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Aliases for MIR30A Gene

Subcategory (RNA class) for MIR30A Gene


Quality Score for this RNA gene is


Aliases for MIR30A Gene

  • MicroRNA 30a 2 3 5
  • Hsa-Mir-30a 3
  • Mir-30a 3
  • MIRN30A 3

External Ids for MIR30A Gene

Previous HGNC Symbols for MIR30A Gene

  • MIRN30A

Previous GeneCards Identifiers for MIR30A Gene

  • GC06M072172
  • GC06M072113

Summaries for MIR30A Gene

Entrez Gene Summary for MIR30A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The encoded miRNA is one of five members of the miR-30 family of highly conserved miRNAs and participates in many cellular processes. It has additionally been implicated in the development of several types of cancer. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2017]

GeneCards Summary for MIR30A Gene

MIR30A (MicroRNA 30a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Parkinsons Disease Pathway.

fRNAdb sequence ontologies for MIR30A Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR30A

Additional gene information for MIR30A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR30A Gene

Genomics for MIR30A Gene

GeneHancer (GH) Regulatory Elements for MIR30A Gene

Promoters and enhancers for MIR30A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I071476 Enhancer 0.9 Ensembl ENCODE 10.9 -75.5 -75460 4.6 USF1 JUN RFX5 ZNF664 RCOR1 FOS FOSL2 CEBPB USF2 EP300 MIR30A OGFRL1 LOC105377853 GC06P071540
GH06I071365 Enhancer 0.9 Ensembl ENCODE 10.4 +36.6 36552 2.3 PKNOX1 ZSCAN4 BMI1 IRF4 RELA GATA3 SCRT2 ZSCAN29 FOSL2 FOS MIR30A GC06P071361 GC06M071383 ENSG00000269966 LINC00472
GH06I071467 Enhancer 0.8 Ensembl ENCODE 11.3 -65.4 -65411 2.3 MNT JUND ZFHX2 NFYB FOS PRDM10 PRDM1 EGR2 GC06P071468 LOC105377853 MIR30A ENSG00000232295
GH06I071489 Enhancer 0.8 Ensembl ENCODE 11.1 -86.3 -86263 1.5 JUN BACH1 ZNF384 DPF2 ZNF217 GATA3 JUND CTBP1 FOS MIR30A RIMS1 LOC105377853 GC06P071540
GH06I071511 Enhancer 0.7 ENCODE 11.4 -106.6 -106642 0.2 CTCF PKNOX1 MZF1 RAD21 RFX5 GATA3 ZSCAN5C ZNF143 SMC3 RUNX3 MIR30A GC06P071540 LOC105377853
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR30A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR30A Gene

Genomic Locations for MIR30A Gene
71 bases
Minus strand

Genomic View for MIR30A Gene

Genes around MIR30A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR30A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR30A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR30A Gene

ORGUL Member Location for MIR30A Gene

ORGUL Member Location for MIR30A gene

Proteins for MIR30A Gene

Post-translational modifications for MIR30A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR30A Gene

Domains & Families for MIR30A Gene

Gene Families for MIR30A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR30A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR30A Gene

Function for MIR30A Gene

Gene Ontology (GO) - Molecular Function for MIR30A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 23086751
genes like me logo Genes that share ontologies with MIR30A: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR30A Gene

Localization for MIR30A Gene

Gene Ontology (GO) - Cellular Components for MIR30A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR30A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR30A Gene

Pathways & Interactions for MIR30A Gene

genes like me logo Genes that share pathways with MIR30A: view

Pathways by source for MIR30A Gene

1 BioSystems pathway for MIR30A Gene
1 KEGG pathway for MIR30A Gene

Interacting Proteins for MIR30A Gene

Gene Ontology (GO) - Biological Process for MIR30A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007179 transforming growth factor beta receptor signaling pathway IDA 23960241
GO:0035195 gene silencing by miRNA IMP 23086751
GO:0043536 positive regulation of blood vessel endothelial cell migration IDA 23960241
GO:0045766 positive regulation of angiogenesis IDA 23960241
genes like me logo Genes that share ontologies with MIR30A: view

No data available for SIGNOR curated interactions for MIR30A Gene

Drugs & Compounds for MIR30A Gene

No Compound Related Data Available

Transcripts for MIR30A Gene

fRNAdb Secondary structures for MIR30A Gene

  • FR207193

mRNA/cDNA for MIR30A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR30A Gene

No ASD Table

Relevant External Links for MIR30A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR30A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR30A Gene:

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR30A Gene

Orthologs for MIR30A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR30A Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia cfa-mir-30a 34
  • 100 (a)
(Pan troglodytes)
Mammalia ptr-mir-30a 34
  • 100 (a)
(Bos Taurus)
Mammalia bta-mir-30a 34
  • 93 (a)
(Monodelphis domestica)
Mammalia mdo-mir-30a 34
  • 88 (a)
(Mus musculus)
Mammalia Mir30a 34
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-30a 34
  • 47 (a)
(Gallus gallus)
Aves gga-mir-30a 34
  • 82 (a)
(Anolis carolinensis)
Reptilia aca-mir-30a 34
  • 47 (a)
(Danio rerio)
Actinopterygii dre-mir-30e-2 34
  • 69 (a)
Species where no ortholog for MIR30A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR30A Gene

Gene Tree for MIR30A (if available)
Gene Tree for MIR30A (if available)

Paralogs for MIR30A Gene

No data available for Paralogs for MIR30A Gene

Variants for MIR30A Gene

Sequence variations from dbSNP and Humsavar for MIR30A Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1002209767 -- 71,405,045(-) C/T upstream_transcript_variant
rs1002503005 -- 71,404,039(-) A/G upstream_transcript_variant
rs1004577200 -- 71,403,797(-) G/A upstream_transcript_variant
rs1005915532 -- 71,404,341(-) A/T upstream_transcript_variant
rs1006570692 -- 71,404,145(-) T/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR30A Gene

Variant ID Type Subtype PubMed ID
nsv499808 OTHER inversion 21111241
nsv603640 CNV gain 21841781
nsv7382 OTHER inversion 18451855
nsv830684 CNV gain 17160897

Additional Variant Information for MIR30A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR30A Gene

Disorders for MIR30A Gene

Additional Disease Information for MIR30A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR30A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR30A Gene

Publications for MIR30A Gene

  1. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J … Wu X (Molecular carcinogenesis 2010) 3 44 58
  2. Genetic variations in microRNA-related genes are associated with survival and recurrence in patients with renal cell carcinoma. (PMID: 20732906) Lin J … Wu X (Carcinogenesis 2010) 3 44 58
  3. Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk. (PMID: 19138993) Ye Y … Wu X (Cancer prevention research (Philadelphia, Pa.) 2008) 3 44 58
  4. A Feedback Loop Between miR-30a/c-5p and DNMT1 Mediates Cisplatin Resistance in Ovarian Cancer Cells. (PMID: 28222434) Han X … Zhao L (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 58
  5. MicroRNA-30a Inhibits Colorectal Cancer Metastasis Through Down-Regulation of Type I Insulin-Like Growth Factor Receptor. (PMID: 28932920) Liu YC … Kim SW (Digestive diseases and sciences 2017) 3 58

Products for MIR30A Gene

Sources for MIR30A Gene

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