Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR302D Gene

Subcategory (RNA class) for MIR302D Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR302D Gene

  • MicroRNA 302d 2 3 5
  • Hsa-Mir-302d 3
  • Mir-302d 3
  • MIRN302D 3

External Ids for MIR302D Gene

Previous HGNC Symbols for MIR302D Gene

  • MIRN302D

Previous GeneCards Identifiers for MIR302D Gene

  • GC04M113796
  • GC04M113570
  • GC04M113574
  • GC04M113583

Summaries for MIR302D Gene

Entrez Gene Summary for MIR302D Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR302D Gene

MIR302D (MicroRNA 302d) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Cell Differentiation - Index.

fRNAdb sequence ontologies for MIR302D Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR302D

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR302D Gene

Genomics for MIR302D Gene

Regulatory Elements for MIR302D Gene

Enhancers for MIR302D Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G112704 1.2 ENCODE dbSUPER 11.3 -58.0 -57966 2.9 PKNOX1 FEZF1 ZNF2 GLIS2 KLF7 SP3 REST ZNF610 GLIS1 KDM1A ENSG00000249532 MIR302A MIR302C MIR302D MIR367 LARP7 RPL7AP30 ZGRF1 ENSG00000250046 WRBP1
GH04G112746 1 ENCODE dbSUPER 11.1 -102.2 -102187 7.2 CTCF TEAD4 RBBP5 ZNF101 ETS1 ZNF316 GATA3 ZBTB48 POLR2A FOS ZGRF1 ENSG00000260526 LARP7 MIR302A MIR302C MIR302D MIR367 ENSG00000249532 GC04M112739 ENSG00000202536
GH04G112754 0.5 dbSUPER 11.1 -106.7 -106741 1.3 GATAD2A FOXA2 NFIA ZNF652 HOMEZ LARP7 ZGRF1 MIR302A MIR302C MIR302D MIR367 ENSG00000249532 ENSG00000202536 GC04M112756 GC04M112739
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR302D on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR302D Gene

Chromosome:
4
Start:
112,648,004 bp from pter
End:
112,648,071 bp from pter
Size:
68 bases
Orientation:
Minus strand

Genomic View for MIR302D Gene

Genes around MIR302D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR302D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR302D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR302D Gene

ORGUL Member Location for MIR302D Gene

ORGUL Member Location for MIR302D gene

Proteins for MIR302D Gene

Post-translational modifications for MIR302D Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR302D Gene

Domains & Families for MIR302D Gene

Gene Families for MIR302D Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR302D: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR302D Gene

Function for MIR302D Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR302D Gene

Localization for MIR302D Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR302D Gene

Pathways & Interactions for MIR302D Gene

SuperPathways for MIR302D Gene

SuperPathway Contained pathways
1 Cell Differentiation - Index
genes like me logo Genes that share pathways with MIR302D: view

Pathways by source for MIR302D Gene

1 BioSystems pathway for MIR302D Gene

Interacting Proteins for MIR302D Gene

Gene Ontology (GO) - Biological Process for MIR302D Gene

None

No data available for SIGNOR curated interactions for MIR302D Gene

Transcripts for MIR302D Gene

fRNAdb Secondary structures for MIR302D Gene

  • hsa-miR-302d-5p_MIMAT0004685_Homo_sapiens_miR-302d-5p_mature

mRNA/cDNA for MIR302D Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR302D Gene

No ASD Table

Relevant External Links for MIR302D Gene

GeneLoc Exon Structure for
MIR302D
ECgene alternative splicing isoforms for
MIR302D

Expression for MIR302D Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR302D Gene:

MIR302D
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR302D Gene

Orthologs for MIR302D Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR302D Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-302d 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir302d 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-302d 35
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-302d 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-302-2 35
  • 81 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-302b 35
  • 76 (a)
ManyToMany
chicken
(Gallus gallus)
Aves gga-mir-302d 35
  • 80 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-302 35
  • 77 (a)
ManyToMany
Species where no ortholog for MIR302D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR302D Gene

ENSEMBL:
Gene Tree for MIR302D (if available)
TreeFam:
Gene Tree for MIR302D (if available)

Paralogs for MIR302D Gene

No data available for Paralogs for MIR302D Gene

Variants for MIR302D Gene

Sequence variations from dbSNP and Humsavar for MIR302D Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1057519017 Pathogenic 112,647,722(+) GGATA(-/AAGGATA)CTGGA nc-transcript-variant, downstream-variant-500B, reference, frameshift-variant
rs1000855041 -- 112,647,944(+) TGGCC(C/T)GTAGC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1000958560 -- 112,648,113(+) TTAAA(C/T)ATATG intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1001109052 -- 112,648,125(+) GCTGC(A/G)GTCAA intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1001866698 -- 112,649,354(+) AGGAA(C/G/T)TCCCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR302D Gene

Variant ID Type Subtype PubMed ID
nsv1006030 CNV gain 25217958
nsv1014926 CNV gain 25217958
nsv525715 CNV loss 19592680

Relevant External Links for MIR302D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR302D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR302D Gene

Disorders for MIR302D Gene

Relevant External Links for MIR302D

Human Genome Epidemiology (HuGE) Navigator
MIR302D
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR302D

No disorders were found for MIR302D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR302D Gene

Publications for MIR302D Gene

  1. Human embryonic stem cells express a unique set of microRNAs. (PMID: 15183728) Suh M.R. … Kim K.S. (Dev. Biol. 2004) 1 3 64
  2. MicroRNA-302 induces proliferation and inhibits oxidant-induced cell death in human adipose tissue-derived mesenchymal stem cells. (PMID: 25144720) Kim J.Y. … Jung J.S. (Cell Death Dis 2014) 3 64
  3. Low expression of miR-449 in gynecologic clear cell carcinoma. (PMID: 25238166) Jang S.G. … Kim H.K. (Int. J. Gynecol. Cancer 2014) 3 64
  4. Genetic polymorphisms in the precursor MicroRNA flanking region and non-small cell lung cancer survival. (PMID: 20889907) Hu Z. … Shen H. (Am. J. Respir. Crit. Care Med. 2011) 3 64
  5. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64

Products for MIR302D Gene

Sources for MIR302D Gene

Content
Loading form....