIR30E Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR30E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-30e 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir30e 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-30e 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-30e 34
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-30d 34
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-30e 34
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-30e 34
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-30e 34
  • 83 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-30d 34
  • 42 (a)
ManyToMany
Species where no ortholog for MIR30E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR30E Gene

ENSEMBL:
Gene Tree for MIR30E (if available)
TreeFam:
Gene Tree for MIR30E (if available)

Paralogs for MIR30E Gene

No data available for Paralogs for MIR30E Gene

Variants for MIR30E Gene

Sequence variations from dbSNP and Humsavar for MIR30E Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1001995007 -- 40,753,938(+) ACTAG(C/T)TGTTT intron-variant, upstream-variant-2KB
rs1002307088 -- 40,753,685(+) TAGTA(C/T)CCTGA intron-variant, upstream-variant-2KB
rs1005941621 -- 40,754,749(+) ACTGG(C/T)TGGAG intron-variant, downstream-variant-500B
rs1007484302 -- 40,754,246(+) GCATC(C/T)TAATG intron-variant, upstream-variant-2KB
rs1009120321 -- 40,752,954(+) TCTCT(C/T)TCTTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR30E Gene

Variant ID Type Subtype PubMed ID
esv3577821 CNV loss 25503493

Relevant External Links for MIR30E Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR30E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR30E Gene

Disorders for MIR30E Gene

Relevant External Links for MIR30E

Genetic Association Database (GAD)
MIR30E
Human Genome Epidemiology (HuGE) Navigator
MIR30E
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR30E

No disorders were found for MIR30E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR30E Gene

Publications for MIR30E Gene

  1. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y … Liu P (Schizophrenia research 2010) 3 45 60
  2. A polymorphism in the microRNA-30e precursor associated with major depressive disorder risk and P300 waveform. (PMID: 20579744) Xu Y … Zhang K (Journal of affective disorders 2010) 3 45 60
  3. Effect of MicroRNA-30e on the Behavior of Vascular Smooth Muscle Cells via Targeting Ubiquitin-Conjugating Enzyme E2I. (PMID: 28123167) Zong Y … Li D (Circulation journal : official journal of the Japanese Circulation Society 2017) 3 60
  4. SOX2 regulates multiple malignant processes of breast cancer development through the SOX2/miR-181a-5p, miR-30e-5p/TUSC3 axis. (PMID: 28288641) Liu K … Lan X (Molecular cancer 2017) 3 60
  5. Association of MicroRNAs and YRNAs With Platelet Function. (PMID: 26646931) Kaudewitz D … Mayr M (Circulation research 2016) 3 60

Products for MIR30E Gene

Sources for MIR30E Gene

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