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Aliases for MIR302A Gene

Subcategory (RNA class) for MIR302A Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR302A Gene

  • MicroRNA 302a 2 3 5
  • MicroRNA 302 2 3
  • Hsa-Mir-302a 3
  • Hsa-Mir-302 3
  • Mir-302a 3
  • MIRN302A 3
  • MIRN302 3

External Ids for MIR302A Gene

Previous HGNC Symbols for MIR302A Gene

  • MIRN302
  • MIRN302A

Previous GeneCards Identifiers for MIR302A Gene

  • GC04M113797
  • GC04M113571
  • GC04M113575
  • GC04M113584

Summaries for MIR302A Gene

Entrez Gene Summary for MIR302A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR302A Gene

MIR302A (MicroRNA 302a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are TGF Beta Signaling Pathway.

fRNAdb sequence ontologies for MIR302A Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR302A

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR302A Gene

Genomics for MIR302A Gene

Regulatory Elements for MIR302A Gene


Promoters for MIR302A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR302A on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR302A Gene

Chromosome:
4
Start:
112,648,183 bp from pter
End:
112,648,251 bp from pter
Size:
69 bases
Orientation:
Minus strand

Genomic View for MIR302A Gene

Genes around MIR302A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR302A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR302A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR302A Gene

ORGUL Member Location for MIR302A Gene

ORGUL Member Location for MIR302A gene

Proteins for MIR302A Gene

Post-translational modifications for MIR302A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR302A Gene

Domains & Families for MIR302A Gene

Gene Families for MIR302A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR302A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR302A Gene

Function for MIR302A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR302A Gene

Localization for MIR302A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR302A Gene

Pathways & Interactions for MIR302A Gene

SuperPathways for MIR302A Gene

Superpath Contained pathways
1 TGF Beta Signaling Pathway
genes like me logo Genes that share pathways with MIR302A: view

Pathways by source for MIR302A Gene

1 BioSystems pathway for MIR302A Gene

Interacting Proteins for MIR302A Gene

Gene Ontology (GO) - Biological Process for MIR302A Gene

None

No data available for SIGNOR curated interactions for MIR302A Gene

Drugs & Compounds for MIR302A Gene

No Compound Related Data Available

Transcripts for MIR302A Gene

fRNAdb Secondary structures for MIR302A Gene

  • FR039758
  • hsa-miR-302a-3p_MIMAT0000684_Homo_sapiens_miR-302a-3p_mature

mRNA/cDNA for MIR302A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR302A Gene

No ASD Table

Relevant External Links for MIR302A Gene

GeneLoc Exon Structure for
MIR302A
ECgene alternative splicing isoforms for
MIR302A

Expression for MIR302A Gene

mRNA expression in normal human tissues for MIR302A Gene

genes like me logo Genes that share expression patterns with MIR302A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR302A Gene

Orthologs for MIR302A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR302A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-302a 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-302a 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-302a 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir302a 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-302-1 36
  • 41 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-302a 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-302a 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 69 (a)
OneToOne
Species with no ortholog for MIR302A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR302A Gene

ENSEMBL:
Gene Tree for MIR302A (if available)
TreeFam:
Gene Tree for MIR302A (if available)

Paralogs for MIR302A Gene

No data available for Paralogs for MIR302A Gene

Variants for MIR302A Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR302A Gene

Variant ID Type Subtype PubMed ID
nsv525715 CNV Loss 19592680

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Variation tolerance and Relevant External Links for MIR302A Gene

Disorders for MIR302A Gene

Relevant External Links for MIR302A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR302A

No disorders were found for MIR302A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR302A Gene

Publications for MIR302A Gene

  1. MicroRNA-302a Suppresses Tumor Cell Proliferation by Inhibiting AKT in Prostate Cancer. (PMID: 25922934) Zhang G.M. … Ye D.W. (PLoS ONE 2015) 3 67
  2. New human and mouse microRNA genes found by homology search. (PMID: 15634332) Weber M.J. (FEBS J. 2005) 1 3
  3. Human embryonic stem cells express a unique set of microRNAs. (PMID: 15183728) Suh M.R. … Kim K.S. (Dev. Biol. 2004) 1 3
  4. Embryonic stem cell-specific MicroRNAs. (PMID: 12919684) Houbaviy H.B. … Sharp P.A. (Dev. Cell 2003) 1 3
  5. MicroRNA-302/367 cluster governs hESC self-renewal by dually regulating cell cycle and apoptosis pathways. (PMID: 25801506) Zhang Z. … Wu W.S. (Stem Cell Reports 2015) 3

Products for MIR302A Gene

Sources for MIR302A Gene

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