Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR27B Gene

Subcategory (RNA class) for MIR27B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR27B Gene

  • MicroRNA 27b 2 3 5
  • Hsa-Mir-27b 3
  • MiRNA27B 3
  • MIR-27b 3
  • MIRN27B 3

External Ids for MIR27B Gene

ORGUL Members for MIR27B Gene

Previous HGNC Symbols for MIR27B Gene

  • MIRN27B

Previous GeneCards Identifiers for MIR27B Gene

  • GC09P096891
  • GC09P097848
  • GC09P097850
  • GC09P097858
  • GC09P097866
  • GC09P095088
  • GC09P095089

Summaries for MIR27B Gene

Entrez Gene Summary for MIR27B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR27B Gene

MIR27B (MicroRNA 27b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR27B Gene

Genomics for MIR27B Gene

Genomic Location for MIR27B Gene

Chromosome:
9
Start:
95,085,435 bp from pter
End:
95,085,542 bp from pter
Size:
108 bases
Orientation:
Plus strand

Genomic View for MIR27B Gene

Genes around MIR27B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR27B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR27B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR27B Gene

No data available for Regulatory Elements for MIR27B Gene

Proteins for MIR27B Gene

Post-translational modifications for MIR27B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR27B Gene

Domains & Families for MIR27B Gene

Gene Families for MIR27B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR27B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR27B Gene

Function for MIR27B Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR27B Gene

Localization for MIR27B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR27B Gene

Pathways & Interactions for MIR27B Gene

genes like me logo Genes that share pathways with MIR27B: view

Pathways by source for MIR27B Gene

2 BioSystems pathways for MIR27B Gene
1 KEGG pathway for MIR27B Gene

Interacting Proteins for MIR27B Gene

Gene Ontology (GO) - Biological Process for MIR27B Gene

None

No data available for SIGNOR curated interactions for MIR27B Gene

Drugs & Compounds for MIR27B Gene

No Compound Related Data Available

Transcripts for MIR27B Gene

mRNA/cDNA for MIR27B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR27B Gene

No ASD Table

Relevant External Links for MIR27B Gene

GeneLoc Exon Structure for
MIR27B
ECgene alternative splicing isoforms for
MIR27B

Expression for MIR27B Gene

mRNA expression in normal human tissues for MIR27B Gene

mRNA differential expression in normal tissues according to GTEx for MIR27B Gene

This gene is overexpressed in Artery - Coronary (x5.0), Artery - Aorta (x4.4), and Skin - Not Sun Exposed (Suprapubic) (x4.3).
genes like me logo Genes that share expression patterns with MIR27B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR27B Gene

Orthologs for MIR27B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR27B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-27b 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-27b 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-27b 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir27b 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-27b 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-27b 36
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves gga-mir-27b 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-27b 36
  • 92 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-27b 36
  • 85 (a)
OneToOne
Species with no ortholog for MIR27B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR27B Gene

ENSEMBL:
Gene Tree for MIR27B (if available)
TreeFam:
Gene Tree for MIR27B (if available)

Paralogs for MIR27B Gene

No data available for Paralogs for MIR27B Gene

Variants for MIR27B Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR27B Gene

Variant ID Type Subtype PubMed ID
nsv831656 CNV Loss 17160897

Relevant External Links for MIR27B Gene

HapMap Linkage Disequilibrium report
MIR27B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR27B Gene

Disorders for MIR27B Gene

Relevant External Links for MIR27B

Human Genome Epidemiology (HuGE) Navigator
MIR27B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR27B

No disorders were found for MIR27B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR27B Gene

Publications for MIR27B Gene

  1. The expression of cysteine-rich secretory protein 2 (CRISP2) and its specific regulator miR-27b in the spermatozoa of patients with asthenozoospermia. (PMID: 25505194) Zhou J.H. … Liu C.D. (Biol. Reprod. 2015) 3
  2. Dual regulation of receptor tyrosine kinase genes EGFR and c-Met by the tumor-suppressive microRNA-23b/27b cluster in bladder cancer. (PMID: 25405368) Chiyomaru T. … Enokida H. (Int. J. Oncol. 2015) 3
  3. MicroRNA-27b targets gremlin 1 to modulate fibrotic responses in pulmonary cells. (PMID: 24633904) Graham J.R. … Yang Z. (J. Cell. Biochem. 2014) 3
  4. Interleukin-6 mediated upregulation of CYP1B1 and CYP2E1 in colorectal cancer involves DNA methylation, miR27b and STAT3. (PMID: 25333344) Patel S.A. … Gooderham N.J. (Br. J. Cancer 2014) 3
  5. MicroRNA miR-27b rescues bone marrow-derived angiogenic cell function and accelerates wound healing in type 2 diabetes mellitus. (PMID: 24177325) Wang J.M. … Chen A.F. (Arterioscler. Thromb. Vasc. Biol. 2014) 3

Products for MIR27B Gene

Sources for MIR27B Gene

Back to Top

Content