Subcategory (RNA class) for MIR30A Gene
Quality Score for this RNA gene is
External Ids for MIR30A Gene
ORGUL Members for MIR30A Gene
Previous HGNC Symbols for MIR30A Gene
Previous GeneCards Identifiers for MIR30A Gene
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The encoded miRNA is one of five members of the miR-30 family of highly conserved miRNAs and participates in many cellular processes. It has additionally been implicated in the development of several types of cancer. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2017]
GeneCards Summary for MIR30A Gene
fRNAdb sequence ontologies for MIR30A Gene - the ORGUL cluster for this gene includes several descriptions:
pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.
nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.