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Aliases for MIR29A Gene

Subcategory (RNA class) for MIR29A Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR29A Gene

  • MicroRNA 29a 2 3 5
  • MicroRNA 29 2 3
  • Hsa-Mir-29a 3
  • Hsa-Mir-29 3
  • MiRNA29A 3
  • Mir-29a 3
  • MIRN29A 3
  • MIRN29 3

External Ids for MIR29A Gene

Previous HGNC Symbols for MIR29A Gene

  • MIRN29
  • MIRN29A

Previous GeneCards Identifiers for MIR29A Gene

  • GC07M130214
  • GC07M130561

Summaries for MIR29A Gene

Entrez Gene Summary for MIR29A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR29A Gene

MIR29A (MicroRNA 29a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR29A Gene

Genomics for MIR29A Gene

Regulatory Elements for MIR29A Gene

Enhancers for MIR29A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F130954 1.7 FANTOM5 Ensembl ENCODE 10.5 -46.0 -45976 9.4 HDGF PKNOX1 ATF1 ARNT WRNIP1 ZNF133 SIN3A ELK1 CBX5 ZNF207 MIR29A RNU6-1010P LINC-PINT MKLN1 GC07M130950 GC07M131055
GH07F131006 1.6 FANTOM5 Ensembl ENCODE 10.4 -98.5 -98508 10.2 ATF1 PKNOX1 ARNT SIN3A ZNF2 GLIS2 ZNF548 FOS JUNB REST RNU6-1010P LINC-PINT MIR29A KLHDC10 MKLN1 GC07M131055 GC07M130950
GH07F130993 1.3 Ensembl ENCODE 10.3 -83.9 -83913 8.0 ARID4B FEZF1 YY1 FOS ZNF263 TSHZ1 REST PPARG CREB3 MEF2D RNU6-1010P LINC-PINT MIR29A GC07M130950 GC07M131055
GH07F130984 1.3 FANTOM5 Ensembl ENCODE 10.3 -74.6 -74558 6.4 BCOR GTF2E2 ZMYM3 BMI1 YY1 ZNF664 ZNF121 ZNF316 ZFHX2 GATA3 RNU6-1010P LINC-PINT MIR29A MKLN1-AS MKLN1 GC07M130950 GC07M131055
GH07F130937 1.3 Ensembl ENCODE 10.1 -30.1 -30113 11.1 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 YY1 MIR29A ENSG00000273319 GC07M130950
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR29A on UCSC Golden Path with GeneCards custom track

Promoters for MIR29A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000634364 1310 4001 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 SLC30A9 CBX5

Genomic Location for MIR29A Gene

Chromosome:
7
Start:
130,876,747 bp from pter
End:
130,913,310 bp from pter
Size:
36,564 bases
Orientation:
Minus strand

Genomic View for MIR29A Gene

Genes around MIR29A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR29A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR29A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR29A Gene

Proteins for MIR29A Gene

Post-translational modifications for MIR29A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR29A Gene

Domains & Families for MIR29A Gene

Gene Families for MIR29A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR29A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR29A Gene

Function for MIR29A Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR29A Gene

Localization for MIR29A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR29A Gene

Pathways & Interactions for MIR29A Gene

genes like me logo Genes that share pathways with MIR29A: view

Pathways by source for MIR29A Gene

1 BioSystems pathway for MIR29A Gene
1 KEGG pathway for MIR29A Gene

Interacting Proteins for MIR29A Gene

Gene Ontology (GO) - Biological Process for MIR29A Gene

None

No data available for SIGNOR curated interactions for MIR29A Gene

Transcripts for MIR29A Gene

mRNA/cDNA for MIR29A Gene

(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR29A Gene

No ASD Table

Relevant External Links for MIR29A Gene

GeneLoc Exon Structure for
MIR29A
ECgene alternative splicing isoforms for
MIR29A

Expression for MIR29A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR29A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR29A Gene:

MIR29A
genes like me logo Genes that share expression patterns with MIR29A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR29A Gene

Orthologs for MIR29A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR29A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-29a 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-29a 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-29a 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-29a-1 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir29a 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-29a-1 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-29a 35
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-29a-1 35
  • 56 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CR749762.2 35
  • 62 (a)
OneToOne
Species where no ortholog for MIR29A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR29A Gene

ENSEMBL:
Gene Tree for MIR29A (if available)
TreeFam:
Gene Tree for MIR29A (if available)

Paralogs for MIR29A Gene

No data available for Paralogs for MIR29A Gene

Variants for MIR29A Gene

Sequence variations from dbSNP and Humsavar for MIR29A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs111826474 -- 130,876,841(+) GAGGG(C/T)TGGGA upstream-variant-2KB
rs112938204 -- 130,877,543(+) AGAAG(-/C)TTTAT downstream-variant-500B, upstream-variant-2KB
rs113362016 -- 130,876,543(+) CATTC(A/G)TGATA downstream-variant-500B
rs116155675 -- 130,877,555(+) ATCTA(C/G/T)TTTTT downstream-variant-500B, upstream-variant-2KB
rs116951982 -- 130,876,957(+) AGTAT(A/G)AAATT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR29A Gene

Variant ID Type Subtype PubMed ID
nsv608422 CNV gain 21841781

Relevant External Links for MIR29A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR29A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR29A Gene

Disorders for MIR29A Gene

Relevant External Links for MIR29A

Genetic Association Database (GAD)
MIR29A
Human Genome Epidemiology (HuGE) Navigator
MIR29A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR29A

No disorders were found for MIR29A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR29A Gene

Publications for MIR29A Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 46 64
  2. Tumor-suppressive microRNA-29 family inhibits cancer cell migration and invasion directly targeting LOXL2 in lung squamous cell carcinoma. (PMID: 26676674) Mizuno K. … Inoue H. (Int. J. Oncol. 2016) 3 64
  3. MicroRNA-29a in Adult Muscle Stem Cells Controls Skeletal Muscle Regeneration During Injury and Exercise Downstream of Fibroblast Growth Factor-2. (PMID: 26731484) Galimov A. … KrA1tzfeldt J. (Stem Cells 2016) 3 64
  4. Fecal miR-29a and miR-224 as the noninvasive biomarkers for colorectal cancer. (PMID: 26756616) Zhu Y. … Sun J. (Cancer Biomark 2016) 3 64
  5. IGF1 3'UTR functions as a ceRNA in promoting angiogenesis by sponging miR-29 family in osteosarcoma. (PMID: 26759259) Gao S. … Wang G. (J. Mol. Histol. 2016) 3 64

Products for MIR29A Gene

Sources for MIR29A Gene

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