Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR302A Gene

Subcategory (RNA class) for MIR302A Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR302A Gene

  • MicroRNA 302a 2 3 5
  • MicroRNA 302 2 3
  • Hsa-Mir-302a 3
  • Hsa-Mir-302 3
  • Mir-302a 3
  • MIRN302A 3
  • MIRN302 3

External Ids for MIR302A Gene

Previous HGNC Symbols for MIR302A Gene

  • MIRN302
  • MIRN302A

Previous GeneCards Identifiers for MIR302A Gene

  • GC04M113797
  • GC04M113571
  • GC04M113575
  • GC04M113584
  • GC04M112649
  • GC04M112653

Summaries for MIR302A Gene

Entrez Gene Summary for MIR302A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR302A Gene

MIR302A (MicroRNA 302a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are TGF-beta Receptor Signaling (WikiPathways) and Cell Differentiation - Index.

fRNAdb sequence ontologies for MIR302A Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR302A

Additional gene information for MIR302A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR302A Gene

Genomics for MIR302A Gene

GeneHancer (GH) Regulatory Elements for MIR302A Gene

Promoters and enhancers for MIR302A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I112704 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 11.3 -57.8 -57785 2.9 PKNOX1 ZNF2 GLIS2 KLF7 SP3 REST ZNF610 GLIS1 SP7 KLF1 ENSG00000250046 LOC109864269 MIR302A MIR302C MIR367 MIR302D LARP7 RPL7AP30 ZGRF1 WRBP1
GH04I112746 Enhancer 0.8 ENCODE dbSUPER 11.1 -102.0 -102007 7.2 ETS1 SP1 GATA3 ZNF316 JUND POLR2A POU5F1 PRDM1 MAFK EZH2 ZGRF1 LARP7 MIR302A MIR302C MIR302D MIR367 LOC109864269 GC04M112739 ENSG00000202536 GC04M112756
GH04I112754 Enhancer 0.2 dbSUPER 11.1 -106.6 -106561 1.3 ENSG00000202536 GC04M112756 ZGRF1 LARP7 MIR302C MIR302D MIR367 MIR302A LOC109864269 GC04M112739
GH04I112645 Enhancer 1.1 FANTOM5 ENCODE dbSUPER 0.8 -2.8 -2767 11.2 PAF1 CTCF USF1 ZNF10 SIN3A ETS1 ZKSCAN1 SP1 NFIC POLR2A LOC109864269 LOC105377372 LARP7 ZGRF1 MIR302A MIR302B MIR302C MIR302D MIR367 GC04M112615
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR302A on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR302A Gene

Genomic Locations for MIR302A Gene
chr4:112,648,183-112,648,251
(GRCh38/hg38)
Size:
69 bases
Orientation:
Minus strand
chr4:113,569,339-113,569,407
(GRCh37/hg19)

Genomic View for MIR302A Gene

Genes around MIR302A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR302A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR302A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR302A Gene

ORGUL Member Location for MIR302A Gene

ORGUL Member Location for MIR302A gene

Proteins for MIR302A Gene

Post-translational modifications for MIR302A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR302A Gene

Domains & Families for MIR302A Gene

Gene Families for MIR302A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR302A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR302A Gene

Function for MIR302A Gene

Phenotypes From GWAS Catalog for MIR302A Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR302A Gene

Localization for MIR302A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR302A Gene

Pathways & Interactions for MIR302A Gene

genes like me logo Genes that share pathways with MIR302A: view

Pathways by source for MIR302A Gene

Interacting Proteins for MIR302A Gene

Gene Ontology (GO) - Biological Process for MIR302A Gene

None

No data available for SIGNOR curated interactions for MIR302A Gene

Drugs & Compounds for MIR302A Gene

No Compound Related Data Available

Transcripts for MIR302A Gene

fRNAdb Secondary structures for MIR302A Gene

  • FR039758
  • hsa-miR-302a-3p_MIMAT0000684_Homo_sapiens_miR-302a-3p_mature

mRNA/cDNA for MIR302A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR302A Gene

No ASD Table

Relevant External Links for MIR302A Gene

GeneLoc Exon Structure for
MIR302A
ECgene alternative splicing isoforms for
MIR302A

Expression for MIR302A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR302A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR302A Gene:

MIR302A
genes like me logo Genes that share expression patterns with MIR302A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR302A Gene

Orthologs for MIR302A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR302A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-302a 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-302a 34
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-302a 34
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir302a 34
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-302a 34
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-302-1 34
  • 41 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-302a 34
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 69 (a)
OneToOne
Species where no ortholog for MIR302A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR302A Gene

ENSEMBL:
Gene Tree for MIR302A (if available)
TreeFam:
Gene Tree for MIR302A (if available)

Paralogs for MIR302A Gene

No data available for Paralogs for MIR302A Gene

Variants for MIR302A Gene

Sequence variations from dbSNP and Humsavar for MIR302A Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1057519017 pathogenic, Alazami syndrome 112,647,715(-) AAAGGATA/AAAGGATAAAGGATA downstream_transcript_variant
rs750946801 likely-pathogenic, not provided 112,649,598(-) AAAAAAAA/AAAAAAA/AAAAAAAAA upstream_transcript_variant
rs1000855041 -- 112,647,944(-) T/C downstream_transcript_variant
rs1000958560 -- 112,648,113(-) T/C downstream_transcript_variant
rs1001109052 -- 112,648,125(-) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR302A Gene

Variant ID Type Subtype PubMed ID
nsv1006030 CNV gain 25217958
nsv1014926 CNV gain 25217958
nsv525715 CNV loss 19592680

Additional Variant Information for MIR302A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR302A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR302A Gene

Disorders for MIR302A Gene

Additional Disease Information for MIR302A

No disorders were found for MIR302A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR302A Gene

Publications for MIR302A Gene

  1. New human and mouse microRNA genes found by homology search. (PMID: 15634332) Weber MJ (The FEBS journal 2005) 1 3 58
  2. Human embryonic stem cells express a unique set of microRNAs. (PMID: 15183728) Suh MR … Kim KS (Developmental biology 2004) 1 3 58
  3. Embryonic stem cell-specific MicroRNAs. (PMID: 12919684) Houbaviy HB … Sharp PA (Developmental cell 2003) 1 3 58
  4. MicroRNA-302a targets GAB2 to suppress cell proliferation, migration and invasion of glioma. (PMID: 28000880) Ma J … Wang L (Oncology reports 2017) 3 58
  5. MicroRNA-302a enhances 5-fluorouracil-induced cell death in human colon cancer cells. (PMID: 27840990) Liu N … Huang C (Oncology reports 2017) 3 58

Products for MIR302A Gene

Sources for MIR302A Gene

Content
Loading form....