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Aliases for MIR301A Gene

Subcategory (RNA class) for MIR301A Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR301A Gene

  • MicroRNA 301a 2 3 5
  • MicroRNA 301 2 3
  • Hsa-Mir-301a 3
  • Hsa-Mir-301 3
  • Mir-301a 3
  • MIRN301A 3
  • MIRN301 3
  • MIR301 3

External Ids for MIR301A Gene

Previous HGNC Symbols for MIR301A Gene

  • MIRN301
  • MIRN301A

Previous GeneCards Identifiers for MIR301A Gene

  • GC17M054587
  • GC17M057228

Summaries for MIR301A Gene

Entrez Gene Summary for MIR301A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR301A Gene

MIR301A (MicroRNA 301a) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR301A Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR301A

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR301A Gene

Genomics for MIR301A Gene

Genomic Location for MIR301A Gene

Chromosome:
17
Start:
59,151,136 bp from pter
End:
59,151,221 bp from pter
Size:
86 bases
Orientation:
Minus strand

Genomic View for MIR301A Gene

Genes around MIR301A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR301A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR301A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR301A Gene

ORGUL Member Location for MIR301A Gene

ORGUL Member Location for MIR301A gene

No data available for Regulatory Elements for MIR301A Gene

Proteins for MIR301A Gene

Post-translational modifications for MIR301A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR301A Gene

Domains & Families for MIR301A Gene

Gene Families for MIR301A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR301A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR301A Gene

Function for MIR301A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR301A Gene

Localization for MIR301A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR301A Gene

Pathways & Interactions for MIR301A Gene

SuperPathways for MIR301A Gene

No Data Available

Interacting Proteins for MIR301A Gene

Gene Ontology (GO) - Biological Process for MIR301A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR301A Gene

Drugs & Compounds for MIR301A Gene

No Compound Related Data Available

Transcripts for MIR301A Gene

fRNAdb Secondary structures for MIR301A Gene

  • hsa-miR-301a-5p_MIMAT0022696_Homo_sapiens_miR-301a-5p_mature
  • hsa-mir-301a_MI0000745_Homo_sapiens_miR-301a_stem-loop_hairpin

mRNA/cDNA for MIR301A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR301A Gene

No ASD Table

Relevant External Links for MIR301A Gene

GeneLoc Exon Structure for
MIR301A
ECgene alternative splicing isoforms for
MIR301A

Expression for MIR301A Gene

mRNA expression in normal human tissues for MIR301A Gene

genes like me logo Genes that share expression patterns with MIR301A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR301A Gene

Orthologs for MIR301A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR301A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-301a 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-301a 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-301 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir301 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-301 36
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-301a 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-301b 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-301a 36
  • 83 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-130a 36
  • 51 (a)
OneToMany
dre-mir-301a 36
  • 79 (a)
OneToMany
Species with no ortholog for MIR301A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR301A Gene

ENSEMBL:
Gene Tree for MIR301A (if available)
TreeFam:
Gene Tree for MIR301A (if available)

Paralogs for MIR301A Gene

No data available for Paralogs for MIR301A Gene

Variants for MIR301A Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR301A Gene

Variant ID Type Subtype PubMed ID
dgv3236n71 CNV Loss 21882294
nsv908644 CNV Loss 21882294
nsv908646 CNV Loss 21882294
nsv833499 CNV Loss 17160897
dgv995e1 CNV Complex 17122850
dgv3237n71 CNV Loss 21882294

Relevant External Links for MIR301A Gene

HapMap Linkage Disequilibrium report
MIR301A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR301A Gene

Disorders for MIR301A Gene

Relevant External Links for MIR301A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR301A

No disorders were found for MIR301A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR301A Gene

Publications for MIR301A Gene

  1. MiR-301a promotes colorectal cancer cell growth and invasion by directly targeting SOCS6. (PMID: 25591765) Fang Y. … Chen Z. (Cell. Physiol. Biochem. 2015) 3 67
  2. New human and mouse microRNA genes found by homology search. (PMID: 15634332) Weber M.J. (FEBS J. 2005) 1 3
  3. Human embryonic stem cells express a unique set of microRNAs. (PMID: 15183728) Suh M.R. … Kim K.S. (Dev. Biol. 2004) 1 3
  4. Embryonic stem cell-specific MicroRNAs. (PMID: 12919684) Houbaviy H.B. … Sharp P.A. (Dev. Cell 2003) 1 3
  5. The microRNA-130/301 family controls vasoconstriction in pulmonary hypertension. (PMID: 25505270) Bertero T. … Chan S.Y. (J. Biol. Chem. 2015) 3

Products for MIR301A Gene

Sources for MIR301A Gene

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