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Aliases for MIR27B Gene

Subcategory (RNA class) for MIR27B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR27B Gene

  • MicroRNA 27b 2 3 5
  • Hsa-Mir-27b 3
  • MiRNA27B 3
  • MIR-27b 3
  • MIRN27B 3

External Ids for MIR27B Gene

ORGUL Members for MIR27B Gene

Previous HGNC Symbols for MIR27B Gene

  • MIRN27B

Previous GeneCards Identifiers for MIR27B Gene

  • GC09P096891
  • GC09P097848
  • GC09P097850
  • GC09P097858
  • GC09P097866
  • GC09P095088
  • GC09P095089
  • GC09P095091
  • GC09P095092

Summaries for MIR27B Gene

Entrez Gene Summary for MIR27B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR27B Gene

MIR27B (MicroRNA 27b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR27B Gene

Genomics for MIR27B Gene

Regulatory Elements for MIR27B Gene

Enhancers for MIR27B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F095016 1.3 Ensembl ENCODE 12.1 -63.6 -63598 10.7 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 YY1 FOS SP5 NFYC PPARGC1A LINC00476 MIR23B MIR27B MIR3074 ENSG00000271659 LOC100132077 C9orf3 MIR6081 LOC101928119
GH09F095053 1 Ensembl ENCODE 12.6 -28.6 -28574 6.2 TAL1 JUN FEZF1 ZIC2 RAD21 HIC1 ZFHX2 POLR2A PRDM10 MAFK MIR23B MIR27B MIR3074 MIR6081 LOC101928119
GH09F095060 0.9 ENCODE 13.7 -21.5 -21478 6.0 ATF1 ARID4B RAD21 RARA YY1 CREM THAP11 SP5 ZNF585B CEBPA MIR23B MIR27B MIR3074 LINC00476 ENSG00000271659 LOC100132077 C9orf3 MIR6081 LOC101928119
GH09F095106 0.5 ENCODE 12.7 +22.2 22176 2.3 CTCF ZNF316 MAFK MIR23B MIR27B MIR3074 PIR48893 PIR51992
GH09F095084 0.6 ENCODE 0.8 +0.4 385 2.0 CTCF SUZ12 POLR2A GLIS1 ZMYM3 EZH2 GC09P095095 MIR27B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR27B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR27B Gene

Chromosome:
9
Start:
95,085,445 bp from pter
End:
95,085,541 bp from pter
Size:
97 bases
Orientation:
Plus strand

Genomic View for MIR27B Gene

Genes around MIR27B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR27B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR27B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR27B Gene

Proteins for MIR27B Gene

Post-translational modifications for MIR27B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR27B Gene

Domains & Families for MIR27B Gene

Gene Families for MIR27B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR27B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR27B Gene

Function for MIR27B Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR27B Gene

Localization for MIR27B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR27B Gene

Pathways & Interactions for MIR27B Gene

genes like me logo Genes that share pathways with MIR27B: view

Pathways by source for MIR27B Gene

2 BioSystems pathways for MIR27B Gene
1 KEGG pathway for MIR27B Gene

Interacting Proteins for MIR27B Gene

Gene Ontology (GO) - Biological Process for MIR27B Gene

None

No data available for SIGNOR curated interactions for MIR27B Gene

Transcripts for MIR27B Gene

mRNA/cDNA for MIR27B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR27B Gene

No ASD Table

Relevant External Links for MIR27B Gene

GeneLoc Exon Structure for
MIR27B
ECgene alternative splicing isoforms for
MIR27B

Expression for MIR27B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR27B Gene

mRNA differential expression in normal tissues according to GTEx for MIR27B Gene

This gene is overexpressed in Artery - Coronary (x5.0), Artery - Aorta (x4.4), and Skin - Not Sun Exposed (Suprapubic) (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of MIR27B Gene:

MIR27B
genes like me logo Genes that share expression patterns with MIR27B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR27B Gene

Orthologs for MIR27B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR27B Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Mir27b 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-27b 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-27b 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-27b 35
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-27b 35
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-27b 35
  • 69 (a)
OneToMany
chicken
(Gallus gallus)
Aves gga-mir-27b 35
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-27b 35
  • 92 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-27b 35
  • 85 (a)
OneToOne
Species where no ortholog for MIR27B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR27B Gene

ENSEMBL:
Gene Tree for MIR27B (if available)
TreeFam:
Gene Tree for MIR27B (if available)

Paralogs for MIR27B Gene

No data available for Paralogs for MIR27B Gene

Variants for MIR27B Gene

Sequence variations from dbSNP and Humsavar for MIR27B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1011784 -- 95,085,732(-) TAGTG(C/G)ATGTT intron-variant, nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs111914249 -- 95,085,836(+) AAATC(A/G)TGTGG intron-variant, nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs114204390 -- 95,083,673(+) ACCTG(C/T)GGCAC intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs115795725 -- 95,083,974(+) AGCAA(C/T)CTAGC intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs117228029 -- 95,084,392(+) GAAAC(A/G)GGACT intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MIR27B Gene

Variant ID Type Subtype PubMed ID
nsv1038106 CNV gain 25217958
nsv1147999 OTHER inversion 26484159
nsv831656 CNV loss 17160897

Relevant External Links for MIR27B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR27B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR27B Gene

Disorders for MIR27B Gene

Relevant External Links for MIR27B

Human Genome Epidemiology (HuGE) Navigator
MIR27B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR27B

No disorders were found for MIR27B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR27B Gene

Publications for MIR27B Gene

  1. MicroRNA-27b suppresses tumor progression by regulating ARFGEF1 and focal adhesion signaling. (PMID: 26473412) Matsuyama R. … Oneyama C. (Cancer Sci. 2016) 3 64
  2. Downregulation of miR-27b is Involved in Loss of Type II Collagen by Directly Targeting Matrix Metalloproteinase 13 (MMP13) in Human Intervertebral Disc Degeneration. (PMID: 26583473) Li H.R. … Zhao L. (Spine 2016) 3 64
  3. The miR27b-CCNG1-P53-miR-508-5p axis regulates multidrug resistance of gastric cancer. (PMID: 26623719) Shang Y. … Fan D. (Oncotarget 2016) 3 64
  4. miR-27b is upregulated in cervical carcinogenesis and promotes cell growth and invasion by regulating CDH11 and epithelial-mesenchymal transition. (PMID: 26706910) Yao J. … Guo K. (Oncol. Rep. 2016) 3 64
  5. MicroRNA-27b suppresses Helicobacter pylori-induced gastric tumorigenesis through negatively regulating Frizzled7. (PMID: 26780940) Geng Y. … Xu J. (Oncol. Rep. 2016) 3 64

Products for MIR27B Gene

Sources for MIR27B Gene

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