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Aliases for MIR302B Gene

Subcategory (RNA class) for MIR302B Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR302B Gene

  • MicroRNA 302b 2 3 5
  • Hsa-Mir-302b 3
  • Mir-302b 3
  • MIRN302B 3

External Ids for MIR302B Gene

Previous HGNC Symbols for MIR302B Gene

  • MIRN302B

Previous GeneCards Identifiers for MIR302B Gene

  • GC04M113799
  • GC04M113573
  • GC04M113577
  • GC04M113568
  • GC04M112651
  • GC04M112655
  • GC04M112656

Summaries for MIR302B Gene

Entrez Gene Summary for MIR302B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR302B Gene

MIR302B (MicroRNA 302b) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR302B Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR302B

Additional gene information for MIR302B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR302B Gene

Genomics for MIR302B Gene

GeneHancer (GH) Regulatory Elements for MIR302B Gene

Promoters and enhancers for MIR302B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I112645 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 0.8 -2.5 -2461 11.2 PAF1 CTCF USF1 ZNF10 SIN3A ETS1 ZKSCAN1 SP1 NFIC POLR2A LOC109864269 LOC105377372 LARP7 ZGRF1 MIR302A MIR302B MIR302C MIR302D MIR367 GC04M112615
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR302B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR302B Gene

Genomic Locations for MIR302B Gene
chr4:112,648,485-112,648,557
(GRCh38/hg38)
Size:
73 bases
Orientation:
Minus strand
chr4:113,567,632-113,571,207
(GRCh37/hg19)

Genomic View for MIR302B Gene

Genes around MIR302B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR302B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR302B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR302B Gene

ORGUL Member Location for MIR302B Gene

ORGUL Member Location for MIR302B gene

Proteins for MIR302B Gene

Post-translational modifications for MIR302B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR302B Gene

Domains & Families for MIR302B Gene

Gene Families for MIR302B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR302B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR302B Gene

Function for MIR302B Gene

Phenotypes From GWAS Catalog for MIR302B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR302B Gene

Localization for MIR302B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR302B Gene

Pathways & Interactions for MIR302B Gene

SuperPathways for MIR302B Gene

No Data Available

Interacting Proteins for MIR302B Gene

Gene Ontology (GO) - Biological Process for MIR302B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR302B Gene

Drugs & Compounds for MIR302B Gene

No Compound Related Data Available

Transcripts for MIR302B Gene

fRNAdb Secondary structures for MIR302B Gene

  • hsa-miR-302b-3p_MIMAT0000715_Homo_sapiens_miR-302b-3p_mature

mRNA/cDNA for MIR302B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR302B Gene

No ASD Table

Relevant External Links for MIR302B Gene

GeneLoc Exon Structure for
MIR302B
ECgene alternative splicing isoforms for
MIR302B

Expression for MIR302B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR302B Gene:

MIR302B
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR302B Gene

Orthologs for MIR302B Gene

Evolution for MIR302B Gene

ENSEMBL:
Gene Tree for MIR302B (if available)
TreeFam:
Gene Tree for MIR302B (if available)

No data available for Orthologs for MIR302B Gene

Paralogs for MIR302B Gene

No data available for Paralogs for MIR302B Gene

Variants for MIR302B Gene

Sequence variations from dbSNP and Humsavar for MIR302B Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs750946801 likely-pathogenic, not provided 112,649,598(-) AAAAAAAA/AAAAAAA/AAAAAAAAA upstream_transcript_variant
rs1000958560 -- 112,648,113(-) T/C downstream_transcript_variant
rs1001109052 -- 112,648,125(-) G/A downstream_transcript_variant
rs1001866698 -- 112,649,354(-) C/G/T upstream_transcript_variant
rs1005751879 -- 112,649,003(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR302B Gene

Variant ID Type Subtype PubMed ID
nsv1006030 CNV gain 25217958
nsv1014926 CNV gain 25217958
nsv525715 CNV loss 19592680

Additional Variant Information for MIR302B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR302B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR302B Gene

Disorders for MIR302B Gene

Additional Disease Information for MIR302B

No disorders were found for MIR302B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR302B Gene

Publications for MIR302B Gene

  1. Human embryonic stem cells express a unique set of microRNAs. (PMID: 15183728) Suh MR … Kim KS (Developmental biology 2004) 1 3 58
  2. The microRNA-302b-inhibited insulin-like growth factor-binding protein 2 signaling pathway induces glioma cell apoptosis by targeting nuclear factor IA. (PMID: 28323865) Lee CC … Chen KC (PloS one 2017) 3 58
  3. MicroRNA-302b-3p Suppresses Cell Proliferation Through AKT Pathway by Targeting IGF-1R in Human Gastric Cancer. (PMID: 28743112) Guo B … Huang C (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 58
  4. miR-302b enhances breast cancer cell sensitivity to cisplatin by regulating E2F1 and the cellular DNA damage response. (PMID: 26623722) Cataldo A … Croce CM (Oncotarget 2016) 3 58
  5. miR-302a/b/c/d cooperatively inhibit BCRP expression to increase drug sensitivity in breast cancer cells. (PMID: 26644266) Wang Y … Wei M (Gynecologic oncology 2016) 3 58

Products for MIR302B Gene

Sources for MIR302B Gene

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