Aliases
for MIR301B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
About This Section
TryGeneCards Plus |
Subcategory (RNA class): miRNA
Quality score for this RNA gene is 3
| Aliases |
|---|
| MicroRNA 301b1 2 | | MIRN301B1 2 | | mir-301b9 |
| External Ids: | HGNC: 336671 | Entrez Gene: 1001263182 | Ensembl: ENSG000002121027 |
Export aliases for MIR301B gene to outside databasesPrevious GC identifer: GC22P020339
|---|
Summaries
for MIR301B gene(According to Entrez Gene,
GeneCards,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
TryGeneCards Plus |
Entrez Gene summary for MIR301B Gene:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of
gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are
transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can
be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme
to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the
cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The
mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through
imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of
the target mRNA. The RefSeq represents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)
GeneCards Summary for MIR301B Gene:
MIR301B (microRNA 301b) is an RNA gene, and is affiliated with the miRNA class.
|
Genomic Views
for MIR301B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 75),
Regulatory elements and Epigenetics data according to
QIAGEN, and/or
SwitchGear Genomics)
About This Section
TryGeneCards Plus | Regulatory elements:
 Search for regulatory transcription factor binding sites for MIR301B
Other transcription factors
Search Chromatin IP Primers for MIR301B
Epigenetics:
| | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIR301B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q11.21 Ensembl cytogenetic band: 22q11.21 HGNC cytogenetic band: 22q11.21MIR301B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P022007: view genomic region (via miRBase)
(about GC identifiers)
Start:
|
22,007,270 bp from pter |
End:
|
22,007,347 bp from pter |
Size:
|
78 bases |
Orientation:
|
plus strand |
|
Proteins
for MIR301B gene
(According to
1UniProtKB,
HORDE,
2neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Antibodies by
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
TryGeneCards Plus |
UniProtKB: --
|
Domains /
Families
for MIR301B gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
TryGeneCards Plus | HGNC Gene Families:
MIR: ncRNAs / Micro RNAs
-- |
Function
for MIR301B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
transcription factor targeting from QIAGEN
and/or HOMER,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
SwitchGear Genomics,
Gene Editing from DNA2.0,
Clones from OriGene,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
ESI BIO,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
About This Section
TryGeneCards Plus |
Animal Models:
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for MIR301B | |  | Browse ESI BIO Cell Lines and PureStem Progenitors for MIR301B  | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIR301B |
Localization
for MIR301B gene
(According to UniProtKB, COMPARTMENTS Subcellular localization database,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
About This Section
TryGeneCards Plus | -- |
Pathways & Interactions
for MIR301B gene
(SuperPaths according to PathCards,
Pathways according to
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
QIAGEN,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene).
About This Section
TryGeneCards Plus |
Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MIR301B
Interactions:
Search GeneGlobe Interaction Network for MIR301B
|
Drugs & Compounds
for MIR301B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience,
ApexBio,
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB)
About This Section
TryGeneCards Plus |  Browse compounds at ApexBio
 Browse Tocris compounds for MIR301B
|
Transcripts
for MIR301B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
SwitchGear Genomics,
Tagged/untagged cDNA clones from
OriGene,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene, and/or
QIAGEN
)
About This Section
TryGeneCards Plus |
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000390813(miRNA)
GeneLoc Exon Structure
|
Expression
for MIR301B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MaxQB,
plus additional links to
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
QIAGEN,
Primers from
OriGene, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
TryGeneCards Plus | Expression evidence for MIR301B:none
See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
MIR301B Protein expression data from MOPED1, PaxDb2 and
MaxQB3:  --
Custom PCR Arrays for MIR301B
Primer
Products: |  | Browse OriGene qPCR
| | | Search Pre-validated RT2 qPCR
Primer Assays in human, mouse, rat MIR301B | | | Search QuantiTect SYBR Green Assays in human, mouse, rat MIR301B | | | Search QuantiFast Probe-based Assays in human, mouse, rat MIR301B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIR301B |
Orthologs
for MIR301B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
TryGeneCards Plus |
This gene was present in the common ancestor of chordates.
Orthologs for MIR301B gene from Selected species (see all 9) About this table
Species with no ortholog for MIR301B
ENSEMBL Gene Tree for MIR301B (if available)
TreeFam Gene Tree for MIR301B (if available) |
Paralogs
for MIR301B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
TryGeneCards Plus | -- |
Genomic Variants
for MIR301B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD), the Human Cytochrome P450 Allele
Nomenclature Database, and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section
TryGeneCards Plus |
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MIR301B (22007270 - 22007347 bp)
Structural Variations
Database of Genomic Variants (DGV) 5 variations for MIR301B: About this table
| | Site Specific Mutation Identification with PCR Assays |
|
Disorders
/ Diseases
for MIR301B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
TryGeneCards Plus | -- |
Publications
for MIR301B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
TryGeneCards Plus |
PubMed articles for MIR301B gene integrated from 10 sources:
(articles sorted by number of sources associating them with MIR301B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Intronic miR-301 feedback regulates its host gene, ska2, in A549 cells by targeting MEOX2 to affect ERK/CREB pathways. (PubMed id 20470754)1 Cao G....Shao N. (Biochem. Biophys. Res. Commun. 2010)
- A mammalian microRNA expression atlas based on small RNA library sequencing. (PubMed id 17604727)1 Landgraf P....Tuschl T. (Cell 2007)
- miRBase: microRNA sequences, targets and gene nomenclature. (PubMed id 16381832)1 Griffiths-Jones S....Enright A.J. (Nucleic Acids Res. 2006)
- Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis. (PubMed id 16954537)1 Berezikov E....Cuppen E. (Genome Res. 2006)
|
External Searches for MIR301B gene (in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
TryGeneCards Plus |
|
Genome Databases showing MIR301B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
TryGeneCards Plus |
|
Other Databases showing MIR301B gene
(According to HUGE)
About This Section
TryGeneCards Plus | -- |
Specialized Databases showing MIR301B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section
TryGeneCards Plus |
| Name | Description |
| PharmGKB entry for MIR301B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
TryGeneCards Plus | Patent Information for MIR301B gene:
Search GeneIP for patents involving MIR301B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MIR301B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or
ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
TryGeneCards Plus |
 | |
 |
| | | | |
 |
 |
|  | Block miRNA regulation of human, mouse, rat MIR301B using miScript Target Protectors | | SeqTarget long-range PCR primers for resequencing MIR301B | | | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIR301B | | Predesigned siRNA for gene silencing in human, mouse, rat MIR301B | | | Search QuantiFast Probe-based Assays in human, mouse, rat MIR301B | | Search QuantiTect SYBR Green Assays in human, mouse, rat MIR301B | | | Custom PCR Arrays for MIR301B | | Search Chromatin IP Primers for MIR301B | | | Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MIR301B | | Search GeneGlobe Interaction Network for MIR301B | | | Search Regulatory tfbs for MIR301B |
| |
 |  |  |  | |
| | | Search Tocris compounds for MIR301B |
| | |  |  |  |
 | | | | |
 |
 |
 |  | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIR301B |
| |  |  |  |  | | | Search ThermoFisher Antibodies for MIR301B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MIR301B |
| | |  |  | | |
|
|
|
GeneCards Homepage -
Last full update: 7 May 2014 -
Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014
View Random Gene
|
Category
|
|
|
|
| GIFtS Group |
|
Developed at the Crown Human Genome Center,
Department of Molecular Genetics,
the Weizmann Institute of Science
Copyright © 1996-2014
, Weizmann Institute of Science. All Rights Reserved.
Version: 3.12.136 22 July 2014
hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4
|
