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microRNA 27a
(Previous symbol: MIRN27A)
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Aliases
for MIR27A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
Subcategory (RNA class): miRNA
Quality score for this RNA gene is 13
| Aliases |
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| MicroRNA 27a1 2 | | MIRN27A1 2 5 | | MIR272 5 | | Hsa-Mir-27a1 | | Mir-27a1 |
| External Ids: | HGNC: 316131 | Entrez Gene: 4070182 | Ensembl: ENSG000002078087 | OMIM: 6121535 |
Export aliases for MIR27A gene to outside databasesPrevious GC identifers: GC19M013846 GC19M013852 GC19M013948
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Summaries
for MIR27A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MIR27A:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of geneexpression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribedby RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be eitherprotein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce anapproximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicerribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporatedinto a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with themiRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeqrepresents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)
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Genomic Views
for MIR27A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for MIR27A
Other transcription factors
Search SABiosciences Chromatin IP Primers for MIR27A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR27A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.13 Ensembl cytogenetic band: 19p13.13 HGNC cytogenetic band: 19p13.13MIR27A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M013952: view genomic region (via miRBase)
(about GC identifiers)
Start:
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13,947,254 bp from pter |
End:
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13,947,331 bp from pter |
Size:
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78 bases |
Orientation:
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minus strand |
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Proteins
for MIR27A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB: --
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Protein
Domains /
Families
for MIR27A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| -- |
Function
for MIR27A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Pathways & Interactions
for MIR27A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIR27A
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Drugs & Compounds
for MIR27A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MIR27A
Search CenterWatch for drugs/clinical trials and news about MIR27A 
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Transcripts
for MIR27A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000385073(miRNA)
GeneLoc Exon Structure
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Expression
for MIR27A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| Expression evidence for MIR27A:none
MIR27A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image SABiosciences Custom PCR Arrays for MIR27A
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat MIR27A | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIR27A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIR27A |
Orthologs
for MIR27A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for MIR27A (if available)
TreeFam Gene Tree for MIR27A (if available) |
Paralogs
for MIR27A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MIR27A gene
- MIR27B2
MIR27A for paralogs About GeneDecksing
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Genomic Variants
for MIR27A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MIR27A
1 CNV: 5088
Human Gene Mutation Database (HGMD): MIR27A
| SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for MIR27A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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MIR27A for disorders About GeneDecksing
OMIM gene information: 612153
OMIM disorders: --
15  diseases for MIR27A: About MalaCardsesophageal squamous cell carcinoma squamous cell carcinoma breast-ovarian cancer familial breast cancer
ovarian cancer gastric adenocarcinoma breast cancer cervical cancer
esophagitis cervicitis gastric cancer pancreatic cancer
adenocarcinoma pancreatitis carcinoma
Human Genome Epidemiology (HuGE) Navigator: MIR27A (3 documents)
Export disorders for MIR27A gene to outside databases
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Publications
for MIR27A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for MIR27A gene, integrated from 9 sources (see all 37):
(articles sorted by number of sources associating them with MIR27A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A polymorphism of microRNA 27a genome region is associated with the development of gastric mucosal atrophy in Japanese male subjects. (PubMed id 17546506)1, 9 Arisawa T....Nakano H. (2007)
- MicroRNA-27a/b controls endothelial cell repulsion and angiogenesis by targeting semaphorin 6A. (PubMed id 22184411)1 Urbich C....Dimmeler S. (2012)
- Androgen-regulated processing of the oncomir miR-27a, which targets Prohibitin in prostate cancer. (PubMed id 22505583)1 Fletcher C.E....Bevan C.L. (2012)
- Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer. (PubMed id 22719192)1 Hezova R....Slaby O. (2012)
- The SNP rs895819 in miR-27a is not associated with fam ilial breast cancer risk in Italians. (PubMed id 22415478)1 Catucci I....Peterlongo P. (2012)
- Lentiviral expression of anti-microRNAs targeting miR- 27a inhibits proliferation and invasiveness of U87 glioma cells. (PubMed id 22614734)1 Feng S.Y....Shao J.F. (2012)
- Keratinization-associated miR-7 and miR-21 regulate tu mor suppressor reversion-inducing cysteine-rich protein with kazal motifs (RECK) in oral cancer. (PubMed id 22761427)1 Jung H.M....Chan E.K. (2012)
- Upregulation of miR-27a contributes to the malignant transformation of human bronchial epithelial cells induced by SV40 small T anti gen. (PubMed id 21460851)1 Wang Q....Chen W. (2011)
- Down-regulation of miR-27a might inhibit proliferatio n and drug resistance of gastric cancer cells. (PubMed id 21569481)1 Zhao X....Hu J. (2011)
- MicroRNA-27a regulates basal transcription by targeti ng the p44 subunit of general transcription factor IIH. (PubMed id 21558443)1 Portal M.M. (2011)
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External Searches for MIR27A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing MIR27A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing MIR27A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MIR27A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for MIR27A | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for MIR27A gene:
Search GeneIP for patents involving MIR27A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for MIR27A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MIR27A | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MIR27A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR27A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MIR27A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MIR27A | | | Search QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MIR27A |
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| | | | Search Tocris compounds for MIR27A |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for MIR27A |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat MIR27A |
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Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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