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Aliases for MIR29B1 Gene

Subcategory (RNA class) for MIR29B1 Gene

miRNA

Quality Score for this RNA gene is

14.2

Aliases for MIR29B1 Gene

  • MicroRNA 29b-1 2 3 5
  • Hsa-Mir-29b-1 3
  • MiRNA29B1 3
  • Mir-29b-1 3
  • MIRN29B1 3
  • MiR-29b 3

External Ids for MIR29B1 Gene

Previous HGNC Symbols for MIR29B1 Gene

  • MIRN29B1

Previous GeneCards Identifiers for MIR29B1 Gene

  • GC07M130215
  • GC07M130562

Summaries for MIR29B1 Gene

Entrez Gene Summary for MIR29B1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR29B1 Gene

MIR29B1 (MicroRNA 29b-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR29B1 include familial breast cancer. Among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR.

fRNAdb sequence ontologies for MIR29B1 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR29B1 Gene

Genomics for MIR29B1 Gene

Regulatory Elements for MIR29B1 Gene

Enhancers for MIR29B1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MIR29B1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR29B1 Gene

Chromosome:
7
Start:
130,877,459 bp from pter
End:
130,877,539 bp from pter
Size:
81 bases
Orientation:
Minus strand

Genomic View for MIR29B1 Gene

Genes around MIR29B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR29B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR29B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR29B1 Gene

ORGUL Member Location for MIR29B1 Gene

ORGUL Member Location for MIR29B1 gene

Proteins for MIR29B1 Gene

Post-translational modifications for MIR29B1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR29B1 Gene

Domains & Families for MIR29B1 Gene

Gene Families for MIR29B1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR29B1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR29B1 Gene

Function for MIR29B1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR29B1 Gene

Localization for MIR29B1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR29B1 Gene

Pathways & Interactions for MIR29B1 Gene

genes like me logo Genes that share pathways with MIR29B1: view

Pathways by source for MIR29B1 Gene

1 BioSystems pathway for MIR29B1 Gene
1 KEGG pathway for MIR29B1 Gene

Interacting Proteins for MIR29B1 Gene

Gene Ontology (GO) - Biological Process for MIR29B1 Gene

None

No data available for SIGNOR curated interactions for MIR29B1 Gene

Drugs & Compounds for MIR29B1 Gene

No Compound Related Data Available

Transcripts for MIR29B1 Gene

mRNA/cDNA for MIR29B1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR29B1 Gene

No ASD Table

Relevant External Links for MIR29B1 Gene

GeneLoc Exon Structure for
MIR29B1
ECgene alternative splicing isoforms for
MIR29B1

Expression for MIR29B1 Gene

mRNA expression in normal human tissues for MIR29B1 Gene

genes like me logo Genes that share expression patterns with MIR29B1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR29B1 Gene

Orthologs for MIR29B1 Gene

Evolution for MIR29B1 Gene

ENSEMBL:
Gene Tree for MIR29B1 (if available)
TreeFam:
Gene Tree for MIR29B1 (if available)

No data available for Orthologs for MIR29B1 Gene

Paralogs for MIR29B1 Gene

No data available for Paralogs for MIR29B1 Gene

Variants for MIR29B1 Gene

Relevant External Links for MIR29B1 Gene

HapMap Linkage Disequilibrium report
MIR29B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR29B1 Gene

Disorders for MIR29B1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR29B1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
familial breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR29B1

Genetic Association Database (GAD)
MIR29B1
Human Genome Epidemiology (HuGE) Navigator
MIR29B1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR29B1
genes like me logo Genes that share disorders with MIR29B1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR29B1 Gene

Publications for MIR29B1 Gene

  1. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J. … Zhao H. (Int. J. Cancer 2009) 3 48 67
  2. c-Myc suppresses microRNA-29b to promote tumor aggressiveness and poor outcomes in non-small cell lung cancer by targeting FHIT. (PMID: 24909176) Wu D.W. … Lee H. (Oncogene 2015) 3
  3. MicroRNA 29 targets nuclear factor-I_B-repressing factor and Claudin 1 to increase intestinal permeability. (PMID: 25277410) Zhou Q. … Verne G.N. (Gastroenterology 2015) 3
  4. NRF2-driven miR-125B1 and miR-29B1 transcriptional regulation controls a novel anti-apoptotic miRNA regulatory network for AML survival. (PMID: 25323587) Shah N.M. … Rushworth S.A. (Cell Death Differ. 2015) 3
  5. microRNA-29b prevents liver fibrosis by attenuating hepatic stellate cell activation and inducing apoptosis through targeting PI3K/AKT pathway. (PMID: 25356754) Wang J. … Yu J. (Oncotarget 2015) 3

Products for MIR29B1 Gene

Sources for MIR29B1 Gene

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