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Aliases for MIR30B Gene

Subcategory (RNA class) for MIR30B Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR30B Gene

  • MicroRNA 30b 2 3 5
  • Hsa-Mir-30b 3
  • Mir-30b 3
  • MIRN30B 3

External Ids for MIR30B Gene

Previous HGNC Symbols for MIR30B Gene

  • MIRN30B

Previous GeneCards Identifiers for MIR30B Gene

  • GC08M135884

Summaries for MIR30B Gene

Entrez Gene Summary for MIR30B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR30B Gene

MIR30B (MicroRNA 30b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR30B Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR30B

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR30B Gene

Genomics for MIR30B Gene

Regulatory Elements for MIR30B Gene

Enhancers for MIR30B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F134830 1.5 FANTOM5 ENCODE 11.1 -31.5 -31504 4.1 HDGF PKNOX1 ARNT MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ENSG00000259820 ZFAT MIR30D MIR30B LOC102723694 ENSG00000254028
GH08F134682 1.5 FANTOM5 Ensembl ENCODE 11 +116.0 116003 3.6 ELF3 PKNOX1 THRB RAD21 RFX5 ZNF143 FOS DEK MIXL1 THAP11 ZFAT MIR30B LOC105375774 ENSG00000271048
GH08F134718 1.3 Ensembl ENCODE 11 +80.0 80044 3.3 PKNOX1 ATF1 ARNT YY1 ELK1 GATA2 FOS JUNB NCOA1 CREB3 MIR30B ENSG00000259820 LOC105375774 ENSG00000278898
GH08F134777 1.2 FANTOM5 Ensembl ENCODE 11.9 +21.0 20971 4.8 CTCF JUN RAD21 JUND SMARCA4 ATF3 FOSL2 BCL6 FOS TRIM28 MIR30B MIR30D GC08P134784 ENSG00000278898
GH08F134733 1.3 FANTOM5 Ensembl ENCODE 10.4 +65.8 65768 1.8 SIX4 ESRRA PKNOX1 MAX FEZF1 RAD21 ZNF7 GATA3 CTBP1 GATA2 MIR30B MIR30D LOC105375774 ENSG00000278898
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR30B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR30B Gene

Chromosome:
8
Start:
134,800,520 bp from pter
End:
134,800,607 bp from pter
Size:
88 bases
Orientation:
Minus strand

Genomic View for MIR30B Gene

Genes around MIR30B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR30B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR30B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR30B Gene

ORGUL Member Location for MIR30B Gene

ORGUL Member Location for MIR30B gene

Proteins for MIR30B Gene

Post-translational modifications for MIR30B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR30B Gene

Domains & Families for MIR30B Gene

Gene Families for MIR30B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR30B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR30B Gene

Function for MIR30B Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR30B Gene

Localization for MIR30B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR30B Gene

Pathways & Interactions for MIR30B Gene

SuperPathways for MIR30B Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR30B: view

Pathways by source for MIR30B Gene

1 KEGG pathway for MIR30B Gene

Interacting Proteins for MIR30B Gene

Gene Ontology (GO) - Biological Process for MIR30B Gene

None

No data available for SIGNOR curated interactions for MIR30B Gene

Transcripts for MIR30B Gene

fRNAdb Secondary structures for MIR30B Gene

  • hsa-miR-30b-5p_MIMAT0000420_Homo_sapiens_miR-30b-5p_mature
  • hsa-mir-30b_MI0000441_Homo_sapiens_miR-30b_stem-loop_hairpin

mRNA/cDNA for MIR30B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR30B Gene

No ASD Table

Relevant External Links for MIR30B Gene

GeneLoc Exon Structure for
MIR30B
ECgene alternative splicing isoforms for
MIR30B

Expression for MIR30B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR30B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR30B Gene:

MIR30B
genes like me logo Genes that share expression patterns with MIR30B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR30B Gene

Orthologs for MIR30B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR30B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-30b 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-30b 35
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-30b 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-30b 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir30b 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-30b 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-30b 35
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-30b 35
  • 86 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-30b 35
  • 61 (a)
ManyToMany
Species where no ortholog for MIR30B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR30B Gene

ENSEMBL:
Gene Tree for MIR30B (if available)
TreeFam:
Gene Tree for MIR30B (if available)

Paralogs for MIR30B Gene

No data available for Paralogs for MIR30B Gene

Variants for MIR30B Gene

Sequence variations from dbSNP and Humsavar for MIR30B Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10095483 -- 134,800,305(+) GTTTT(A/C)ACTAC intron-variant, downstream-variant-500B
rs111424617 -- 134,800,593(-) CAGTT(C/T)ATGTA intron-variant, nc-transcript-variant
rs11166766 -- 134,802,200(+) ATTAA(C/T)CAGGC intron-variant, upstream-variant-2KB
rs112403089 -- 134,801,986(+) TTTTT(C/T)TGCAG intron-variant, upstream-variant-2KB
rs112573883 -- 134,801,735(+) AAAAA(G/T)GGTCT intron-variant, upstream-variant-2KB

Relevant External Links for MIR30B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR30B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR30B Gene

Disorders for MIR30B Gene

Relevant External Links for MIR30B

Genetic Association Database (GAD)
MIR30B
Human Genome Epidemiology (HuGE) Navigator
MIR30B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR30B

No disorders were found for MIR30B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR30B Gene

Publications for MIR30B Gene

  1. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y. … Liu P. (Schizophr. Res. 2010) 3 46 64
  2. Identification of tissue-specific microRNAs from mouse. (PMID: 12007417) Lagos-Quintana M. … Tuschl T. (Curr. Biol. 2002) 1 3 64
  3. Overexpression of blood microRNAs 103a, 30b, and 29a in L-dopa-treated patients with PD. (PMID: 25596505) Serafin A. … Schwienbacher C. (Neurology 2015) 3 64
  4. miR-24, miR-30b, and miR-142-3p regulate phagocytosis in myeloid inflammatory cells. (PMID: 25601927) Naqvi A.R. … Nares S. (J. Immunol. 2015) 3 64
  5. Association between tissue miR-141, miR-200c and miR-30b and bladder cancer: a matched case-control study. (PMID: 25703910) Mahdavinezhad A. … Saidijam M. (Urol J 2015) 3 64

Products for MIR30B Gene

Sources for MIR30B Gene

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