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Aliases for MIR30A Gene

Subcategory (RNA class) for MIR30A Gene

miRNA

Quality Score for this RNA gene is

14.2

Aliases for MIR30A Gene

  • MicroRNA 30a 2 3
  • MIRN30A 3 6
  • Hsa-Mir-30a 3

External Ids for MIR30A Gene

Previous Symbols for MIR30A Gene

  • MIRN30A

Summaries for MIR30A Gene

Entrez Gene Summary for MIR30A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR30A Gene

MIR30A (MicroRNA 30a) is a RNA Gene, and belongs to miRNA RNA class. Diseases associated with MIR30A include esophageal cancer. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR30A Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR30A

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR30A Gene

Genomics for MIR30A Gene

Genomic Location for MIR30A Gene

Start:
71,403,551 bp from pter
End:
71,403,621 bp from pter
Size:
71 bases
Orientation:
Minus strand

Genomic View for MIR30A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR30A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR30A Gene

ORGUL Member Location for MIR30A Gene

ORGUL Member Location for MIR30A gene

No data available for Regulatory Elements for MIR30A Gene

Proteins for MIR30A Gene

Post-translational modifications for MIR30A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR30A Gene

Domains for MIR30A Gene

Gene Families for MIR30A Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIR30A: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIR30A Gene

Function for MIR30A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR30A Gene

Localization for MIR30A Gene

No data available for Gene Ontology (GO) - Cellular Components for MIR30A Gene

Pathways for MIR30A Gene

SuperPathways for MIR30A Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR30A: view

Pathways by source for MIR30A Gene

1 KEGG pathway for MIR30A Gene

Interacting Proteins for MIR30A Gene

Gene Ontology (GO) - Biological Process for MIR30A Gene

None

Transcripts for MIR30A Gene

fRNAdb Secondary structures for MIR30A Gene

  • FR207193

mRNA/cDNA for MIR30A Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR30A Gene

No ASD Table

Relevant External Links for MIR30A Gene

GeneLoc Exon Structure for
MIR30A
ECgene alternative splicing isoforms for
MIR30A

Expression for MIR30A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

genes like me logo Genes that share expressions with MIR30A: view

Orthologs for MIR30A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR30A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-30a 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-30a 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-30a 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir30a 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-30a 37
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-30a 37
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-30a 37
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-30a 37
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-30e-2 37
  • 69 (a)
OneToOne
Species with no ortholog for MIR30A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR30A Gene

ENSEMBL:
Gene Tree for MIR30A (if available)
TreeFam:
Gene Tree for MIR30A (if available)

Paralogs for MIR30A Gene

No data available for Paralogs for MIR30A Gene

Variants for MIR30A Gene

Sequence variations from dbSNP and Humsavar for MIR30A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs2779 -- 71,403,289(+) aaaaa(A/T)aataa downstream-variant-500B
rs361518 -- 71,403,290(+) AAAAW(-/A/T)ATAAA downstream-variant-500B
rs1358379 -- 71,403,739(-) TTTGA(A/G)TGAGG upstream-variant-2KB
rs2222722 -- 71,404,009(-) CTTTA(C/T)GCTGT upstream-variant-2KB
rs9346469 -- 71,404,166(+) TCCCA(A/G)AGAGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR30A Gene

Variant ID Type Subtype PubMed ID
nsv499808 OTHER Inversion 21111241
nsv7382 OTHER Inversion 18451855
nsv830684 CNV Gain 17160897

Relevant External Links for MIR30A Gene

HapMap Linkage Disequilibrium report
MIR30A

Disorders for MIR30A Gene

(1) MalaCards Diseases for MIR30A Gene

Search for MIR30A Gene in MalaCards »

Relevant External Links for MIR30A

Genetic Association Database (GAD)
MIR30A
Human Genome Epidemiology (HuGE) Navigator
MIR30A
genes like me logo Genes that share disorders with MIR30A: view

No data available for UniProtKB/Swiss-Prot for MIR30A Gene

Publications for MIR30A Gene

  1. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J. … Wu X. (Carcinogenesis 2010) 3 49
  2. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J. … Wu X. (Mol. Carcinog. 2010) 3 49
  3. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y. … Wu X. (Cancer Prev Res (Phila) 2008) 3 49
  4. MicroRNA expression profiles predictive of human renal allograft status. (PMID: 19289845) Anglicheau D. … Suthanthiran M. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3
  5. Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells. (PMID: 19535919) Zhu H. … Yang J.M. (Autophagy 2009) 3

Products for MIR30A Gene

Sources for MIR30A Gene

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