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Aliases for MIR296 Gene

Subcategory (RNA class) for MIR296 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR296 Gene

  • MicroRNA 296 2 3
  • Hsa-Mir-296 3
  • MiRNA296 3
  • Mir-296 3
  • MIRN296 3

External Ids for MIR296 Gene

Previous HGNC Symbols for MIR296 Gene

  • MIRN296

Previous GeneCards Identifiers for MIR296 Gene

  • GC20U900416
  • GC20M056839
  • GC20M057392

Summaries for MIR296 Gene

Entrez Gene Summary for MIR296 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR296 Gene

MIR296 (MicroRNA 296) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR296 Gene

Genomics for MIR296 Gene

Genomic Location for MIR296 Gene

Chromosome:
20
Start:
58,817,615 bp from pter
End:
58,817,694 bp from pter
Size:
80 bases
Orientation:
Minus strand

Genomic View for MIR296 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR296 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR296 Gene

No data available for Regulatory Elements for MIR296 Gene

Proteins for MIR296 Gene

Post-translational modifications for MIR296 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR296 Gene

Domains & Families for MIR296 Gene

Gene Families for MIR296 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR296: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR296 Gene

Function for MIR296 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR296 Gene

Localization for MIR296 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR296 Gene

Pathways & Interactions for MIR296 Gene

SuperPathways for MIR296 Gene

No Data Available

Interacting Proteins for MIR296 Gene

Gene Ontology (GO) - Biological Process for MIR296 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR296 Gene

Drugs & Compounds for MIR296 Gene

No Compound Related Data Available

Transcripts for MIR296 Gene

mRNA/cDNA for MIR296 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR296 Gene

No ASD Table

Relevant External Links for MIR296 Gene

GeneLoc Exon Structure for
MIR296
ECgene alternative splicing isoforms for
MIR296

Expression for MIR296 Gene

mRNA expression in normal human tissues for MIR296 Gene

mRNA differential expression in normal tissues according to GTEx for MIR296 Gene

This gene is overexpressed in Pituitary (x5.2) and Testis (x4.4).
genes like me logo Genes that share expression patterns with MIR296: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR296 Gene

Orthologs for MIR296 Gene

Evolution for MIR296 Gene

ENSEMBL:
Gene Tree for MIR296 (if available)
TreeFam:
Gene Tree for MIR296 (if available)

No data available for Orthologs for MIR296 Gene

Paralogs for MIR296 Gene

No data available for Paralogs for MIR296 Gene

Variants for MIR296 Gene

Sequence variations from dbSNP and Humsavar for MIR296 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs3746710 -- 58,817,196(-) GTTAC(A/G)TTGTC downstream-variant-500B
rs7509482 -- 58,817,699(+) TTTCT(A/C/T)CTCAC upstream-variant-2KB
rs112576342 -- 58,817,599(+) GCTGC(A/G)GGTGC downstream-variant-500B
rs117258475 -- 58,817,631(+) GGAGA(A/G)CCTCC nc-transcript-variant
rs138887616 -- 58,817,364(+) CCTCC(A/G)GAAGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR296 Gene

Variant ID Type Subtype PubMed ID
nsv912963 CNV Gain 21882294
nsv912964 CNV Loss 21882294

Relevant External Links for MIR296 Gene

HapMap Linkage Disequilibrium report
MIR296

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR296 Gene

Disorders for MIR296 Gene

Relevant External Links for MIR296

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR296
genes like me logo Genes that share disorders with MIR296: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR296 Gene

Publications for MIR296 Gene

  1. miR-296/Scribble axis is deregulated in human breast cancer and miR-296 restoration reduces tumour growth in vivo. (PMID: 24527800) Savi F. … Bosari S. (Clin. Sci. 2014) 67
  2. MicroRNA-296-5p (miR-296-5p) functions as a tumor suppressor in prostate cancer by directly targeting Pin1. (PMID: 24915000) Lee K.H. … Lu P.J. (Biochim. Biophys. Acta 2014) 67
  3. MiR-296-3p regulates cell growth and multi-drug resistance of human glioblastoma by targeting ether-A -go-go (EAG1). (PMID: 22999387) Bai Y. … Guo L. (Eur. J. Cancer 2013) 67
  4. Human microRNA hsa-miR-296-5p suppresses enterovirus 71 replication by targeting the viral genome. (PMID: 23468506) Zheng Z. … Wang H. (J. Virol. 2013) 67
  5. miR-296 regulation of a cell polarity-cell plasticity module controls tumor progression. (PMID: 21643016) Vaira V. … Bosari S. (Oncogene 2012) 67

Products for MIR296 Gene

Sources for MIR296 Gene

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