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Aliases for MIR301B Gene

Subcategory (RNA class) for MIR301B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR301B Gene

  • MicroRNA 301b 2 3 5
  • Hsa-Mir-301b 3
  • Mir-301b 3
  • MIRN301B 3

External Ids for MIR301B Gene

ORGUL Members for MIR301B Gene

Previous HGNC Symbols for MIR301B Gene

  • MIRN301B

Previous GeneCards Identifiers for MIR301B Gene

  • GC22P020339
  • GC22P022007
  • GC22P021744
  • GC22P021814
  • GC22P021829
  • GC22P021859
  • GC22P021875
  • GC22P021912

Summaries for MIR301B Gene

Entrez Gene Summary for MIR301B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR301B Gene

MIR301B (MicroRNA 301b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR301B include Colonic Benign Neoplasm.

Additional gene information for MIR301B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR301B Gene

Genomics for MIR301B Gene

Regulatory Elements for MIR301B Gene

Enhancers for MIR301B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H021579 0.9 dbSUPER 11.3 -72.9 -72889 0 HNRNPUL1 HDGF PTBP1 ARNT NFXL1 ZNF121 SMARCA5 CEBPB ZNF217 IKZF1 YDJC CCDC116 SDF2L1 TOP3B ABHD17AP4 MIR301B PPIL2 ENSG00000275293 PIR33609
GH22H021582 0.8 dbSUPER 11.2 -69.6 -69646 1 KLF1 ARNT TSC22D4 YBX1 CEBPG IRF9 ZFHX2 SCRT2 EGR2 ZBTB2 CCDC116 PPIL2 TOP3B IGLV5-52 SDF2L1 YDJC ABHD17AP4 THAP7 MIR301B LZTR1
GH22H021581 0.6 dbSUPER 11.2 -70.9 -70927 0 ZNF362 ZBTB2 TSC22D4 IRF9 NCOR1 POLR2A GLIS1 PRDM10 MLLT1 SUPT5H CCDC116 YDJC SDF2L1 ABHD17AP4 MIR301B PPIL2 ENSG00000275293 PIR33609
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR301B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR301B Gene

Chromosome:
22
Start:
21,652,981 bp from pter
End:
21,653,058 bp from pter
Size:
78 bases
Orientation:
Plus strand

Genomic View for MIR301B Gene

Genes around MIR301B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR301B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR301B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR301B Gene

Proteins for MIR301B Gene

Post-translational modifications for MIR301B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR301B Gene

Domains & Families for MIR301B Gene

Gene Families for MIR301B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR301B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR301B Gene

Function for MIR301B Gene

Phenotypes From GWAS Catalog for MIR301B Gene

Gene Ontology (GO) - Molecular Function for MIR301B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 26501192
genes like me logo Genes that share ontologies with MIR301B: view

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR301B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR301B Gene

Localization for MIR301B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR301B Gene

Pathways & Interactions for MIR301B Gene

SuperPathways for MIR301B Gene

No Data Available

Interacting Proteins for MIR301B Gene

Gene Ontology (GO) - Biological Process for MIR301B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 26501192
GO:0042953 lipoprotein transport IDA 26501192
GO:0090370 negative regulation of cholesterol efflux IDA 26501192
genes like me logo Genes that share ontologies with MIR301B: view

No data available for Pathways by source and SIGNOR curated interactions for MIR301B Gene

Drugs & Compounds for MIR301B Gene

No Compound Related Data Available

Transcripts for MIR301B Gene

mRNA/cDNA for MIR301B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR301B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR301B Gene

No ASD Table

Relevant External Links for MIR301B Gene

GeneLoc Exon Structure for
MIR301B
ECgene alternative splicing isoforms for
MIR301B

Expression for MIR301B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR301B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR301B Gene:

MIR301B
genes like me logo Genes that share expression patterns with MIR301B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR301B Gene

Orthologs for MIR301B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR301B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-301b 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-301b 34
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-301b 34
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir301b 34
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-130c-2 34
  • 54 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-130b 34
  • 34 (a)
ManyToMany
chicken
(Gallus gallus)
Aves gga-mir-301a 34
  • 59 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-301b 34
  • 58 (a)
ManyToMany
aca-mir-130b 34
  • 34 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii dre-mir-301b 34
  • 62 (a)
ManyToMany
Species where no ortholog for MIR301B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR301B Gene

ENSEMBL:
Gene Tree for MIR301B (if available)
TreeFam:
Gene Tree for MIR301B (if available)

Paralogs for MIR301B Gene

No data available for Paralogs for MIR301B Gene

Variants for MIR301B Gene

Sequence variations from dbSNP and Humsavar for MIR301B Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000988729 -- 21,651,210(+) AAATG(C/T)CAGGT upstream-variant-2KB
rs1001230778 -- 21,652,187(+) TCAGC(C/G)GGTTA upstream-variant-2KB
rs1002427025 -- 21,652,800(+) CCACC(A/T)CAATC upstream-variant-2KB
rs1003179449 -- 21,651,454(+) CCGTT(C/G)AACAG upstream-variant-2KB
rs1004394849 -- 21,653,139(+) CCTCC(C/T)CCCTA downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR301B Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER inversion 18451855

Relevant External Links for MIR301B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR301B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR301B Gene

Disorders for MIR301B Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR301B Gene - From: DISEASES

Disorder Aliases PubMed IDs
colonic benign neoplasm
  • colon neoplasm
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR301B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR301B
genes like me logo Genes that share disorders with MIR301B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR301B Gene

Publications for MIR301B Gene

  1. Hypoxia induced upregulation of miR-301a/b contributes to increased cell autophagy and viability of prostate cancer cells by targeting NDRG2. (PMID: 26813459) Guo YJ … Guan YW (European review for medical and pharmacological sciences 2016) 3 60
  2. A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2. (PMID: 27197190) Yang S … Hussain SP (Cancer research 2016) 3 60
  3. Hypoxia-induced microRNA-301b regulates apoptosis by targeting Bim in lung cancer. (PMID: 27352910) Wu D … Wang M (Cell proliferation 2016) 3 60
  4. MicroRNA301 is a potential diagnostic biomarker for hepatocellular cancer. (PMID: 26191271) He K … Zhou J (International journal of clinical and experimental pathology 2015) 3 60
  5. The microRNA-130/301 family controls vasoconstriction in pulmonary hypertension. (PMID: 25505270) Bertero T … Chan SY (The Journal of biological chemistry 2015) 3 60

Products for MIR301B Gene

Sources for MIR301B Gene

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