Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR29B1 Gene

Subcategory (RNA class) for MIR29B1 Gene

miRNA

Quality Score for this RNA gene is

14.2

Aliases for MIR29B1 Gene

  • MicroRNA 29b-1 2 3 5
  • Hsa-Mir-29b-1 3
  • MiRNA29B1 3
  • Mir-29b-1 3
  • MIRN29B1 3
  • MiR-29b 3

External Ids for MIR29B1 Gene

Previous HGNC Symbols for MIR29B1 Gene

  • MIRN29B1

Previous GeneCards Identifiers for MIR29B1 Gene

  • GC07M130215
  • GC07M130562

Summaries for MIR29B1 Gene

Entrez Gene Summary for MIR29B1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR29B1 Gene

MIR29B1 (MicroRNA 29b-1) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR29B1 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

Additional gene information for MIR29B1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR29B1 Gene

Genomics for MIR29B1 Gene

Regulatory Elements for MIR29B1 Gene

Enhancers for MIR29B1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H130883 2.1 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -18.4 -18370 24 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ENSG00000226380 MKLN1 RNU6-1010P LINC-PINT KLHDC10 GC07P130900 GC07M130884 MIR29B1 GC07M130879
GH07H130881 0.8 ENCODE dbSUPER 0.7 -4.6 -4634 2 IRF9 ZNF316 POLR2A CEBPA CEBPB HNF4A CEBPG ENSG00000226380 RNU6-1010P LINC-PINT GC07M130879 GC07M130884 MIR29B1 GC07P130900
GH07H130880 0.6 dbSUPER 0.7 -3.3 -3260 0 IRF9 POLR2A CEBPA HLF CEBPB NR3C1 CEBPG ENSG00000226380 GC07M130879 GC07M130884 MIR29B1 GC07P130900
GH07H130879 0.6 ENCODE dbSUPER 0.7 -1.9 -1858 0 GFI1B GC07M130879 GC07M130884 MIR29B1 GC07P130900
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR29B1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR29B1 Gene

Chromosome:
7
Start:
130,877,459 bp from pter
End:
130,877,539 bp from pter
Size:
81 bases
Orientation:
Minus strand

Genomic View for MIR29B1 Gene

Genes around MIR29B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR29B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR29B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR29B1 Gene

ORGUL Member Location for MIR29B1 Gene

ORGUL Member Location for MIR29B1 gene

Proteins for MIR29B1 Gene

Post-translational modifications for MIR29B1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR29B1 Gene

Domains & Families for MIR29B1 Gene

Gene Families for MIR29B1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR29B1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR29B1 Gene

Function for MIR29B1 Gene

Phenotypes From GWAS Catalog for MIR29B1 Gene

Gene Ontology (GO) - Molecular Function for MIR29B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IMP 27030318
genes like me logo Genes that share ontologies with MIR29B1: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MIR29B1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR29B1 Gene

Localization for MIR29B1 Gene

Gene Ontology (GO) - Cellular Components for MIR29B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:0005634 nucleus IDA 17204650
GO:0005737 cytoplasm IDA 17204650
GO:0005739 mitochondrion IEA --
GO:0070062 extracellular exosome IDA 28159509
genes like me logo Genes that share ontologies with MIR29B1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR29B1 Gene

Pathways & Interactions for MIR29B1 Gene

genes like me logo Genes that share pathways with MIR29B1: view

Pathways by source for MIR29B1 Gene

2 BioSystems pathways for MIR29B1 Gene
1 KEGG pathway for MIR29B1 Gene

Interacting Proteins for MIR29B1 Gene

Gene Ontology (GO) - Biological Process for MIR29B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IDA 19850741
GO:0010628 positive regulation of gene expression IGI 22269326
GO:0010629 negative regulation of gene expression IMP 27030318
GO:0010719 negative regulation of epithelial to mesenchymal transition IDA 25032858
GO:0030335 positive regulation of cell migration IDA 25435433
genes like me logo Genes that share ontologies with MIR29B1: view

No data available for SIGNOR curated interactions for MIR29B1 Gene

Drugs & Compounds for MIR29B1 Gene

No Compound Related Data Available

Transcripts for MIR29B1 Gene

mRNA/cDNA for MIR29B1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MIR29B1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR29B1 Gene

No ASD Table

Relevant External Links for MIR29B1 Gene

GeneLoc Exon Structure for
MIR29B1
ECgene alternative splicing isoforms for
MIR29B1

Expression for MIR29B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR29B1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR29B1 Gene:

MIR29B1
genes like me logo Genes that share expression patterns with MIR29B1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR29B1 Gene

Orthologs for MIR29B1 Gene

Evolution for MIR29B1 Gene

ENSEMBL:
Gene Tree for MIR29B1 (if available)
TreeFam:
Gene Tree for MIR29B1 (if available)

No data available for Orthologs for MIR29B1 Gene

Paralogs for MIR29B1 Gene

No data available for Paralogs for MIR29B1 Gene

Variants for MIR29B1 Gene

Sequence variations from dbSNP and Humsavar for MIR29B1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000549166 -- 130,878,608(+) TCGTT(C/G)TATAA intron-variant, upstream-variant-2KB
rs1000643866 -- 130,878,268(+) TTTTT(C/T)GCCGT intron-variant, upstream-variant-2KB
rs1005208224 -- 130,877,036(+) CCCCT(G/T)GGATA downstream-variant-500B, upstream-variant-2KB
rs1006194073 -- 130,877,364(+) TGTGA(C/G)GCAGG downstream-variant-500B, upstream-variant-2KB
rs1007315390 -- 130,878,704(+) TACAT(C/G)CAACT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR29B1 Gene

Variant ID Type Subtype PubMed ID
nsv608422 CNV gain 21841781

Relevant External Links for MIR29B1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR29B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR29B1 Gene

Disorders for MIR29B1 Gene

Relevant External Links for MIR29B1

Genetic Association Database (GAD)
MIR29B1
Human Genome Epidemiology (HuGE) Navigator
MIR29B1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR29B1

No disorders were found for MIR29B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR29B1 Gene

Publications for MIR29B1 Gene

  1. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 45 60
  2. Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis. (PMID: 28159509) Beltrami C … Emanueli C (Molecular therapy : the journal of the American Society of Gene Therapy 2017) 3 60
  3. MicroRNA-29b Inhibits Angiogenesis by Targeting VEGFA through the MAPK/ERK and PI3K/Akt Signaling Pathways in Endometrial Carcinoma. (PMID: 28222438) Chen HX … Zhou XD (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 60
  4. MiR-29b Downregulation Induces Phenotypic Modulation of Vascular Smooth Muscle Cells: Implication for Intracranial Aneurysm Formation and Progression to Rupture. (PMID: 28214880) Sun L … Wu Z (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 60
  5. MicroRNA hsa-miR-29b potentiates etoposide toxicity in HeLa cells via down-regulation of Mcl-1. (PMID: 28185889) Kollinerová S … Modrianský M (Toxicology in vitro : an international journal published in association with BIBRA 2017) 3 60

Products for MIR29B1 Gene

Sources for MIR29B1 Gene

Content
Loading form....