Aliases for MIR298 Gene
Subcategory (RNA class) for MIR298 Gene
Quality Score for this RNA gene is
External Ids for MIR298 Gene
- HGNC: 33634
- Entrez Gene: 100126296
- Ensembl: ENSG00000216031
- OMIM: 614914
- miRBase: hsa-mir-298
ORGUL Members for MIR298 Gene
Previous HGNC Symbols for MIR298 Gene
- MIRN298
Previous GeneCards Identifiers for MIR298 Gene
- GC20M056836
- GC20M056837
- GC20M057393
Summaries for MIR298 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR298 Gene
MIR298 (MicroRNA 298) is an RNA Gene, and is affiliated with the miRNA class.
Additional gene information for MIR298 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR298 Gene
Genomics for MIR298 Gene
GeneHancer (GH) Regulatory Elements for MIR298 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH20I058817 | Enhancer | 0.6 | ENCODE | 550.8 | -0.7 | -728 | 2.9 | FOXA2 NRF1 JUNB BATF BCL11A SCRT2 RUNX3 EGR2 TCF7L2 | ENSG00000268649 MIR296 MIR298 GNAS-AS1 ENSG00000268333 | |
GH20I058844 | Enhancer | 0.3 | ENCODE | 12 | -26.5 | -26489 | 0.8 | CREB1 | MIR296 MIR298 ENSG00000276722 ENSG00000274491 GNAS GNAS-AS1 | |
GH20I058782 | Enhancer | 0.2 | ENCODE | 12.3 | +34.5 | 34494 | 1.7 | PIEZO1P2 MIR296 MIR298 GNAS GNAS-AS1 LOC105372695 | ||
GH20I058820 | Enhancer | 0.9 | ENCODE dbSUPER | 0.4 | -7.4 | -7366 | 9.5 | SIX4 CTCF ESRRA PKNOX1 SIN3A YBX1 RAD21 ZNF7 ZKSCAN1 ZNF316 | NELFCD ENSG00000270951 LOC101927932 GNAS-AS1 MIR298 ENSG00000268333 | |
GH20I058835 | Enhancer | 0.4 | dbSUPER | 0.4 | -18.0 | -17987 | 1.4 | SCRT2 MNT COPS2 | ENSG00000268333 GNAS GNAS-AS1 MIR298 |
Regulatory Element Products
Genomic Locations for MIR298 Gene
- chr20:58,818,226-58,818,313
- (GRCh38/hg38)
- Size:
- 88 bases
- Orientation:
- Minus strand
- chr20:57,393,281-57,393,368
- (GRCh37/hg19)
Genomic View for MIR298 Gene
- Cytogenetic band:
-
- 20q13.32 by Ensembl
- 20q13.32 by Entrez Gene
- 20q13.32 by HGNC


RefSeq DNA sequence for MIR298 Gene
ORGUL Member Location for MIR298 Gene

Proteins for MIR298 Gene
Post-translational modifications for MIR298 Gene
Antibody Products
- Search GeneTex for Antibodies for MIR298
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR298
- Origene Custom Protein Services for MIR298
- Search GeneTex for Proteins for MIR298
No data available for DME Specific Peptides for MIR298 Gene
Domains & Families for MIR298 Gene
Gene Families for MIR298 Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR298 Gene
Function for MIR298 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IDA | 20190813 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR298
-
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CRISPR Products
- Browse CRISPR knockouts for MIR298
- Applied Biological Materials CRISPR for MIR298
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR298
Clone Products
- GenScript: Custom all cDNA clones Services for MIR298
- VectorBuilder custom plasmid, inducible vectors for MIR298
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR298
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR298
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR298 Gene
Localization for MIR298 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR298 Gene
Pathways & Interactions for MIR298 Gene
Interacting Proteins for MIR298 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0035278 | miRNA mediated inhibition of translation | IDA | 20190813 |
No data available for Pathways by source and SIGNOR curated interactions for MIR298 Gene
Transcripts for MIR298 Gene
mRNA/cDNA for MIR298 Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIR298
- Applied Biological Materials CRISPR for MIR298
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR298
Clone Products
- GenScript: Custom all cDNA clones Services for MIR298
- VectorBuilder custom plasmid, inducible vectors for MIR298
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR298
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR298
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIR298 Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR298 Gene:
MIR298Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR298 Gene
Orthologs for MIR298 Gene
This gene was present in the common ancestor of human and mouse.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-298 34 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Mir298 34 |
|
OneToOne |
- Species where no ortholog for MIR298 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for MIR298 Gene
No data available for Paralogs for MIR298 Gene
Variants for MIR298 Gene
SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000887067 | -- | 58,819,782(-) | A/T | upstream_transcript_variant | |
rs1001104002 | -- | 58,820,070(-) | C/T | upstream_transcript_variant | |
rs1001557382 | -- | 58,818,386(-) | T/G | upstream_transcript_variant | |
rs1003255338 | -- | 58,819,479(-) | G/A | upstream_transcript_variant | |
rs1003880834 | -- | 58,819,432(-) | C/A/T | upstream_transcript_variant |
Additional Variant Information for MIR298 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR298
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR298 Gene
Disorders for MIR298 Gene
Additional Disease Information for MIR298
No disorders were found for MIR298 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR298 Gene
Publications for MIR298 Gene
- Increased expression of P-glycoprotein and doxorubicin chemoresistance of metastatic breast cancer is regulated by miR-298. (PMID: 22521303) Bao L … Dash S (The American journal of pathology 2012) 3 58
- Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3' untranslated region. (PMID: 20190813) Wu S … He X (Oncogene 2010) 3 58
- A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P … Tuschl T (Cell 2007) 3 58
- miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58
Products for MIR298 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
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- Browse Proteins and Enzymes
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- Novus Biologicals
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- Cloud-Clone Corp. disease models service
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- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR298
- VectorBuilder custom plasmid, inducible vectors for MIR298
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR298
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for MIR298
- Search GeneTex for Proteins for MIR298
Sources for MIR298 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
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- (122) MedlinePlus
- (123) CDC
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- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
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- (133) ENCODE
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- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew