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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MIR302A Gene

RNA gene   GIFtS: 18
GCID: GC04M113575

microRNA 302a

(Previous name: microRNA 302 )
(Previous symbols: MIRN302, MIRN302A)
  Search for MIR302A
in
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Biological research products
for MIR302A    

Aliases
for MIR302A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Subcategory (RNA class): miRNA

Quality score for this RNA gene is 13

Aliases
MicroRNA 302a1 2     Hsa-Mir-302a1
MIRN3021 2     MicroRNA 3021
MIRN302A1 2     Mir-302a1
Hsa-Mir-3021     

External Ids:    HGNC: 316231   Entrez Gene: 4070282   Ensembl: ENSG000002079277   OMIM: 6145965   
ORGUL members:    fRNAdb10:FR162411 FR039758      
miRBase: MI0000738    

Export aliases for MIR302A gene to outside databases

Previous GC identifers: GC04M113797 GC04M113571


Summaries
for MIR302A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MIR302A:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene
expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed
by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either
protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an
approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer
ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated
into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the
miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq
represents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)




Genomic Views
for MIR302A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MIR302A
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR302A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q25   Ensembl cytogenetic band:  4q25   HGNC cytogenetic band: 4q25

MIR302A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIR302A gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M113575:  view genomic region (via miRBase)     (about GC identifiers)

Start:
 113,569,339 bp from pter      End:
 113,569,407 bp from pter
Size:
 69 bases      Orientation:
 minus strand

Proteins
for MIR302A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB: --

Protein Domains /
Families
for MIR302A gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
   --

Function
for MIR302A gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Animal Models:
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miRNA
Products:    		miRTarBase genes targeted by MIR302A:
CDKN1A(MIRT004660), CCND1(MIRT003637), LEFTY2(MIRT005557), CDK4(MIRT003636), LEFTY1(MIRT005556)

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Inhib. RNA
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In Situ Assay
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Pathways & Interactions
for MIR302A gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIR302A

Drugs & Compounds
for MIR302A gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MIR302A
Search CenterWatch for drugs/clinical trials and news about MIR302A 

Transcripts
for MIR302A gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000385192(miRNA)

miRNA
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Inhib. RNA
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Clone
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Primer
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GeneLoc Exon Structure


Expression
for MIR302A gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for MIR302A:none

MIR302A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
MIR302A Expression
About this image

MIR302A expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

Stem Cell Differentiation: 1 LifeMap Cell 
NameCategory
Line H7 (WA07) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization
    SABiosciences Custom PCR Arrays for MIR302A
Primer
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In Situ
Assay Products: 
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Orthologs
for MIR302A gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
   --

ENSEMBL Gene Tree for MIR302A (if available)
TreeFam Gene Tree for MIR302A (if available) 

Paralogs
for MIR302A gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for MIR302A gene
MIR302C2  MIR302B2  MIR302D2  

MIR302A for paralogs           About GeneDecksing



Genomic Variants
for MIR302A gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MIR302A
DNA2.0 Custom Variant and Variant Library Synthesis for MIR302A

Disorders / Diseases
for MIR302A gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
MIR302A for disorders           About MalaCards

MIR302A for disorders           About GeneDecksing

OMIM gene information: 614596    OMIM disorders: --


Export disorders for MIR302A gene to outside databases

Publications
for MIR302A gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MIR302A gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with MIR302A)		    Utopia: connect your pdf to the dynamic
world of online information

  1. The microRNA-302-367 cluster suppresses the proliferat ion of cervical carcinoma cells through the novel target AKT1. (PubMed id 23185040)1 Cai N....Zheng P.S. (2013)
  2. Hyaluronan-CD44v3 interaction with Oct4-Sox2-Nanog pro motes miR-302 expression leading to self-renewal, clonal formation, and cisplati n resistance in cancer stem cells from head and neck squamous cell carcinoma. (PubMed id 22847005)1 Bourguignon L.Y....Chen L. (2012)
  3. Establishment and optimal culture conditions of micror na-induced pluripotent stem cells generated from HEK293 cells via transfection o f microrna-302s expression vector. (PubMed id 22515122)1 Koide N....Takei Y. (2012)
  4. Ascl2 knockdown results in tumor growth arrest by miRN A-302b-related inhibition of colon cancer progenitor cells. (PubMed id 22384170)1 Zhu R....Wang R. (2012)
  5. Reactive oxygen species mediate microRNA-302 regulatio n of AT-rich interacting domain 4a and C-C motif ligand 5 expression during tran sitions between quiescence and proliferation. (PubMed id 22732186)1 Kumar M.G....Goswami P.C. (2012)
  6. MicroRNAs regulate p21(Waf1/Cip1) protein expression a nd the DNA damage response in human embryonic stem cells. (PubMed id 22511267)1 Dolezalova D....Hampl A. (2012)
  7. Inhibition of microRNA-302 (miR-302) by bone morphogen etic protein 4 (BMP4) facilitates the BMP signaling pathway. (PubMed id 22988237)1 Kang H....Hata A. (2012)
  8. Multiple targets of miR-302 and miR-372 promote repro gramming of human fibroblasts to induced pluripotent stem cells. (PubMed id 21490602)1 Subramanyam D....Blelloch R. (2011)
  9. MicroRNA cluster 302-367 enhances somatic cell reprog ramming by accelerating a mesenchymal-to-epithelial transition. (PubMed id 21454525)1 Liao B....Pei D. (2011)
  10. The Nodal inhibitor Lefty is negatively modulated by the microRNA miR-302 in human embryonic stem cells. (PubMed id 21266536)1 Barroso-delJesus A....Menendez P. (2011)

External Searches for MIR302A gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing MIR302A gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 407028 HGNC: 31623 Ensembl:ENSG00000207927 miRBase: hsa-mir-302a euGenes: HUgn407028
ECgene: MIR302A H-InvDB: MIR302A

Other Databases showing MIR302A gene

(According to HUGE)
About This Section
   --

Specialized Databases showing MIR302A gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for MIR302A Pharmacogenomics, SNPs, Pathways

Intellectual Property
for MIR302A gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for MIR302A gene:
Search GeneIP for patents involving MIR302A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for MIR302A gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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