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Aliases for MIR26B Gene

Subcategory (RNA class) for MIR26B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR26B Gene

  • MicroRNA 26b 2 3 5
  • Hsa-Mir-26b 3
  • MiR-26b 3
  • MIRN26B 3

External Ids for MIR26B Gene

ORGUL Members for MIR26B Gene

Previous HGNC Symbols for MIR26B Gene

  • MIRN26B

Previous GeneCards Identifiers for MIR26B Gene

  • GC02P218976
  • GC02P219267

Summaries for MIR26B Gene

Entrez Gene Summary for MIR26B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR26B Gene

MIR26B (MicroRNA 26b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Parkinsons Disease Pathway and MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR26B Gene

Genomics for MIR26B Gene

Regulatory Elements for MIR26B Gene

Enhancers for MIR26B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F218470 1.2 FANTOM5 Ensembl ENCODE 12.2 +69.2 69229 2.7 RFX1 HMBOX1 FOS ETV6 NFE2 MAFK CNOT9 MIR26B MIR6513 TMBIM1 AAMP PNKD PLCD4 USP37 RN7SKP38 VIL1
GH02F218301 1.1 Ensembl ENCODE 12 -101.1 -101058 0.9 ATF1 ARNT ZFP64 ARID4B DMAP1 ZNF48 ZNF2 GTF3C2 ZNF121 SLC30A9 AAMP PNKD CNOT9 NHEJ1 SLC11A1 CTDSP1 MIR26B USP37 SLC23A3 BCS1L
GH02F218281 1 FANTOM5 ENCODE 12 -112.4 -112408 17.9 HDGF PKNOX1 ARNT MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ENSG00000261338 SLC11A1 RNF25 CNOT9 CTDSP1 MIR26B STK36 AAMP ARPC2 TMBIM1
GH02F218412 0.7 Ensembl 0.4 +10.4 10355 0.4 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 ZNF143 VIL1 MIR26B
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR26B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR26B Gene

Chromosome:
2
Start:
218,402,646 bp from pter
End:
218,402,722 bp from pter
Size:
77 bases
Orientation:
Plus strand

Genomic View for MIR26B Gene

Genes around MIR26B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR26B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR26B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR26B Gene

Proteins for MIR26B Gene

Post-translational modifications for MIR26B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR26B Gene

Domains & Families for MIR26B Gene

Gene Families for MIR26B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR26B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR26B Gene

Function for MIR26B Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR26B Gene

Localization for MIR26B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR26B Gene

Pathways & Interactions for MIR26B Gene

genes like me logo Genes that share pathways with MIR26B: view

Pathways by source for MIR26B Gene

1 BioSystems pathway for MIR26B Gene
1 KEGG pathway for MIR26B Gene

Interacting Proteins for MIR26B Gene

Gene Ontology (GO) - Biological Process for MIR26B Gene

None

No data available for SIGNOR curated interactions for MIR26B Gene

Transcripts for MIR26B Gene

mRNA/cDNA for MIR26B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR26B Gene

No ASD Table

Relevant External Links for MIR26B Gene

GeneLoc Exon Structure for
MIR26B
ECgene alternative splicing isoforms for
MIR26B

Expression for MIR26B Gene

mRNA expression in normal human tissues for MIR26B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR26B Gene:

MIR26B
genes like me logo Genes that share expression patterns with MIR26B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR26B Gene

Orthologs for MIR26B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR26B Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia cfa-mir-26b 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-26b 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-26b 35
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-26-2 35
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir26b 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-26-1 35
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-26-1 35
  • 65 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii dre-mir-26b 35
  • 52 (a)
OneToOne
Species where no ortholog for MIR26B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR26B Gene

ENSEMBL:
Gene Tree for MIR26B (if available)
TreeFam:
Gene Tree for MIR26B (if available)

Paralogs for MIR26B Gene

No data available for Paralogs for MIR26B Gene

Variants for MIR26B Gene

Sequence variations from dbSNP and Humsavar for MIR26B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs112233275 -- 218,400,897(+) CCCCA(A/G)GTCTG intron-variant, upstream-variant-2KB, reference, missense
rs112546602 -- 218,402,951(+) TCTGC(C/T)TCCCT intron-variant, downstream-variant-500B
rs112758322 -- 218,401,910(+) TTTTC(-/C)TACCT intron-variant, upstream-variant-2KB
rs115211340 -- 218,402,884(+) TTCCC(C/T)AGCAG intron-variant, downstream-variant-500B
rs115254818 -- 218,400,954(+) GAAAG(C/G)CTAGT intron-variant, upstream-variant-2KB, splice-donor-variant

Structural Variations from Database of Genomic Variants (DGV) for MIR26B Gene

Variant ID Type Subtype PubMed ID
nsv3166 CNV insertion 18451855
nsv519829 CNV loss 19592680

Relevant External Links for MIR26B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR26B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR26B Gene

Disorders for MIR26B Gene

Relevant External Links for MIR26B

Genetic Association Database (GAD)
MIR26B
Human Genome Epidemiology (HuGE) Navigator
MIR26B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR26B

No disorders were found for MIR26B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR26B Gene

Publications for MIR26B Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 46 64
  2. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y. … Liu P. (Schizophr. Res. 2010) 3 46 64
  3. Elevated plasma CaM expression in patients with acute cerebral infarction predicts poor outcomes and is inversely associated with miR-26b expression. (PMID: 26001204) Yuan M. … Yuan H. (Int. J. Neurosci. 2016) 3 64
  4. miR-26b-3p Regulates Human Umbilical Cord-Derived Mesenchymal Stem Cell Proliferation by Targeting Estrogen Receptor. (PMID: 26723394) Wang Q. … Liu H. (Stem Cells Dev. 2016) 3 64
  5. MicroRNA-26b Enhances the Radiosensitivity of Hepatocellular Carcinoma Cells by Targeting EphA2. (PMID: 26843134) Jin Q. … Cao P.G. (Tohoku J. Exp. Med. 2016) 3 64

Products for MIR26B Gene

Sources for MIR26B Gene

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