Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR23B Gene

Subcategory (RNA class) for MIR23B Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR23B Gene

  • MicroRNA 23b 2 3 5
  • Hsa-Mir-23b 3
  • MiRNA23B 3
  • Mir-23b 3
  • MIRN23B 3

External Ids for MIR23B Gene

ORGUL Members for MIR23B Gene

Previous HGNC Symbols for MIR23B Gene

  • MIRN23B

Previous GeneCards Identifiers for MIR23B Gene

  • GC09P096890
  • GC09P097847

Summaries for MIR23B Gene

Entrez Gene Summary for MIR23B Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR23B Gene

MIR23B (MicroRNA 23b) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Spinal Cord Injury and MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR23B Gene

Genomics for MIR23B Gene

Regulatory Elements for MIR23B Gene

Enhancers for MIR23B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F095060 0.5 ENCODE 13.7 -21.2 -21241 6.0 ATF1 ARID4B RAD21 RARA YY1 CREM THAP11 SP5 ZNF585B CEBPA MIR23B MIR27B MIR3074 LINC00476 ENSG00000271659 LOC100132077 C9orf3 MIR6081 LOC101928119
GH09F095106 1 ENCODE 12.7 +22.4 22413 2.3 CTCF ZNF316 MAFK MIR23B MIR27B MIR3074 PIR48893 PIR51992
GH09F095053 0.8 Ensembl ENCODE 12.6 -28.3 -28337 6.2 TAL1 JUN FEZF1 ZIC2 RAD21 HIC1 ZFHX2 POLR2A PRDM10 MAFK MIR23B MIR27B MIR3074 MIR6081 LOC101928119
GH09F095016 1.1 Ensembl ENCODE 12.1 -63.4 -63361 10.7 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 YY1 FOS SP5 NFYC PPARGC1A LINC00476 MIR23B MIR27B MIR3074 ENSG00000271659 LOC100132077 C9orf3 MIR6081 LOC101928119
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR23B on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR23B Gene

Chromosome:
9
Start:
95,085,208 bp from pter
End:
95,085,304 bp from pter
Size:
97 bases
Orientation:
Plus strand

Genomic View for MIR23B Gene

Genes around MIR23B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR23B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR23B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR23B Gene

Proteins for MIR23B Gene

Post-translational modifications for MIR23B Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR23B Gene

Domains & Families for MIR23B Gene

Gene Families for MIR23B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR23B: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR23B Gene

Function for MIR23B Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR23B Gene

Localization for MIR23B Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR23B Gene

Pathways & Interactions for MIR23B Gene

genes like me logo Genes that share pathways with MIR23B: view

Pathways by source for MIR23B Gene

2 BioSystems pathways for MIR23B Gene
1 KEGG pathway for MIR23B Gene

Interacting Proteins for MIR23B Gene

Gene Ontology (GO) - Biological Process for MIR23B Gene

None

No data available for SIGNOR curated interactions for MIR23B Gene

Transcripts for MIR23B Gene

mRNA/cDNA for MIR23B Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR23B Gene

No ASD Table

Relevant External Links for MIR23B Gene

GeneLoc Exon Structure for
MIR23B
ECgene alternative splicing isoforms for
MIR23B

Expression for MIR23B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR23B Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR23B Gene:

MIR23B
genes like me logo Genes that share expression patterns with MIR23B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR23B Gene

Orthologs for MIR23B Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR23B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-23b 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-23b 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-23b 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-23b 35
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir23b 35
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-23b 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-23b 35
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-23b 35
  • 90 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CR847548.1 35
  • 86 (a)
OneToMany
dre-mir-23b 35
  • 83 (a)
OneToMany
Species where no ortholog for MIR23B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR23B Gene

ENSEMBL:
Gene Tree for MIR23B (if available)
TreeFam:
Gene Tree for MIR23B (if available)

Paralogs for MIR23B Gene

No data available for Paralogs for MIR23B Gene

Variants for MIR23B Gene

Sequence variations from dbSNP and Humsavar for MIR23B Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1011784 -- 95,085,732(-) TAGTG(C/G)ATGTT intron-variant, nc-transcript-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs10821447 -- 95,083,223(+) TCATC(A/G)GCTGG intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs114204390 -- 95,083,673(+) ACCTG(C/T)GGCAC intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs114313010 -- 95,083,282(+) GTAGC(A/G)CACAC intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs115795725 -- 95,083,974(+) AGCAA(C/T)CTAGC intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MIR23B Gene

Variant ID Type Subtype PubMed ID
nsv1038106 CNV gain 25217958
nsv1147999 OTHER inversion 26484159
nsv831656 CNV loss 17160897

Relevant External Links for MIR23B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR23B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR23B Gene

Disorders for MIR23B Gene

Relevant External Links for MIR23B

Human Genome Epidemiology (HuGE) Navigator
MIR23B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR23B

No disorders were found for MIR23B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR23B Gene

Publications for MIR23B Gene

  1. Up-Regulation of Plasma miR-23b is Associated with Poor Prognosis of Gastric Cancer. (PMID: 26835790) Zhuang K. … Zhang L. (Med. Sci. Monit. 2016) 3 64
  2. MiR-23b targets cyclin G1 and suppresses ovarian cancer tumorigenesis and progression. (PMID: 26872615) Yan J. … Zong Z.H. (J. Exp. Clin. Cancer Res. 2016) 3 64
  3. miR-23b/SP1/c-myc forms a feed-forward loop supporting multiple myeloma cell growth. (PMID: 26771806) Fulciniti M. … Munshi N.C. (Blood Cancer J 2016) 3 64
  4. Effects and mechanism of miR-23b on glucose-mediated epithelial-to-mesenchymal transition in diabetic nephropathy. (PMID: 26646104) Liu H. … Li H. (Int. J. Biochem. Cell Biol. 2016) 3 64
  5. MAPK and JAK/STAT pathways targeted by miR-23a and miR-23b in prostate cancer: computational and in vitro approaches. (PMID: 25604141) Aghaee-Bakhtiari S.H. … Soleimani M. (Tumour Biol. 2015) 3 64

Products for MIR23B Gene

Sources for MIR23B Gene

Content
Loading form....