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Aliases for MIR302C Gene

Subcategory (RNA class) for MIR302C Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR302C Gene

  • MicroRNA 302c 2 3 5
  • Hsa-Mir-302c 3
  • Mir-302c 3
  • MIRN302C 3

External Ids for MIR302C Gene

Previous HGNC Symbols for MIR302C Gene

  • MIRN302C

Previous GeneCards Identifiers for MIR302C Gene

  • GC04M113798
  • GC04M113572
  • GC04M113576
  • GC04M113585
  • GC04M112650
  • GC04M112654

Summaries for MIR302C Gene

Entrez Gene Summary for MIR302C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR302C Gene

MIR302C (MicroRNA 302c) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Mesodermal Commitment Pathway and Cell Differentiation - Index.

fRNAdb sequence ontologies for MIR302C Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR302C

Additional gene information for MIR302C Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR302C Gene

Genomics for MIR302C Gene

GeneHancer (GH) Regulatory Elements for MIR302C Gene

Promoters and enhancers for MIR302C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I112704 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 11.3 -57.6 -57606 2.9 PKNOX1 ZNF2 GLIS2 KLF7 SP3 REST ZNF610 GLIS1 SP7 KLF1 ENSG00000250046 LOC109864269 MIR302A MIR302C MIR302D MIR367 LARP7 RPL7AP30 ZGRF1 WRBP1
GH04I112746 Enhancer 0.8 ENCODE dbSUPER 11.1 -101.8 -101828 7.2 ETS1 SP1 GATA3 ZNF316 JUND POLR2A POU5F1 PRDM1 MAFK EZH2 ZGRF1 LARP7 MIR302A MIR302C MIR302D MIR367 LOC109864269 GC04M112739 ENSG00000202536 GC04M112756
GH04I112754 Enhancer 0.2 dbSUPER 11.1 -106.4 -106382 1.3 ENSG00000202536 GC04M112756 ZGRF1 LARP7 MIR302A MIR302C MIR302D MIR367 LOC109864269 GC04M112739
GH04I112645 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 0.8 -2.6 -2588 11.2 PAF1 CTCF USF1 ZNF10 SIN3A ETS1 ZKSCAN1 SP1 NFIC POLR2A LOC109864269 LOC105377372 LARP7 ZGRF1 MIR302A MIR302B MIR302C MIR302D MIR367 GC04M112615
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR302C on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR302C Gene

Genomic Locations for MIR302C Gene
chr4:112,648,363-112,648,430
(GRCh38/hg38)
Size:
68 bases
Orientation:
Minus strand
chr4:113,569,519-113,569,586
(GRCh37/hg19)

Genomic View for MIR302C Gene

Genes around MIR302C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR302C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR302C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR302C Gene

ORGUL Member Location for MIR302C Gene

ORGUL Member Location for MIR302C gene

Proteins for MIR302C Gene

Post-translational modifications for MIR302C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR302C Gene

Domains & Families for MIR302C Gene

Gene Families for MIR302C Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR302C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR302C Gene

Function for MIR302C Gene

Phenotypes From GWAS Catalog for MIR302C Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR302C Gene

Localization for MIR302C Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR302C Gene

Pathways & Interactions for MIR302C Gene

genes like me logo Genes that share pathways with MIR302C: view

Pathways by source for MIR302C Gene

2 BioSystems pathways for MIR302C Gene

Interacting Proteins for MIR302C Gene

Gene Ontology (GO) - Biological Process for MIR302C Gene

None

No data available for SIGNOR curated interactions for MIR302C Gene

Drugs & Compounds for MIR302C Gene

No Compound Related Data Available

Transcripts for MIR302C Gene

fRNAdb Secondary structures for MIR302C Gene

  • FR041335
  • hsa-mir-302c_MI0000773_Homo_sapiens_miR-302c_stem-loop_hairpin

mRNA/cDNA for MIR302C Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR302C Gene

No ASD Table

Relevant External Links for MIR302C Gene

GeneLoc Exon Structure for
MIR302C
ECgene alternative splicing isoforms for
MIR302C

Expression for MIR302C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR302C Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR302C Gene:

MIR302C
genes like me logo Genes that share expression patterns with MIR302C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR302C Gene

Orthologs for MIR302C Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR302C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-302c 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-302c 34
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-302c 34
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir302c 34
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-302c 34
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-302c 34
  • 89 (a)
OneToOne
Species where no ortholog for MIR302C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR302C Gene

ENSEMBL:
Gene Tree for MIR302C (if available)
TreeFam:
Gene Tree for MIR302C (if available)

Paralogs for MIR302C Gene

No data available for Paralogs for MIR302C Gene

Variants for MIR302C Gene

Sequence variations from dbSNP and Humsavar for MIR302C Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs750946801 likely-pathogenic, not provided 112,649,598(-) AAAAAAAA/AAAAAAA/AAAAAAAAA upstream_transcript_variant
rs1000855041 -- 112,647,944(-) T/C downstream_transcript_variant
rs1000958560 -- 112,648,113(-) T/C downstream_transcript_variant
rs1001109052 -- 112,648,125(-) G/A downstream_transcript_variant
rs1001866698 -- 112,649,354(-) C/G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR302C Gene

Variant ID Type Subtype PubMed ID
nsv1006030 CNV gain 25217958
nsv1014926 CNV gain 25217958
nsv525715 CNV loss 19592680

Additional Variant Information for MIR302C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR302C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR302C Gene

Disorders for MIR302C Gene

Additional Disease Information for MIR302C

No disorders were found for MIR302C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR302C Gene

Publications for MIR302C Gene

  1. Human embryonic stem cells express a unique set of microRNAs. (PMID: 15183728) Suh MR … Kim KS (Developmental biology 2004) 1 3 58
  2. MiR-302c-3p suppresses invasion and proliferation of glioma cells via down-regulating metadherin (MTDH) expression. (PMID: 26176806) Wang Y … Wang G (Cancer biology & therapy 2015) 3 58
  3. Loss of RACK1 Promotes Metastasis of Gastric Cancer by Inducing a miR-302c/IL8 Signaling Loop. (PMID: 26199092) Chen L … Gu J (Cancer research 2015) 3 58
  4. MiR-302c inhibits tumor growth of hepatocellular carcinoma by suppressing the endothelial-mesenchymal transition of endothelial cells. (PMID: 25027009) Zhu K … Zhou J (Scientific reports 2014) 3 58
  5. MicroRNA-302 induces proliferation and inhibits oxidant-induced cell death in human adipose tissue-derived mesenchymal stem cells. (PMID: 25144720) Kim JY … Jung JS (Cell death & disease 2014) 3 58

Products for MIR302C Gene

Sources for MIR302C Gene

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