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Aliases for MIR29B2 Gene

Subcategory (RNA class) for MIR29B2 Gene

miRNA

Quality Score for this RNA gene is

14.2

Aliases for MIR29B2 Gene

  • MicroRNA 29b-2 2 3
  • Hsa-Mir-29b-2 3
  • Mir-29b-2 3
  • MIRN29B2 3

External Ids for MIR29B2 Gene

Previous Symbols for MIR29B2 Gene

  • MIRN29B2

Summaries for MIR29B2 Gene

Entrez Gene Summary for MIR29B2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR29B2 Gene

MIR29B2 (MicroRNA 29b-2) is a RNA Gene, and belongs to miRNA RNA class. Diseases associated with MIR29B2 include familial breast cancer. Among its related pathways are MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR29B2 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR29B2 Gene

Genomics for MIR29B2 Gene

Genomic Location for MIR29B2 Gene

Start:
207,802,440 bp from pter
End:
207,802,523 bp from pter
Size:
84 bases
Orientation:
Minus strand

Genomic View for MIR29B2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR29B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR29B2 Gene

ORGUL Member Location for MIR29B2 Gene

ORGUL Member Location for MIR29B2 gene

No data available for Regulatory Elements for MIR29B2 Gene

Proteins for MIR29B2 Gene

Post-translational modifications for MIR29B2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR29B2 Gene

Domains for MIR29B2 Gene

Gene Families for MIR29B2 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIR29B2: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIR29B2 Gene

Function for MIR29B2 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR29B2 Gene

Localization for MIR29B2 Gene

No data available for Gene Ontology (GO) - Cellular Components for MIR29B2 Gene

Pathways for MIR29B2 Gene

SuperPathways for MIR29B2 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR29B2: view

Pathways by source for MIR29B2 Gene

1 KEGG pathway for MIR29B2 Gene

Interacting Proteins for MIR29B2 Gene

Gene Ontology (GO) - Biological Process for MIR29B2 Gene

None

Transcripts for MIR29B2 Gene

mRNA/cDNA for MIR29B2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR29B2 Gene

No ASD Table

Relevant External Links for MIR29B2 Gene

GeneLoc Exon Structure for
MIR29B2
ECgene alternative splicing isoforms for
MIR29B2

Expression for MIR29B2 Gene

mRNA expression in normal human tissues for MIR29B2 Gene

genes like me logo Genes that share expressions with MIR29B2: view

Orthologs for MIR29B2 Gene

Evolution for MIR29B2 Gene

ENSEMBL:
Gene Tree for MIR29B2 (if available)
TreeFam:
Gene Tree for MIR29B2 (if available)

No data available for Orthologs for MIR29B2 Gene

Paralogs for MIR29B2 Gene

No data available for Paralogs for MIR29B2 Gene

Variants for MIR29B2 Gene

Sequence variations from dbSNP and Humsavar for MIR29B2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs73088772 -- 207,804,286(+) TTCTG(C/G)AATAC upstream-variant-2KB
rs138060154 -- 207,804,110(+) TCAAA(C/T)GAGGG upstream-variant-2KB
rs143711615 -- 207,804,330(+) GCCCC(A/G)CCCCC upstream-variant-2KB
rs150348354 -- 207,803,971(+) TGGGG(A/C)AGATC upstream-variant-2KB
rs181566981 -- 207,804,223(+) CCCGC(A/G)GTGAT upstream-variant-2KB

Relevant External Links for MIR29B2 Gene

HapMap Linkage Disequilibrium report
MIR29B2
Human Gene Mutation Database (HGMD)
MIR29B2

No data available for Structural Variations from Database of Genomic Variants (DGV) for MIR29B2 Gene

Disorders for MIR29B2 Gene

(1) MalaCards Diseases for MIR29B2 Gene

Search for MIR29B2 Gene in MalaCards »

Relevant External Links for MIR29B2

Genetic Association Database (GAD)
MIR29B2
Human Genome Epidemiology (HuGE) Navigator
MIR29B2
genes like me logo Genes that share disorders with MIR29B2: view

No data available for UniProtKB/Swiss-Prot for MIR29B2 Gene

Publications for MIR29B2 Gene

  1. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J. … Zhao H. (Int. J. Cancer 2009) 3 49
  2. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 49
  3. MicroRNA-29b regulates the expression level of human progranulin, a secreted glycoprotein implicated in frontotemporal dementia. (PMID: 20479936) Jiao J. … Gao F.B. (PLoS ONE 2010) 3
  4. MicroRNA-29 in aortic dilation: implications for aneurysm formation. (PMID: 21903938) Boon R.A. … Dimmeler S. (Circ. Res. 2011) 3
  5. Histone deacetylases mediate the silencing of miR-15a, miR-16, and miR-29b in chronic lymphocytic leukemia. (PMID: 22096249) Sampath D. … Keating M.J. (Blood 2012) 3

Products for MIR29B2 Gene

Sources for MIR29B2 Gene

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