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Aliases for MIR30C2 Gene

Subcategory (RNA class) for MIR30C2 Gene

miRNA

Quality Score for this RNA gene is

13

Aliases for MIR30C2 Gene

  • MicroRNA 30c-2 2 3 5
  • Hsa-Mir-30c-2 3
  • Mir-30c-2 3
  • MIRN30C2 3
  • MiR-30c 3

External Ids for MIR30C2 Gene

Previous HGNC Symbols for MIR30C2 Gene

  • MIRN30C2

Previous GeneCards Identifiers for MIR30C2 Gene

  • GC06M072146
  • GC06M072086
  • GC06M071380
  • GC06M071381

Summaries for MIR30C2 Gene

Entrez Gene Summary for MIR30C2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR30C2 Gene

MIR30C2 (MicroRNA 30c-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR30C2 include familial breast cancer. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR30C2 Gene

Genomics for MIR30C2 Gene

Genomic Location for MIR30C2 Gene

Chromosome:
6
Start:
71,376,933 bp from pter
End:
71,377,045 bp from pter
Size:
113 bases
Orientation:
Minus strand

Genomic View for MIR30C2 Gene

Genes around MIR30C2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR30C2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR30C2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR30C2 Gene

No data available for Regulatory Elements for MIR30C2 Gene

Proteins for MIR30C2 Gene

Post-translational modifications for MIR30C2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR30C2 Gene

Domains & Families for MIR30C2 Gene

Gene Families for MIR30C2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR30C2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR30C2 Gene

Function for MIR30C2 Gene

miRNA for MIR30C2 Gene

miRTarBase miRNAs that target MIR30C2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR30C2 Gene

Localization for MIR30C2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR30C2 Gene

Pathways & Interactions for MIR30C2 Gene

SuperPathways for MIR30C2 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR30C2: view

Pathways by source for MIR30C2 Gene

1 KEGG pathway for MIR30C2 Gene

Interacting Proteins for MIR30C2 Gene

Gene Ontology (GO) - Biological Process for MIR30C2 Gene

None

No data available for SIGNOR curated interactions for MIR30C2 Gene

Drugs & Compounds for MIR30C2 Gene

No Compound Related Data Available

Transcripts for MIR30C2 Gene

mRNA/cDNA for MIR30C2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR30C2 Gene

No ASD Table

Relevant External Links for MIR30C2 Gene

GeneLoc Exon Structure for
MIR30C2
ECgene alternative splicing isoforms for
MIR30C2

Expression for MIR30C2 Gene

mRNA expression in normal human tissues for MIR30C2 Gene

genes like me logo Genes that share expression patterns with MIR30C2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR30C2 Gene

Orthologs for MIR30C2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR30C2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-30f 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-30c-2 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-30c-1 36
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir30c-2 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-30c-2 36
  • 52 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-30c-2 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-30c-2 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-30c 36
  • 53 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-30c 36
  • 63 (a)
OneToMany
Species with no ortholog for MIR30C2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR30C2 Gene

ENSEMBL:
Gene Tree for MIR30C2 (if available)
TreeFam:
Gene Tree for MIR30C2 (if available)

Paralogs for MIR30C2 Gene

No data available for Paralogs for MIR30C2 Gene

Variants for MIR30C2 Gene

Sequence variations from dbSNP and Humsavar for MIR30C2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1057816 -- 71,377,103(-) GTATC(A/T)TCAAA upstream-variant-2KB
rs1192037 -- 71,377,372(+) GCCAA(A/T)CTCCT upstream-variant-2KB
rs1192038 -- 71,377,638(-) TATTA(A/G)CAATT upstream-variant-2KB
rs1192039 -- 71,378,254(+) CATCC(A/G)ATAGA upstream-variant-2KB
rs3071012 -- 71,377,928(+) ATTCA(-/TTCA/TTCATTCA)ACAAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR30C2 Gene

Variant ID Type Subtype PubMed ID
nsv499808 OTHER Inversion 21111241
nsv7382 OTHER Inversion 18451855

Relevant External Links for MIR30C2 Gene

HapMap Linkage Disequilibrium report
MIR30C2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR30C2 Gene

Disorders for MIR30C2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR30C2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
familial breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR30C2

Genetic Association Database (GAD)
MIR30C2
Human Genome Epidemiology (HuGE) Navigator
MIR30C2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR30C2
genes like me logo Genes that share disorders with MIR30C2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR30C2 Gene

Publications for MIR30C2 Gene

  1. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J. … Zhao H. (Int. J. Cancer 2009) 3 48 67
  2. Combinations of serum prostate-specific antigen and plasma expression levels of let-7c, miR-30c, miR-141, and miR-375 as potential better diagnostic biomarkers for prostate cancer. (PMID: 25521481) Kachakova D. … Kaneva R. (DNA Cell Biol. 2015) 3
  3. MicroRNA-30c serves as an independent biochemical recurrence predictor and potential tumor suppressor for prostate cancer. (PMID: 24452717) Ling X.H. … Wu C.L. (Mol. Biol. Rep. 2014) 3
  4. Characterization of serum microRNAs profile of PCOS and identification of novel non-invasive biomarkers. (PMID: 24802714) Long W. … Liu J. (Cell. Physiol. Biochem. 2014) 3
  5. Low expression of microRNA-30c promotes invasion by inducing epithelial mesenchymal transition in non-small cell lung cancer. (PMID: 25119247) Zhong Z. … Chen Y. (Mol Med Rep 2014) 3

Products for MIR30C2 Gene

Sources for MIR30C2 Gene

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