Aliases for MIR296 Gene
Subcategory (RNA class) for MIR296 Gene
miRNA
Quality Score for this RNA gene is
8
External Ids for MIR296 Gene
- HGNC: 31617
- Entrez Gene: 407022
- Ensembl: ENSG00000284040
- OMIM: 610945
- miRBase: hsa-mir-296
ORGUL Members for MIR296 Gene
Previous HGNC Symbols for MIR296 Gene
- MIRN296
Previous GeneCards Identifiers for MIR296 Gene
- GC20U900416
- GC20M056839
- GC20M057392
Summaries for MIR296 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR296 Gene
MIR296 (MicroRNA 296) is an RNA Gene, and is affiliated with the miRNA class.
fRNAdb sequence ontologies for MIR296 Gene - the ORGUL cluster for this gene includes several descriptions:
-
miRNA: Small, ~22-nt, RNA molecule that is the endogenous transcript of a miRNA gene. Micro RNAs are produced from precursor molecules (SO:0000647) that can form local hairpin structures, which ordinarily are processed (via the Dicer pathway) such that a single miRNA molecule accumulates from one arm of a hairpin precursor molecule. Micro RNAs may trigger the cleavage of their target molecules or act as translational repressors.
-
pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.
Additional gene information for MIR296 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR296 Gene
Genomics for MIR296 Gene
GeneHancer (GH) Regulatory Elements for MIR296 Gene
Promoters and enhancers for MIR296 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH20I058817 | Enhancer | 0.6 | ENCODE | 550.8 | -1.3 | -1347 | 2.9 | FOXA2 NRF1 JUNB BATF BCL11A SCRT2 RUNX3 EGR2 TCF7L2 | ENSG00000268649 MIR296 MIR298 GNAS-AS1 ENSG00000268333 | |
| GH20I058844 | Enhancer | 0.3 | ENCODE | 12 | -27.1 | -27108 | 0.8 | CREB1 | MIR296 MIR298 ENSG00000276722 GNAS-AS1 GNAS ENSG00000274491 | |
| GH20I058782 | Enhancer | 0.2 | ENCODE | 12.3 | +33.9 | 33875 | 1.7 | PIEZO1P2 MIR296 MIR298 GNAS GNAS-AS1 LOC105372695 | ||
| GH20I058815 | Enhancer | 0.2 | ENCODE | 0.8 | +2.0 | 2033 | 0.2 | MIR296 GC20P058804 PIR62878 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around MIR296 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for MIR296 Gene
Genomic Locations for MIR296 Gene
- chr20:58,817,615-58,817,694
- (GRCh38/hg38)
- Size:
- 80 bases
- Orientation:
- Minus strand
- chr20:57,392,187-57,392,780
- (GRCh37/hg19)
Genomic View for MIR296 Gene
Genes around MIR296 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.32 by Ensembl
- 20q13.32 by Entrez Gene
- 20q13.32 by HGNC
MIR296 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for MIR296 Gene
ORGUL Member Location for MIR296 Gene
Proteins for MIR296 Gene
Post-translational modifications for MIR296 Gene
No Post-translational modifications
Antibody Products
- Search GeneTex for Antibodies for MIR296
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR296
- Origene Custom Protein Services for MIR296
- Search GeneTex for Proteins for MIR296
No data available for DME Specific Peptides for MIR296 Gene
Domains & Families for MIR296 Gene
Gene Families for MIR296 Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR296 Gene
Function for MIR296 Gene
Phenotypes From GWAS Catalog for MIR296 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR296
-
- Search ViGene Biosciences for MIR296
CRISPR Products
- Browse CRISPR knockouts for MIR296
- Applied Biological Materials CRISPR for MIR296
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR296
Clone Products
- GenScript: Custom all cDNA clones Services for MIR296
- VectorBuilder custom plasmid, inducible vectors for MIR296
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR296
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR296
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR296 Gene
Localization for MIR296 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR296 Gene
Transcripts for MIR296 Gene
fRNAdb Secondary structures for MIR296 Gene
mRNA/cDNA for MIR296 Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIR296
- Applied Biological Materials CRISPR for MIR296
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR296
Clone Products
- GenScript: Custom all cDNA clones Services for MIR296
- VectorBuilder custom plasmid, inducible vectors for MIR296
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR296
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR296
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIR296 Gene
mRNA differential expression in normal tissues according to GTEx for MIR296 Gene
This gene is overexpressed in Pituitary (x5.2) and Testis (x4.4).
NURSA nuclear receptor signaling pathways regulating expression of MIR296 Gene:
MIR296Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR296 Gene
Orthologs for MIR296 Gene
No data available for Orthologs for MIR296 Gene
Paralogs for MIR296 Gene
No data available for Paralogs for MIR296 Gene
Variants for MIR296 Gene
| SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1001557382 | -- | 58,818,386(-) | T/G | upstream_transcript_variant | |
| rs1003255338 | -- | 58,819,479(-) | G/A | upstream_transcript_variant | |
| rs1003880834 | -- | 58,819,432(-) | C/A/T | upstream_transcript_variant | |
| rs1004576145 | -- | 58,819,616(-) | C/T | upstream_transcript_variant | |
| rs1004866808 | -- | 58,818,016(-) | C/T | upstream_transcript_variant |
Additional Variant Information for MIR296 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR296
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR296 Gene
Disorders for MIR296 Gene
Additional Disease Information for MIR296
No disorders were found for MIR296 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR296 Gene
Publications for MIR296 Gene
- New human and mouse microRNA genes found by homology search. (PMID: 15634332) Weber MJ (The FEBS journal 2005) 1 3 58
- Human embryonic stem cells express a unique set of microRNAs. (PMID: 15183728) Suh MR … Kim KS (Developmental biology 2004) 1 3 58
- Embryonic stem cell-specific MicroRNAs. (PMID: 12919684) Houbaviy HB … Sharp PA (Developmental cell 2003) 1 3 58
- miR-296-5p suppresses cell viability by directly targeting PLK1 in non-small cell lung cancer. (PMID: 26549165) Xu C … Zhao J (Oncology reports 2016) 3 58
- Epigenetic modulation of a miR-296-5p:HMGA1 axis regulates Sox2 expression and glioblastoma stem cells. (PMID: 26898758) Lopez-Bertoni H … Laterra J (Oncogene 2016) 3 58
Products for MIR296 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse cDNA Clones
- Browse Cell Culture Products
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- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
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- Cloud-Clone Corp. primary cells service
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR296
- VectorBuilder custom plasmid, inducible vectors for MIR296
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR296
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for MIR296
- Search GeneTex for Proteins for MIR296
Sources for MIR296 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew