MIR296 Gene

Aliases
for MIR296 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC20U900416 GC20M056839

Summaries
for MIR296 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for MIR296 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Browse SwitchGear Promoter luciferase reporter plasmids

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIR296

MIR296 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M057392:  view genomic region (via miRBase)     (about GC identifiers)

Proteins
for MIR296 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Domains /
Families
for MIR296 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Function
for MIR296 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Localization
for MIR296 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Pathways & Interactions
for MIR296 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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Drugs & Compounds
for MIR296 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Transcripts
for MIR296 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for MIR296 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for MIR296:none

See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

Primer Products:		Browse OriGene qPCR
		Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MIR296
		Search QuantiTect SYBR Green Assays in human, mouse, rat MIR296
		Search QuantiFast Probe-based Assays in human, mouse, rat MIR296

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIR296

Orthologs
for MIR296 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for MIR296 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Genomic Variants
for MIR296 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MIR296 (see all 19)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1437182201,2		--	57392172(+)	ATACAA/GGAGCA	1	--	ds5001		0	--	--	--	--
rs1480827161,2		--	57392185(+)	CATCCA/GCCACT	1	--	ds5001		0	--	--	--	--
rs37467101,2	H	--	57392251(-)	GTTACG/ATTGTC	1	--	ds5001		4		NS EA	420
rs1409620271,2		--	57392261(+)	CAATCC/TGCAAG	1	--	ds5001		0	--	--	--	--
rs1461328041,2		--	57392363(+)	AGGTCA/GGGGAA	1	--	ds5001		0	--	--	--	--
rs1388876161,2		--	57392419(+)	CCTCCA/GGAAGG	1	--	ds5001		0	--	--	--	--
rs1428985051,2		--	57392444(+)	CGAGGA/GTGGCA	1	--	ds5001		0	--	--	--	--
rs1928709791,2		--	57392537(+)	AGGCGA/CGGCAC	1	--	ds5001		0	--	--	--	--
rs1125763421,2	F	--	57392654(+)	GCTGCG/AGGTGC	1	--	ds5001		1		CSA	4
rs1172584751,2	C,F	--	57392686(+)	GGAGAG/ACCTCC	1	--	nc-transcript-variant		2		NA EU	1123

HapMap Linkage Disequilibrium report for MIR296 (57392187 - 57392780 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for MIR296:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv912964	CNV	Loss	21882294
nsv912963	CNV	Gain	21882294

Site Specific Mutation Identification with PCR Assays

Search QIAGEN SeqTarget long-range PCR primers for resequencing MIR296

DNA2.0 Custom Variant and Variant Library Synthesis for MIR296

Disorders / Diseases
for MIR296 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Publications
for MIR296 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MIR296 gene, integrated from 10 sources (see all 14): (articles sorted by number of sources associating them with MIR296)

Utopia: connect your pdf to the dynamic world of online information

1. MiR-296-3p regulates cell growth and multi-drug resistance of human glioblastoma by targeting ether-A -go-go (EAG1). (PubMed id 22999387)¹ Bai Y....Guo L. (Eur. J. Cancer 2013)
2. Human microRNA hsa-miR-296-5p suppresses enterovirus 71 replication by targeting the viral genome. (PubMed id 23468506)¹ Zheng Z....Wang H. (J. Virol. 2013)
3. miR-296 regulation of a cell polarity-cell plasticity module controls tumor progression. (PubMed id 21643016)¹ Vaira V....Bosari S. (Oncogene 2012)
4. MicroRNA-296 is enriched in cancer cells and downregulates p21WAF1 mRNA expression via interaction with its 3' untranslated region. (PubMed id 21724611)¹ Yoon A.R....Wadhwa R. (Nucleic Acids Res. 2011)
5. Regulation of HMGA1 expression by microRNA-296 affects prostate cancer growth and invasion. (PubMed id 21138859)¹ Wei J.J....Lee P. (Clin. Cancer Res. 2011)
6. Differential expression of microRNAs in human parathyroid carcinomas compared with normal parathyroid tissue. (PubMed id 19926710)¹ Corbetta S....Spada A. (Endocr. Relat. Cancer 2010)
7. The prognostic and chemotherapeutic value of miR-296 in esophageal squamous cell carcinoma. (PubMed id 20485139)¹ Hong L....Fan D. (Ann. Surg. 2010)
8. Human with-no-lysine kinase-4 3'-UTR acting as the enhancer and being targeted by miR-296. (PubMed id 20561597)¹ Mao J....Zhao Y. (amp 2010)
9. Patterns of known and novel small RNAs in human cervical cancer. (PubMed id 17616659)¹ Lui W.O....Fire A. (Cancer Res. 2007)
10. A mammalian microRNA expression atlas based on small RNA library sequencing. (PubMed id 17604727)¹ Landgraf P....Tuschl T. (Cell 2007)

External Searches for MIR296 gene

Genome Databases showing MIR296 gene

Other Databases showing MIR296 gene

Specialized Databases showing MIR296 gene

Products
for MIR296 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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