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Aliases for MIR30C2 Gene

Subcategory (RNA class) for MIR30C2 Gene


Quality Score for this RNA gene is


Aliases for MIR30C2 Gene

  • MicroRNA 30c-2 2 3
  • Hsa-Mir-30c-2 3
  • MIRN30C2 3

External Ids for MIR30C2 Gene

Previous HGNC Symbols for MIR30C2 Gene

  • MIRN30C2

Previous GeneCards Identifiers for MIR30C2 Gene

  • GC06M072146
  • GC06M072086

Summaries for MIR30C2 Gene

Entrez Gene Summary for MIR30C2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR30C2 Gene

MIR30C2 (MicroRNA 30c-2) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR30C2 include familial breast cancer. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR30C2 Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR30C2 Gene

Genomics for MIR30C2 Gene

Genomic Location for MIR30C2 Gene

71,376,933 bp from pter
71,377,045 bp from pter
113 bases
Minus strand

Genomic View for MIR30C2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR30C2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR30C2 Gene

No data available for Regulatory Elements for MIR30C2 Gene

Proteins for MIR30C2 Gene

Post-translational modifications for MIR30C2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR30C2 Gene

Domains for MIR30C2 Gene

Gene Families for MIR30C2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR30C2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR30C2 Gene

Function for MIR30C2 Gene

miRNA for MIR30C2 Gene

miRTarBase miRNAs that target MIR30C2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for MIR30C2 Gene

Localization for MIR30C2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR30C2 Gene

Pathways for MIR30C2 Gene

SuperPathways for MIR30C2 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR30C2: view

Pathways by source for MIR30C2 Gene

1 KEGG pathway for MIR30C2 Gene

Interacting Proteins for MIR30C2 Gene

Gene Ontology (GO) - Biological Process for MIR30C2 Gene


Transcripts for MIR30C2 Gene

mRNA/cDNA for MIR30C2 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR30C2 Gene

No ASD Table

Relevant External Links for MIR30C2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR30C2 Gene

mRNA expression in normal human tissues for MIR30C2 Gene

genes like me logo Genes that share expressions with MIR30C2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR30C2 Gene

Orthologs for MIR30C2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR30C2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-30f 36
  • 80 (a)
(Canis familiaris)
Mammalia cfa-mir-30c-2 36
  • 89 (a)
(Monodelphis domestica)
Mammalia mdo-mir-30c-1 36
  • 60 (a)
(Mus musculus)
Mammalia Mir30c-2 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-30c-2 36
  • 52 (a)
(Pan troglodytes)
Mammalia ptr-mir-30c-2 36
  • 100 (a)
(Gallus gallus)
Aves gga-mir-30c-2 36
  • 94 (a)
(Anolis carolinensis)
Reptilia aca-mir-30c 36
  • 53 (a)
(Danio rerio)
Actinopterygii dre-mir-30c 36
  • 63 (a)
Species with no ortholog for MIR30C2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR30C2 Gene

Gene Tree for MIR30C2 (if available)
Gene Tree for MIR30C2 (if available)

Paralogs for MIR30C2 Gene

No data available for Paralogs for MIR30C2 Gene

Variants for MIR30C2 Gene

Sequence variations from dbSNP and Humsavar for MIR30C2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs539966535 -- 71,376,569(+) TAAAA(G/T)AGCAA downstream-variant-500B
rs539303993 -- 71,378,222(+) AGTGT(A/G)GCTTA upstream-variant-2KB
rs537215316 -- 71,376,672(+) GGTAA(C/T)GTGTT downstream-variant-500B
rs537138043 -- 71,376,675(+) TCTAT(C/T)TTTCC downstream-variant-500B
rs535621501 -- 71,378,639(+) CAGTG(A/C)GTGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR30C2 Gene

Variant ID Type Subtype PubMed ID
nsv499808 OTHER Inversion 21111241
nsv7382 OTHER Inversion 18451855

Relevant External Links for MIR30C2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR30C2 Gene

Disorders for MIR30C2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MIR30C2 Gene in MalaCards »

(1) Disease for MIR30C2 Gene

Relevant External Links for MIR30C2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MIR30C2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MIR30C2 Gene

Publications for MIR30C2 Gene

  1. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J. … Zhao H. (Int. J. Cancer 2009) 3 48
  2. Genetic polymorphisms in the precursor MicroRNA flanking region and non-small cell lung cancer survival. (PMID: 20889907) Hu Z. … Shen H. (Am. J. Respir. Crit. Care Med. 2011) 3
  3. MicroRNA-30c promotes human adipocyte differentiation and co-represses PAI-1 and ALK2. (PMID: 21878751) Karbiener M. … Scheideler M. (RNA Biol 2011) 3
  4. Polymorphism in pre-miR-30c contributes to gastric cancer risk in a Chinese population. (PMID: 22108846) Mu Y.P. … Su X.L. (Med. Oncol. 2012) 3
  5. MicroRNA-30c-2* limits expression of proadaptive factor XBP1 in the unfolded protein response. (PMID: 22431749) Byrd A.E. … Brewer J.W. (J. Cell Biol. 2012) 3

Products for MIR30C2 Gene

Sources for MIR30C2 Gene

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