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Aliases for MIR28 Gene

Subcategory (RNA class) for MIR28 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR28 Gene

  • MicroRNA 28 2 3 5
  • Hsa-Mir-28 3
  • MiR-28 3
  • MIRN28 3

External Ids for MIR28 Gene

Previous HGNC Symbols for MIR28 Gene

  • MIRN28

Previous GeneCards Identifiers for MIR28 Gene

  • GC03P189891
  • GC03P188406

Summaries for MIR28 Gene

Entrez Gene Summary for MIR28 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR28 Gene

MIR28 (MicroRNA 28) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR28 Gene

Genomics for MIR28 Gene

Regulatory Elements for MIR28 Gene

Enhancers for MIR28 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F188662 0.2 Ensembl 11.8 -26.7 -26681 0.2 CEBPA MIR28 LPP-AS1
GH03F188656 1.5 FANTOM5 Ensembl ENCODE 11.6 -32.2 -32208 1.1 MIR28 LPP-AS1
GH03F188720 0.9 Ensembl 11.4 +31.9 31920 0.6 MLX ARID4B SLC30A9 SP5 MXD4 MIER2 PPARG KAT8 SSRP1 MIER3 MIR28 GC03P188886
GH03F188744 0.6 ENCODE 11.4 +57.5 57454 4.0 ATF1 MLX ARID4B DMAP1 YY1 SP5 MXD4 MIER2 PPARG PPARGC1A MIR28 LPP GC03P188886
GH03F188729 0.2 Ensembl 11.2 +40.8 40820 0.8 MAFK SPI1 MIR28 LPP GC03P188886
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR28 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR28 Gene

Chromosome:
3
Start:
188,688,781 bp from pter
End:
188,688,866 bp from pter
Size:
86 bases
Orientation:
Plus strand

Genomic View for MIR28 Gene

Genes around MIR28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR28 Gene

Proteins for MIR28 Gene

Post-translational modifications for MIR28 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR28 Gene

Domains & Families for MIR28 Gene

Gene Families for MIR28 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR28: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR28 Gene

Function for MIR28 Gene

Animal Model Products

miRNA Products

Clone Products

  • Addgene plasmids for MIR28

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR28 Gene

Localization for MIR28 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR28 Gene

Pathways & Interactions for MIR28 Gene

SuperPathways for MIR28 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR28: view

Pathways by source for MIR28 Gene

1 KEGG pathway for MIR28 Gene

Interacting Proteins for MIR28 Gene

Gene Ontology (GO) - Biological Process for MIR28 Gene

None

No data available for SIGNOR curated interactions for MIR28 Gene

Transcripts for MIR28 Gene

mRNA/cDNA for MIR28 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

  • Addgene plasmids for MIR28

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR28 Gene

No ASD Table

Relevant External Links for MIR28 Gene

GeneLoc Exon Structure for
MIR28
ECgene alternative splicing isoforms for
MIR28

Expression for MIR28 Gene

mRNA expression in normal human tissues for MIR28 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR28 Gene:

MIR28
genes like me logo Genes that share expression patterns with MIR28: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR28 Gene

Orthologs for MIR28 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-28 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-28 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-28 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir28 35
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 68 (a)
ManyToMany
-- 35
  • 66 (a)
ManyToMany
-- 35
  • 63 (a)
ManyToMany
-- 35
  • 62 (a)
ManyToMany
-- 35
  • 59 (a)
ManyToMany
-- 35
  • 51 (a)
ManyToMany
Species where no ortholog for MIR28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR28 Gene

ENSEMBL:
Gene Tree for MIR28 (if available)
TreeFam:
Gene Tree for MIR28 (if available)

Paralogs for MIR28 Gene

No data available for Paralogs for MIR28 Gene

Variants for MIR28 Gene

Sequence variations from dbSNP and Humsavar for MIR28 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs112724389 -- 188,688,897(+) ATTTC(-/A)GTGTT intron-variant, downstream-variant-500B
rs114557024 -- 188,688,495(+) TGCCA(A/G)GATAG intron-variant, upstream-variant-2KB
rs143071650 -- 188,687,252(+) CTCCC(C/T)CACCC intron-variant, upstream-variant-2KB
rs143988101 -- 188,687,084(+) ATGAG(C/T)CTTTA intron-variant, upstream-variant-2KB
rs145340603 -- 188,688,921(+) AATCC(C/T)GCCTC intron-variant, downstream-variant-500B

Relevant External Links for MIR28 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR28 Gene

Disorders for MIR28 Gene

Relevant External Links for MIR28

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR28

No disorders were found for MIR28 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR28 Gene

Publications for MIR28 Gene

  1. MiR-28-3p as a potential plasma marker in diagnosis of pulmonary embolism. (PMID: 26702486) Zhou X. … Chen Y. (Thromb. Res. 2016) 3 64
  2. MicroRNA 28-5p regulates ATP-binding cassette transporter A1 via inhibiting extracellular signal-regulated kinase 2. (PMID: 26718613) Liu J. … Zhou Y.T. (Mol Med Rep 2016) 3 64
  3. miR-28-5p-IL-34-macrophage feedback loop modulates hepatocellular carcinoma metastasis. (PMID: 26754294) Zhou S.L. … Zhou J. (Hepatology 2016) 3 64
  4. Down-regulated miR-28-5p in human hepatocellular carcinoma correlated with tumor proliferation and migration by targeting insulin-like growth factor-1 (IGF-1). (PMID: 26160280) Shi X. … Teng F. (Mol. Cell. Biochem. 2015) 3 64
  5. miR-28-3p is a cellular restriction factor that inhibits human T cell leukemia virus, type 1 (HTLV-1) replication and virus infection. (PMID: 25568327) Bai X.T. … Nicot C. (J. Biol. Chem. 2015) 3 64

Products for MIR28 Gene

Sources for MIR28 Gene

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