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Aliases for MIR29C Gene

Subcategory (RNA class) for MIR29C Gene

miRNA

Quality Score for this RNA gene is

10.2

Aliases for MIR29C Gene

  • MicroRNA 29c 2 3 5
  • Hsa-Mir-29c 3
  • MiRNA29C 3
  • Mir-29c 3
  • MIRN29C 3

External Ids for MIR29C Gene

Previous HGNC Symbols for MIR29C Gene

  • MIRN29C

Previous GeneCards Identifiers for MIR29C Gene

  • GC01M206043
  • GC01M207975

Summaries for MIR29C Gene

Entrez Gene Summary for MIR29C Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR29C Gene

MIR29C (MicroRNA 29c) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR29C include Progesterone Resistance. Among its related pathways are MicroRNAs in cancer and Metastatic brain tumor.

fRNAdb sequence ontologies for MIR29C Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR29C

Additional gene information for MIR29C Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR29C Gene

Genomics for MIR29C Gene

Regulatory Elements for MIR29C Gene

Enhancers for MIR29C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H207796 1.1 Ensembl ENCODE 0.7 +4.4 4407 1.1 PKNOX1 ATF1 ARNT BATF RAD21 RFX5 ZNF143 FOS CREM DEK CR1L MIR29C CDCA4P4
GH01H207799 0.5 ENCODE 0.7 +2.8 2809 0.2 POLR2A CBFB EED RUNX3 MIR29C CDCA4P4
GH01H207798 0.5 Ensembl 0.7 +3.0 3038 0.2 POLR2A CBFB EED CD46 MIR29C CDCA4P4
GH01H207789 0.6 ENCODE 0.4 +11.3 11319 2.6 SMARCE1 HLF DPF2 ATF2 GATA3 CTBP1 ATF7 PRDM1 TCF7L2 CR1L MIR29C CDCA4P4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR29C on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR29C Gene

Genomic Locations for MIR29C Gene
chr1:207,801,852-207,801,939
(GRCh38/hg38)
Size:
88 bases
Orientation:
Minus strand
chr1:207,974,863-208,042,495
(GRCh37/hg19)

Genomic View for MIR29C Gene

Genes around MIR29C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR29C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR29C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR29C Gene

ORGUL Member Location for MIR29C Gene

ORGUL Member Location for MIR29C gene

Proteins for MIR29C Gene

Post-translational modifications for MIR29C Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR29C Gene

Domains & Families for MIR29C Gene

Gene Families for MIR29C Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR29C: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR29C Gene

Function for MIR29C Gene

Gene Ontology (GO) - Molecular Function for MIR29C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 18390668
genes like me logo Genes that share ontologies with MIR29C: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR29C Gene

Localization for MIR29C Gene

Gene Ontology (GO) - Cellular Components for MIR29C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:0005622 intracellular IEA --
GO:0005739 mitochondrion IEA --
GO:0070062 extracellular exosome IDA 28159509
genes like me logo Genes that share ontologies with MIR29C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR29C Gene

Pathways & Interactions for MIR29C Gene

genes like me logo Genes that share pathways with MIR29C: view

Pathways by source for MIR29C Gene

1 BioSystems pathway for MIR29C Gene
1 KEGG pathway for MIR29C Gene

Interacting Proteins for MIR29C Gene

Gene Ontology (GO) - Biological Process for MIR29C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001953 negative regulation of cell-matrix adhesion IDA 23936390
GO:0008285 negative regulation of cell proliferation IDA 20086245
GO:0010629 negative regulation of gene expression IDA 20570858
GO:0030336 negative regulation of cell migration IDA 23936390
GO:0035195 gene silencing by miRNA IDA 18390668
genes like me logo Genes that share ontologies with MIR29C: view

No data available for SIGNOR curated interactions for MIR29C Gene

Drugs & Compounds for MIR29C Gene

No Compound Related Data Available

Transcripts for MIR29C Gene

fRNAdb Secondary structures for MIR29C Gene

  • FR390016
  • FR185304

mRNA/cDNA for MIR29C Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR29C Gene

No ASD Table

Relevant External Links for MIR29C Gene

GeneLoc Exon Structure for
MIR29C
ECgene alternative splicing isoforms for
MIR29C

Expression for MIR29C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR29C Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR29C Gene:

MIR29C
genes like me logo Genes that share expression patterns with MIR29C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR29C Gene

Orthologs for MIR29C Gene

Evolution for MIR29C Gene

ENSEMBL:
Gene Tree for MIR29C (if available)
TreeFam:
Gene Tree for MIR29C (if available)

No data available for Orthologs for MIR29C Gene

Paralogs for MIR29C Gene

No data available for Paralogs for MIR29C Gene

Variants for MIR29C Gene

Sequence variations from dbSNP and Humsavar for MIR29C Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000416979 -- 207,802,346(+) TCCCT(A/G)GACTT nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB
rs1001828775 -- 207,802,550(+) GAAGG(A/G)AGATT nc-transcript-variant, upstream-variant-2KB
rs1001861430 -- 207,801,386(+) TAATG(A/T)CTGGC downstream-variant-500B
rs1003668706 -- 207,802,574(+) CAGCC(G/T)CTGCC nc-transcript-variant, upstream-variant-2KB
rs1004693670 -- 207,803,929(+) CCCAC(-/G)GGGGG intron-variant, upstream-variant-2KB

Relevant External Links for MIR29C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR29C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR29C Gene

Disorders for MIR29C Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR29C Gene - From: GeneCards

Disorder Aliases PubMed IDs
progesterone resistance
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR29C

Human Genome Epidemiology (HuGE) Navigator
MIR29C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR29C
genes like me logo Genes that share disorders with MIR29C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR29C Gene

Publications for MIR29C Gene

  1. Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis. (PMID: 28159509) Beltrami C … Emanueli C (Molecular therapy : the journal of the American Society of Gene Therapy 2017) 3 60
  2. Circular RNA hsa_circ_0001564 facilitates tumorigenesis of osteosarcoma via sponging miR-29c-3p. (PMID: 28789596) Li JF … Song YZ (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 60
  3. Altered miRNA-29 Expression in Type 2 Diabetes Influences Glucose and Lipid Metabolism in Skeletal Muscle. (PMID: 28404597) Massart J … Krook A (Diabetes 2017) 3 60
  4. p53 target miR-29c-3p suppresses colon cancer cell invasion and migration through inhibition of PHLDB2. (PMID: 28392396) Chen G … Sun L (Biochemical and biophysical research communications 2017) 3 60
  5. Tumor suppressor miR-29c regulates radioresistance in lung cancer cells. (PMID: 28345453) Arechaga-Ocampo E … Garcia-Carranca A (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 60

Products for MIR29C Gene

Sources for MIR29C Gene

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