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Aliases for MIR27A Gene

Subcategory (RNA class) for MIR27A Gene

miRNA

Quality Score for this RNA gene is

14

Aliases for MIR27A Gene

  • MicroRNA 27a 2 3 5
  • Hsa-Mir-27a 3
  • Mir-27a 3
  • MIRN27A 3
  • MIR27 3

External Ids for MIR27A Gene

Previous HGNC Symbols for MIR27A Gene

  • MIRN27A

Previous GeneCards Identifiers for MIR27A Gene

  • GC19M013846
  • GC19M013852
  • GC19M013948
  • GC19M013952
  • GC19M013957
  • GC19M013964
  • GC19M013861
  • GC19M013866
  • GC19M013871
  • GC19M013877

Summaries for MIR27A Gene

Entrez Gene Summary for MIR27A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR27A Gene

MIR27A (MicroRNA 27a) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR27A include Familial Breast Cancer. Among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR.

fRNAdb sequence ontologies for MIR27A Gene

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR27A

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR27A Gene

Genomics for MIR27A Gene

Regulatory Elements for MIR27A Gene

Enhancers for MIR27A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F013793 1.2 ENCODE 12.6 +40.7 40670 5.5 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 MIR24-2 C19orf53 MRI1 MIR23A MIR27A ITGB1P1 FARSA ENSG00000267582 ZSWIM4
GH19F013787 0.9 ENCODE 12.6 +47.5 47457 4.0 FEZF1 ZNF48 ZNF121 SCRT2 SP5 CEBPB PPARG NR2F2 ZSCAN16 ETV4 C19orf53 MIR23A MIR24-2 MIR27A MRI1 MIR1199 ENSG00000280221
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR27A on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR27A Gene

Chromosome:
19
Start:
13,836,440 bp from pter
End:
13,836,517 bp from pter
Size:
78 bases
Orientation:
Minus strand

Genomic View for MIR27A Gene

Genes around MIR27A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR27A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR27A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR27A Gene

ORGUL Member Location for MIR27A Gene

ORGUL Member Location for MIR27A gene

Proteins for MIR27A Gene

Post-translational modifications for MIR27A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR27A Gene

Domains & Families for MIR27A Gene

Gene Families for MIR27A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR27A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR27A Gene

Function for MIR27A Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR27A Gene

Localization for MIR27A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR27A Gene

Pathways & Interactions for MIR27A Gene

genes like me logo Genes that share pathways with MIR27A: view

Pathways by source for MIR27A Gene

1 BioSystems pathway for MIR27A Gene
1 KEGG pathway for MIR27A Gene

Interacting Proteins for MIR27A Gene

Gene Ontology (GO) - Biological Process for MIR27A Gene

None

No data available for SIGNOR curated interactions for MIR27A Gene

Drugs & Compounds for MIR27A Gene

(2) Drugs for MIR27A Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Capecitabine Approved, Investigational Pharma RNA processing inhibitor and thymidylate synthase inhibitor, F-pyrimidines 1296
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 1791
genes like me logo Genes that share compounds with MIR27A: view

Transcripts for MIR27A Gene

fRNAdb Secondary structures for MIR27A Gene

  • AF480561
  • hsa-miR-27a-3p_MIMAT0000084_Homo_sapiens_miR-27a-3p_mature

mRNA/cDNA for MIR27A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR27A Gene

No ASD Table

Relevant External Links for MIR27A Gene

GeneLoc Exon Structure for
MIR27A
ECgene alternative splicing isoforms for
MIR27A

Expression for MIR27A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR27A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR27A Gene:

MIR27A
genes like me logo Genes that share expression patterns with MIR27A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR27A Gene

Orthologs for MIR27A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR27A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-27a 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-27a 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-27a 35
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir27a 35
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-27a 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-27a 35
  • 67 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-27a 35
  • 66 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii dre-mir-27c-2 35 35
  • 55 (a)
ManyToMany
dre-mir-27d 35
  • 54 (a)
ManyToMany
dre-mir-27e 35
  • 45 (a)
ManyToMany
dre-mir-27a 35
  • 41 (a)
ManyToMany
Species where no ortholog for MIR27A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR27A Gene

ENSEMBL:
Gene Tree for MIR27A (if available)
TreeFam:
Gene Tree for MIR27A (if available)

Paralogs for MIR27A Gene

No data available for Paralogs for MIR27A Gene

Variants for MIR27A Gene

Sequence variations from dbSNP and Humsavar for MIR27A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10422126 -- 13,837,498(+) CTCAC(A/G)CCTGT upstream-variant-2KB
rs10423627 -- 13,836,955(+) CCTCA(C/T)TGAGC upstream-variant-2KB
rs111251582 -- 13,837,836(+) AGGCT(A/G)GAGTG upstream-variant-2KB
rs114246707 -- 13,838,207(+) CACAG(A/T)GTCTG upstream-variant-2KB
rs115255566 -- 13,837,535(+) CAGGA(A/G)AGTCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR27A Gene

Variant ID Type Subtype PubMed ID
nsv833757 CNV loss 17160897
nsv953979 CNV deletion 24416366

Relevant External Links for MIR27A Gene

Human Gene Mutation Database (HGMD)
MIR27A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR27A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR27A Gene

Disorders for MIR27A Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR27A Gene - From: GeneCards

Disorder Aliases PubMed IDs
familial breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR27A

Genetic Association Database (GAD)
MIR27A
Human Genome Epidemiology (HuGE) Navigator
MIR27A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR27A
genes like me logo Genes that share disorders with MIR27A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR27A Gene

Publications for MIR27A Gene

  1. A genetic variant in the pre-miR-27a oncogene is associated with a reduced familial breast cancer risk. (PMID: 19921425) Yang R. … Burwinkel B. (Breast Cancer Res. Treat. 2010) 3 46 64
  2. Single nucleotide polymorphisms in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high-risk women. (PMID: 19950226) Kontorovich T. … Friedman E. (Int. J. Cancer 2010) 3 46 64
  3. Hsa-mir-27a genetic variant contributes to gastric cancer susceptibility through affecting miR-27a and target gene expression. (PMID: 20666778) Sun Q. … Wang B. (Cancer Sci. 2010) 3 46 64
  4. A polymorphism of microRNA 27a genome region is associated with the development of gastric mucosal atrophy in Japanese male subjects. (PMID: 17546506) Arisawa T. … Nakano H. (Dig. Dis. Sci. 2007) 3 22 64
  5. Proteomic screening identifies calreticulin as a miR-27a direct target repressing MHC class I cell surface exposure in colorectal cancer. (PMID: 26913609) Colangelo T. … Colantuoni V. (Cell Death Dis 2016) 3 64

Products for MIR27A Gene

Sources for MIR27A Gene

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