Free for academic non-profit institutions. Other users need a Commercial license

MIR301B Gene(RNA Gene)

MicroRNA 301b

GCID:
GC22P021978
GIFtS:
17
Genes Participants
UDN Logo

Aliases for MIR301B Gene

Subcategory (RNA class) for MIR301B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR301B Gene

  • MicroRNA 301b 2 3 5
  • Hsa-Mir-301b 3
  • Mir-301b 3
  • MIRN301B 3

External Ids for MIR301B Gene

ORGUL Members for MIR301B Gene

Previous HGNC Symbols for MIR301B Gene

  • MIRN301B

Previous GeneCards Identifiers for MIR301B Gene

  • GC22P020339
  • GC22P022007
  • GC22P021744
  • GC22P021814
  • GC22P021829
  • GC22P021859
  • GC22P021875
  • GC22P021912
  • GC22P021947

Summaries for MIR301B Gene

Entrez Gene Summary for MIR301B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR301B Gene

MIR301B (MicroRNA 301b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR301B include Colonic Benign Neoplasm.

Additional gene information for MIR301B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR301B Gene

Genomics for MIR301B Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MIR301B Gene

Promoters and enhancers for MIR301B Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH22I021650 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 550.8 -0.7 -650 2.8 PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 GLIS2 GATA2 GC22P021989 GC22P021991 MIR130B MIR301B PPIL2 YDJC CCDC116 ABHD17AP4 PIR47183
GH22I021579 Enhancer 0.8 dbSUPER 11.3 -72.9 -72889 0.7 HDAC1 HDGF HNRNPUL1 ARNT NFXL1 ZNF121 ARID2 SMARCA5 RXRA CEBPB YDJC CCDC116 SDF2L1 TOP3B ABHD17AP4 MIR301B PPIL2 ENSG00000275293 UBE2L3 PIR33609
GH22I021582 Enhancer 0.8 dbSUPER 11.2 -69.6 -69646 1.4 HDAC1 KLF1 ARNT TSC22D4 CEBPG YBX1 ZNF280A IRF9 ZFHX2 POLR2B CCDC116 PPIL2 TOP3B IGLV5-52 YDJC SDF2L1 ABHD17AP4 THAP7 MIR301B LZTR1
GH22I021581 Enhancer 0.6 dbSUPER 11.2 -70.9 -70927 0.6 ZNF362 ZBTB2 TSC22D4 IRF9 POLR2B NCOR1 POLR2A GLIS1 MLLT1 PRDM10 CCDC116 YDJC SDF2L1 ABHD17AP4 MIR301B PPIL2 ENSG00000275293 UBE2L3 PIR33609
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR301B on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR301B Gene

Genomic Locations for MIR301B Gene
chr22:21,652,981-21,653,058
(GRCh38/hg38)
Size:
78 bases
Orientation:
Plus strand
chr22:22,007,270-22,007,347
(GRCh37/hg19)

Genomic View for MIR301B Gene

Genes around MIR301B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR301B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR301B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR301B Gene

Proteins for MIR301B Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR301B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR301B Gene

Domains & Families for MIR301B Gene

Gene Families for MIR301B Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR301B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR301B Gene

Function for MIR301B Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Phenotypes From GWAS Catalog for MIR301B Gene

Gene Ontology (GO) - Molecular Function for MIR301B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 26501192
genes like me logo Genes that share ontologies with MIR301B: view

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR301B Gene

Localization for MIR301B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR301B Gene

Pathways & Interactions for MIR301B Gene

SuperPathways for MIR301B Gene

PathCards logo More details on SuperPathways for MIR301B
No Data Available

Interacting Proteins for MIR301B Gene

Gene Ontology (GO) - Biological Process for MIR301B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 26501192
GO:0042953 lipoprotein transport IDA 26501192
GO:0090370 negative regulation of cholesterol efflux IDA 26501192
genes like me logo Genes that share ontologies with MIR301B: view

No data available for Pathways by source and SIGNOR curated interactions for MIR301B Gene

Drugs & Compounds for MIR301B Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR301B Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR301B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR301B Gene

No ASD Table

Relevant External Links for MIR301B Gene

GeneLoc Exon Structure for
MIR301B
ECgene alternative splicing isoforms for
MIR301B

Expression for MIR301B Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR301B Gene

mRNA expression in normal human tissues for MIR301B Gene
mRNA expression by GTEx for MIR301B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR301B Gene:

MIR301B
genes like me logo Genes that share expression patterns with MIR301B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR301B Gene

Orthologs for MIR301B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR301B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-301b 34
  • 100 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia cfa-mir-301b 34
  • 96 (a)
 OneToOne
cow
(Bos Taurus)
 Mammalia bta-mir-301b 34
  • 77 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Mir301b 34
  • 73 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia mdo-mir-130c-2 34
  • 54 (a)
 ManyToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia oan-mir-130b 34
  • 34 (a)
 ManyToMany
chicken
(Gallus gallus)
 Aves gga-mir-301a 34
  • 59 (a)
 ManyToMany
lizard
(Anolis carolinensis)
 Reptilia aca-mir-301b 34
  • 58 (a)
 ManyToMany
aca-mir-130b 34
  • 34 (a)
 ManyToMany
zebrafish
(Danio rerio)
 Actinopterygii dre-mir-301b 34
  • 62 (a)
 ManyToMany
Species where no ortholog for MIR301B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR301B Gene

ENSEMBL:
Gene Tree for MIR301B (if available)
TreeFam:
Gene Tree for MIR301B (if available)

Paralogs for MIR301B Gene

No data available for Paralogs for MIR301B Gene

Variants for MIR301B Gene

Sequence variations from dbSNP and Humsavar for MIR301B Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
rs1000988729 -- 21,651,210(+) C/T upstream_transcript_variant
rs1001230778 -- 21,652,187(+) G/C upstream_transcript_variant
rs1002427025 -- 21,652,800(+) T/A upstream_transcript_variant
rs1003179449 -- 21,651,454(+) C/G upstream_transcript_variant
rs1004394849 -- 21,653,139(+) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR301B Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER inversion 18451855

Additional Variant Information for MIR301B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR301B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR301B Gene

Disorders for MIR301B Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR301B Gene - From: DISEASES

Disorder Aliases PubMed IDs
colonic benign neoplasm
  • colon neoplasm
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR301B

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR301B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR301B Gene

Publications for MIR301B Gene

  1. Hypoxia induced upregulation of miR-301a/b contributes to increased cell autophagy and viability of prostate cancer cells by targeting NDRG2. (PMID: 26813459) Guo YJ … Guan YW (European review for medical and pharmacological sciences 2016) 3 58
  2. A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2. (PMID: 27197190) Yang S … Hussain SP (Cancer research 2016) 3 58
  3. Hypoxia-induced microRNA-301b regulates apoptosis by targeting Bim in lung cancer. (PMID: 27352910) Wu D … Wang M (Cell proliferation 2016) 3 58
  4. The microRNA-130/301 family controls vasoconstriction in pulmonary hypertension. (PMID: 25505270) Bertero T … Chan SY (The Journal of biological chemistry 2015) 3 58
  5. MicroRNA301 is a potential diagnostic biomarker for hepatocellular cancer. (PMID: 26191271) He K … Zhou J (International journal of clinical and experimental pathology 2015) 3 58

Products for MIR301B Gene

Sources for MIR301B Gene

Content
Loading form....