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Aliases for MIR297 Gene

Subcategory (RNA class) for MIR297 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR297 Gene

  • MicroRNA 297 2 3 5
  • Hsa-Mir-297 3
  • MIRN297 3

External Ids for MIR297 Gene

Previous HGNC Symbols for MIR297 Gene

  • MIRN297

Previous GeneCards Identifiers for MIR297 Gene

  • GC04U900961
  • GC04M112003
  • GC04M111781

Summaries for MIR297 Gene

Entrez Gene Summary for MIR297 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR297 Gene

MIR297 (MicroRNA 297) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR297 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR297

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR297 Gene

Genomics for MIR297 Gene

Regulatory Elements for MIR297 Gene

Enhancers for MIR297 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G110850 1.1 Ensembl ENCODE 0.4 +9.6 9648 1.2 PKNOX1 ZSCAN4 FEZF1 GLI4 ZEB1 ZNF302 ZNF366 ZNF391 EGR2 SP3 MIR297 LINC01438
GH04G110868 0.6 ENCODE 0.4 -8.7 -8655 1.2 MTA2 OVOL3 DPF2 EP300 YY1 OSR2 ATF3 IKZF2 SPI1 MIR297 GC04P110917
GH04G110853 0.6 ENCODE 0.4 +6.0 5991 1.6 ZBTB21 BHLHE40 ZNF664 OSR2 SMARCA4 POLR2A ZNF629 ZSCAN5C MIR297 LINC01438
GH04G110865 0.6 ENCODE 0.4 -5.2 -5179 1.2 OSR2 PRDM6 FEZF1 ZBTB8A ZNF843 ZXDB MIR297 GC04P110917
GH04G110913 1.2 VISTA 0.2 -53.3 -53291 1.3 GC04P110917 MIR297
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR297 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR297 Gene

Chromosome:
4
Start:
110,860,582 bp from pter
End:
110,860,647 bp from pter
Size:
66 bases
Orientation:
Minus strand

Genomic View for MIR297 Gene

Genes around MIR297 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR297 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR297 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR297 Gene

ORGUL Member Location for MIR297 Gene

ORGUL Member Location for MIR297 gene

Proteins for MIR297 Gene

Post-translational modifications for MIR297 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR297 Gene

Domains & Families for MIR297 Gene

Gene Families for MIR297 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR297: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR297 Gene

Function for MIR297 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR297 Gene

Localization for MIR297 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR297 Gene

Pathways & Interactions for MIR297 Gene

SuperPathways for MIR297 Gene

No Data Available

Interacting Proteins for MIR297 Gene

Gene Ontology (GO) - Biological Process for MIR297 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR297 Gene

Drugs & Compounds for MIR297 Gene

No Compound Related Data Available

Transcripts for MIR297 Gene

fRNAdb Secondary structures for MIR297 Gene

  • hsa-miR-297_MIMAT0004450_Homo_sapiens_miR-297_mature

mRNA/cDNA for MIR297 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR297 Gene

No ASD Table

Relevant External Links for MIR297 Gene

GeneLoc Exon Structure for
MIR297
ECgene alternative splicing isoforms for
MIR297

Expression for MIR297 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR297 Gene:

MIR297
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR297 Gene

Orthologs for MIR297 Gene

Evolution for MIR297 Gene

ENSEMBL:
Gene Tree for MIR297 (if available)
TreeFam:
Gene Tree for MIR297 (if available)

No data available for Orthologs for MIR297 Gene

Paralogs for MIR297 Gene

No data available for Paralogs for MIR297 Gene

Variants for MIR297 Gene

Sequence variations from dbSNP and Humsavar for MIR297 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000257643 -- 110,861,454(+) TTTGG(A/G)AGTCT upstream-variant-2KB
rs1000741884 -- 110,861,677(+) CGACA(G/T)AGCAA upstream-variant-2KB
rs1001340019 -- 110,860,089(+) TCTAT(G/T)AAGAG downstream-variant-500B
rs1002049720 -- 110,860,300(+) TGTTA(C/T)GTATT downstream-variant-500B
rs1003922229 -- 110,862,368(+) TGAAA(A/T)TTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR297 Gene

Variant ID Type Subtype PubMed ID
nsv1007337 CNV loss 25217958

Relevant External Links for MIR297 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR297

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR297 Gene

Disorders for MIR297 Gene

Relevant External Links for MIR297

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR297

No disorders were found for MIR297 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR297 Gene

Publications for MIR297 Gene

  1. Suppression of microRNA-silencing pathway by HIV-1 during virus replication. (PMID: 17322031) Triboulet R. … Benkirane M. (Science 2007) 1 3 64
  2. Changes in the Level of Circulating hsa-miR-297 and hsa-miR-19b-3p miRNA Are Associated with Generalization of Prostate Cancer. (PMID: 28091918) Osip'yants A.I. … Alekseev B.Y. (Bull. Exp. Biol. Med. 2017) 3 64
  3. miR-297 acts as an oncogene by targeting GPC5 in lung adenocarcinoma. (PMID: 27554041) Sun Y. … Bi J. (Cell Prolif. 2016) 3 64
  4. A miR-297/hypoxia/DGK-I+ axis regulating glioblastoma survival. (PMID: 24158111) Kefas B. … Purow B. (Neuro-oncology 2013) 3 64
  5. miR-297 modulates multidrug resistance in human colorectal carcinoma by down-regulating MRP-2. (PMID: 22676135) Xu K. … Liu J. (Biochem. J. 2012) 3 64

Products for MIR297 Gene

Sources for MIR297 Gene

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