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Aliases for MIR301A Gene

Subcategory (RNA class) for MIR301A Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR301A Gene

  • MicroRNA 301a 2 3 5
  • MicroRNA 301 2 3
  • Hsa-Mir-301a 3
  • Hsa-Mir-301 3
  • Mir-301a 3
  • MIRN301A 3
  • MIRN301 3
  • MIR301 3

External Ids for MIR301A Gene

Previous HGNC Symbols for MIR301A Gene

  • MIRN301
  • MIRN301A

Previous GeneCards Identifiers for MIR301A Gene

  • GC17M054587
  • GC17M057228

Summaries for MIR301A Gene

Entrez Gene Summary for MIR301A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR301A Gene

MIR301A (MicroRNA 301a) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR301A Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR301A

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR301A Gene

Genomics for MIR301A Gene

Regulatory Elements for MIR301A Gene

Enhancers for MIR301A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G059110 0.6 dbSUPER 11.6 +39.2 39189 2.7 PKNOX1 ZNF362 PRDM6 ZNF157 ETV6 NFXL1 ZNF384 TRIM37 MIR301A MIR454 PRR11 SKA2 GC17M059110
GH17G059123 0.5 FANTOM5 12.2 +28.0 28019 0.1 ZNF121 ZNF362 MIR301A PRR11 SKA2 SMG8 GDPD1 GC17M059121 RNU2-58P
GH17G059121 0.5 dbSUPER 12.2 +29.1 29078 0.6 ZNF362 RNF2 ETV6 NFXL1 BCLAF1 MIR301A PRR11 SKA2 SMG8 GC17M059121 RNU2-58P
GH17G059046 0.5 ENCODE 11 +104.8 104797 0.1 FOSL1 ATF1 ZBTB11 BHLHE40 CREM MIR301A SMG8 MTMR4 GC17P059054 GC17M059024
GH17G059120 0.4 dbSUPER 12.2 +30.7 30680 0.9 PKNOX1 RAD51 MIR301A PRR11 SKA2 SMG8 GC17M059121 GC17M059110
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR301A on UCSC Golden Path with GeneCards custom track

Promoters for MIR301A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000096330 -1679 201 PRDM6 ZBTB40

Genomic Location for MIR301A Gene

Chromosome:
17
Start:
59,151,136 bp from pter
End:
59,151,221 bp from pter
Size:
86 bases
Orientation:
Minus strand

Genomic View for MIR301A Gene

Genes around MIR301A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR301A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR301A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR301A Gene

ORGUL Member Location for MIR301A Gene

ORGUL Member Location for MIR301A gene

Proteins for MIR301A Gene

Post-translational modifications for MIR301A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR301A Gene

Domains & Families for MIR301A Gene

Gene Families for MIR301A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR301A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR301A Gene

Function for MIR301A Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR301A Gene

Localization for MIR301A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR301A Gene

Pathways & Interactions for MIR301A Gene

SuperPathways for MIR301A Gene

No Data Available

Interacting Proteins for MIR301A Gene

Gene Ontology (GO) - Biological Process for MIR301A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR301A Gene

Transcripts for MIR301A Gene

fRNAdb Secondary structures for MIR301A Gene

  • hsa-miR-301a-5p_MIMAT0022696_Homo_sapiens_miR-301a-5p_mature
  • hsa-mir-301a_MI0000745_Homo_sapiens_miR-301a_stem-loop_hairpin

mRNA/cDNA for MIR301A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR301A Gene

No ASD Table

Relevant External Links for MIR301A Gene

GeneLoc Exon Structure for
MIR301A
ECgene alternative splicing isoforms for
MIR301A

Expression for MIR301A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR301A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR301A Gene:

MIR301A
genes like me logo Genes that share expression patterns with MIR301A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR301A Gene

Orthologs for MIR301A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR301A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-301a 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-301a 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-301 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-301a 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir301 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-301 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-301b 35
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-301a 35
  • 83 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-301a 35
  • 79 (a)
OneToMany
dre-mir-130a 35
  • 51 (a)
OneToMany
Species where no ortholog for MIR301A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR301A Gene

ENSEMBL:
Gene Tree for MIR301A (if available)
TreeFam:
Gene Tree for MIR301A (if available)

Paralogs for MIR301A Gene

No data available for Paralogs for MIR301A Gene

Variants for MIR301A Gene

Sequence variations from dbSNP and Humsavar for MIR301A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1001565228 -- 59,151,970(+) GAAAA(G/T)AATGA intron-variant, upstream-variant-2KB
rs1001994806 -- 59,151,584(+) TGCAG(A/G)GATGT intron-variant, upstream-variant-2KB
rs1005672495 -- 59,152,789(+) AGTAA(C/T)AATTA intron-variant, upstream-variant-2KB
rs1007392127 -- 59,150,934(+) ATATA(A/C)AAAAT intron-variant, downstream-variant-500B
rs1009932346 -- 59,152,957(+) AATAC(C/T)ACCCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR301A Gene

Variant ID Type Subtype PubMed ID
dgv3270n100 CNV gain 25217958
dgv3271n100 CNV gain 25217958
esv2758699 CNV gain 17122850
esv3573764 CNV gain 25503493
nsv1065063 CNV gain 25217958
nsv575802 CNV loss 21841781
nsv833499 CNV loss 17160897

Relevant External Links for MIR301A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR301A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR301A Gene

Disorders for MIR301A Gene

Relevant External Links for MIR301A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR301A

No disorders were found for MIR301A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR301A Gene

Publications for MIR301A Gene

  1. New human and mouse microRNA genes found by homology search. (PMID: 15634332) Weber M.J. (FEBS J. 2005) 1 3 64
  2. Human embryonic stem cells express a unique set of microRNAs. (PMID: 15183728) Suh M.R. … Kim K.S. (Dev. Biol. 2004) 1 3 64
  3. Embryonic stem cell-specific MicroRNAs. (PMID: 12919684) Houbaviy H.B. … Sharp P.A. (Dev. Cell 2003) 1 3 64
  4. miRNA-301a induces apoptosis of chronic myelogenous leukemia cells by directly targeting TIMP2/ERK1/2 and AKT pathways. (PMID: 28035415) Huang X. … Chen G. (Oncol. Rep. 2017) 3 64
  5. Hypoxia induced upregulation of miR-301a/b contributes to increased cell autophagy and viability of prostate cancer cells by targeting NDRG2. (PMID: 26813459) Guo Y.J. … Guan Y.W. (Eur Rev Med Pharmacol Sci 2016) 3 64

Products for MIR301A Gene

Sources for MIR301A Gene

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