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Aliases for MIR28 Gene

Subcategory (RNA class) for MIR28 Gene


Quality Score for this RNA gene is


Aliases for MIR28 Gene

  • MicroRNA 28 2 3
  • Hsa-Mir-28 3
  • MiR-28 3
  • MIRN28 3

External Ids for MIR28 Gene

Previous HGNC Symbols for MIR28 Gene

  • MIRN28

Previous GeneCards Identifiers for MIR28 Gene

  • GC03P189891
  • GC03P188406

Summaries for MIR28 Gene

Entrez Gene Summary for MIR28 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR28 Gene

MIR28 (MicroRNA 28) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR28 Gene

Genomics for MIR28 Gene

Genomic Location for MIR28 Gene

188,688,781 bp from pter
188,688,866 bp from pter
86 bases
Plus strand

Genomic View for MIR28 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR28 Gene

No data available for Regulatory Elements for MIR28 Gene

Proteins for MIR28 Gene

Post-translational modifications for MIR28 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR28 Gene

Domains & Families for MIR28 Gene

Gene Families for MIR28 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR28: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR28 Gene

Function for MIR28 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR28 Gene

Localization for MIR28 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR28 Gene

Pathways & Interactions for MIR28 Gene

SuperPathways for MIR28 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR28: view

Pathways by source for MIR28 Gene

1 KEGG pathway for MIR28 Gene

Interacting Proteins for MIR28 Gene

Gene Ontology (GO) - Biological Process for MIR28 Gene


No data available for SIGNOR curated interactions for MIR28 Gene

Drugs & Compounds for MIR28 Gene

No Compound Related Data Available

Transcripts for MIR28 Gene

mRNA/cDNA for MIR28 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR28 Gene

No ASD Table

Relevant External Links for MIR28 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR28 Gene

mRNA expression in normal human tissues for MIR28 Gene

genes like me logo Genes that share expression patterns with MIR28: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR28 Gene

Orthologs for MIR28 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR28 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-28 36
  • 98 (a)
(Canis familiaris)
Mammalia cfa-mir-28 36
  • 99 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 71 (a)
(Mus musculus)
Mammalia Mir28 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
-- 36
  • 51 (a)
-- 36
  • 63 (a)
-- 36
  • 68 (a)
-- 36
  • 66 (a)
-- 36
  • 59 (a)
(Pan troglodytes)
Mammalia ptr-mir-28 36
  • 100 (a)
Species with no ortholog for MIR28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR28 Gene

Gene Tree for MIR28 (if available)
Gene Tree for MIR28 (if available)

Paralogs for MIR28 Gene

No data available for Paralogs for MIR28 Gene

Variants for MIR28 Gene

Relevant External Links for MIR28 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR28 Gene

Disorders for MIR28 Gene

Relevant External Links for MIR28

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MIR28: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR28 Gene

Publications for MIR28 Gene

  1. miR-28-3p is a cellular restriction factor that inhibits human T cell leukemia virus, type 1 (HTLV-1) replication and virus infection. (PMID: 25568327) Bai X.T. … Nicot C. (J. Biol. Chem. 2015) 67
  2. miR-28-5p promotes chromosomal instability in VHL-associated cancers by inhibiting Mad2 translation. (PMID: 24491803) Hell M.P. … Krek W. (Cancer Res. 2014) 67
  3. MicroRNA 28 controls cell proliferation and is down-regulated in B-cell lymphomas. (PMID: 24843176) Schneider C. … Basso K. (Proc. Natl. Acad. Sci. U.S.A. 2014) 67
  4. Strand-specific miR-28-5p and miR-28-3p have distinct effects in colorectal cancer cells. (PMID: 22240480) Almeida M.I. … Calin G.A. (Gastroenterology 2012) 67
  5. MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism. (PMID: 21638050) Yang M. … Zhou Q. (Breast Cancer Res. Treat. 2011) 67

Products for MIR28 Gene

Sources for MIR28 Gene

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