Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR29B1 Gene

Subcategory (RNA class) for MIR29B1 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR29B1 Gene

  • MicroRNA 29b-1 2 3
  • Hsa-Mir-29b-1 3
  • MicroRNA 29a 5
  • MiRNA29B1 3
  • Mir-29b-1 3
  • MIRN29B1 3
  • MiR-29b 3
  • MIR29A 5

External Ids for MIR29B1 Gene

Previous HGNC Symbols for MIR29B1 Gene

  • MIRN29B1

Previous GeneCards Identifiers for MIR29B1 Gene

  • GC07M130215
  • GC07M130562

Summaries for MIR29B1 Gene

Entrez Gene Summary for MIR29B1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR29B1 Gene

MIR29B1 (MicroRNA 29b-1) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR29B1 Gene

Genomics for MIR29B1 Gene

Regulatory Elements for MIR29B1 Gene

Enhancers for MIR29B1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F130883 1.5 FANTOM5 Ensembl ENCODE 16.2 +25.5 25463 8.5 ELF3 TBP HDAC1 YBX3 ARID4B SIN3A RARA SCRT2 RCOR1 FOS MIR29B1 RNU6-1010P LINC-PINT MKLN1 GC07M130880 GC07P130900
GH07F130892 1.8 FANTOM5 Ensembl ENCODE 12.6 +13.0 13048 15.7 HDGF PKNOX1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 MIR29B1 RNU6-1010P LINC-PINT KLHDC10 MKLN1 GC07P130900 GC07M130880
GH07F130881 0.7 ENCODE 17.2 +31.1 31138 2.1 ZNF146 CEBPB CEBPG YY1 NR2F2 IRF9 ZNF316 CBX5 POLR2A IKZF1 MIR29B1 RNU6-1010P LINC-PINT GC07M130880 GC07P130900
GH07F130873 0.9 ENCODE 12.2 +36.8 36794 5.4 HDAC1 CBX3 SIN3A RAD21 YY1 ZNF766 CBX5 SCRT2 ZNF143 CREM MIR29B1 GC07M130879 GC07P130871
GH07F130837 1 Ensembl ENCODE 10.2 +74.1 74089 2.8 HDGF JUN ZNF316 FOS NFE2 TCF7L2 RFX1 BHLHE40 MAFG DPF2 MIR29B1 LOC100133252 LOC105375509
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR29B1 on UCSC Golden Path with GeneCards custom track

Promoters for MIR29B1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000634364 1310 4001 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 SLC30A9 CBX5

Genomic Location for MIR29B1 Gene

Chromosome:
7
Start:
130,876,747 bp from pter
End:
130,913,310 bp from pter
Size:
36,564 bases
Orientation:
Minus strand

Genomic View for MIR29B1 Gene

Genes around MIR29B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR29B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR29B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR29B1 Gene

Proteins for MIR29B1 Gene

Post-translational modifications for MIR29B1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR29B1 Gene

Domains & Families for MIR29B1 Gene

Gene Families for MIR29B1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR29B1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR29B1 Gene

Function for MIR29B1 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR29B1 Gene

Localization for MIR29B1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR29B1 Gene

Pathways & Interactions for MIR29B1 Gene

genes like me logo Genes that share pathways with MIR29B1: view

Pathways by source for MIR29B1 Gene

1 BioSystems pathway for MIR29B1 Gene
1 KEGG pathway for MIR29B1 Gene

Interacting Proteins for MIR29B1 Gene

Gene Ontology (GO) - Biological Process for MIR29B1 Gene

None

No data available for SIGNOR curated interactions for MIR29B1 Gene

Transcripts for MIR29B1 Gene

mRNA/cDNA for MIR29B1 Gene

(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR29B1 Gene

No ASD Table

Relevant External Links for MIR29B1 Gene

GeneLoc Exon Structure for
MIR29B1
ECgene alternative splicing isoforms for
MIR29B1

Expression for MIR29B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR29B1 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR29B1 Gene:

MIR29B1
genes like me logo Genes that share expression patterns with MIR29B1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR29B1 Gene

Orthologs for MIR29B1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR29B1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-29a 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-29a 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-29a 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-29a-1 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir29a 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-29a-1 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-29a 35
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-29a-1 35
  • 56 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CR749762.2 35
  • 62 (a)
OneToOne
Species where no ortholog for MIR29B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR29B1 Gene

ENSEMBL:
Gene Tree for MIR29B1 (if available)
TreeFam:
Gene Tree for MIR29B1 (if available)

Paralogs for MIR29B1 Gene

No data available for Paralogs for MIR29B1 Gene

Variants for MIR29B1 Gene

Sequence variations from dbSNP and Humsavar for MIR29B1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs112938204 -- 130,877,543(+) AGAAG(-/C)TTTAT downstream-variant-500B, upstream-variant-2KB
rs115497975 -- 130,879,225(+) AGGCT(C/G)GTTTT intron-variant, upstream-variant-2KB
rs116155675 -- 130,877,555(+) ATCTA(C/G/T)TTTTT downstream-variant-500B, upstream-variant-2KB
rs116321870 -- 130,879,232(+) TTTTT(A/T)AAAAA intron-variant, upstream-variant-2KB
rs138169765 -- 130,877,922(+) AGAAC(C/T)GTCCG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR29B1 Gene

Variant ID Type Subtype PubMed ID
nsv608422 CNV gain 21841781

Relevant External Links for MIR29B1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR29B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR29B1 Gene

Disorders for MIR29B1 Gene

Relevant External Links for MIR29B1

Genetic Association Database (GAD)
MIR29B1
Human Genome Epidemiology (HuGE) Navigator
MIR29B1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR29B1

No disorders were found for MIR29B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR29B1 Gene

Publications for MIR29B1 Gene

  1. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J. … Zhao H. (Int. J. Cancer 2009) 3 46 64
  2. Neurotensin signaling stimulates glioblastoma cell proliferation by upregulating c-Myc and inhibiting miR-29b-1 and miR-129-3p. (PMID: 26180082) Ouyang Q. … Yi L. (Neuro-oncology 2016) 3 64
  3. Regulation of podoplanin expression by microRNA-29b associates with its antiapoptotic effect in angiotensin II-induced injury of human podocytes. (PMID: 26867059) Eisenreich A. … Kreutz R. (J. Hypertens. 2016) 3 64
  4. miR-29b and miR-198 overexpression in CD8+ T cells of renal cell carcinoma patients down-modulates JAK3 and MCL-1 leading to immune dysfunction. (PMID: 27063186) Gigante M. … Ranieri E. (J Transl Med 2016) 3 64
  5. Activated mineralocorticoid receptor regulates micro-RNA-29b in vascular smooth muscle cells. (PMID: 26728178) Bretschneider M. … Grossmann C. (FASEB J. 2016) 3 64

Products for MIR29B1 Gene

Sources for MIR29B1 Gene

Content
Loading form....