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Aliases for MIR29B1 Gene

Subcategory (RNA class) for MIR29B1 Gene

miRNA

Quality Score for this RNA gene is

14.2

Aliases for MIR29B1 Gene

  • MicroRNA 29b-1 2 3 5
  • Hsa-Mir-29b-1 3
  • MiRNA29B1 3
  • Mir-29b-1 3
  • MIRN29B1 3
  • MiR-29b 3

External Ids for MIR29B1 Gene

Previous HGNC Symbols for MIR29B1 Gene

  • MIRN29B1

Previous GeneCards Identifiers for MIR29B1 Gene

  • GC07M130215
  • GC07M130562

Summaries for MIR29B1 Gene

Entrez Gene Summary for MIR29B1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR29B1 Gene

MIR29B1 (MicroRNA 29b-1) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Metastatic brain tumor and MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR29B1 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR29B1 Gene

Genomics for MIR29B1 Gene

Regulatory Elements for MIR29B1 Gene

Enhancers for MIR29B1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G130883 2.1 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -18.4 -18370 24.6 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 ENSG00000226380 RNU6-1010P LINC-PINT KLHDC10 MKLN1 GC07P130900 MIR29B1 GC07M130879 GC07M130881
GH07G130881 1 ENCODE dbSUPER 0.7 -4.6 -4634 2.1 ZNF146 CEBPG YY1 IRF9 ZNF316 GATA2 POLR2A CBX5 FOS CEBPB ENSG00000226380 RNU6-1010P LINC-PINT GC07M130879 MIR29B1 GC07M130881 GC07P130900
GH07G130879 0.8 ENCODE dbSUPER 0.7 -1.9 -1858 0.2 POLR2A PBX2 GFI1B FOXP2 TCF7L2 GC07M130879 GC07M130881 MIR29B1 GC07P130900
GH07G130880 0.6 dbSUPER 0.7 -3.3 -3260 0.4 HLF CEBPB NR3C1 CEBPG IRF9 POLR2A CEBPA ZZZ3 ENSG00000226380 GC07M130879 MIR29B1 GC07M130881 GC07P130900
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR29B1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR29B1 Gene

Chromosome:
7
Start:
130,877,459 bp from pter
End:
130,877,539 bp from pter
Size:
81 bases
Orientation:
Minus strand

Genomic View for MIR29B1 Gene

Genes around MIR29B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR29B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR29B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR29B1 Gene

ORGUL Member Location for MIR29B1 Gene

ORGUL Member Location for MIR29B1 gene

Proteins for MIR29B1 Gene

Post-translational modifications for MIR29B1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR29B1 Gene

Domains & Families for MIR29B1 Gene

Gene Families for MIR29B1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR29B1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR29B1 Gene

Function for MIR29B1 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR29B1 Gene

Localization for MIR29B1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR29B1 Gene

Pathways & Interactions for MIR29B1 Gene

genes like me logo Genes that share pathways with MIR29B1: view

Pathways by source for MIR29B1 Gene

2 BioSystems pathways for MIR29B1 Gene
1 KEGG pathway for MIR29B1 Gene

Interacting Proteins for MIR29B1 Gene

Gene Ontology (GO) - Biological Process for MIR29B1 Gene

None

No data available for SIGNOR curated interactions for MIR29B1 Gene

Transcripts for MIR29B1 Gene

mRNA/cDNA for MIR29B1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR29B1 Gene

No ASD Table

Relevant External Links for MIR29B1 Gene

GeneLoc Exon Structure for
MIR29B1
ECgene alternative splicing isoforms for
MIR29B1

Expression for MIR29B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR29B1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR29B1 Gene:

MIR29B1
genes like me logo Genes that share expression patterns with MIR29B1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR29B1 Gene

Orthologs for MIR29B1 Gene

Evolution for MIR29B1 Gene

ENSEMBL:
Gene Tree for MIR29B1 (if available)
TreeFam:
Gene Tree for MIR29B1 (if available)

No data available for Orthologs for MIR29B1 Gene

Paralogs for MIR29B1 Gene

No data available for Paralogs for MIR29B1 Gene

Variants for MIR29B1 Gene

Sequence variations from dbSNP and Humsavar for MIR29B1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000549166 -- 130,878,608(+) TCGTT(C/G)TATAA intron-variant, upstream-variant-2KB
rs1000643866 -- 130,878,268(+) TTTTT(C/T)GCCGT intron-variant, upstream-variant-2KB
rs1005208224 -- 130,877,036(+) CCCCT(G/T)GGATA downstream-variant-500B, upstream-variant-2KB
rs1006194073 -- 130,877,364(+) TGTGA(C/G)GCAGG downstream-variant-500B, upstream-variant-2KB
rs1007315390 -- 130,878,704(+) TACAT(C/G)CAACT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR29B1 Gene

Variant ID Type Subtype PubMed ID
nsv608422 CNV gain 21841781

Relevant External Links for MIR29B1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR29B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR29B1 Gene

Disorders for MIR29B1 Gene

Relevant External Links for MIR29B1

Genetic Association Database (GAD)
MIR29B1
Human Genome Epidemiology (HuGE) Navigator
MIR29B1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR29B1

No disorders were found for MIR29B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR29B1 Gene

Publications for MIR29B1 Gene

  1. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J. … Zhao H. (Int. J. Cancer 2009) 3 46 64
  2. Regulation of metastasis-promoting LOXL2 gene expression by antitumor microRNAs in prostate cancer. (PMID: 27278788) Kato M. … Seki N. (J. Hum. Genet. 2017) 3 64
  3. miR-29b and miR-198 overexpression in CD8+ T cells of renal cell carcinoma patients down-modulates JAK3 and MCL-1 leading to immune dysfunction. (PMID: 27063186) Gigante M. … Ranieri E. (J Transl Med 2016) 3 64
  4. MiR-29b suppresses the proliferation and migration of osteosarcoma cells by targeting CDK6. (PMID: 27230400) Zhu K. … Zhou G. (Protein Cell 2016) 3 64
  5. Expression analysis of three miRNAs, miR-26a, miR-29b and miR-519d, in relation to MMP-2 expression level in non-small cell lung cancer patients: a pilot study. (PMID: 27447710) Pastuszak-Lewandoska D. … BrzeziaA8ska-Lasota E. (Med. Oncol. 2016) 3 64

Products for MIR29B1 Gene

Sources for MIR29B1 Gene

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