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Aliases for MIR27A Gene

Subcategory (RNA class) for MIR27A Gene

miRNA

Quality Score for this RNA gene is

14

Aliases for MIR27A Gene

  • MicroRNA 27a 2 3
  • MIRN27A 3 6
  • MIR27 3 6
  • Hsa-Mir-27a 3

External Ids for MIR27A Gene

Previous HGNC Symbols for MIR27A Gene

  • MIRN27A

Previous GeneCards Identifiers for MIR27A Gene

  • GC19M013846
  • GC19M013852
  • GC19M013948
  • GC19M013952
  • GC19M013957
  • GC19M013964

Summaries for MIR27A Gene

Entrez Gene Summary for MIR27A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR27A Gene

MIR27A (MicroRNA 27a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR27A include gastric adenocarcinoma and familial breast cancer. Among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR.

fRNAdb sequence ontologies for MIR27A Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR27A

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR27A Gene

Genomics for MIR27A Gene

Genomic Location for MIR27A Gene

Start:
13,836,440 bp from pter
End:
13,836,517 bp from pter
Size:
78 bases
Orientation:
Minus strand

Genomic View for MIR27A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR27A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR27A Gene

ORGUL Member Location for MIR27A Gene

ORGUL Member Location for MIR27A gene

No data available for Regulatory Elements for MIR27A Gene

Proteins for MIR27A Gene

Post-translational modifications for MIR27A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR27A Gene

Domains for MIR27A Gene

Gene Families for MIR27A Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR27A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR27A Gene

Function for MIR27A Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR27A Gene

Localization for MIR27A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR27A Gene

Pathways for MIR27A Gene

genes like me logo Genes that share pathways with MIR27A: view

Pathways by source for MIR27A Gene

1 BioSystems pathway for MIR27A Gene
1 KEGG pathway for MIR27A Gene

Interacting Proteins for MIR27A Gene

Gene Ontology (GO) - Biological Process for MIR27A Gene

None

Transcripts for MIR27A Gene

fRNAdb Secondary structures for MIR27A Gene

  • AF480561
  • hsa-miR-27a-3p_MIMAT0000084_Homo_sapiens_miR-27a-3p_mature

mRNA/cDNA for MIR27A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIR27A

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR27A Gene

No ASD Table

Relevant External Links for MIR27A Gene

GeneLoc Exon Structure for
MIR27A
ECgene alternative splicing isoforms for
MIR27A

Expression for MIR27A Gene

mRNA expression in normal human tissues for MIR27A Gene

genes like me logo Genes that share expressions with MIR27A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR27A Gene

Orthologs for MIR27A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR27A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-27a 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-27a 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-27a 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir27a 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-27a 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-27a 36
  • 67 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-27a 36
  • 66 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii dre-mir-27a 36
  • 41 (a)
ManyToMany
dre-mir-27c-2 36
  • 55 (a)
ManyToMany
dre-mir-27c-2 36
  • 55 (a)
ManyToMany
dre-mir-27d 36
  • 54 (a)
ManyToMany
dre-mir-27e 36
  • 45 (a)
ManyToMany
Species with no ortholog for MIR27A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR27A Gene

ENSEMBL:
Gene Tree for MIR27A (if available)
TreeFam:
Gene Tree for MIR27A (if available)

Paralogs for MIR27A Gene

No data available for Paralogs for MIR27A Gene

Variants for MIR27A Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR27A Gene

Variant ID Type Subtype PubMed ID
nsv833757 CNV Loss 17160897
nsv911097 CNV Loss 21882294
nsv911098 CNV Loss 21882294
dgv3738n71 CNV Loss 21882294

Relevant External Links for MIR27A Gene

HapMap Linkage Disequilibrium report
MIR27A
Human Gene Mutation Database (HGMD)
MIR27A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR27A Gene

Disorders for MIR27A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for MIR27A Gene including...

Search for MIR27A Gene in MalaCards »

Relevant External Links for MIR27A

Genetic Association Database (GAD)
MIR27A
Human Genome Epidemiology (HuGE) Navigator
MIR27A
genes like me logo Genes that share disorders with MIR27A: view

No data available for UniProtKB/Swiss-Prot for MIR27A Gene

Publications for MIR27A Gene

  1. Hsa-mir-27a genetic variant contributes to gastric cancer susceptibility through affecting miR-27a and target gene expression. (PMID: 20666778) Sun Q. … Wang B. (Cancer Sci. 2010) 3 48
  2. A polymorphism of microRNA 27a genome region is associated with the development of gastric mucosal atrophy in Japanese male subjects. (PMID: 17546506) Arisawa T. … Nakano H. (Dig. Dis. Sci. 2007) 3 23
  3. Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. (PMID: 19950226) Kontorovich T. … Friedman E. (Int. J. Cancer 2010) 3 48
  4. A genetic variant in the pre-miR-27a oncogene is associated with a reduced familial breast cancer risk. (PMID: 19921425) Yang R. … Burwinkel B. (Breast Cancer Res. Treat. 2010) 3 48
  5. Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes. (PMID: 19948051) Tardif G. … Martel-Pelletier J. (BMC Musculoskelet Disord 2009) 3

Products for MIR27A Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR27A
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR27A
    • Block miRNA regulation of MIR27A using miScript Target Protectors

    Sources for MIR27A Gene

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