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Aliases for MIR30D Gene

Subcategory (RNA class) for MIR30D Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR30D Gene

  • MicroRNA 30d 2 3 5
  • Hsa-Mir-30d 3
  • Mir-30d 3
  • MIRN30D 3

External Ids for MIR30D Gene

Previous HGNC Symbols for MIR30D Gene

  • MIRN30D

Previous GeneCards Identifiers for MIR30D Gene

  • GC08M135889

Summaries for MIR30D Gene

Entrez Gene Summary for MIR30D Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR30D Gene

MIR30D (MicroRNA 30d) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNA targets in ECM and membrane receptors and MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR30D Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR30D

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR30D Gene

Genomics for MIR30D Gene

Regulatory Elements for MIR30D Gene

Enhancers for MIR30D Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G134830 1.5 FANTOM5 ENCODE 11.2 -27.2 -27166 4.1 HDGF PKNOX1 MLX CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 YY1 ENSG00000259820 ZFAT MIR30D MIR30B ENSG00000254028 LOC102723694
GH08G134733 1.3 FANTOM5 Ensembl ENCODE 10.3 +70.1 70106 1.8 SIX4 PKNOX1 ESRRA MAX FEZF1 RBBP5 RAD21 ZNF7 CTBP1 GATA3 MIR30B MIR30D ENSG00000272456 ENSG00000278898
GH08G134777 1.2 FANTOM5 Ensembl ENCODE 11.1 +25.3 25309 4.8 CTCF RFX1 JUN SUPT20H RAD21 FOSL1 JUND ATF3 SMARCA4 GATA2 MIR30B MIR30D GC08P134784 ENSG00000278898
GH08G134754 0.9 ENCODE 11 +50.7 50743 0.3 ELF3 FOXA2 ATF1 ARID4B THRB ZSCAN9 RAD21 RARA YY1 GATA4 MIR30B MIR30D ENSG00000278898 ENSG00000272456
GH08G134891 0.8 Ensembl ENCODE 9.6 -88.2 -88190 2.6 JUND GATA2 JUN BHLHE40 FOS ZBTB40 MIR30B MIR30D PIR33431 GC08M134943
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR30D on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR30D Gene

Chromosome:
8
Start:
134,804,876 bp from pter
End:
134,804,945 bp from pter
Size:
70 bases
Orientation:
Minus strand

Genomic View for MIR30D Gene

Genes around MIR30D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR30D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR30D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR30D Gene

ORGUL Member Location for MIR30D Gene

ORGUL Member Location for MIR30D gene

Proteins for MIR30D Gene

Post-translational modifications for MIR30D Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR30D Gene

Domains & Families for MIR30D Gene

Gene Families for MIR30D Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR30D: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR30D Gene

Function for MIR30D Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR30D Gene

Localization for MIR30D Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR30D Gene

Pathways & Interactions for MIR30D Gene

genes like me logo Genes that share pathways with MIR30D: view

Pathways by source for MIR30D Gene

1 BioSystems pathway for MIR30D Gene
1 KEGG pathway for MIR30D Gene

Interacting Proteins for MIR30D Gene

Gene Ontology (GO) - Biological Process for MIR30D Gene

None

No data available for SIGNOR curated interactions for MIR30D Gene

Drugs & Compounds for MIR30D Gene

No Compound Related Data Available

Transcripts for MIR30D Gene

fRNAdb Secondary structures for MIR30D Gene

  • hsa-mir-30d_MI0000255_Homo_sapiens_miR-30d_stem-loop_hairpin

mRNA/cDNA for MIR30D Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR30D Gene

No ASD Table

Relevant External Links for MIR30D Gene

GeneLoc Exon Structure for
MIR30D
ECgene alternative splicing isoforms for
MIR30D

Expression for MIR30D Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR30D Gene:

MIR30D
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR30D Gene

Orthologs for MIR30D Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR30D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-30d 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-30d 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-30d 35
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir30d 35
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-30d 35
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-30d 35
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-30d 35
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-30a 35
  • 67 (a)
OneToOne
Species where no ortholog for MIR30D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR30D Gene

ENSEMBL:
Gene Tree for MIR30D (if available)
TreeFam:
Gene Tree for MIR30D (if available)

Paralogs for MIR30D Gene

No data available for Paralogs for MIR30D Gene

Variants for MIR30D Gene

Sequence variations from dbSNP and Humsavar for MIR30D Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1003339394 -- 134,805,811(+) ACCCT(A/G)CCTCT intron-variant, upstream-variant-2KB
rs1007378940 -- 134,806,526(+) TAGGC(A/T)CATGA intron-variant, upstream-variant-2KB
rs1007861639 -- 134,806,263(+) CTGTG(A/G)TAATA intron-variant, upstream-variant-2KB
rs1008073450 -- 134,805,746(+) GGCAG(A/G)TGGAT intron-variant, upstream-variant-2KB
rs1009123468 -- 134,804,719(+) GTTAT(C/T)AGGAG intron-variant, downstream-variant-500B

Relevant External Links for MIR30D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR30D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR30D Gene

Disorders for MIR30D Gene

Relevant External Links for MIR30D

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR30D

No disorders were found for MIR30D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR30D Gene

Publications for MIR30D Gene

  1. Roles of microRNA-124a and microRNA-30d in breast cancer patients with type 2 diabetes mellitus. (PMID: 26897751) Zhang S. … Luo D.L. (Tumour Biol. 2016) 3 64
  2. TET3 inhibits TGF-I^1-induced epithelial-mesenchymal transition by demethylating miR-30d precursor gene in ovarian cancer cells. (PMID: 27141829) Ye Z. … Zhao L. (J. Exp. Clin. Cancer Res. 2016) 3 64
  3. Diagnostic value of miR-30d-5p and miR-125b-5p in acute myocardial infarction. (PMID: 27176713) Jia K. … Wang J. (Mol Med Rep 2016) 3 64
  4. TGF-I^ induces miR-30d down-regulation and podocyte injury through Smad2/3 and HDAC3-associated transcriptional repression. (PMID: 26432290) Liu L. … Liu Z. (J. Mol. Med. 2016) 3 64
  5. Mir-30d increases intracellular survival of Helicobacter pylori through inhibition of autophagy pathway. (PMID: 27099441) Yang X.J. … Gao P. (World J. Gastroenterol. 2016) 3 64

Products for MIR30D Gene

Sources for MIR30D Gene

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