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MIR296 Gene(RNA Gene)

MicroRNA 296

GCID:
GC20M058817
GIFtS:
19
Genes Participants
UDN Logo

Aliases for MIR296 Gene

Subcategory (RNA class) for MIR296 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR296 Gene

  • MicroRNA 296 2 3 5
  • Hsa-Mir-296 3
  • MiRNA296 3
  • Mir-296 3
  • MIRN296 3

External Ids for MIR296 Gene

ORGUL Members for MIR296 Gene

Previous HGNC Symbols for MIR296 Gene

  • MIRN296

Previous GeneCards Identifiers for MIR296 Gene

  • GC20U900416
  • GC20M056839
  • GC20M057392

Summaries for MIR296 Gene

Entrez Gene Summary for MIR296 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR296 Gene

MIR296 (MicroRNA 296) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR296 Gene - the ORGUL cluster for this gene includes several descriptions:

  • miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR296

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR296 Gene

Genomics for MIR296 Gene

Products:

  1. Regulatory Element

Regulatory Elements for MIR296 Gene

Enhancers for MIR296 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G058844 0.5 ENCODE 12 -27.1 -27108 0.8 BCOR ZNF146 CREB1 FOXA1 MIR296 MIR298 ENSG00000276722 ENSG00000274491
GH20G058782 0.4 ENCODE 12.3 +33.9 33875 1.7 MNT MIR298 MIR296 GNAS GNAS-AS1 PIEZO1P2 LOC105372695
GH20G058815 0.8 ENCODE 0.7 +2.0 2034 0.2 ATF1 SUZ12 GTF2E2 ZNF644 RELA ZKSCAN1 SLC30A9 POLR2A ZNF207 ZNF639 MIR296 GC20P058804 PIR62878
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR296 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR296 Gene

Chromosome:
20
Start:
58,817,615 bp from pter
End:
58,817,694 bp from pter
Size:
80 bases
Orientation:
Minus strand

Genomic View for MIR296 Gene

Genes around MIR296 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR296 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR296 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for MIR296 Gene

ORGUL Member Location for MIR296 Gene

ORGUL Member Location for MIR296 gene

Proteins for MIR296 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

Post-translational modifications for MIR296 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR296 Gene

Domains & Families for MIR296 Gene

Gene Families for MIR296 Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR296: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR296 Gene

Function for MIR296 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR296 Gene

Localization for MIR296 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR296 Gene

Pathways & Interactions for MIR296 Gene

SuperPathways for MIR296 Gene

PathCards logo More details on SuperPathways for MIR296
No Data Available

Interacting Proteins for MIR296 Gene

Gene Ontology (GO) - Biological Process for MIR296 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR296 Gene

Drugs & Compounds for MIR296 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for MIR296 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

fRNAdb Secondary structures for MIR296 Gene

  • hsa-mir-296_MI0000747_Homo_sapiens_miR-296_stem-loop_hairpin
  • hsa-miR-296-5p_MIMAT0000690_Homo_sapiens_miR-296-5p_mature

mRNA/cDNA for MIR296 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR296 Gene

No ASD Table

Relevant External Links for MIR296 Gene

GeneLoc Exon Structure for
MIR296
ECgene alternative splicing isoforms for
MIR296

Expression for MIR296 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR296 Gene

mRNA expression in normal human tissues for MIR296 Gene
mRNA expression by GTEx for MIR296 Gene

mRNA differential expression in normal tissues according to GTEx for MIR296 Gene

This gene is overexpressed in Pituitary (x5.2) and Testis (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of MIR296 Gene:

MIR296
genes like me logo Genes that share expression patterns with MIR296: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR296 Gene

Orthologs for MIR296 Gene

Evolution for MIR296 Gene

ENSEMBL:
Gene Tree for MIR296 (if available)
TreeFam:
Gene Tree for MIR296 (if available)

No data available for Orthologs for MIR296 Gene

Paralogs for MIR296 Gene

No data available for Paralogs for MIR296 Gene

Variants for MIR296 Gene

Sequence variations from dbSNP and Humsavar for MIR296 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1001557382 -- 58,818,386(+) GATCT(G/T)TAGGA upstream-variant-2KB
rs1003255338 -- 58,819,479(+) AAGCA(A/G)TTATG intron-variant, upstream-variant-2KB
rs1003880834 -- 58,819,432(+) TTTCA(A/C/T)GGGCA intron-variant, upstream-variant-2KB
rs1004576145 -- 58,819,616(+) CAGGG(C/T)CCTCA intron-variant, upstream-variant-2KB
rs1004866808 -- 58,818,016(+) ACGTG(C/T)TGCCG downstream-variant-500B, upstream-variant-2KB

Relevant External Links for MIR296 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR296

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR296 Gene

Disorders for MIR296 Gene

Relevant External Links for MIR296

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR296

No disorders were found for MIR296 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR296 Gene

Publications for MIR296 Gene

  1. New human and mouse microRNA genes found by homology search. (PMID: 15634332) Weber M.J. (FEBS J. 2005) 1 3 64
  2. Human embryonic stem cells express a unique set of microRNAs. (PMID: 15183728) Suh M.R. … Kim K.S. (Dev. Biol. 2004) 1 3 64
  3. Embryonic stem cell-specific MicroRNAs. (PMID: 12919684) Houbaviy H.B. … Sharp P.A. (Dev. Cell 2003) 1 3 64
  4. miR-296-5p suppresses cell viability by directly targeting PLK1 in non-small cell lung cancer. (PMID: 26549165) Xu C. … Zhao J. (Oncol. Rep. 2016) 3 64
  5. Neurofibromatosis 2 (NF2) controls the invasiveness of glioblastoma through YAP-dependent expression of CYR61/CCN1 and miR-296-3p. (PMID: 26923924) Lee H. … Kim H.H. (Biochim. Biophys. Acta 2016) 3 64

Products for MIR296 Gene

Sources for MIR296 Gene

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