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Aliases for MIR30D Gene

Subcategory (RNA class) for MIR30D Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR30D Gene

  • MicroRNA 30d 2 3 5
  • Hsa-Mir-30d 3
  • Mir-30d 3
  • MIRN30D 3

External Ids for MIR30D Gene

Previous HGNC Symbols for MIR30D Gene

  • MIRN30D

Previous GeneCards Identifiers for MIR30D Gene

  • GC08M135889

Summaries for MIR30D Gene

Entrez Gene Summary for MIR30D Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR30D Gene

MIR30D (MicroRNA 30d) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR30D Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR30D

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR30D Gene

Genomics for MIR30D Gene

Regulatory Elements for MIR30D Gene

Enhancers for MIR30D Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F134830 1.5 FANTOM5 ENCODE 11.2 -27.2 -27166 4.1 HDGF PKNOX1 ARNT MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ENSG00000259820 ZFAT MIR30D MIR30B ENSG00000254028 LOC102723694
GH08F134733 1.3 FANTOM5 Ensembl ENCODE 10.3 +70.1 70106 1.8 SIX4 ESRRA PKNOX1 MAX FEZF1 RAD21 ZNF7 GATA3 CTBP1 GATA2 MIR30B MIR30D LOC105375774 ENSG00000278898
GH08F134777 1.2 FANTOM5 Ensembl ENCODE 11.1 +25.3 25309 4.8 CTCF JUN RAD21 JUND SMARCA4 ATF3 FOSL2 BCL6 FOS TRIM28 MIR30B MIR30D GC08P134784 ENSG00000278898
GH08F134754 0.9 ENCODE 11 +50.7 50743 0.3 ELF3 ATF1 ARID4B THRB ZSCAN9 RAD21 RARA YY1 GATA4 CREM MIR30B MIR30D ENSG00000278898 LOC105375774
GH08F134886 0.8 ENCODE 9.6 -81.7 -81658 0.2 SOX13 CTCF ZNF384 RAD21 ZNF316 FOXK2 ZNF143 SMC3 MAFK CREM MIR30B MIR30D PIR33431 GC08M134943
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR30D on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR30D Gene

Chromosome:
8
Start:
134,804,876 bp from pter
End:
134,804,945 bp from pter
Size:
70 bases
Orientation:
Minus strand

Genomic View for MIR30D Gene

Genes around MIR30D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR30D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR30D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR30D Gene

ORGUL Member Location for MIR30D Gene

ORGUL Member Location for MIR30D gene

Proteins for MIR30D Gene

Post-translational modifications for MIR30D Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR30D Gene

Domains & Families for MIR30D Gene

Gene Families for MIR30D Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR30D: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR30D Gene

Function for MIR30D Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR30D Gene

Localization for MIR30D Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR30D Gene

Pathways & Interactions for MIR30D Gene

SuperPathways for MIR30D Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR30D: view

Pathways by source for MIR30D Gene

1 KEGG pathway for MIR30D Gene

Interacting Proteins for MIR30D Gene

Gene Ontology (GO) - Biological Process for MIR30D Gene

None

No data available for SIGNOR curated interactions for MIR30D Gene

Transcripts for MIR30D Gene

fRNAdb Secondary structures for MIR30D Gene

  • hsa-mir-30d_MI0000255_Homo_sapiens_miR-30d_stem-loop_hairpin

mRNA/cDNA for MIR30D Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR30D Gene

No ASD Table

Relevant External Links for MIR30D Gene

GeneLoc Exon Structure for
MIR30D
ECgene alternative splicing isoforms for
MIR30D

Expression for MIR30D Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR30D Gene:

MIR30D
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR30D Gene

Orthologs for MIR30D Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR30D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-30d 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-30d 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-30d 35
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir30d 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-30d 35
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-30d 35
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-30d 35
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-30a 35
  • 67 (a)
OneToOne
Species where no ortholog for MIR30D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR30D Gene

ENSEMBL:
Gene Tree for MIR30D (if available)
TreeFam:
Gene Tree for MIR30D (if available)

Paralogs for MIR30D Gene

No data available for Paralogs for MIR30D Gene

Variants for MIR30D Gene

Sequence variations from dbSNP and Humsavar for MIR30D Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1014598 -- 134,806,404(+) TTGAA(A/G)AAAAA intron-variant, upstream-variant-2KB
rs10505631 -- 134,804,476(+) GCATA(C/T)TGCTG intron-variant, downstream-variant-500B
rs113659576 -- 134,804,843(+) GGACA(C/G)AATTA intron-variant, downstream-variant-500B
rs114615785 -- 134,806,122(+) TGAGC(A/G)TGCAT intron-variant, upstream-variant-2KB
rs115058799 -- 134,805,641(+) TAAAT(A/C/T)TGCAT intron-variant, upstream-variant-2KB

Relevant External Links for MIR30D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR30D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR30D Gene

Disorders for MIR30D Gene

Relevant External Links for MIR30D

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR30D

No disorders were found for MIR30D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR30D Gene

Publications for MIR30D Gene

  1. TGF-I^ induces miR-30d down-regulation and podocyte injury through Smad2/3 and HDAC3-associated transcriptional repression. (PMID: 26432290) Liu L. … Liu Z. (J. Mol. Med. 2016) 3 64
  2. TET3 inhibits TGF-I^1-induced epithelial-mesenchymal transition by demethylating miR-30d precursor gene in ovarian cancer cells. (PMID: 27141829) Ye Z. … Zhao L. (J. Exp. Clin. Cancer Res. 2016) 3 64
  3. MicroRNA-30d and microRNA-181a regulate HOXA11 expression in the uterosacral ligaments and are overexpressed in pelvic organ prolapse. (PMID: 25630974) Jeon M.J. … Bai S.W. (J. Cell. Mol. Med. 2015) 3 64
  4. Downregulation of miR-221, -30d, and -15a contributes to pathogenesis of prostate cancer by targeting Bmi-1. (PMID: 25761682) Xuan H. … Huang Y. (Biochemistry Mosc. 2015) 3 64
  5. MicroRNA-30d-5p inhibits tumour cell proliferation and motility by directly targeting CCNE2 in non-small cell lung cancer. (PMID: 25843294) Chen D. … He X. (Cancer Lett. 2015) 3 64

Products for MIR30D Gene

Sources for MIR30D Gene

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