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MicroRNA 296
(Previous symbol: MIRN296)
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Aliases
for MIR296 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
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Subcategory (RNA class): miRNA
Quality score for this RNA gene is 3
| Aliases |
|---|
| MicroRNA 2961 2 | | MIRN2961 2 5 | | miRNA2962 | | mir-2969 |
Export aliases for MIR296 gene to outside databasesPrevious GC identifers: GC20U900416 GC20M056839 |
Summaries
for MIR296 gene(According to Entrez Gene,
GeneCards,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
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Entrez Gene summary for MIR296 Gene:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of
gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are
transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can
be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme
to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the
cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The
mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through
imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of
the target mRNA. The RefSeq represents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)
GeneCards Summary for MIR296 Gene:
MIR296 (microRNA 296) is an RNA gene, and is affiliated with the miRNA class. Diseases associated with MIR296 include esophageal squamous cell carcinoma, and parathyroid carcinoma.
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Genomic Views
for MIR296 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 75),
Regulatory elements and Epigenetics data according to
QIAGEN, and/or
SwitchGear Genomics)
About This Section
TryGeneCards Plus | Regulatory elements:
 Search for regulatory transcription factor binding sites for MIR296
Other transcription factors
Search Chromatin IP Primers for MIR296
Epigenetics:
| | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIR296 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.32 Ensembl cytogenetic band: 20q13.32 HGNC cytogenetic band: 20q13.32MIR296 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M057392: view genomic region (via miRBase)
(about GC identifiers)
Start:
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57,392,187 bp from pter |
End:
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57,392,780 bp from pter |
Size:
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594 bases |
Orientation:
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minus strand |
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Proteins
for MIR296 gene
(According to
1UniProtKB,
HORDE,
2neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Antibodies by
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
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UniProtKB: --
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Domains /
Families
for MIR296 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
TryGeneCards Plus | HGNC Gene Families:
MIR: ncRNAs / Micro RNAs
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Function
for MIR296 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
transcription factor targeting from QIAGEN
and/or HOMER,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
SwitchGear Genomics,
Gene Editing from DNA2.0,
Clones from OriGene,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
ESI BIO,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Animal Models:
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for MIR296 | |  | Browse ESI BIO Cell Lines and PureStem Progenitors for MIR296  | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIR296 |
Localization
for MIR296 gene
(According to UniProtKB, COMPARTMENTS Subcellular localization database,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Pathways & Interactions
for MIR296 gene
(SuperPaths according to PathCards,
Pathways according to
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
QIAGEN,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene).
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Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MIR296
Interactions:
Search GeneGlobe Interaction Network for MIR296
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Drugs & Compounds
for MIR296 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience,
ApexBio,
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB)
About This Section
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 Browse compounds at ApexBio
 Browse Tocris compounds for MIR296
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Transcripts
for MIR296 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
SwitchGear Genomics,
Tagged/untagged cDNA clones from
OriGene,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene, and/or
QIAGEN
)
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2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000596276(lincRNA) ENST00000385215(lincRNA)(uc002xzr.1)
GeneLoc Exon Structure
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Expression
for MIR296 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MaxQB,
plus additional links to
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
QIAGEN,
Primers from
OriGene, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for MIR296:none
See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
MIR296 Protein expression data from MOPED1, PaxDb2 and
MaxQB3:  --
Custom PCR Arrays for MIR296
Primer
Products: |  | Browse OriGene qPCR
| | | Search Pre-validated RT2 qPCR
Primer Assays in human, mouse, rat MIR296 | | | Search QuantiTect SYBR Green Assays in human, mouse, rat MIR296 | | | Search QuantiFast Probe-based Assays in human, mouse, rat MIR296 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIR296 |
Orthologs
for MIR296 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
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--
ENSEMBL Gene Tree for MIR296 (if available)
TreeFam Gene Tree for MIR296 (if available) |
Paralogs
for MIR296 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Genomic Variants
for MIR296 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD), the Human Cytochrome P450 Allele
Nomenclature Database, and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for MIR296 (57392187 - 57392780 bp)
Structural Variations
Database of Genomic Variants (DGV) 2 variations for MIR296: About this table
| | Site Specific Mutation Identification with PCR Assays |
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Disorders
/ Diseases
for MIR296 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
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OMIM gene information: 610945
OMIM disorders: --
8  diseases for MIR296:
About MalaCardsesophageal squamous cell carcinoma parathyroid carcinoma cervical cancer cervicitis
esophagitis squamous cell carcinoma prostate cancer prostatitis
MIR296 for disorders About GeneDecksing
Export disorders for MIR296 gene to outside databases
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Publications
for MIR296 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for MIR296 gene, integrated from 10 sources (see all 14):
(articles sorted by number of sources associating them with MIR296) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- MiR-296-3p regulates cell growth and multi-drug resistance of human glioblastoma by targeting ether-A -go-go (EAG1). (PubMed id 22999387)1 Bai Y....Guo L. (Eur. J. Cancer 2013)
- Human microRNA hsa-miR-296-5p suppresses enterovirus 71 replication by targeting the viral genome. (PubMed id 23468506)1 Zheng Z....Wang H. (J. Virol. 2013)
- miR-296 regulation of a cell polarity-cell plasticity module controls tumor progression. (PubMed id 21643016)1 Vaira V....Bosari S. (Oncogene 2012)
- MicroRNA-296 is enriched in cancer cells and downregulates p21WAF1 mRNA expression via interaction with its 3' untranslated region. (PubMed id 21724611)1 Yoon A.R....Wadhwa R. (Nucleic Acids Res. 2011)
- Regulation of HMGA1 expression by microRNA-296 affects prostate cancer growth and invasion. (PubMed id 21138859)1 Wei J.J....Lee P. (Clin. Cancer Res. 2011)
- Differential expression of microRNAs in human parathyroid carcinomas compared with normal parathyroid tissue. (PubMed id 19926710)1 Corbetta S....Spada A. (Endocr. Relat. Cancer 2010)
- The prognostic and chemotherapeutic value of miR-296 in esophageal squamous cell carcinoma. (PubMed id 20485139)1 Hong L....Fan D. (Ann. Surg. 2010)
- Human with-no-lysine kinase-4 3'-UTR acting as the enhancer and being targeted by miR-296. (PubMed id 20561597)1 Mao J....Zhao Y. (amp 2010)
- Patterns of known and novel small RNAs in human cervical cancer. (PubMed id 17616659)1 Lui W.O....Fire A. (Cancer Res. 2007)
- A mammalian microRNA expression atlas based on small RNA library sequencing. (PubMed id 17604727)1 Landgraf P....Tuschl T. (Cell 2007)
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External Searches for MIR296 gene (in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing MIR296 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
Other Databases showing MIR296 gene
(According to HUGE)
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Specialized Databases showing MIR296 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for MIR296 | Pharmacogenomics, SNPs, Pathways |
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About This Section
TryGeneCards Plus | Patent Information for MIR296 gene:
Search GeneIP for patents involving MIR296
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MIR296 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or
ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
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|  | Block miRNA regulation of human, mouse, rat MIR296 using miScript Target Protectors | | SeqTarget long-range PCR primers for resequencing MIR296 | | | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIR296 | | Predesigned siRNA for gene silencing in human, mouse, rat MIR296 | | | Search QuantiFast Probe-based Assays in human, mouse, rat MIR296 | | Search QuantiTect SYBR Green Assays in human, mouse, rat MIR296 | | | Custom PCR Arrays for MIR296 | | Search Chromatin IP Primers for MIR296 | | | Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MIR296 | | Search GeneGlobe Interaction Network for MIR296 | | | Search Regulatory tfbs for MIR296 |
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| | | Search Tocris compounds for MIR296 |
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 |  | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIR296 |
| |  |  |  |  | | | Search ThermoFisher Antibodies for MIR296 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MIR296 |
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