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Aliases for MIR30B Gene

Subcategory (RNA class) for MIR30B Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR30B Gene

  • MicroRNA 30b 2 3
  • Hsa-Mir-30b 3
  • MIRN30B 3

External Ids for MIR30B Gene

Previous Symbols for MIR30B Gene

  • MIRN30B

Summaries for MIR30B Gene

Entrez Gene Summary for MIR30B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR30B Gene

MIR30B (MicroRNA 30b) is a RNA Gene, and belongs to miRNA RNA class. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR30B Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR30B

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR30B Gene

Genomics for MIR30B Gene

Genomic Location for MIR30B Gene

Start:
134,800,520 bp from pter
End:
134,800,607 bp from pter
Size:
88 bases
Orientation:
Minus strand

Genomic View for MIR30B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR30B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR30B Gene

ORGUL Member Location for MIR30B Gene

ORGUL Member Location for MIR30B gene

No data available for Regulatory Elements for MIR30B Gene

Proteins for MIR30B Gene

Post-translational modifications for MIR30B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR30B Gene

Domains for MIR30B Gene

Gene Families for MIR30B Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIR30B: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIR30B Gene

Function for MIR30B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR30B Gene

Localization for MIR30B Gene

No data available for Gene Ontology (GO) - Cellular Components for MIR30B Gene

Pathways for MIR30B Gene

SuperPathways for MIR30B Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR30B: view

Pathways by source for MIR30B Gene

1 KEGG pathway for MIR30B Gene

Interacting Proteins for MIR30B Gene

Gene Ontology (GO) - Biological Process for MIR30B Gene

None

Transcripts for MIR30B Gene

fRNAdb Secondary structures for MIR30B Gene

  • hsa-miR-30b-5p_MIMAT0000420_Homo_sapiens_miR-30b-5p_mature
  • hsa-mir-30b_MI0000441_Homo_sapiens_miR-30b_stem-loop_hairpin

mRNA/cDNA for MIR30B Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR30B Gene

No ASD Table

Relevant External Links for MIR30B Gene

GeneLoc Exon Structure for
MIR30B
ECgene alternative splicing isoforms for
MIR30B

Expression for MIR30B Gene

mRNA expression in normal human tissues for MIR30B Gene

genes like me logo Genes that share expressions with MIR30B: view

Orthologs for MIR30B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR30B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-30b 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-30b 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-30b 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir30b 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-30b 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-30b 37
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-30b 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-30b 37
  • 86 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-30b 37
  • 61 (a)
ManyToMany
Species with no ortholog for MIR30B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR30B Gene

ENSEMBL:
Gene Tree for MIR30B (if available)
TreeFam:
Gene Tree for MIR30B (if available)

Paralogs for MIR30B Gene

No data available for Paralogs for MIR30B Gene

Variants for MIR30B Gene

Sequence variations from dbSNP and Humsavar for MIR30B Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs2953503 -- 134,802,390(-) ATTGC(A/G)TCGAG upstream-variant-2KB
rs2975797 -- 134,802,436(-) ACCCA(A/G)AAATG upstream-variant-2KB
rs3115697 -- 134,801,564(-) TTAAT(C/T)TTGAG upstream-variant-2KB
rs7460121 -- 134,800,173(+) CCAGA(A/G)CCTTA downstream-variant-500B
rs10095483 -- 134,800,305(+) GTTTT(A/C)ACTAC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR30B Gene

Variant ID Type Subtype PubMed ID
nsv891474 CNV Gain 21882294

Relevant External Links for MIR30B Gene

HapMap Linkage Disequilibrium report
MIR30B

Disorders for MIR30B Gene

Relevant External Links for MIR30B

Genetic Association Database (GAD)
MIR30B
Human Genome Epidemiology (HuGE) Navigator
MIR30B
genes like me logo Genes that share disorders with MIR30B: view

No data available for UniProtKB/Swiss-Prot for MIR30B Gene

Publications for MIR30B Gene

  1. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y. … Liu P. (Schizophr. Res. 2010) 3 49
  2. Genetic polymorphisms in the precursor MicroRNA flanking region and non-small cell lung cancer survival. (PMID: 20889907) Hu Z. … Shen H. (Am. J. Respir. Crit. Care Med. 2011) 3
  3. miR-30b/30d regulation of GalNAc transferases enhances invasion and immunosuppression during metastasis. (PMID: 21741600) Gaziel-Sovran A. … Hernando E. (Cancer Cell 2011) 3
  4. Compromised autophagy by MIR30B benefits the intracellular survival of Helicobacter pylori. (PMID: 22647547) Tang B. … Mao X.H. (Autophagy 2012) 3
  5. MicroRNA-30b-mediated regulation of catalase expression in human ARPE-19 cells. (PMID: 22880027) Haque R. … Kim H. (PLoS ONE 2012) 3

Products for MIR30B Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR30B
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR30B
    • Block miRNA regulation of MIR30B using miScript Target Protectors

    Sources for MIR30B Gene

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