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Aliases for MIR3074 Gene

Subcategory (RNA class) for MIR3074 Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR3074 Gene

  • MicroRNA 3074 2 3 5
  • Hsa-Mir-3074 3
  • Mir-3074 3

External Ids for MIR3074 Gene

Previous GeneCards Identifiers for MIR3074 Gene

  • GC09U901548
  • GC09M067457
  • GC09M097848

Summaries for MIR3074 Gene

Entrez Gene Summary for MIR3074 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR3074 Gene

MIR3074 (MicroRNA 3074) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are DNA damage response and miRNAs involved in DDR.

fRNAdb sequence ontologies for MIR3074 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR3074

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR3074 Gene

Genomics for MIR3074 Gene

Regulatory Elements for MIR3074 Gene

Enhancers for MIR3074 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F095016 1.3 Ensembl ENCODE 12.1 +64.2 64247 10.7 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 YY1 FOS SP5 NFYC PPARGC1A LINC00476 MIR23B MIR27B MIR3074 ENSG00000271659 LOC100132077 C9orf3 MIR6081 LOC101928119
GH09F095053 1 Ensembl ENCODE 12.6 +29.2 29223 6.2 TAL1 JUN FEZF1 ZIC2 RAD21 HIC1 ZFHX2 POLR2A PRDM10 MAFK MIR23B MIR27B MIR3074 MIR6081 LOC101928119
GH09F095060 0.9 ENCODE 13.7 +22.1 22127 6.0 ATF1 ARID4B RAD21 RARA YY1 CREM THAP11 SP5 ZNF585B CEBPA MIR23B MIR27B MIR3074 LINC00476 ENSG00000271659 LOC100132077 C9orf3 MIR6081 LOC101928119
GH09F095106 0.5 ENCODE 12.7 -21.5 -21527 2.3 CTCF ZNF316 MAFK MIR23B MIR27B MIR3074 PIR48893 PIR51992
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR3074 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR3074 Gene

Chromosome:
9
Start:
95,086,014 bp from pter
End:
95,086,094 bp from pter
Size:
81 bases
Orientation:
Minus strand

Genomic View for MIR3074 Gene

Genes around MIR3074 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR3074 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR3074 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR3074 Gene

ORGUL Member Location for MIR3074 Gene

ORGUL Member Location for MIR3074 gene

Proteins for MIR3074 Gene

Post-translational modifications for MIR3074 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR3074 Gene

Domains & Families for MIR3074 Gene

Gene Families for MIR3074 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR3074: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR3074 Gene

Function for MIR3074 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR3074 Gene

Localization for MIR3074 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR3074 Gene

Pathways & Interactions for MIR3074 Gene

genes like me logo Genes that share pathways with MIR3074: view

Pathways by source for MIR3074 Gene

2 BioSystems pathways for MIR3074 Gene

Interacting Proteins for MIR3074 Gene

Gene Ontology (GO) - Biological Process for MIR3074 Gene

None

No data available for SIGNOR curated interactions for MIR3074 Gene

Transcripts for MIR3074 Gene

fRNAdb Secondary structures for MIR3074 Gene

  • hsa-miR-3074-5p_MIMAT0019208_Homo_sapiens_miR-3074-5p_mature

mRNA/cDNA for MIR3074 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR3074 Gene

No ASD Table

Relevant External Links for MIR3074 Gene

GeneLoc Exon Structure for
MIR3074
ECgene alternative splicing isoforms for
MIR3074

Expression for MIR3074 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR3074 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR3074 Gene:

MIR3074
genes like me logo Genes that share expression patterns with MIR3074: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR3074 Gene

Orthologs for MIR3074 Gene

Evolution for MIR3074 Gene

ENSEMBL:
Gene Tree for MIR3074 (if available)
TreeFam:
Gene Tree for MIR3074 (if available)

No data available for Orthologs for MIR3074 Gene

Paralogs for MIR3074 Gene

No data available for Paralogs for MIR3074 Gene

Variants for MIR3074 Gene

Sequence variations from dbSNP and Humsavar for MIR3074 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1011784 -- 95,085,732(-) TAGTG(C/G)ATGTT intron-variant, nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1045275 -- 95,086,134(+) CCGAG(C/G)TCAGG intron-variant, nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1045276 -- 95,086,402(+) GAGAA(C/T)AGTTA intron-variant, nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs10821449 -- 95,087,117(+) AGAAT(C/T)TAAGA intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs111296134 -- 95,087,165(+) TACGT(A/G)TTTGC intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MIR3074 Gene

Variant ID Type Subtype PubMed ID
nsv1038106 CNV gain 25217958
nsv1147999 OTHER inversion 26484159
nsv831656 CNV loss 17160897

Relevant External Links for MIR3074 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR3074

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR3074 Gene

Disorders for MIR3074 Gene

Relevant External Links for MIR3074

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR3074

No disorders were found for MIR3074 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR3074 Gene

Publications for MIR3074 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  2. Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene. (PMID: 21199797) Persson H. … Rovira C. (Cancer Res. 2011) 3 64
  3. Characterization of the Melanoma miRNAome by Deep Sequencing. (PMID: 20300190) Stark M.S. … Hayward N.K. (PLoS ONE 2010) 3 64
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64
  5. Identification and classification of conserved RNA secondary structures in the human genome. (PMID: 16628248) Pedersen J.S. … Haussler D. (PLoS Comput. Biol. 2006) 1

Products for MIR3074 Gene

Sources for MIR3074 Gene

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