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microRNA 27b
(Previous symbol: MIRN27B)
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Aliases
for MIR27B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Subcategory (RNA class): miRNA
Quality score for this RNA gene is 13
| Aliases |
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| MicroRNA 27b1 2 | | MIRN27B1 2 5 | | MIR-27b1 2 | | Hsa-Mir-27b1 | | MiRNA27B1 | | Mir-27b1 |
| External Ids: | HGNC: 316141 | Entrez Gene: 4070192 | Ensembl: ENSG000002078647 | OMIM: 6106365 |
Export aliases for MIR27B gene to outside databasesPrevious GC identifers: GC09P096891 GC09P097848
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Summaries
for MIR27B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MIR27B:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of geneexpression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribedby RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be eitherprotein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce anapproximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicerribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporatedinto a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with themiRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeqrepresents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)
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Genomic Views
for MIR27B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MIR27B
Other transcription factors
Search SABiosciences Chromatin IP Primers for MIR27B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR27B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q22.32 Ensembl cytogenetic band: 9q22.32 HGNC cytogenetic band: 9q22.32MIR27B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P097850: view genomic region (via miRBase)
(about GC identifiers)
Start:
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97,847,727 bp from pter |
End:
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97,847,823 bp from pter |
Size:
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97 bases |
Orientation:
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plus strand |
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Proteins
for MIR27B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB: --
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Protein
Domains /
Families
for MIR27B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| -- |
Function
for MIR27B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Pathways & Interactions
for MIR27B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIR27B
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Drugs & Compounds
for MIR27B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
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 Browse Tocris compounds for MIR27B
Search CenterWatch for drugs/clinical trials and news about MIR27B 
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Transcripts
for MIR27B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000385129(miRNA)
GeneLoc Exon Structure
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Expression
for MIR27B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for MIR27B:none
MIR27B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image SABiosciences Custom PCR Arrays for MIR27B
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MIR27B | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIR27B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIR27B |
Orthologs
for MIR27B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for MIR27B (if available)
TreeFam Gene Tree for MIR27B (if available) |
Paralogs
for MIR27B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MIR27B gene
- MIR27A2
MIR27B for paralogs About GeneDecksing
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Genomic Variants
for MIR27B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for MIR27B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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MIR27B for disorders About GeneDecksing
OMIM gene information: 610636
OMIM disorders: --
8  diseases for MIR27B: About MalaCardssquamous cell carcinoma cervical cancer cervicitis osteoarthritis
lung cancer atherosclerosis carcinoma neuronitis
Human Genome Epidemiology (HuGE) Navigator: MIR27B (1 document)
Export disorders for MIR27B gene to outside databases
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Publications
for MIR27B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for MIR27B gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with MIR27B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- MicroRNA-27a/b controls endothelial cell repulsion and angiogenesis by targeting semaphorin 6A. (PubMed id 22184411)1 Urbich C....Dimmeler S. (2012)
- The altered expression of MiR-221/-222 and MiR-23b/-27 b is associated with the development of human castration resistant prostate canc er. (PubMed id 22127852)1 Sun T....Kantoff P.W. (2012)
- Signature of VDR miRNAs and epigenetic modulation of v itamin D signaling in melanoma cell lines. (PubMed id 22213330)1 Essa S....Reichrath J. (2012)
- Altered microRNA expression profile with miR-27b down- regulation correlated with disease activity of oral lichen planus. (PubMed id 22077423)1 Zhang W.Y....Tang G.Y. (2012)
- MiR-27b targets PPARg to inhibit growth, tumor progres sion and the inflammatory response in neuroblastoma cells. (PubMed id 22120719)1 Lee J.J....Struhl K. (2012)
- Regulation of microRNA expression by hepatocyte growt h factor in human head and neck squamous cell carcinoma. (PubMed id 21899661)1 Susuki D....Itoh H. (2011)
- Identification of miR-130a, miR-27b and miR-210 as se rum biomarkers for atherosclerosis obliterans. (PubMed id 20888330)1 Li T....Zhang W. (2011)
- Expression and function of miR-27b in human glioma. (PubMed id 21922148)1 Chen L....Kang C. (2011)
- PPARa is regulated by miR-21 and miR-27b in human live r. (PubMed id 21562928)1 Kida K....Yokoi T. (2011)
- MicroRNA-27b contributes to lipopolysaccharide-mediat ed peroxisome proliferator-activated receptor gamma (PPARgamma) mRNA destabiliz ation. (PubMed id 20164187)1 Jennewein C....BrA1ne B. (2010)
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External Searches for MIR27B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing MIR27B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing MIR27B gene
(According to HUGE)
About This Section
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Specialized Databases showing MIR27B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for MIR27B | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for MIR27B gene:
Search GeneIP for patents involving MIR27B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MIR27B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MIR27B | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MIR27B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR27B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MIR27B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIR27B | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIR27B |
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| | | | Search Tocris compounds for MIR27B |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for MIR27B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MIR27B |
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Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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