Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR30C1 Gene

Subcategory (RNA class) for MIR30C1 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR30C1 Gene

  • MicroRNA 30c-1 2 3 5
  • Hsa-Mir-30c-1 3
  • Mir-30c-1 3
  • MIRN30C1 3
  • MiR-30c 3

External Ids for MIR30C1 Gene

ORGUL Members for MIR30C1 Gene

Previous HGNC Symbols for MIR30C1 Gene

  • MIRN30C1

Previous GeneCards Identifiers for MIR30C1 Gene

  • GC01P040996
  • GC01P041222

Summaries for MIR30C1 Gene

Entrez Gene Summary for MIR30C1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR30C1 Gene

MIR30C1 (MicroRNA 30c-1) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRNA targets in ECM and membrane receptors and MicroRNAs in cancer.

Additional gene information for MIR30C1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR30C1 Gene

Genomics for MIR30C1 Gene

Regulatory Elements for MIR30C1 Gene

Enhancers for MIR30C1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H040708 1.7 FANTOM5 ENCODE dbSUPER 11.2 -46.0 -46046 6 PKNOX1 FOXA2 ARNT SIN3A ARID4B FEZF1 DMAP1 YY1 SLC30A9 ZNF143 EXO5 RLF RIMS3 LOC105378674 MIR30E MIR30C1 TRIT1 ZFP69 NFYC KCNQ4
GH01H040698 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.1 -57.7 -57742 1 HDGF ATF1 ZBTB40 BATF ZNF121 FOS ATF7 RUNX3 CREM IKZF2 RIMS3 LOC105378674 MIR30E MIR30C1 NFYC ZNF684 KCNQ4 EXO5 CITED4 ZFP69
GH01H040801 1.5 Ensembl ENCODE dbSUPER 11.1 +45.4 45373 2 HDGF ATF1 ARNT GLIS2 ZNF207 ATF7 SP3 NCOA1 SMARCA4 RCOR2 MIR30C1 MIR30E NFYC KCNQ4 NFYC-AS1 GC01M040775
GH01H040735 1.3 Ensembl ENCODE dbSUPER 12.2 -21.1 -21099 1 ZBTB21 TAL1 JUN MAX CEBPG TCF12 ZNF316 ZNF366 SCRT2 ZNF600 RIMS3 LOC105378674 MIR30C1 NFYC KCNQ4 GC01P040752 NFYC-AS1
GH01H040690 1.4 ENCODE dbSUPER 11.1 -64.6 -64583 4 ZFP64 DMAP1 YY1 SLC30A9 SP3 NFYC MEF2D ZNF610 GLIS1 NBN ENSG00000259943 RIMS3 EXO5 NFYC-AS1 RLF LOC105378674 ZFP69 SLFNL1 TRIT1 MIR30C1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR30C1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR30C1 Gene

Chromosome:
1
Start:
40,757,284 bp from pter
End:
40,757,372 bp from pter
Size:
89 bases
Orientation:
Plus strand

Genomic View for MIR30C1 Gene

Genes around MIR30C1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR30C1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR30C1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR30C1 Gene

Proteins for MIR30C1 Gene

Post-translational modifications for MIR30C1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR30C1 Gene

Domains & Families for MIR30C1 Gene

Gene Families for MIR30C1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR30C1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR30C1 Gene

Function for MIR30C1 Gene

Phenotypes From GWAS Catalog for MIR30C1 Gene

Gene Ontology (GO) - Molecular Function for MIR30C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 23749231
genes like me logo Genes that share ontologies with MIR30C1: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MIR30C1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR30C1 Gene

Localization for MIR30C1 Gene

Gene Ontology (GO) - Cellular Components for MIR30C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR30C1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR30C1 Gene

Pathways & Interactions for MIR30C1 Gene

genes like me logo Genes that share pathways with MIR30C1: view

Pathways by source for MIR30C1 Gene

1 BioSystems pathway for MIR30C1 Gene
1 KEGG pathway for MIR30C1 Gene

Interacting Proteins for MIR30C1 Gene

Gene Ontology (GO) - Biological Process for MIR30C1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010868 negative regulation of triglyceride biosynthetic process IDA 23749231
GO:0035195 gene silencing by miRNA IDA 23749231
GO:0045717 negative regulation of fatty acid biosynthetic process IDA 23749231
GO:0050709 negative regulation of protein secretion IDA 23749231
GO:0071072 negative regulation of phospholipid biosynthetic process IDA 23749231
genes like me logo Genes that share ontologies with MIR30C1: view

No data available for SIGNOR curated interactions for MIR30C1 Gene

Drugs & Compounds for MIR30C1 Gene

No Compound Related Data Available

Transcripts for MIR30C1 Gene

mRNA/cDNA for MIR30C1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MIR30C1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR30C1 Gene

No ASD Table

Relevant External Links for MIR30C1 Gene

GeneLoc Exon Structure for
MIR30C1
ECgene alternative splicing isoforms for
MIR30C1

Expression for MIR30C1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR30C1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR30C1 Gene:

MIR30C1
genes like me logo Genes that share expression patterns with MIR30C1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR30C1 Gene

Orthologs for MIR30C1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR30C1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia cfa-mir-30c-1 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-30c-1 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-30c-2 34
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir30c-1 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-30c 34
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-30c-1 34
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-30c-1 34
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 85 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-30c 34
  • 70 (a)
OneToMany
Species where no ortholog for MIR30C1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR30C1 Gene

ENSEMBL:
Gene Tree for MIR30C1 (if available)
TreeFam:
Gene Tree for MIR30C1 (if available)

Paralogs for MIR30C1 Gene

No data available for Paralogs for MIR30C1 Gene

Variants for MIR30C1 Gene

Sequence variations from dbSNP and Humsavar for MIR30C1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1001422170 -- 40,755,413(+) AAATA(C/G)TGAAT intron-variant, upstream-variant-2KB
rs1002599406 -- 40,755,732(+) AACAC(A/C)AACCT intron-variant, upstream-variant-2KB
rs1003531088 -- 40,757,660(+) TGTCC(C/T)CCTTG intron-variant, downstream-variant-500B
rs1003849118 -- 40,757,105(+) CCCTG(A/G)ATAAG intron-variant, upstream-variant-2KB
rs1005706023 -- 40,756,965(+) TTGAG(A/G)GCACC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR30C1 Gene

Variant ID Type Subtype PubMed ID
esv3577821 CNV loss 25503493

Relevant External Links for MIR30C1 Gene

Human Gene Mutation Database (HGMD)
MIR30C1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR30C1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR30C1 Gene

Disorders for MIR30C1 Gene

Relevant External Links for MIR30C1

Genetic Association Database (GAD)
MIR30C1
Human Genome Epidemiology (HuGE) Navigator
MIR30C1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR30C1

No disorders were found for MIR30C1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR30C1 Gene

Publications for MIR30C1 Gene

  1. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J … Wu X (Carcinogenesis 2010) 3 45 60
  2. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J … Wu X (Molecular carcinogenesis 2010) 3 45 60
  3. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 45 60
  4. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y … Wu X (Cancer prevention research (Philadelphia, Pa.) 2008) 3 45 60
  5. Curcumin increases the sensitivity of Paclitaxel-resistant NSCLC cells to Paclitaxel through microRNA-30c-mediated MTA1 reduction. (PMID: 28443468) Lu Y … Lu X (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 60

Products for MIR30C1 Gene

Sources for MIR30C1 Gene

Content
Loading form....