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Aliases for MIR29A Gene

Subcategory (RNA class) for MIR29A Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR29A Gene

  • MicroRNA 29a 2 3
  • MicroRNA 29 2 3
  • MIRN29A 3 6
  • Hsa-Mir-29a 3
  • Hsa-Mir-29 3
  • MiRNA29A 3
  • MIRN29 3

External Ids for MIR29A Gene

Previous Symbols for MIR29A Gene

  • MIRN29
  • MIRN29A

Summaries for MIR29A Gene

Entrez Gene Summary for MIR29A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR29A Gene

MIR29A (MicroRNA 29a) is a RNA Gene, and belongs to miRNA RNA class. Diseases associated with MIR29A include alk-negative anaplastic large cell lymphoma and mantle cell lymphoma. Among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR.

fRNAdb sequence ontologies for MIR29A Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

View fRNAdb secondary structures for MIR29A

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR29A Gene

Genomics for MIR29A Gene

Genomic Location for MIR29A Gene

Start:
130,876,736 bp from pter
End:
130,876,821 bp from pter
Size:
86 bases
Orientation:
Minus strand

Genomic View for MIR29A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR29A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR29A Gene

ORGUL Member Location for MIR29A Gene

ORGUL Member Location for MIR29A gene

No data available for Regulatory Elements for MIR29A Gene

Proteins for MIR29A Gene

Post-translational modifications for MIR29A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR29A Gene

Domains for MIR29A Gene

Gene Families for MIR29A Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIR29A: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIR29A Gene

Function for MIR29A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR29A Gene

Localization for MIR29A Gene

No data available for Gene Ontology (GO) - Cellular Components for MIR29A Gene

Pathways for MIR29A Gene

genes like me logo Genes that share pathways with MIR29A: view

Pathways by source for MIR29A Gene

1 KEGG pathway for MIR29A Gene

Interacting Proteins for MIR29A Gene

Gene Ontology (GO) - Biological Process for MIR29A Gene

None

Transcripts for MIR29A Gene

fRNAdb Secondary structures for MIR29A Gene

  • FR062169

mRNA/cDNA for MIR29A Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR29A Gene

No ASD Table

Relevant External Links for MIR29A Gene

GeneLoc Exon Structure for
MIR29A
ECgene alternative splicing isoforms for
MIR29A

Expression for MIR29A Gene

mRNA expression in normal human tissues for MIR29A Gene

genes like me logo Genes that share expressions with MIR29A: view

Orthologs for MIR29A Gene

Evolution for MIR29A Gene

ENSEMBL:
Gene Tree for MIR29A (if available)
TreeFam:
Gene Tree for MIR29A (if available)

No data available for Orthologs for MIR29A Gene

Paralogs for MIR29A Gene

No data available for Paralogs for MIR29A Gene

Variants for MIR29A Gene

Sequence variations from dbSNP and Humsavar for MIR29A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs24168 -- 130,876,526(-) CTTTA(C/T)AGAAA downstream-variant-500B
rs12671082 -- 130,876,442(+) ATCAT(A/C)TAAGC downstream-variant-500B
rs34005176 -- 130,876,461(+) ATTTT(-/C)CCCCA downstream-variant-500B
rs34772568 -- 130,876,506(+) CCCCC(A/G)CCAAG downstream-variant-500B
rs57826832 -- 130,876,587(+) ACATG(A/C)AATTC downstream-variant-500B

Relevant External Links for MIR29A Gene

HapMap Linkage Disequilibrium report
MIR29A

No data available for Structural Variations from Database of Genomic Variants (DGV) for MIR29A Gene

Disorders for MIR29A Gene

Relevant External Links for MIR29A

Genetic Association Database (GAD)
MIR29A
Human Genome Epidemiology (HuGE) Navigator
MIR29A
genes like me logo Genes that share disorders with MIR29A: view

No data available for UniProtKB/Swiss-Prot for MIR29A Gene

Publications for MIR29A Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 49
  2. microRNA-29a induces aberrant self-renewal capacity in hematopoietic progenitors, biased myeloid development, and acute myeloid leukemia. (PMID: 20212066) Han Y.C. … Gu H. (J. Exp. Med. 2010) 3
  3. miR-29 modulates Wnt signaling in human osteoblasts through a positive feedback loop. (PMID: 20551325) Kapinas K. … Delany A.M. (J. Biol. Chem. 2010) 3
  4. Transcriptional suppression of mir-29b-1/mir-29a promoter by c-Myc, hedgehog, and NF-kappaB. (PMID: 20564213) Mott J.L. … Fernandez-Zapico M.E. (J. Cell. Biochem. 2010) 3
  5. Chronic lymphocytic leukemia modeled in mouse by targeted miR-29 expression. (PMID: 20566844) Santanam U. … Pekarsky Y. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3

Products for MIR29A Gene

Sources for MIR29A Gene

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