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Aliases for MIR24-1 Gene

Subcategory (RNA class) for MIR24-1 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR24-1 Gene

  • MicroRNA 24-1 2 3
  • C9orf3 4 5
  • Chromosome 9 Open Reading Frame 3 5
  • Hsa-Mir-24-1 3
  • MicroRNA-24 3
  • EC 3.4.11.- 4
  • MiRNA24-1 3
  • MiR-24-1 3
  • MIRN24-1 3
  • MIR189 3
  • AOPEP 4
  • ONPEP 4
  • AP-O 4

External Ids for MIR24-1 Gene

Previous HGNC Symbols for MIR24-1 Gene

  • MIRN24-1

Previous GeneCards Identifiers for MIR24-1 Gene

  • GC09P096892
  • GC09P097849
  • GC09P097851
  • GC09P097859
  • GC09P097867
  • GC09P095086

Summaries for MIR24-1 Gene

Entrez Gene Summary for MIR24-1 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR24-1 Gene

MIR24-1 (MicroRNA 24-1) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR24-1 include Arteriosclerosis Obliterans. Among its related pathways are miRNAs involved in DDR. An important paralog of this gene is RNPEP.

UniProtKB/Swiss-Prot for MIR24-1 Gene

  • Aminopeptidases catalyze the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. Able to cleave angiotensin III to generate angiotensin IV, a bioactive peptide of the renin-angiotensin pathway. Not able to cleave angiotensin I and angiotensin II. May play a role in the proteolytic processing of bioactive peptides in tissues such as testis and heart.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR24-1 Gene

Genomics for MIR24-1 Gene

Regulatory Elements for MIR24-1 Gene

Enhancers for MIR24-1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MIR24-1 on UCSC Golden Path with GeneCards custom track

Promoters for MIR24-1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MIR24-1 Gene

Chromosome:
9
Start:
94,726,701 bp from pter
End:
95,087,218 bp from pter
Size:
360,518 bases
Orientation:
Plus strand

Genomic View for MIR24-1 Gene

Genes around MIR24-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR24-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR24-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR24-1 Gene

Proteins for MIR24-1 Gene

  • Protein details for MIR24-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6M6-AMPO_HUMAN
    Recommended name:
    Aminopeptidase O
    Protein Accession:
    Q8N6M6
    Secondary Accessions:
    • Q5T9B1
    • Q5T9B3
    • Q5T9B4
    • Q8WUL6
    • Q96M23
    • Q96SS1

    Protein attributes for MIR24-1 Gene

    Size:
    819 amino acids
    Molecular mass:
    93572 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH20194.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55210.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MIR24-1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR24-1 Gene

Post-translational modifications for MIR24-1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MIR24-1 Gene

Domains & Families for MIR24-1 Gene

Gene Families for MIR24-1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N6M6

UniProtKB/Swiss-Prot:

AMPO_HUMAN :
  • Belongs to the peptidase M1 family.
Family:
  • Belongs to the peptidase M1 family.
genes like me logo Genes that share domains with MIR24-1: view

No data available for Suggested Antigen Peptide Sequences for MIR24-1 Gene

Function for MIR24-1 Gene

Molecular function for MIR24-1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=6 uM for Arg-AMC {ECO:0000269 PubMed:15687497};
UniProtKB/Swiss-Prot EnzymeRegulation:
Strongly inhibited by ophenanthroline, a metalloprotease inhibitor. Inhibited by arphamenine A, a potent inhibitor of aminopeptidases. Not affected by AEBSF and E-64, which are common inhibitors of serine- and cysteine-proteases, respectively.
UniProtKB/Swiss-Prot Function:
Aminopeptidases catalyze the hydrolysis of amino acid residues from the N-terminus of peptide or protein substrates. Able to cleave angiotensin III to generate angiotensin IV, a bioactive peptide of the renin-angiotensin pathway. Not able to cleave angiotensin I and angiotensin II. May play a role in the proteolytic processing of bioactive peptides in tissues such as testis and heart.

Enzyme Numbers (IUBMB) for MIR24-1 Gene

Gene Ontology (GO) - Molecular Function for MIR24-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008237 metallopeptidase activity IDA --
GO:0008270 zinc ion binding IBA --
GO:0042277 peptide binding IBA --
GO:0070006 metalloaminopeptidase activity IBA --
genes like me logo Genes that share ontologies with MIR24-1: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR24-1 Gene

Localization for MIR24-1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR24-1 Gene

Gene Ontology (GO) - Cellular Components for MIR24-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IBA --
GO:0005737 cytoplasm IBA --
GO:0005886 plasma membrane IBA --
genes like me logo Genes that share ontologies with MIR24-1: view

No data available for Subcellular locations from COMPARTMENTS for MIR24-1 Gene

Pathways & Interactions for MIR24-1 Gene

SuperPathways for MIR24-1 Gene

Superpath Contained pathways
1 miRNAs involved in DDR
genes like me logo Genes that share pathways with MIR24-1: view

Pathways by source for MIR24-1 Gene

1 BioSystems pathway for MIR24-1 Gene

Interacting Proteins for MIR24-1 Gene

Gene Ontology (GO) - Biological Process for MIR24-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA --
GO:0043171 peptide catabolic process IBA --
genes like me logo Genes that share ontologies with MIR24-1: view

No data available for SIGNOR curated interactions for MIR24-1 Gene

Drugs & Compounds for MIR24-1 Gene

No Compound Related Data Available

Transcripts for MIR24-1 Gene

mRNA/cDNA for MIR24-1 Gene

(23) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR24-1 Gene

No ASD Table

Relevant External Links for MIR24-1 Gene

GeneLoc Exon Structure for
MIR24-1
ECgene alternative splicing isoforms for
MIR24-1

Expression for MIR24-1 Gene

mRNA Expression by UniProt/SwissProt for MIR24-1 Gene:

Q8N6M6-AMPO_HUMAN
Tissue specificity: Predominantly expressed in pancreas, placenta, liver, testis and heart. Expressed at lower level in brain, lung and kidney.

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR24-1 Gene

Orthologs for MIR24-1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MIR24-1 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia C9orf3 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 28 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia C9orf3 35
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C9orf3 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2010111I01Rik 35
  • 76 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C9orf3 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves C9orf3 35
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C9orf3 35
  • 67 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C8H9orf3 35
  • 56 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LAP2 35
  • 20 (a)
OneToMany
Species where no ortholog for MIR24-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR24-1 Gene

ENSEMBL:
Gene Tree for MIR24-1 (if available)
TreeFam:
Gene Tree for MIR24-1 (if available)

Paralogs for MIR24-1 Gene

Paralogs for MIR24-1 Gene

genes like me logo Genes that share paralogs with MIR24-1: view

Variants for MIR24-1 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR24-1 Gene

Variant ID Type Subtype PubMed ID
nsv1038106 CNV gain 25217958
nsv1147999 OTHER inversion 26484159
nsv831656 CNV loss 17160897

Relevant External Links for MIR24-1 Gene

Human Gene Mutation Database (HGMD)
MIR24-1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR24-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for MIR24-1 Gene

Disorders for MIR24-1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR24-1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
arteriosclerosis obliterans
  • arteriosclerosis obliterans [ambiguous]
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR24-1

Genetic Association Database (GAD)
MIR24-1
Human Genome Epidemiology (HuGE) Navigator
MIR24-1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR24-1
genes like me logo Genes that share disorders with MIR24-1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR24-1 Gene

Publications for MIR24-1 Gene

  1. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y. … Liu P. (Schizophr. Res. 2010) 3 46 65
  2. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J. … Zhao H. (Int. J. Cancer 2009) 3 46 65
  3. MicroRNA-24 inhibits serotonin reuptake transporter expression and aggravates irritable bowel syndrome. (PMID: 26631964) Liao X.J. … Shao S.X. (Biochem. Biophys. Res. Commun. 2016) 3 65
  4. Mir-24-3p downregulation contributes to VP16-DDP resistance in small-cell lung cancer by targeting ATG4A. (PMID: 25426560) Pan B. … Chen L. (Oncotarget 2015) 3 65
  5. Down-regulation of miR-24-3p in colorectal cancer is associated with malignant behavior. (PMID: 25502080) Gao Y. … Wang C. (Med. Oncol. 2015) 3 65

Products for MIR24-1 Gene

Sources for MIR24-1 Gene

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