Aliases for MIR301B Gene
Subcategory (RNA class) for MIR301B Gene
Quality Score for this RNA gene is
External Ids for MIR301B Gene
- HGNC: 33667
- Entrez Gene: 100126318
- Ensembl: ENSG00000212102
- miRBase: hsa-mir-301b
Previous HGNC Symbols for MIR301B Gene
- MIRN301B
Previous GeneCards Identifiers for MIR301B Gene
- GC22P020339
- GC22P022007
- GC22P021744
- GC22P021814
- GC22P021829
- GC22P021859
- GC22P021875
- GC22P021912
- GC22P021947
Summaries for MIR301B Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR301B Gene
MIR301B (MicroRNA 301b) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR301B include Colonic Benign Neoplasm.
Additional gene information for MIR301B Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR301B Gene
Genomics for MIR301B Gene
GeneHancer (GH) Regulatory Elements for MIR301B Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH22I021650 | Promoter/Enhancer | 1.6 | Ensembl ENCODE dbSUPER | 550.8 | -0.7 | -650 | 2.8 | PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 GLIS2 GATA2 | GC22P021989 GC22P021991 MIR130B MIR301B PPIL2 YDJC CCDC116 ABHD17AP4 PIR47183 | |
GH22I021579 | Enhancer | 0.8 | dbSUPER | 11.3 | -72.9 | -72889 | 0.7 | HDAC1 HDGF HNRNPUL1 ARNT NFXL1 ZNF121 ARID2 SMARCA5 RXRA CEBPB | YDJC CCDC116 SDF2L1 TOP3B ABHD17AP4 MIR301B PPIL2 ENSG00000275293 UBE2L3 PIR33609 | |
GH22I021582 | Enhancer | 0.8 | dbSUPER | 11.2 | -69.6 | -69646 | 1.4 | HDAC1 KLF1 ARNT TSC22D4 CEBPG YBX1 ZNF280A IRF9 ZFHX2 POLR2B | CCDC116 PPIL2 TOP3B IGLV5-52 YDJC SDF2L1 ABHD17AP4 THAP7 MIR301B LZTR1 | |
GH22I021581 | Enhancer | 0.6 | dbSUPER | 11.2 | -70.9 | -70927 | 0.6 | ZNF362 ZBTB2 TSC22D4 IRF9 POLR2B NCOR1 POLR2A GLIS1 MLLT1 PRDM10 | CCDC116 YDJC SDF2L1 ABHD17AP4 MIR301B PPIL2 ENSG00000275293 UBE2L3 PIR33609 |
Regulatory Element Products
Genomic Locations for MIR301B Gene
- chr22:21,652,981-21,653,058
- (GRCh38/hg38)
- Size:
- 78 bases
- Orientation:
- Plus strand
- chr22:22,007,270-22,007,347
- (GRCh37/hg19)
Genomic View for MIR301B Gene
- Cytogenetic band:
-
- 22q11.21 by Ensembl
- 22q11.21 by Entrez Gene
- 22q11.21 by HGNC


RefSeq DNA sequence for MIR301B Gene
Proteins for MIR301B Gene
Post-translational modifications for MIR301B Gene
Antibody Products
- Search GeneTex for Antibodies for MIR301B
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR301B
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- Search GeneTex for Proteins for MIR301B
No data available for DME Specific Peptides for MIR301B Gene
Domains & Families for MIR301B Gene
Gene Families for MIR301B Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR301B Gene
Function for MIR301B Gene
Phenotypes From GWAS Catalog for MIR301B Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 26501192 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
- Search ViGene Biosciences for MIR301B
CRISPR Products
- Browse CRISPR knockouts for MIR301B
- Applied Biological Materials CRISPR for MIR301B
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR301B
Clone Products
- GenScript: Custom all cDNA clones Services for MIR301B
- VectorBuilder custom plasmid, inducible vectors for MIR301B
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR301B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR301B Gene
Localization for MIR301B Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR301B Gene
Pathways & Interactions for MIR301B Gene
Interacting Proteins for MIR301B Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0035195 | gene silencing by miRNA | IDA | 26501192 |
GO:0042953 | lipoprotein transport | IDA | 26501192 |
GO:0090370 | negative regulation of cholesterol efflux | IDA | 26501192 |
No data available for Pathways by source and SIGNOR curated interactions for MIR301B Gene
Transcripts for MIR301B Gene
mRNA/cDNA for MIR301B Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIR301B
- Applied Biological Materials CRISPR for MIR301B
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR301B
Clone Products
- GenScript: Custom all cDNA clones Services for MIR301B
- VectorBuilder custom plasmid, inducible vectors for MIR301B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR301B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR301B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIR301B Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR301B Gene:
MIR301BPrimer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR301B Gene
Orthologs for MIR301B Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-301b 34 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | cfa-mir-301b 34 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | bta-mir-301b 34 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Mir301b 34 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-130c-2 34 |
|
ManyToMany | |
platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-130b 34 |
|
ManyToMany | |
chicken (Gallus gallus) |
Aves | gga-mir-301a 34 |
|
ManyToMany | |
lizard (Anolis carolinensis) |
Reptilia | aca-mir-301b 34 |
|
ManyToMany | |
aca-mir-130b 34 |
|
ManyToMany | |||
zebrafish (Danio rerio) |
Actinopterygii | dre-mir-301b 34 |
|
ManyToMany |
- Species where no ortholog for MIR301B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for MIR301B Gene
No data available for Paralogs for MIR301B Gene
Variants for MIR301B Gene
SNP ID | Clin | Chr 22 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000988729 | -- | 21,651,210(+) | C/T | upstream_transcript_variant | |
rs1001230778 | -- | 21,652,187(+) | G/C | upstream_transcript_variant | |
rs1002427025 | -- | 21,652,800(+) | T/A | upstream_transcript_variant | |
rs1003179449 | -- | 21,651,454(+) | C/G | upstream_transcript_variant | |
rs1004394849 | -- | 21,653,139(+) | C/T | downstream_transcript_variant |
Additional Variant Information for MIR301B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR301B
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR301B Gene
Disorders for MIR301B Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
colonic benign neoplasm |
|
|
Additional Disease Information for MIR301B
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR301B Gene
Publications for MIR301B Gene
- Hypoxia induced upregulation of miR-301a/b contributes to increased cell autophagy and viability of prostate cancer cells by targeting NDRG2. (PMID: 26813459) Guo YJ … Guan YW (European review for medical and pharmacological sciences 2016) 3 58
- A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2. (PMID: 27197190) Yang S … Hussain SP (Cancer research 2016) 3 58
- Hypoxia-induced microRNA-301b regulates apoptosis by targeting Bim in lung cancer. (PMID: 27352910) Wu D … Wang M (Cell proliferation 2016) 3 58
- The microRNA-130/301 family controls vasoconstriction in pulmonary hypertension. (PMID: 25505270) Bertero T … Chan SY (The Journal of biological chemistry 2015) 3 58
- MicroRNA301 is a potential diagnostic biomarker for hepatocellular cancer. (PMID: 26191271) He K … Zhou J (International journal of clinical and experimental pathology 2015) 3 58
Products for MIR301B Gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR301B
- VectorBuilder custom plasmid, inducible vectors for MIR301B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR301B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for MIR301B
- Search GeneTex for Proteins for MIR301B
Sources for MIR301B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
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- (69) OCA
- (70) Proteopedia
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- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
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