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MIR298 Gene(RNA Gene)

MicroRNA 298

GCID:
GC20M058818
GIFtS:
15
Genes Participants
UDN Logo

Aliases for MIR298 Gene

Subcategory (RNA class) for MIR298 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR298 Gene

  • MicroRNA 298 2 3 5
  • Hsa-Mir-298 3
  • MIRN298 3

External Ids for MIR298 Gene

ORGUL Members for MIR298 Gene

Previous HGNC Symbols for MIR298 Gene

  • MIRN298

Previous GeneCards Identifiers for MIR298 Gene

  • GC20M056836
  • GC20M056837
  • GC20M057393

Summaries for MIR298 Gene

Entrez Gene Summary for MIR298 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR298 Gene

MIR298 (MicroRNA 298) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR298 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR298 Gene

Genomics for MIR298 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for MIR298 Gene

Promoters and enhancers for MIR298 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH20I058817 Enhancer 0.6 ENCODE 550.8 -0.7 -728 2.9 FOXA2 NRF1 JUNB BATF BCL11A SCRT2 RUNX3 EGR2 TCF7L2 ENSG00000268649 MIR296 MIR298 GNAS-AS1 ENSG00000268333
GH20I058844 Enhancer 0.3 ENCODE 12 -26.5 -26489 0.8 CREB1 MIR296 MIR298 ENSG00000276722 ENSG00000274491 GNAS GNAS-AS1
GH20I058782 Enhancer 0.2 ENCODE 12.3 +34.5 34494 1.7 PIEZO1P2 MIR296 MIR298 GNAS GNAS-AS1 LOC105372695
GH20I058820 Enhancer 0.9 ENCODE dbSUPER 0.4 -7.4 -7366 9.5 SIX4 CTCF ESRRA PKNOX1 SIN3A YBX1 RAD21 ZNF7 ZKSCAN1 ZNF316 NELFCD ENSG00000270951 LOC101927932 GNAS-AS1 MIR298 ENSG00000268333
GH20I058835 Enhancer 0.4 dbSUPER 0.4 -18.0 -17987 1.4 SCRT2 MNT COPS2 ENSG00000268333 GNAS GNAS-AS1 MIR298
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR298 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR298 Gene

Genomic Locations for MIR298 Gene
chr20:58,818,226-58,818,313
(GRCh38/hg38)
Size:
88 bases
Orientation:
Minus strand
chr20:57,393,281-57,393,368
(GRCh37/hg19)

Genomic View for MIR298 Gene

Genes around MIR298 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR298 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR298 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR298 Gene

ORGUL Member Location for MIR298 Gene

ORGUL Member Location for MIR298 gene

Proteins for MIR298 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR298 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR298 Gene

Domains & Families for MIR298 Gene

Gene Families for MIR298 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR298: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR298 Gene

Function for MIR298 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Gene Ontology (GO) - Molecular Function for MIR298 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 20190813
genes like me logo Genes that share ontologies with MIR298: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR298 Gene

Localization for MIR298 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR298 Gene

Pathways & Interactions for MIR298 Gene

SuperPathways for MIR298 Gene

PathCards logo More details on SuperPathways for MIR298
No Data Available

Interacting Proteins for MIR298 Gene

Gene Ontology (GO) - Biological Process for MIR298 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035278 miRNA mediated inhibition of translation IDA 20190813
genes like me logo Genes that share ontologies with MIR298: view

No data available for Pathways by source and SIGNOR curated interactions for MIR298 Gene

Drugs & Compounds for MIR298 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR298 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for MIR298 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR298 Gene

No ASD Table

Relevant External Links for MIR298 Gene

GeneLoc Exon Structure for
MIR298
ECgene alternative splicing isoforms for
MIR298

Expression for MIR298 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR298 Gene

mRNA expression in normal human tissues for MIR298 Gene
mRNA expression by GTEx for MIR298 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR298 Gene:

MIR298
genes like me logo Genes that share expression patterns with MIR298: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR298 Gene

Orthologs for MIR298 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for MIR298 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia ptr-mir-298 34
  • 100 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Mir298 34
  • 72 (a)
 OneToOne
Species where no ortholog for MIR298 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR298 Gene

ENSEMBL:
Gene Tree for MIR298 (if available)
TreeFam:
Gene Tree for MIR298 (if available)

Paralogs for MIR298 Gene

No data available for Paralogs for MIR298 Gene

Variants for MIR298 Gene

Sequence variations from dbSNP and Humsavar for MIR298 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000887067 -- 58,819,782(-) A/T upstream_transcript_variant
rs1001104002 -- 58,820,070(-) C/T upstream_transcript_variant
rs1001557382 -- 58,818,386(-) T/G upstream_transcript_variant
rs1003255338 -- 58,819,479(-) G/A upstream_transcript_variant
rs1003880834 -- 58,819,432(-) C/A/T upstream_transcript_variant

Additional Variant Information for MIR298 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR298

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR298 Gene

Disorders for MIR298 Gene

Additional Disease Information for MIR298

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR298 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR298 Gene

Publications for MIR298 Gene

  1. Increased expression of P-glycoprotein and doxorubicin chemoresistance of metastatic breast cancer is regulated by miR-298. (PMID: 22521303) Bao L … Dash S (The American journal of pathology 2012) 3 58
  2. Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 3' untranslated region. (PMID: 20190813) Wu S … He X (Oncogene 2010) 3 58
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P … Tuschl T (Cell 2007) 3 58
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 58

Products for MIR298 Gene

Sources for MIR298 Gene

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