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MIR301B Gene(RNA Gene)

MicroRNA 301b

GCID:
GC22P021829
GIFtS:
17
Genes Participants
UDN Logo

Aliases for MIR301B Gene

Subcategory (RNA class) for MIR301B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR301B Gene

  • MicroRNA 301b 2 3 5
  • Hsa-Mir-301b 3
  • Mir-301b 3
  • MIRN301B 3

External Ids for MIR301B Gene

ORGUL Members for MIR301B Gene

Previous HGNC Symbols for MIR301B Gene

  • MIRN301B

Previous GeneCards Identifiers for MIR301B Gene

  • GC22P020339
  • GC22P022007
  • GC22P021744
  • GC22P021814

Summaries for MIR301B Gene

Entrez Gene Summary for MIR301B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR301B Gene

MIR301B (MicroRNA 301b) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR301B Gene

Genomics for MIR301B Gene

Products:

  1. Regulatory Element

Genomic Location for MIR301B Gene

Chromosome:
22
Start:
21,652,981 bp from pter
End:
21,653,058 bp from pter
Size:
78 bases
Orientation:
Plus strand

Genomic View for MIR301B Gene

Genes around MIR301B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR301B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR301B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR301B Gene

No data available for Regulatory Elements for MIR301B Gene

Proteins for MIR301B Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR301B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR301B Gene

Domains & Families for MIR301B Gene

Gene Families for MIR301B Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR301B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR301B Gene

Function for MIR301B Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR301B Gene

Localization for MIR301B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR301B Gene

Pathways & Interactions for MIR301B Gene

SuperPathways for MIR301B Gene

PathCards logoMore details on SuperPathways for MIR301B
No Data Available

Interacting Proteins for MIR301B Gene

Gene Ontology (GO) - Biological Process for MIR301B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR301B Gene

Drugs & Compounds for MIR301B Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR301B Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for MIR301B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR301B Gene

No ASD Table

Relevant External Links for MIR301B Gene

GeneLoc Exon Structure for
MIR301B
ECgene alternative splicing isoforms for
MIR301B

Expression for MIR301B Gene

Products:

  1. Primer

mRNA expression in normal human tissues for MIR301B Gene

mRNA expression in normal human tissues for MIR301B Gene
mRNA expression by GTEx for MIR301B Gene
genes like me logo Genes that share expression patterns with MIR301B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR301B Gene

Orthologs for MIR301B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR301B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia bta-mir-301b 36
  • 77 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia cfa-mir-301b 36
  • 96 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia mdo-mir-130c-2 36
  • 54 (a)
 ManyToMany
mouse
(Mus musculus)
 Mammalia Mir301b 36
  • 73 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia oan-mir-130b 36
  • 34 (a)
 ManyToMany
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-301b 36
  • 100 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves gga-mir-301a 36
  • 59 (a)
 ManyToMany
lizard
(Anolis carolinensis)
 Reptilia aca-mir-130b 36
  • 34 (a)
 ManyToMany
aca-mir-301b 36
  • 58 (a)
 ManyToMany
zebrafish
(Danio rerio)
 Actinopterygii dre-mir-301b 36
  • 62 (a)
 ManyToMany
Species with no ortholog for MIR301B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR301B Gene

ENSEMBL:
Gene Tree for MIR301B (if available)
TreeFam:
Gene Tree for MIR301B (if available)

Paralogs for MIR301B Gene

No data available for Paralogs for MIR301B Gene

Variants for MIR301B Gene

Sequence variations from dbSNP and Humsavar for MIR301B Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs57349125 -- 21,651,303(+) TTTGC(A/C)AGAAG upstream-variant-2KB
rs534882914 -- 21,651,265(+) AGCCA(A/G)CCCTA upstream-variant-2KB
rs184896932 -- 21,651,037(+) AGTGA(A/G)GTGAG upstream-variant-2KB
rs371651142 -- 21,651,047(+) GGAGT(A/G)TTGAC upstream-variant-2KB
rs371919574 -- 21,651,259(+) GGCAA(C/T)AGCCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR301B Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
nsv914458 CNV Loss 21882294
dgv4881n71 CNV Loss 21882294
dgv4882n71 CNV Loss 21882294
nsv914469 CNV Loss 21882294

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for MIR301B Gene

Disorders for MIR301B Gene

Relevant External Links for MIR301B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR301B

No disorders were found for MIR301B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR301B Gene

Publications for MIR301B Gene

  1. The microRNA-130/301 family controls vasoconstriction in pulmonary hypertension. (PMID: 25505270) Bertero T. … Chan S.Y. (J. Biol. Chem. 2015) 3 67
  2. MicroRNA301 is a potential diagnostic biomarker for hepatocellular cancer. (PMID: 26191271) He K. … Zhou J. (Int J Clin Exp Pathol 2015) 3
  3. MicroRNA-301b promotes cell invasiveness through targeting TP63 in pancreatic carcinoma cells. (PMID: 24398967) Funamizu N. … Yanaga K. (Int. J. Oncol. 2014) 3
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3
  5. Intronic miR-301 feedback regulates its host gene, ska2, in A549 cells by targeting MEOX2 to affect ERK/CREB pathways. (PMID: 20470754) Cao G. … Shao N. (Biochem. Biophys. Res. Commun. 2010) 3

Products for MIR301B Gene

Sources for MIR301B Gene

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