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Aliases for MIR296 Gene

Subcategory (RNA class) for MIR296 Gene


Quality Score for this RNA gene is


Aliases for MIR296 Gene

  • MicroRNA 296 2 3 5
  • Hsa-Mir-296 3
  • MiRNA296 3
  • Mir-296 3
  • MIRN296 3

External Ids for MIR296 Gene

Previous HGNC Symbols for MIR296 Gene

  • MIRN296

Previous GeneCards Identifiers for MIR296 Gene

  • GC20U900416
  • GC20M056839
  • GC20M057392

Summaries for MIR296 Gene

Entrez Gene Summary for MIR296 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR296 Gene

MIR296 (MicroRNA 296) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR296 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR296

Additional gene information for MIR296 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR296 Gene

Genomics for MIR296 Gene

GeneHancer (GH) Regulatory Elements for MIR296 Gene

Promoters and enhancers for MIR296 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I058817 Enhancer 0.6 ENCODE 550.8 -1.3 -1347 2.9 FOXA2 NRF1 JUNB BATF BCL11A SCRT2 RUNX3 EGR2 TCF7L2 ENSG00000268649 MIR296 MIR298 GNAS-AS1 ENSG00000268333
GH20I058844 Enhancer 0.3 ENCODE 12 -27.1 -27108 0.8 CREB1 MIR296 MIR298 ENSG00000276722 GNAS-AS1 GNAS ENSG00000274491
GH20I058782 Enhancer 0.2 ENCODE 12.3 +33.9 33875 1.7 PIEZO1P2 MIR296 MIR298 GNAS GNAS-AS1 LOC105372695
GH20I058815 Enhancer 0.2 ENCODE 0.8 +2.0 2033 0.2 MIR296 GC20P058804 PIR62878
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR296 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR296 Gene

Genomic Locations for MIR296 Gene
80 bases
Minus strand

Genomic View for MIR296 Gene

Genes around MIR296 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR296 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR296 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR296 Gene

ORGUL Member Location for MIR296 Gene

ORGUL Member Location for MIR296 gene

Proteins for MIR296 Gene

Post-translational modifications for MIR296 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR296 Gene

Domains & Families for MIR296 Gene

Gene Families for MIR296 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR296: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR296 Gene

Function for MIR296 Gene

Phenotypes From GWAS Catalog for MIR296 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR296 Gene

Localization for MIR296 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR296 Gene

Pathways & Interactions for MIR296 Gene

SuperPathways for MIR296 Gene

No Data Available

Interacting Proteins for MIR296 Gene

Gene Ontology (GO) - Biological Process for MIR296 Gene


No data available for Pathways by source and SIGNOR curated interactions for MIR296 Gene

Drugs & Compounds for MIR296 Gene

No Compound Related Data Available

Transcripts for MIR296 Gene

fRNAdb Secondary structures for MIR296 Gene

  • hsa-mir-296_MI0000747_Homo_sapiens_miR-296_stem-loop_hairpin
  • hsa-miR-296-5p_MIMAT0000690_Homo_sapiens_miR-296-5p_mature

mRNA/cDNA for MIR296 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR296 Gene

No ASD Table

Relevant External Links for MIR296 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR296 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR296 Gene

mRNA differential expression in normal tissues according to GTEx for MIR296 Gene

This gene is overexpressed in Pituitary (x5.2) and Testis (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of MIR296 Gene:

genes like me logo Genes that share expression patterns with MIR296: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR296 Gene

Orthologs for MIR296 Gene

Evolution for MIR296 Gene

Gene Tree for MIR296 (if available)
Gene Tree for MIR296 (if available)

No data available for Orthologs for MIR296 Gene

Paralogs for MIR296 Gene

No data available for Paralogs for MIR296 Gene

Variants for MIR296 Gene

Sequence variations from dbSNP and Humsavar for MIR296 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1001557382 -- 58,818,386(-) T/G upstream_transcript_variant
rs1003255338 -- 58,819,479(-) G/A upstream_transcript_variant
rs1003880834 -- 58,819,432(-) C/A/T upstream_transcript_variant
rs1004576145 -- 58,819,616(-) C/T upstream_transcript_variant
rs1004866808 -- 58,818,016(-) C/T upstream_transcript_variant

Additional Variant Information for MIR296 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR296 Gene

Disorders for MIR296 Gene

Additional Disease Information for MIR296

No disorders were found for MIR296 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR296 Gene

Publications for MIR296 Gene

  1. New human and mouse microRNA genes found by homology search. (PMID: 15634332) Weber MJ (The FEBS journal 2005) 1 3 58
  2. Human embryonic stem cells express a unique set of microRNAs. (PMID: 15183728) Suh MR … Kim KS (Developmental biology 2004) 1 3 58
  3. Embryonic stem cell-specific MicroRNAs. (PMID: 12919684) Houbaviy HB … Sharp PA (Developmental cell 2003) 1 3 58
  4. miR-296-5p suppresses cell viability by directly targeting PLK1 in non-small cell lung cancer. (PMID: 26549165) Xu C … Zhao J (Oncology reports 2016) 3 58
  5. Epigenetic modulation of a miR-296-5p:HMGA1 axis regulates Sox2 expression and glioblastoma stem cells. (PMID: 26898758) Lopez-Bertoni H … Laterra J (Oncogene 2016) 3 58

Products for MIR296 Gene

Sources for MIR296 Gene

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