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Aliases for MIR302B Gene

Subcategory (RNA class) for MIR302B Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR302B Gene

  • MicroRNA 302b 2 3 5
  • Hsa-Mir-302b 3
  • Mir-302b 3
  • MIRN302B 3

External Ids for MIR302B Gene

Previous HGNC Symbols for MIR302B Gene

  • MIRN302B

Previous GeneCards Identifiers for MIR302B Gene

  • GC04M113799
  • GC04M113573
  • GC04M113577
  • GC04M113568
  • GC04M112651
  • GC04M112655

Summaries for MIR302B Gene

Entrez Gene Summary for MIR302B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR302B Gene

MIR302B (MicroRNA 302b) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR302B Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR302B

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR302B Gene

Genomics for MIR302B Gene

Genomic Location for MIR302B Gene

Chromosome:
4
Start:
112,648,485 bp from pter
End:
112,648,557 bp from pter
Size:
73 bases
Orientation:
Minus strand

Genomic View for MIR302B Gene

Genes around MIR302B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR302B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR302B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR302B Gene

ORGUL Member Location for MIR302B Gene

ORGUL Member Location for MIR302B gene

No data available for Regulatory Elements for MIR302B Gene

Proteins for MIR302B Gene

Post-translational modifications for MIR302B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR302B Gene

Domains & Families for MIR302B Gene

Gene Families for MIR302B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR302B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR302B Gene

Function for MIR302B Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR302B Gene

Localization for MIR302B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR302B Gene

Pathways & Interactions for MIR302B Gene

SuperPathways for MIR302B Gene

No Data Available

Interacting Proteins for MIR302B Gene

Gene Ontology (GO) - Biological Process for MIR302B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR302B Gene

Drugs & Compounds for MIR302B Gene

No Compound Related Data Available

Transcripts for MIR302B Gene

fRNAdb Secondary structures for MIR302B Gene

  • hsa-miR-302b-3p_MIMAT0000715_Homo_sapiens_miR-302b-3p_mature

mRNA/cDNA for MIR302B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR302B Gene

No ASD Table

Relevant External Links for MIR302B Gene

GeneLoc Exon Structure for
MIR302B
ECgene alternative splicing isoforms for
MIR302B

Expression for MIR302B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR302B Gene:

MIR302B
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR302B Gene

Orthologs for MIR302B Gene

Evolution for MIR302B Gene

ENSEMBL:
Gene Tree for MIR302B (if available)
TreeFam:
Gene Tree for MIR302B (if available)

No data available for Orthologs for MIR302B Gene

Paralogs for MIR302B Gene

No data available for Paralogs for MIR302B Gene

Variants for MIR302B Gene

Sequence variations from dbSNP and Humsavar for MIR302B Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000958560 -- 112,648,113(+) TTAAA(C/T)ATATG intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1001109052 -- 112,648,125(+) GCTGC(A/G)GTCAA intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1001866698 -- 112,649,354(+) AGGAA(C/G/T)TCCCT intron-variant, upstream-variant-2KB
rs1005751879 -- 112,649,003(+) GTGCT(C/T)CCACT intron-variant, upstream-variant-2KB
rs1006161088 -- 112,648,307(+) GTAAC(C/G)TTAAA intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR302B Gene

Variant ID Type Subtype PubMed ID
nsv1006030 CNV gain 25217958
nsv1014926 CNV gain 25217958
nsv525715 CNV loss 19592680

Relevant External Links for MIR302B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR302B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR302B Gene

Disorders for MIR302B Gene

Relevant External Links for MIR302B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR302B

No disorders were found for MIR302B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR302B Gene

Publications for MIR302B Gene

  1. Human embryonic stem cells express a unique set of microRNAs. (PMID: 15183728) Suh M.R. … Kim K.S. (Dev. Biol. 2004) 1 3 64
  2. miR-302a/b/c/d cooperatively inhibit BCRP expression to increase drug sensitivity in breast cancer cells. (PMID: 26644266) Wang Y. … Wei M. (Gynecol. Oncol. 2016) 3 64
  3. miR-302b enhances breast cancer cell sensitivity to cisplatin by regulating E2F1 and the cellular DNA damage response. (PMID: 26623722) Cataldo A. … Croce C.M. (Oncotarget 2016) 3 64
  4. MicroRNA-302 induces proliferation and inhibits oxidant-induced cell death in human adipose tissue-derived mesenchymal stem cells. (PMID: 25144720) Kim J.Y. … Jung J.S. (Cell Death Dis 2014) 3 64
  5. miR-302b is a potential molecular marker of esophageal squamous cell carcinoma and functions as a tumor suppressor by targeting ErbB4. (PMID: 24438167) Zhang M. … Wang J. (J. Exp. Clin. Cancer Res. 2014) 3 64

Products for MIR302B Gene

Sources for MIR302B Gene

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