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Aliases for MIR300 Gene

Subcategory (RNA class) for MIR300 Gene


Quality Score for this RNA gene is


Aliases for MIR300 Gene

  • MicroRNA 300 2 3 5
  • Hsa-Mir-300 3
  • MIRN300 3

External Ids for MIR300 Gene

ORGUL Members for MIR300 Gene

Previous HGNC Symbols for MIR300 Gene

  • MIRN300

Previous GeneCards Identifiers for MIR300 Gene

  • GC14P100823
  • GC14P100866
  • GC14P101512
  • GC14P101541
  • GC14P101574
  • GC14P101615
  • GC14P101643
  • GC14P101676
  • GC14P101713
  • GC14P101755
  • GC14P101814
  • GC14P101954
  • GC14P102150
  • GC14P101252
  • GC14P101859
  • GC14P102112
  • GC14P102348
  • GC14P102519
  • GC14P102698

Summaries for MIR300 Gene

Entrez Gene Summary for MIR300 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR300 Gene

MIR300 (MicroRNA 300) is an RNA Gene, and is affiliated with the undefined RNA class.

Additional gene information for MIR300 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR300 Gene

Genomics for MIR300 Gene

Regulatory Elements for MIR300 Gene

Enhancers for MIR300 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H101287 1 ENCODE 9.4 +247.6 247558 2 FOXA2 ATF1 MLX ZFP64 ARID4B YY1 SP5 ZHX2 NFYC REST MEG3 MIR1185-2 MIR381 MIR487B MIR539 MIR544A MIR889 MIR655 MIR300 MIR376C
GH14H101004 0.8 Ensembl ENCODE 10.9 -36.3 -36279 1 GATA3 MNT MYC TCF7L2 MIR487A MIR134 MIR485 MIR323B MIR154 MIR496 MIR377 MIR376C MIR300 MIR654
GH14H101096 0.8 FANTOM5 ENCODE 10.7 +57.0 56985 3 POLR2A JUN MAFK RTL1 LOC105370670 MEG9 MIR656 MIR541 MIR412 MIR410 MIR409 MIR369 MIR496
GH14H101330 0.9 ENCODE 8.9 +289.5 289492 0 ELF3 FOXA2 MLX ARID4B RAD21 THRB ZSCAN9 RARA CREM MIXL1 MIR1185-1 MIR1185-2 MIR300 MIR381 MIR487B MIR539 MIR544A MIR655 MIR889 MIR376C
GH14H101333 0.9 ENCODE 8.9 +293.7 293694 2 ELF3 FOXA2 ARID4B ZSCAN9 RAD21 RARA YY1 CREM MIXL1 THAP11 MIR381 MIR487B MIR539 MIR544A MIR889 MIR655 MIR376C MIR1185-1 MIR1185-2 MIR300
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR300 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR300 Gene

101,041,363 bp from pter
101,041,445 bp from pter
83 bases
Plus strand

Genomic View for MIR300 Gene

Genes around MIR300 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR300 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR300 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR300 Gene

Proteins for MIR300 Gene

Post-translational modifications for MIR300 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR300 Gene

Domains & Families for MIR300 Gene

Gene Families for MIR300 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR300: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR300 Gene

Function for MIR300 Gene

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR300
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR300 Gene

Localization for MIR300 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR300 Gene

Pathways & Interactions for MIR300 Gene

SuperPathways for MIR300 Gene

No Data Available

Interacting Proteins for MIR300 Gene

Gene Ontology (GO) - Biological Process for MIR300 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR300 Gene

Drugs & Compounds for MIR300 Gene

No Compound Related Data Available

Transcripts for MIR300 Gene

mRNA/cDNA for MIR300 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR300
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR300 Gene

No ASD Table

Relevant External Links for MIR300 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR300 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR300 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR300 Gene:

genes like me logo Genes that share expression patterns with MIR300: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR300 Gene

Orthologs for MIR300 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR300 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-300 34
  • 99 (a)
(Canis familiaris)
Mammalia cfa-mir-300 34
  • 79 (a)
(Mus musculus)
Mammalia mmu-mir-300 34
  • 74 (a)
(Bos Taurus)
Mammalia bta-mir-453 34
  • 34 (a)
Species where no ortholog for MIR300 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR300 Gene

Gene Tree for MIR300 (if available)
Gene Tree for MIR300 (if available)

Paralogs for MIR300 Gene

No data available for Paralogs for MIR300 Gene

Variants for MIR300 Gene

Sequence variations from dbSNP and Humsavar for MIR300 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1002530539 -- 101,041,060(+) CATTG(A/G)CCTTG downstream-variant-500B, upstream-variant-2KB
rs1002993194 -- 101,040,828(+) TAATC(A/G)TAGAG nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB
rs1003009472 -- 101,039,870(+) GAACA(C/T)GTGCT downstream-variant-500B, upstream-variant-2KB
rs1003604401 -- 101,041,217(+) AATAG(A/G)TGTGT downstream-variant-500B, upstream-variant-2KB
rs1004674820 -- 101,041,701(+) GGCCG(G/T)GCACG downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR300 Gene

Variant ID Type Subtype PubMed ID
esv3635521 CNV gain 21293372
nsv1040993 CNV gain 25217958
nsv565859 CNV gain 21841781
nsv565860 CNV gain 21841781

Relevant External Links for MIR300 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR300 Gene

Disorders for MIR300 Gene

Relevant External Links for MIR300

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR300 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR300 Gene

Publications for MIR300 Gene

  1. Long non-coding RNA TUG1 promotes cell proliferation and metastasis by negatively regulating miR-300 in gallbladder carcinoma. (PMID: 28178615) Ma F … Quan ZW (Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017) 3 60
  2. WISP-1 promotes VEGF-C-dependent lymphangiogenesis by inhibiting miR-300 in human oral squamous cell carcinoma cells. (PMID: 26824419) Lin CC … Tung KC (Oncotarget 2016) 3 60
  3. miR-300 promotes proliferation and EMT-mediated colorectal cancer migration and invasion by targeting p53. (PMID: 27779716) Wang L … Yu P (Oncology reports 2016) 3 60
  4. The PTTG1-targeting miRNAs miR-329, miR-300, miR-381, and miR-655 inhibit pituitary tumor cell tumorigenesis and are involved in a p53/PTTG1 regulation feedback loop. (PMID: 26320179) Liang HQ … Zhang S (Oncotarget 2015) 3 60
  5. Up-Regulation of MiR-300 Promotes Proliferation and Invasion of Osteosarcoma by Targeting BRD7. (PMID: 26010572) Xue Z … Ni L (PloS one 2015) 3 60

Products for MIR300 Gene

Sources for MIR300 Gene

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