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Aliases for MIR300 Gene

Subcategory (RNA class) for MIR300 Gene


Quality Score for this RNA gene is


Aliases for MIR300 Gene

  • MicroRNA 300 2 3 5
  • Hsa-Mir-300 3
  • MIRN300 3

External Ids for MIR300 Gene

ORGUL Members for MIR300 Gene

Previous HGNC Symbols for MIR300 Gene

  • MIRN300

Previous GeneCards Identifiers for MIR300 Gene

  • GC14P100823
  • GC14P100866
  • GC14P101512
  • GC14P101541
  • GC14P101574
  • GC14P101615
  • GC14P101643
  • GC14P101676
  • GC14P101713
  • GC14P101755
  • GC14P101814
  • GC14P101954
  • GC14P102150
  • GC14P101252
  • GC14P101859
  • GC14P102112
  • GC14P102348

Summaries for MIR300 Gene

Entrez Gene Summary for MIR300 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR300 Gene

MIR300 (MicroRNA 300) is an RNA Gene, and is affiliated with the undefined RNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR300 Gene

Genomics for MIR300 Gene

Regulatory Elements for MIR300 Gene

Enhancers for MIR300 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F101096 1.1 FANTOM5 ENCODE 10.7 +57.0 56985 3.2 CTCF SUZ12 JUN ZIC2 ZNF335 GLIS2 ZNF366 POLR2A SCRT2 PATZ1 RTL1 LOC105370670 MEG9 MIR369 MIR409 MIR410 MIR412 MIR541 MIR656 MIR154
GH14F101215 1 ENCODE 9.9 +175.4 175362 2.8 HDGF ARID4B ZNF48 GATA2 SSRP1 ZNF658 ETV4 HNF4A KDM1A ZNF785 MIR6764 SNORD113-4 SNORD113-3 SNORD113-6 SNORD113-7 SNORD113-8 SNORD113-9 MIR543 ENSG00000222185 ENSG00000222095
GH14F101287 1 ENCODE 9.4 +247.6 247558 2.5 ATF1 MLX ZFP64 ARID4B ZNF48 YY1 SP5 NFYC MIER2 PPARG MEG3 MIR655 MIR1185-1 MIR300 MIR376C MIR654 MIR1185-2 MIR381 MIR487B MIR539
GH14F101004 0.8 Ensembl ENCODE 10.9 -36.1 -36088 2.3 GATA3 MAX MNT ZIC2 MYC TCF7L2 MIR134 MIR487A MIR154 MIR323B MIR485 MIR377 MIR496 MIR376C MIR654 MIR1185-1
GH14F101330 0.9 ENCODE 8.9 +289.5 289492 0.3 ELF3 MLX ARID4B THRB ZNF48 ZSCAN9 RAD21 RARA CREM MIXL1 MIR381 MIR487B MIR889 MIR655 MIR544A MIR539 MIR1185-1 MIR1185-2 MIR300 MIR376C
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR300 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR300 Gene

101,041,363 bp from pter
101,041,445 bp from pter
83 bases
Plus strand

Genomic View for MIR300 Gene

Genes around MIR300 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR300 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR300 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR300 Gene

Proteins for MIR300 Gene

Post-translational modifications for MIR300 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR300 Gene

Domains & Families for MIR300 Gene

Gene Families for MIR300 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR300: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR300 Gene

Function for MIR300 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR300 Gene

Localization for MIR300 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR300 Gene

Pathways & Interactions for MIR300 Gene

SuperPathways for MIR300 Gene

No Data Available

Interacting Proteins for MIR300 Gene

Gene Ontology (GO) - Biological Process for MIR300 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR300 Gene

Transcripts for MIR300 Gene

mRNA/cDNA for MIR300 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR300 Gene

No ASD Table

Relevant External Links for MIR300 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR300 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR300 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR300 Gene:

genes like me logo Genes that share expression patterns with MIR300: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR300 Gene

Orthologs for MIR300 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR300 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-300 35
  • 99 (a)
(Canis familiaris)
Mammalia cfa-mir-300 35
  • 79 (a)
(Mus musculus)
Mammalia mmu-mir-300 35
  • 74 (a)
(Bos Taurus)
Mammalia bta-mir-453 35
  • 34 (a)
Species where no ortholog for MIR300 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR300 Gene

Gene Tree for MIR300 (if available)
Gene Tree for MIR300 (if available)

Paralogs for MIR300 Gene

No data available for Paralogs for MIR300 Gene

Variants for MIR300 Gene

Sequence variations from dbSNP and Humsavar for MIR300 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs112009054 -- 101,040,731(+) TCTGA(C/T)GACTC downstream-variant-500B, upstream-variant-2KB
rs112745626 -- 101,041,204(+) GGGCT(A/G)TGGAA downstream-variant-500B, upstream-variant-2KB
rs113577939 -- 101,041,520(+) GGGGT(A/G)TGGAT downstream-variant-500B, upstream-variant-2KB
rs114035552 -- 101,039,996(+) GCTCT(C/T)CTCTG downstream-variant-500B, upstream-variant-2KB
rs117381856 -- 101,039,673(+) ACTCA(A/G)TCCTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR300 Gene

Variant ID Type Subtype PubMed ID
nsv565860 CNV gain 21841781
nsv565859 CNV gain 21841781
nsv1040993 CNV gain 25217958
esv3635521 CNV gain 21293372

Relevant External Links for MIR300 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR300 Gene

Disorders for MIR300 Gene

Relevant External Links for MIR300

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR300 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR300 Gene

Publications for MIR300 Gene

  1. Up-Regulation of MiR-300 Promotes Proliferation and Invasion of Osteosarcoma by Targeting BRD7. (PMID: 26010572) Xue Z. … Ni L. (PLoS ONE 2015) 3 64
  2. The PTTG1-targeting miRNAs miR-329, miR-300, miR-381, and miR-655 inhibit pituitary tumor cell tumorigenesis and are involved in a p53/PTTG1 regulation feedback loop. (PMID: 26320179) Liang H.Q. … Zhang S. (Oncotarget 2015) 3 64
  3. mir-300 promotes self-renewal and inhibits the differentiation of glioma stem-like cells. (PMID: 24464870) Zhang D. … Zhao S. (J. Mol. Neurosci. 2014) 3 64
  4. miR-300 inhibits epithelial to mesenchymal transition and metastasis by targeting Twist in human epithelial cancer. (PMID: 24885626) Yu J. … Xu Q. (Mol. Cancer 2014) 3 64
  5. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3 64

Products for MIR300 Gene

Sources for MIR300 Gene

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