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MIR30D Gene

RNA gene   GIFtS: 22
GCID: GC08M135889

MicroRNA 30d


(Previous symbol: MIRN30D)
  Search for MIR30D
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Subcategory (RNA class): miRNA

Quality score for this RNA gene is 8.2

Aliases
MicroRNA 30d1 2
MIRN30D1 2
mir-30d9

External Ids:    HGNC: 316281   Entrez Gene: 4070332   Ensembl: ENSG000001991537   
ORGUL members:    fRNAdb10:FR253482 FR253482      
miRBase: MIMAT0000245 MIMAT0004551 MI0000255    
RNAdb15:EVF25279    

Export aliases for MIR30D gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MIR30D Gene:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of
gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are
transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can
be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme
to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the
cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The
mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through
imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of
the target mRNA. The RefSeq represents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)

GeneCards Summary for MIR30D Gene:
MIR30D (microRNA 30d) is an RNA gene, and is affiliated with the miRNA class.



fRNAdb sequence ontology for MIR30D:
nc_conserved_region - Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR30D

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for MIR30D
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MIR30D

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIR30D


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.22   Ensembl cytogenetic band:  8q24.22   HGNC cytogenetic band: 8q24.22

MIR30D Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIR30D gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M135889:  view genomic region (via miRBase)     (about GC identifiers)

Start:
135,817,119 bp from pter      End:
135,817,188 bp from pter
Size:
70 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
MIR: ncRNAs / Micro RNAs

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for MIR30D About    
See pathways by source

SuperPathContained pathways About
1MicroRNAs in cancer
MicroRNAs in cancer


Find genes that share SuperPaths with MIR30D           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



1 Kegg Pathway  (Kegg details for MIR30D):
    MicroRNAs in cancer

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MIR30D
Interactions:

    Search GeneGlobe Interaction Network for MIR30D

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MIR30D



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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1 fRNAdb Secondary structure:


1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000362283(miRNA)
miRNA
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for MIR30D:miRBase

See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

MIR30D Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
    Custom PCR Arrays for MIR30D
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for MIR30D gene from Selected species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves gga-mir-30d6
gga-mir-30d
89(a)
1 ↔ 1
2(142229501-142229564) ENSGALG00000018290
lizard
(Anolis carolinensis)
Reptilia aca-mir-30d6
aca-mir-30d
63(a)
1 ↔ 1
4(1751101-1751196)
zebrafish
(Danio rerio)
Actinopterygii dre-mir-30a6
dre-mir-30a
67(a)
1 ↔ 1
19(4497677-4497765)
        Species with no ortholog for MIR30D

ENSEMBL Gene Tree for MIR30D (if available)
TreeFam Gene Tree for MIR30D (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MIR30D (see all 66)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs7603421,2
H--135816648(-) GTCCTC/TTTAGC 1 -- ds50014Minor allele frequency- T:0.00NS EA 420
rs1436855141,2
--135816653(+) GAGGAC/TGGAGA 1 -- ds50010--------
rs105056311,2
C,F,H--135816719(+) GCATAC/TTGCTG 1 -- ds500117Minor allele frequency- T:0.04NS EA NA CSA WA 792
rs1510759581,2
--135816731(+) GTGGTA/TGTGAT 1 -- ds50010--------
rs1815432021,2
--135816871(+) AGGAAC/TAGGCG 1 -- ds50010--------
rs766326041,2
F--135816941(+) AAGCTC/TGAGAC 1 -- ds50011Minor allele frequency- T:0.02WA 118
rs412723931,2
C,F--135816955(+) ATATCC/TTGTTA 1 -- ds50011Minor allele frequency- T:0.04NA 120
rs1136595761,2
C,F--135817086(+) GGACAG/CAATTA 1 -- ds50012Minor allele frequency- C:0.04CSA WA 120
rs1425294581,2
--135817113(+) GTGAAC/TAGCCG 1 -- ds50010--------
rs1858024101,2
--135817129(+) AGCAAA/GCATCT 1 -- nc-transcript-variant0--------

HapMap Linkage Disequilibrium report for MIR30D (135817119 - 135817188 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for MIR30D:    About this table    
Variant IDTypeSubtypePubMed ID
nsv891474CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing MIR30D
DNA2.0 Custom Variant and Variant Library Synthesis for MIR30D

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MIR30D gene, integrated from 10 sources (see all 19):
(articles sorted by number of sources associating them with MIR30D)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Regulation of autophagy by miR-30d impacts sensitivity of anaplastic thyroid carcinoma to cisplatin. (PubMed id 24345332)1 Zhang Y....Yang J.M. (Biochem. Pharmacol. 2014)
  2. EZH2-miR-30d-KPNB1 pathway regulates malignant peripheral nerve sheath tumour cell survival and tumourigenesis. (PubMed id 24132643)1 Zhang P....Pollock R.E. (J. Pathol. 2014)
  3. miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer. (PubMed id 23085757)1 Su S.F....Liang G. (Oncogene 2013)
  4. mir-30d Regulates multiple genes in the autophagy pathway and impairs autophagy process in human cancer cells. (PubMed id 23274497)1 Yang X....Zhang L. (Biochem. Biophys. Res. Commun. 2013)
  5. MiR-30d induces apoptosis and is regulated by the Akt/FOXO pathway in renal cell carcinoma. (PubMed id 23416459)1 Wu C....Mao Z. (Cell. Signal. 2013)
  6. Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci. (PubMed id 24001895)1 Kelly T.N....He J. (Hypertension 2013)
  7. Evaluation of dynamic change of serum miR-21 and miR-24 in pre- and post-operative lung carcinoma patients. (PubMed id 22782668)1 Le H.B....Zhang Y.K. (Med. Oncol. 2012)
  8. Identification of miR-30d as a novel prognostic maker of prostate cancer. (PubMed id 23231923)1 Kobayashi N....Ishiguro H. (Oncotarget 2012)
  9. A combined array-based comparative genomic hybridization and functional library screening approach identifies mir-30d as an oncomir in cancer. (PubMed id 22058146)1 Li N....Zhang L. (Cancer Res. 2012)
  10. Urinary microRNA-10a and microRNA-30d serve as novel, sensitive and specific biomarkers for kidney injury. (PubMed id 23272089)1 Wang N....Zen K. (PLoS ONE 2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 407033 HGNC: 31628 Ensembl:ENSG00000199153 miRBase: hsa-mir-30d euGenes: HUgn407033
ECgene: MIR30D Kegg: 407033 H-InvDB: MIR30D

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MIR30D Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MIR30D gene:
Search GeneIP for patents involving MIR30D

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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