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Aliases for MIR30A Gene

Subcategory (RNA class) for MIR30A Gene

miRNA

Quality Score for this RNA gene is

14.2

Aliases for MIR30A Gene

  • MicroRNA 30a 2 3 5
  • Hsa-Mir-30a 3
  • Mir-30a 3
  • MIRN30A 3

External Ids for MIR30A Gene

Previous HGNC Symbols for MIR30A Gene

  • MIRN30A

Previous GeneCards Identifiers for MIR30A Gene

  • GC06M072172
  • GC06M072113

Summaries for MIR30A Gene

Entrez Gene Summary for MIR30A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR30A Gene

MIR30A (MicroRNA 30a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR30A Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR30A

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR30A Gene

Genomics for MIR30A Gene

Regulatory Elements for MIR30A Gene

Promoters for MIR30A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR30A on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR30A Gene

Chromosome:
6
Start:
71,403,551 bp from pter
End:
71,403,621 bp from pter
Size:
71 bases
Orientation:
Minus strand

Genomic View for MIR30A Gene

Genes around MIR30A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR30A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR30A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR30A Gene

ORGUL Member Location for MIR30A Gene

ORGUL Member Location for MIR30A gene

Proteins for MIR30A Gene

Post-translational modifications for MIR30A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR30A Gene

Domains & Families for MIR30A Gene

Gene Families for MIR30A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR30A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR30A Gene

Function for MIR30A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR30A Gene

Localization for MIR30A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR30A Gene

Pathways & Interactions for MIR30A Gene

SuperPathways for MIR30A Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR30A: view

Pathways by source for MIR30A Gene

1 KEGG pathway for MIR30A Gene

Interacting Proteins for MIR30A Gene

Gene Ontology (GO) - Biological Process for MIR30A Gene

None

No data available for SIGNOR curated interactions for MIR30A Gene

Drugs & Compounds for MIR30A Gene

No Compound Related Data Available

Transcripts for MIR30A Gene

fRNAdb Secondary structures for MIR30A Gene

  • FR207193

mRNA/cDNA for MIR30A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR30A Gene

No ASD Table

Relevant External Links for MIR30A Gene

GeneLoc Exon Structure for
MIR30A
ECgene alternative splicing isoforms for
MIR30A

Expression for MIR30A Gene

No Expression Related Data Available

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR30A Gene

Orthologs for MIR30A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR30A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-30a 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-30a 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-30a 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir30a 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-30a 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-30a 36
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-30a 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-30a 36
  • 47 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-30e-2 36
  • 69 (a)
OneToOne
Species with no ortholog for MIR30A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR30A Gene

ENSEMBL:
Gene Tree for MIR30A (if available)
TreeFam:
Gene Tree for MIR30A (if available)

Paralogs for MIR30A Gene

No data available for Paralogs for MIR30A Gene

Variants for MIR30A Gene

Sequence variations from dbSNP and Humsavar for MIR30A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs361518 -- 71,403,290(+) AAAAW(-/A/T)ATAAA downstream-variant-500B
rs1358379 -- 71,403,739(-) TTTGA(A/G)TGAGG upstream-variant-2KB
rs11754194 -- 71,405,197(+) CAGTG(A/G)CAAGT upstream-variant-2KB
rs34419769 -- 71,404,612(+) TACTG(-/G)AAACT upstream-variant-2KB
rs28522820 -- 71,403,289(+) AAAAA(A/T)AATAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR30A Gene

Variant ID Type Subtype PubMed ID
nsv499808 OTHER Inversion 21111241
nsv7382 OTHER Inversion 18451855
nsv830684 CNV Gain 17160897

Relevant External Links for MIR30A Gene

HapMap Linkage Disequilibrium report
MIR30A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR30A Gene

Disorders for MIR30A Gene

Relevant External Links for MIR30A

Genetic Association Database (GAD)
MIR30A
Human Genome Epidemiology (HuGE) Navigator
MIR30A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR30A

No disorders were found for MIR30A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR30A Gene

Publications for MIR30A Gene

  1. Genetic variation in MicroRNA genes and risk of oral premalignant lesions. (PMID: 19851984) Clague J. … Wu X. (Mol. Carcinog. 2010) 3 48 67
  2. Antitumor effects of pharmacological EZH2 inhibition on malignant peripheral nerve sheath tumor through the miR-30a and KPNB1 pathway. (PMID: 25890085) Zhang P. … Pollock R.E. (Mol. Cancer 2015) 3
  3. MiRNA-30a-mediated autophagy inhibition sensitizes renal cell carcinoma cells to sorafenib. (PMID: 25712526) Zheng B. … Shan Y. (Biochem. Biophys. Res. Commun. 2015) 3
  4. Overexpression of microRNA-30a inhibits hepatitis B virus X protein-induced autophagosome formation in hepatic cells. (PMID: 25620738) Kumar S. … Venugopal S.K. (FEBS J. 2015) 3
  5. Association of SOX4 regulated by tumor suppressor miR-30a with poor prognosis in low-grade chondrosarcoma. (PMID: 25572678) Lu N. … Li J. (Tumour Biol. 2015) 3

Products for MIR30A Gene

Sources for MIR30A Gene

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