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Aliases for MIR296 Gene

Subcategory (RNA class) for MIR296 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR296 Gene

  • MicroRNA 296 2 3 5
  • Hsa-Mir-296 3
  • MiRNA296 3
  • Mir-296 3
  • MIRN296 3

External Ids for MIR296 Gene

Previous HGNC Symbols for MIR296 Gene

  • MIRN296

Previous GeneCards Identifiers for MIR296 Gene

  • GC20U900416
  • GC20M056839
  • GC20M057392

Summaries for MIR296 Gene

Entrez Gene Summary for MIR296 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR296 Gene

MIR296 (MicroRNA 296) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR296 Gene

Genomics for MIR296 Gene

Regulatory Elements for MIR296 Gene

Enhancers for MIR296 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F058754 0.8 ENCODE 6.8 +61.5 61512 2.4 CTCF ATF1 CREB3L1 CEBPG RAD21 GATA3 POLR2A KLF13 MAZ L3MBTL2 MIR296 ENSG00000270279 LOC105372695
GH20F058844 0.4 ENCODE 12 -27.1 -27077 0.8 BCOR ZNF146 MIR296 MIR298 ENSG00000276722 ENSG00000274491
GH20F058782 0.2 ENCODE 12.3 +33.9 33906 1.7 MIR296 MIR298 GNAS GNAS-AS1 PIEZO1P2 LOC105372695
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR296 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR296 Gene

Chromosome:
20
Start:
58,817,132 bp from pter
End:
58,817,725 bp from pter
Size:
594 bases
Orientation:
Minus strand

Genomic View for MIR296 Gene

Genes around MIR296 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR296 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR296 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR296 Gene

Proteins for MIR296 Gene

Post-translational modifications for MIR296 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR296 Gene

Domains & Families for MIR296 Gene

Gene Families for MIR296 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR296: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR296 Gene

Function for MIR296 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR296 Gene

Localization for MIR296 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR296 Gene

Pathways & Interactions for MIR296 Gene

SuperPathways for MIR296 Gene

No Data Available

Interacting Proteins for MIR296 Gene

Gene Ontology (GO) - Biological Process for MIR296 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR296 Gene

Transcripts for MIR296 Gene

mRNA/cDNA for MIR296 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR296 Gene

No ASD Table

Relevant External Links for MIR296 Gene

GeneLoc Exon Structure for
MIR296
ECgene alternative splicing isoforms for
MIR296

Expression for MIR296 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR296 Gene

mRNA differential expression in normal tissues according to GTEx for MIR296 Gene

This gene is overexpressed in Pituitary (x5.2) and Testis (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of MIR296 Gene:

MIR296
genes like me logo Genes that share expression patterns with MIR296: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR296 Gene

Orthologs for MIR296 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR296 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-296 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-296 35
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 35
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir296 35
  • 86 (a)
OneToOne
Species where no ortholog for MIR296 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR296 Gene

ENSEMBL:
Gene Tree for MIR296 (if available)
TreeFam:
Gene Tree for MIR296 (if available)

Paralogs for MIR296 Gene

No data available for Paralogs for MIR296 Gene

Variants for MIR296 Gene

Sequence variations from dbSNP and Humsavar for MIR296 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs111431585 -- 58,819,402(+) ACGGC(C/G)AGAAC intron-variant, upstream-variant-2KB
rs111931015 -- 58,818,326(+) CTCCC(A/G)GGTCC upstream-variant-2KB
rs112033207 -- 58,818,911(+) GTAGG(C/T)TCTGT intron-variant, upstream-variant-2KB
rs112576342 -- 58,817,599(+) GCTGC(A/G)GGTGC downstream-variant-500B
rs117258475 -- 58,817,631(+) GGAGA(A/G)CCTCC nc-transcript-variant

Relevant External Links for MIR296 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR296

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR296 Gene

Disorders for MIR296 Gene

Relevant External Links for MIR296

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR296

No disorders were found for MIR296 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR296 Gene

Publications for MIR296 Gene

  1. miR-296-5p suppresses cell viability by directly targeting PLK1 in non-small cell lung cancer. (PMID: 26549165) Xu C. … Zhao J. (Oncol. Rep. 2016) 3 64
  2. Neurofibromatosis 2 (NF2) controls the invasiveness of glioblastoma through YAP-dependent expression of CYR61/CCN1 and miR-296-3p. (PMID: 26923924) Lee H. … Kim H.H. (Biochim. Biophys. Acta 2016) 3 64
  3. Expression of miR-296-5p as predictive marker for radiotherapy resistance in early-stage laryngeal carcinoma. (PMID: 26264462) Maia D. … Vettore A.L. (J Transl Med 2015) 3 64
  4. miR-296/Scribble axis is deregulated in human breast cancer and miR-296 restoration reduces tumour growth in vivo. (PMID: 24527800) Savi F. … Bosari S. (Clin. Sci. 2014) 3 64
  5. MicroRNA-296-5p (miR-296-5p) functions as a tumor suppressor in prostate cancer by directly targeting Pin1. (PMID: 24915000) Lee K.H. … Lu P.J. (Biochim. Biophys. Acta 2014) 3 64

Products for MIR296 Gene

Sources for MIR296 Gene

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