Aliases
for MIR298 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
About This Section
TryGeneCards Plus |
Subcategory (RNA class): miRNA
Quality score for this RNA gene is 3
| Aliases |
|---|
| MicroRNA 2981 2 | | MIRN2981 2 | | hsa-mir-2982 | | mir-2989 |
| External Ids: | HGNC: 336341 | Entrez Gene: 1001262962 | Ensembl: ENSG000002160317 | OMIM: 6149145 |
Export aliases for MIR298 gene to outside databasesPrevious GC identifers: GC20M056836 GC20M056837
|---|
Summaries
for MIR298 gene(According to Entrez Gene,
GeneCards,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
TryGeneCards Plus |
Entrez Gene summary for MIR298 Gene:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of
gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are
transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can
be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme
to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the
cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The
mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through
imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of
the target mRNA. The RefSeq represents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)
GeneCards Summary for MIR298 Gene:
MIR298 (microRNA 298) is an RNA gene, and is affiliated with the miRNA class. Diseases associated with MIR298 include breast cancer.
|
Genomic Views
for MIR298 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 75),
Regulatory elements and Epigenetics data according to
QIAGEN, and/or
SwitchGear Genomics)
About This Section
TryGeneCards Plus | Regulatory elements:
 Search for regulatory transcription factor binding sites for MIR298
Other transcription factors
Search Chromatin IP Primers for MIR298
Epigenetics:
| | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIR298 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.32 Ensembl cytogenetic band: 20q13.32 HGNC cytogenetic band: 20q13.32MIR298 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M057393: view genomic region (via miRBase)
(about GC identifiers)
Start:
|
57,393,281 bp from pter |
End:
|
57,393,368 bp from pter |
Size:
|
88 bases |
Orientation:
|
minus strand |
|
Proteins
for MIR298 gene
(According to
1UniProtKB,
HORDE,
2neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Antibodies by
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
TryGeneCards Plus |
UniProtKB: --
|
Domains /
Families
for MIR298 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
TryGeneCards Plus | HGNC Gene Families:
MIR: ncRNAs / Micro RNAs
-- |
Function
for MIR298 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
transcription factor targeting from QIAGEN
and/or HOMER,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
SwitchGear Genomics,
Gene Editing from DNA2.0,
Clones from OriGene,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
ESI BIO,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
About This Section
TryGeneCards Plus |
Animal Models:
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for MIR298 | |  | Browse ESI BIO Cell Lines and PureStem Progenitors for MIR298  | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIR298 |
Localization
for MIR298 gene
(According to UniProtKB, COMPARTMENTS Subcellular localization database,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
About This Section
TryGeneCards Plus | -- |
Pathways & Interactions
for MIR298 gene
(SuperPaths according to PathCards,
Pathways according to
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
QIAGEN,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene).
About This Section
TryGeneCards Plus |
Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MIR298
Interactions:
Search GeneGlobe Interaction Network for MIR298
|
Drugs & Compounds
for MIR298 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience,
ApexBio,
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB)
About This Section
TryGeneCards Plus |  Browse compounds at ApexBio
 Browse Tocris compounds for MIR298
|
Transcripts
for MIR298 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
SwitchGear Genomics,
Tagged/untagged cDNA clones from
OriGene,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene, and/or
QIAGEN
)
About This Section
TryGeneCards Plus |
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000401212(miRNA)
GeneLoc Exon Structure
|
Expression
for MIR298 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MaxQB,
plus additional links to
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
QIAGEN,
Primers from
OriGene, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
TryGeneCards Plus | Expression evidence for MIR298:none
See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
MIR298 Protein expression data from MOPED1, PaxDb2 and
MaxQB3:  --
Custom PCR Arrays for MIR298
Primer
Products: |  | Browse OriGene qPCR
| | | Search Pre-validated RT2 qPCR
Primer Assays in human, mouse, rat MIR298 | | | Search QuantiTect SYBR Green Assays in human, mouse, rat MIR298 | | | Search QuantiFast Probe-based Assays in human, mouse, rat MIR298 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIR298 |
Orthologs
for MIR298 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
TryGeneCards Plus |
--
ENSEMBL Gene Tree for MIR298 (if available)
TreeFam Gene Tree for MIR298 (if available) |
Paralogs
for MIR298 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
TryGeneCards Plus | -- |
Genomic Variants
for MIR298 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD), the Human Cytochrome P450 Allele
Nomenclature Database, and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section
TryGeneCards Plus | Structural Variations
Database of Genomic Variants (DGV) 2 variations for MIR298: About this table
| | Site Specific Mutation Identification with PCR Assays |
|
Disorders
/ Diseases
for MIR298 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
TryGeneCards Plus |
OMIM gene information: 614914
OMIM disorders: --
1  disease for MIR298: About MalaCardsbreast cancer
MIR298 for disorders About GeneDecksing
Export disorders for MIR298 gene to outside databases
|
Publications
for MIR298 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
TryGeneCards Plus |
PubMed articles for MIR298 gene integrated from 10 sources:
(articles sorted by number of sources associating them with MIR298) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Increased expression of P-glycoprotein and doxorubicin chemoresistance of metastatic breast cancer is regulated by miR-298. (PubMed id 22521303)1 Bao L....Dash S. (Am. J. Pathol. 2012)
- A mammalian microRNA expression atlas based on small RNA library sequencing. (PubMed id 17604727)1 Landgraf P....Tuschl T. (Cell 2007)
- miRBase: microRNA sequences, targets and gene nomenclature. (PubMed id 16381832)1 Griffiths-Jones S....Enright A.J. (Nucleic Acids Res. 2006)
|
External Searches for MIR298 gene (in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
TryGeneCards Plus |
|
Genome Databases showing MIR298 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
TryGeneCards Plus |
|
Other Databases showing MIR298 gene
(According to HUGE)
About This Section
TryGeneCards Plus | -- |
Specialized Databases showing MIR298 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section
TryGeneCards Plus |
| Name | Description |
| PharmGKB entry for MIR298 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
TryGeneCards Plus | Patent Information for MIR298 gene:
Search GeneIP for patents involving MIR298
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MIR298 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or
ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
TryGeneCards Plus |
 | |
 |
| | | | |
 |
 |
|  | Block miRNA regulation of human, mouse, rat MIR298 using miScript Target Protectors | | SeqTarget long-range PCR primers for resequencing MIR298 | | | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIR298 | | Predesigned siRNA for gene silencing in human, mouse, rat MIR298 | | | Search QuantiFast Probe-based Assays in human, mouse, rat MIR298 | | Search QuantiTect SYBR Green Assays in human, mouse, rat MIR298 | | | Custom PCR Arrays for MIR298 | | Search Chromatin IP Primers for MIR298 | | | Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MIR298 | | Search GeneGlobe Interaction Network for MIR298 | | | Search Regulatory tfbs for MIR298 |
| |
 |  |  |  | |
| | | Search Tocris compounds for MIR298 |
| | |  |  |  |
 | | | | |
 |
 |
 |  | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIR298 |
| |  |  |  |  | | | Search ThermoFisher Antibodies for MIR298 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MIR298 |
| | |  |  | | |
|
|
|
GeneCards Homepage -
Last full update: 7 May 2014 -
Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014
View Random Gene
|
Category
|
|
|
|
| GIFtS Group |
|
Developed at the Crown Human Genome Center,
Department of Molecular Genetics,
the Weizmann Institute of Science
Copyright © 1996-2014
, Weizmann Institute of Science. All Rights Reserved.
Version: 3.12.136 22 July 2014
hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4
|
