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Aliases for MIR28 Gene

Subcategory (RNA class) for MIR28 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR28 Gene

  • MicroRNA 28 2 3
  • MIRN28 3 6
  • Hsa-Mir-28 3
  • MiR-28 3

External Ids for MIR28 Gene

Previous HGNC Symbols for MIR28 Gene

  • MIRN28

Previous GeneCards Identifiers for MIR28 Gene

  • GC03P189891
  • GC03P188406

Summaries for MIR28 Gene

Entrez Gene Summary for MIR28 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR28 Gene

MIR28 (MicroRNA 28) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR28 Gene

Genomics for MIR28 Gene

Genomic Location for MIR28 Gene

Start:
188,688,781 bp from pter
End:
188,688,866 bp from pter
Size:
86 bases
Orientation:
Plus strand

Genomic View for MIR28 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR28 Gene

No data available for Regulatory Elements for MIR28 Gene

Proteins for MIR28 Gene

Post-translational modifications for MIR28 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR28 Gene

Domains for MIR28 Gene

Gene Families for MIR28 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR28: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR28 Gene

Function for MIR28 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR28 Gene

Localization for MIR28 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR28 Gene

Pathways for MIR28 Gene

SuperPathways for MIR28 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR28: view

Pathways by source for MIR28 Gene

1 KEGG pathway for MIR28 Gene

Interacting Proteins for MIR28 Gene

Gene Ontology (GO) - Biological Process for MIR28 Gene

None

Transcripts for MIR28 Gene

mRNA/cDNA for MIR28 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR28 Gene

No ASD Table

Relevant External Links for MIR28 Gene

GeneLoc Exon Structure for
MIR28
ECgene alternative splicing isoforms for
MIR28

Expression for MIR28 Gene

mRNA expression in normal human tissues for MIR28 Gene

genes like me logo Genes that share expressions with MIR28: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR28 Gene

Orthologs for MIR28 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR28 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-28 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-28 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir28 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
-- 36
  • 66 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-28 36
  • 100 (a)
OneToOne
Species with no ortholog for MIR28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR28 Gene

ENSEMBL:
Gene Tree for MIR28 (if available)
TreeFam:
Gene Tree for MIR28 (if available)

Paralogs for MIR28 Gene

No data available for Paralogs for MIR28 Gene

Variants for MIR28 Gene

Relevant External Links for MIR28 Gene

HapMap Linkage Disequilibrium report
MIR28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for MIR28 Gene

Disorders for MIR28 Gene

No disorders were found for MIR28 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MIR28 Gene

Publications for MIR28 Gene

  1. Identification of novel genes coding for small expressed RNAs. (PMID: 11679670) Lagos-Quintana M. … Tuschl T. (Science 2001) 3
  2. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  3. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3
  4. Patterns of known and novel small RNAs in human cervical cancer. (PMID: 17616659) Lui W.O. … Fire A. (Cancer Res. 2007) 3
  5. New miRNAs cloned from neuroblastoma. (PMID: 18230126) Afanasyeva E.A. … Westermann F. (BMC Genomics 2008) 3

Products for MIR28 Gene

Sources for MIR28 Gene

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