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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MIR26A1 Gene

RNA gene   GIFtS: 20
GCID: GC03P038010

microRNA 26a-1


(Previous symbol: MIRN26A1)
 Explore 12 diseases affiliated with
MIR26A1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MIR26A1    

Aliases
for MIR26A1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Subcategory (RNA class): miRNA

Quality score for this RNA gene is 10

Aliases
MicroRNA 26a-11 2
MIRN26A11 2 5
MIR26A2 5
Hsa-Mir-26a-11
Mir-26a-11

External Ids:    HGNC: 316101   Entrez Gene: 4070152   Ensembl: ENSG000001990757   OMIM: 6121515   
ORGUL members:    fRNAdb10:FR089609 FR016074      
miRBase: MI0000083 MIMAT0000082 MIMAT0004499    
NCBI:AP000497    
Rfam:RF00244    

Export aliases for MIR26A1 gene to outside databases

Previous GC identifer: GC03P037988


Summaries
for MIR26A1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MIR26A1:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene
expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed
by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either
protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an
approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer
ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated
into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the
miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq
represents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)



fRNAdb sequence ontology for MIR26A1:
pre_miRNA - The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR26A1

Genomic Views
for MIR26A1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
 Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MIR26A1
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR26A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.2   Ensembl cytogenetic band:  3p22.2   HGNC cytogenetic band: 3p22.2

MIR26A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIR26A1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P038010:  view genomic region (via miRBase)     (about GC identifiers)

Start:
 38,010,895 bp from pter      End:
 38,010,971 bp from pter
Size:
 77 bases      Orientation:
 plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for MIR26A1

Proteins
for MIR26A1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB: --

Protein Domains /
Families
for MIR26A1 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
   --

Function
for MIR26A1 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Animal Models:
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miRNA
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Inhib. RNA
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Pathways & Interactions
for MIR26A1 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIR26A1

Drugs & Compounds
for MIR26A1 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MIR26A1
Search CenterWatch for drugs/clinical trials and news about MIR26A1 

Transcripts
for MIR26A1 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
 1 fRNAdb Secondary structure:


1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000362205(miRNA)

miRNA
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Inhib. RNA
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GeneLoc Exon Structure


Expression
for MIR26A1 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for MIR26A1:miRBase

MIR26A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
MIR26A1 Expression
About this image    SABiosciences Custom PCR Arrays for MIR26A1

Primer
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In Situ
Assay Products: 
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Orthologs
for MIR26A1 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
   --

ENSEMBL Gene Tree for MIR26A1 (if available)
TreeFam Gene Tree for MIR26A1 (if available) 

Paralogs
for MIR26A1 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for MIR26A1 gene
MIR26A22  MIR26B2  

MIR26A1 for paralogs           About GeneDecksing



Genomic Variants
for MIR26A1 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MIR26A1
     1 CNV: 3425
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MIR26A1
DNA2.0 Custom Variant and Variant Library Synthesis for MIR26A1

Disorders / Diseases
for MIR26A1 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
MIR26A1 for disorders           About GeneDecksing

OMIM gene information: 612151OMIM information: 608592    
12 diseases for MIR26A1:    About MalaCards
muscle hypertrophy    renal cell carcinoma    liver cancer    hepatocellular carcinoma
esophageal cancer    cervical cancer    esophagitis    cervicitis
colon cancer    lung cancer    breast cancer    carcinoma

Human Genome Epidemiology (HuGE) Navigator: MIR26A1 (5 documents)

Export disorders for MIR26A1 gene to outside databases

Publications
for MIR26A1 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MIR26A1 gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with MIR26A1)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Trastuzumab produces therapeutic actions by upregulati ng miR-26a and miR-30b in breast cancer cells. (PubMed id 22384020)1 Ichikawa T....Shimizu K. (2012)
  2. MicroRNA-26a regulates tumorigenic properties of EZH2 in human lung carcinoma cells. (PubMed id 22469510)1 Dang X....Luo Y. (2012)
  3. MiR-26a enhances metastasis potential of lung cancer c ells via AKT pathway by targeting PTEN. (PubMed id 22885155)1 Liu B....Xu K. (2012)
  4. Downregulation of HMGA-targeting microRNAs has a criti cal role in human pituitary tumorigenesis. (PubMed id 22139073)1 Palmieri D....Fusco A. (2012)
  5. The regulatory network menin-microRNA 26a as a possibl e target for RNA-based therapy of bone diseases. (PubMed id 22409234)1 Luzi E....Brandi M.L. (2012)
  6. MicroRNA-26a is a novel regulator of vascular smooth muscle cell function. (PubMed id 20857419)1 Leeper N.J....Spin J.M. (2011)
  7. MiR-26a inhibits cell growth and tumorigenesis of nas opharyngeal carcinoma through repression of EZH2. (PubMed id 21199804)1 Lu J....Li X.P. (2011)
  8. Tumor-specific expression of microRNA-26a suppresses human hepatocellular carcinoma growth via cyclin-dependent and -independent pat hways. (PubMed id 21610700)1 Chen L....Cai Z. (2011)
  9. Brain derived neurotrophic factor (BDNF) expression is regulated by microRNAs miR-26a and miR-26b allele-specific binding. (PubMed id 22194877)1 Caputo V....Pizzuti A. (2011)
  10. Pathologically decreased miR-26a antagonizes apoptosi s and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancer. (PubMed id 20952513)1 Zhang B....Zhao Q. (2011)

External Searches for MIR26A1 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing MIR26A1 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 407015 HGNC: 31610 Ensembl:ENSG00000199075 miRBase: hsa-mir-26a-1 euGenes: HUgn407015
ECgene: MIR26A1 H-InvDB: MIR26A1

Other Databases showing MIR26A1 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing MIR26A1 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for MIR26A1 Pharmacogenomics, SNPs, Pathways

Intellectual Property
for MIR26A1 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for MIR26A1 gene:
Search GeneIP for patents involving MIR26A1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
for MIR26A1 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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