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Aliases for MIR26A2 Gene

Subcategory (RNA class) for MIR26A2 Gene

miRNA

Quality Score for this RNA gene is

10.2

Aliases for MIR26A2 Gene

  • MicroRNA 26a-2 2 3 5
  • Hsa-Mir-26a-2 3
  • Mir-26a-2 3
  • MIRN26A2 3

External Ids for MIR26A2 Gene

Previous HGNC Symbols for MIR26A2 Gene

  • MIRN26A2

Previous GeneCards Identifiers for MIR26A2 Gene

  • GC12M056507
  • GC12M058218

Summaries for MIR26A2 Gene

Entrez Gene Summary for MIR26A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR26A2 Gene

MIR26A2 (MicroRNA 26a-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Parkinsons Disease Pathway and miRs in Muscle Cell Differentiation.

fRNAdb sequence ontologies for MIR26A2 Gene - the ORGUL cluster for this gene includes several descriptions:

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR26A2

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR26A2 Gene

Genomics for MIR26A2 Gene

Regulatory Elements for MIR26A2 Gene

Enhancers for MIR26A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F057886 1.2 FANTOM5 Ensembl ENCODE 11.8 -68.6 -68604 13.7 HDGF PKNOX1 ZNF2 ZNF121 GLIS2 ZNF143 FOS SP3 JUNB REST ATP23 METTL21B CTDSP2 TSFM MIR26A2 AVIL RNU6-1083P MARCH9 LOC283387 GLI1
GH12F057905 0.5 Ensembl ENCODE 11.5 -80.8 -80838 1.1 WRNIP1 ARID4B SIN3A ZNF2 YY1 ZNF143 DEK ZNF263 ZHX2 MXD4 ATP23 CTDSP2 MIR26A2 RNU6-1083P AVIL TSFM CYP27B1 METTL1 METTL21B CDK4
GH12F057795 0.8 ENCODE 11.4 +29.0 28991 1.0 GATA3 CTBP1 JUN DPF2 FOS ATF2 MIR26A2 METTL1 METTL21B CYP27B1 ENSG00000270039 TSFM
GH12F057863 1.3 FANTOM5 Ensembl ENCODE 11.4 -40.2 -40227 2.6 SIN3A GLIS2 SCRT2 EGR2 SP3 CEBPB REST SMARCB1 TFDP1 ZFP69B METTL21B MIR26A2 CDK4 AVIL RNU6-1083P TSFM METTL1 CYP27B1 MARCH9 CTDSP2
GH12F057868 1.7 FANTOM5 Ensembl ENCODE 11.4 -44.7 -44675 2.0 PKNOX1 SMARCA4 POLR2A SCRT2 KLF17 ZBTB8A FOXP2 METTL21B AVIL CTDSP2 MIR26A2 TSFM METTL1 CYP27B1 RNU6-1083P CDK4 MARCH9
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR26A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR26A2 Gene

Chromosome:
12
Start:
57,824,609 bp from pter
End:
57,824,692 bp from pter
Size:
84 bases
Orientation:
Minus strand

Genomic View for MIR26A2 Gene

Genes around MIR26A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR26A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR26A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR26A2 Gene

ORGUL Member Location for MIR26A2 Gene

ORGUL Member Location for MIR26A2 gene

Proteins for MIR26A2 Gene

Post-translational modifications for MIR26A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR26A2 Gene

Domains & Families for MIR26A2 Gene

Gene Families for MIR26A2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR26A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR26A2 Gene

Function for MIR26A2 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR26A2 Gene

Localization for MIR26A2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR26A2 Gene

Pathways & Interactions for MIR26A2 Gene

genes like me logo Genes that share pathways with MIR26A2: view

Pathways by source for MIR26A2 Gene

2 BioSystems pathways for MIR26A2 Gene
1 KEGG pathway for MIR26A2 Gene

Interacting Proteins for MIR26A2 Gene

Gene Ontology (GO) - Biological Process for MIR26A2 Gene

None

No data available for SIGNOR curated interactions for MIR26A2 Gene

Transcripts for MIR26A2 Gene

fRNAdb Secondary structures for MIR26A2 Gene

  • hsa-mir-26a-2_MI0000750_Homo_sapiens_miR-26a-2_stem-loop_hairpin

mRNA/cDNA for MIR26A2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR26A2 Gene

No ASD Table

Relevant External Links for MIR26A2 Gene

GeneLoc Exon Structure for
MIR26A2
ECgene alternative splicing isoforms for
MIR26A2

Expression for MIR26A2 Gene

mRNA expression in normal human tissues for MIR26A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR26A2 Gene:

MIR26A2
genes like me logo Genes that share expression patterns with MIR26A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR26A2 Gene

Orthologs for MIR26A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR26A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-26a-2 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-26a-2 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-26a-2 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir26a-2 35
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-26-1 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 66 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 73 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-26a-1 35
  • 72 (a)
ManyToMany
Species where no ortholog for MIR26A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR26A2 Gene

ENSEMBL:
Gene Tree for MIR26A2 (if available)
TreeFam:
Gene Tree for MIR26A2 (if available)

Paralogs for MIR26A2 Gene

No data available for Paralogs for MIR26A2 Gene

Variants for MIR26A2 Gene

Sequence variations from dbSNP and Humsavar for MIR26A2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs111589440 -- 57,824,887(+) ACCCT(A/T)ACGAT intron-variant, upstream-variant-2KB
rs111857325 -- 57,825,930(+) TCCCT(A/G/T)CCTGT intron-variant, upstream-variant-2KB
rs113443562 -- 57,824,306(+) GCCTC(A/T)TGAGC downstream-variant-500B, reference, missense
rs113514774 -- 57,825,583(+) TGACC(A/G)GGGCC intron-variant, upstream-variant-2KB
rs113598599 -- 57,824,295(+) ATCCA(C/T)ATAAG downstream-variant-500B, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MIR26A2 Gene

Variant ID Type Subtype PubMed ID
nsv559046 CNV gain 21841781
nsv726 CNV insertion 18451855
nsv983335 CNV duplication 23825009

Relevant External Links for MIR26A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR26A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR26A2 Gene

Disorders for MIR26A2 Gene

Relevant External Links for MIR26A2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR26A2

No disorders were found for MIR26A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR26A2 Gene

Publications for MIR26A2 Gene

  1. Identification of novel genes coding for small expressed RNAs. (PMID: 11679670) Lagos-Quintana M. … Tuschl T. (Science 2001) 1 3 64
  2. MicroRNA-26a suppresses epithelial-mesenchymal transition in human hepatocellular carcinoma by repressing enhancer of zeste homolog 2. (PMID: 26733151) Ma D.N. … Tang Z.Y. (J Hematol Oncol 2016) 3 64
  3. MicroRNA-26a inhibits TGF-I^-induced extracellular matrix protein expression in podocytes by targeting CTGF and is downregulated in diabetic nephropathy. (PMID: 26063197) Koga K. … Mukoyama M. (Diabetologia 2015) 3 64
  4. Serum miR-26a as a diagnostic and prognostic biomarker in cholangiocarcinoma. (PMID: 26087181) Wang L.J. … Shi S.J. (Oncotarget 2015) 3 64
  5. Mutant p53 induces EZH2 expression and promotes epithelial-mesenchymal transition by disrupting p68-Drosha complex assembly and attenuating miR-26a processing. (PMID: 26587974) Jiang F.Z. … Wan X.P. (Oncotarget 2015) 3 64

Products for MIR26A2 Gene

Sources for MIR26A2 Gene

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