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Aliases for MIR29A Gene

Subcategory (RNA class) for MIR29A Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR29A Gene

  • MicroRNA 29a 2 3 5
  • MicroRNA 29 2 3
  • Hsa-Mir-29a 3
  • Hsa-Mir-29 3
  • MiRNA29A 3
  • Mir-29a 3
  • MIRN29A 3
  • MIRN29 3

External Ids for MIR29A Gene

Previous HGNC Symbols for MIR29A Gene

  • MIRN29
  • MIRN29A

Previous GeneCards Identifiers for MIR29A Gene

  • GC07M130214
  • GC07M130561

Summaries for MIR29A Gene

Entrez Gene Summary for MIR29A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR29A Gene

MIR29A (MicroRNA 29a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Metastatic brain tumor and MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR29A Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

View fRNAdb secondary structures for MIR29A

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR29A Gene

Genomics for MIR29A Gene

Regulatory Elements for MIR29A Gene

Enhancers for MIR29A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G130908 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -39.2 -39216 15.2 HDGF PKNOX1 FOXA2 MLX ARNT WRNIP1 ZFP64 ARID4B SIN3A FEZF1 MIR29A RNU6-1010P LINC-PINT LINC00513 TMEM209 MKLN1 GC07P130916 PIR43822
GH07G130954 2 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -82.3 -82257 9.0 HDGF PKNOX1 ARNT WRNIP1 SIN3A ZNF766 CBX5 ZNF143 ZNF207 FOS MIR29A RNU6-1010P LINC-PINT MKLN1 GC07M130950 GC07M131055
GH07G131006 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.3 -133.6 -133592 7.3 HDGF PKNOX1 ATF1 ARNT SIN3A ZNF2 ZNF766 GLIS2 ELK1 FOS RNU6-1010P LINC-PINT MIR29A KLHDC10 MKLN1 GC07M131055 GC07M130950
GH07G130929 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -54.0 -53969 2.4 CTCF ARNT GTF2E2 SIN3A RAD21 ZBTB40 YY1 ZNF316 SCRT2 MAFK MIR29A RNU6-1010P LINC-PINT MKLN1 LINC00513 ENSG00000271204 GC07P130916
GH07G130984 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -111.1 -111058 6.4 BCOR GTF2E2 ZMYM3 BMI1 YY1 ZNF664 ZNF121 ZFHX2 CTBP1 ZNF316 RNU6-1010P LINC-PINT MIR29A MKLN1-AS MKLN1 GC07M130950 GC07M131055
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR29A on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR29A Gene

Chromosome:
7
Start:
130,876,747 bp from pter
End:
130,876,810 bp from pter
Size:
64 bases
Orientation:
Minus strand

Genomic View for MIR29A Gene

Genes around MIR29A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR29A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR29A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR29A Gene

ORGUL Member Location for MIR29A Gene

ORGUL Member Location for MIR29A gene

Proteins for MIR29A Gene

Post-translational modifications for MIR29A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR29A Gene

Domains & Families for MIR29A Gene

Gene Families for MIR29A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR29A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR29A Gene

Function for MIR29A Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR29A Gene

Localization for MIR29A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR29A Gene

Pathways & Interactions for MIR29A Gene

genes like me logo Genes that share pathways with MIR29A: view

Pathways by source for MIR29A Gene

2 BioSystems pathways for MIR29A Gene
1 KEGG pathway for MIR29A Gene

Interacting Proteins for MIR29A Gene

Gene Ontology (GO) - Biological Process for MIR29A Gene

None

No data available for SIGNOR curated interactions for MIR29A Gene

Drugs & Compounds for MIR29A Gene

No Compound Related Data Available

Transcripts for MIR29A Gene

fRNAdb Secondary structures for MIR29A Gene

  • FR401283

mRNA/cDNA for MIR29A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR29A Gene

No ASD Table

Relevant External Links for MIR29A Gene

GeneLoc Exon Structure for
MIR29A
ECgene alternative splicing isoforms for
MIR29A

Expression for MIR29A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR29A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR29A Gene:

MIR29A
genes like me logo Genes that share expression patterns with MIR29A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR29A Gene

Orthologs for MIR29A Gene

Evolution for MIR29A Gene

ENSEMBL:
Gene Tree for MIR29A (if available)
TreeFam:
Gene Tree for MIR29A (if available)

No data available for Orthologs for MIR29A Gene

Paralogs for MIR29A Gene

No data available for Paralogs for MIR29A Gene

Variants for MIR29A Gene

Sequence variations from dbSNP and Humsavar for MIR29A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000549166 -- 130,878,608(+) TCGTT(C/G)TATAA intron-variant, upstream-variant-2KB
rs1000643866 -- 130,878,268(+) TTTTT(C/T)GCCGT intron-variant, upstream-variant-2KB
rs1005208224 -- 130,877,036(+) CCCCT(G/T)GGATA downstream-variant-500B, upstream-variant-2KB
rs1006194073 -- 130,877,364(+) TGTGA(C/G)GCAGG downstream-variant-500B, upstream-variant-2KB
rs1007315390 -- 130,878,704(+) TACAT(C/G)CAACT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR29A Gene

Variant ID Type Subtype PubMed ID
nsv608422 CNV gain 21841781

Relevant External Links for MIR29A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR29A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR29A Gene

Disorders for MIR29A Gene

Relevant External Links for MIR29A

Genetic Association Database (GAD)
MIR29A
Human Genome Epidemiology (HuGE) Navigator
MIR29A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR29A

No disorders were found for MIR29A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR29A Gene

Publications for MIR29A Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 46 64
  2. Regulation of metastasis-promoting LOXL2 gene expression by antitumor microRNAs in prostate cancer. (PMID: 27278788) Kato M. … Seki N. (J. Hum. Genet. 2017) 3 64
  3. Elevated Plasma miR-29a Levels Are Associated with Increased Carotid Intima-Media Thickness in Atherosclerosis Patients. (PMID: 28250354) Liu C.Z. … Huang Y.Q. (Tohoku J. Exp. Med. 2017) 3 64
  4. miR-29a suppresses MCF-7 cell growth by downregulating tumor necrosis factor receptor 1. (PMID: 28222663) Zhao Y. … Sun P. (Tumour Biol. 2017) 3 64
  5. Plasma miR-92a-2 as a biomarker for small cell lung cancer. (PMID: 28106539) Yu Y. … Tu J. (Cancer Biomark 2017) 3 64

Products for MIR29A Gene

Sources for MIR29A Gene

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