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Aliases for MIR23A Gene

Subcategory (RNA class) for MIR23A Gene

miRNA

Quality Score for this RNA gene is

14.2

Aliases for MIR23A Gene

  • MicroRNA 23a 2 3 5
  • Hsa-Mir-23a 3
  • MiRNA23A 3
  • Mir-23a 3
  • MIRN23A 3

External Ids for MIR23A Gene

Previous HGNC Symbols for MIR23A Gene

  • MIRN23A

Previous GeneCards Identifiers for MIR23A Gene

  • GC19M013847
  • GC19M013853
  • GC19M013950
  • GC19M013953
  • GC19M013958
  • GC19M013968
  • GC19M013862
  • GC19M013867
  • GC19M013872
  • GC19M013878
  • GC19M013886
  • GC19M013896

Summaries for MIR23A Gene

Entrez Gene Summary for MIR23A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR23A Gene

MIR23A (MicroRNA 23a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR23A Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR23A

Additional gene information for MIR23A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR23A Gene

Genomics for MIR23A Gene

Regulatory Elements for MIR23A Gene

Enhancers for MIR23A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H013793 1.3 ENCODE dbSUPER 12.6 +40.8 40812 5 HDGF PKNOX1 FOXA2 ARID4B SIN3A ZNF2 ZBTB7B YY1 ZNF143 ZNF207 LOC284454 DDX39A C19orf53 MRI1 MIR23A MIR24-2 MIR27A DCAF15 RFX1 FARSA
GH19H013787 1 Ensembl ENCODE 12.6 +47.6 47630 4 BCOR JUN ZMYM3 MAX CEBPG ZNF121 POLR2A ADNP RFX1 ZNF687 C19orf53 MIR23A MIR24-2 MIR27A MRI1 MISP3 GC19P013795
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR23A on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR23A Gene

Chromosome:
19
Start:
13,836,587 bp from pter
End:
13,836,659 bp from pter
Size:
73 bases
Orientation:
Minus strand

Genomic View for MIR23A Gene

Genes around MIR23A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR23A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR23A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR23A Gene

ORGUL Member Location for MIR23A Gene

ORGUL Member Location for MIR23A gene

Proteins for MIR23A Gene

Post-translational modifications for MIR23A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR23A Gene

Domains & Families for MIR23A Gene

Gene Families for MIR23A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR23A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR23A Gene

Function for MIR23A Gene

Phenotypes From GWAS Catalog for MIR23A Gene

Gene Ontology (GO) - Molecular Function for MIR23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IDA 15131085
genes like me logo Genes that share ontologies with MIR23A: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MIR23A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR23A Gene

Localization for MIR23A Gene

Gene Ontology (GO) - Cellular Components for MIR23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 18766170
GO:0070062 extracellular exosome IDA 28159509
genes like me logo Genes that share ontologies with MIR23A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR23A Gene

Pathways & Interactions for MIR23A Gene

genes like me logo Genes that share pathways with MIR23A: view

Pathways by source for MIR23A Gene

1 KEGG pathway for MIR23A Gene

Interacting Proteins for MIR23A Gene

Gene Ontology (GO) - Biological Process for MIR23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035195 gene silencing by miRNA IDA 15131085
GO:0061049 cell growth involved in cardiac muscle cell development ISS --
genes like me logo Genes that share ontologies with MIR23A: view

No data available for SIGNOR curated interactions for MIR23A Gene

Drugs & Compounds for MIR23A Gene

No Compound Related Data Available

Transcripts for MIR23A Gene

fRNAdb Secondary structures for MIR23A Gene

  • AF480558

mRNA/cDNA for MIR23A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MIR23A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR23A Gene

No ASD Table

Relevant External Links for MIR23A Gene

GeneLoc Exon Structure for
MIR23A
ECgene alternative splicing isoforms for
MIR23A

Expression for MIR23A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR23A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR23A Gene:

MIR23A
genes like me logo Genes that share expression patterns with MIR23A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR23A Gene

Orthologs for MIR23A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR23A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-23a 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-23a 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-23a 34
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir23a 34
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-23a 34
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-23a 34 34
  • 69 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-23a 34
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-23a-3 34
  • 60 (a)
OneToMany
dre-mir-23a-1 34
  • 56 (a)
OneToMany
dre-mir-23a-4 34 34
  • 47 (a)
OneToMany
Species where no ortholog for MIR23A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR23A Gene

ENSEMBL:
Gene Tree for MIR23A (if available)
TreeFam:
Gene Tree for MIR23A (if available)

Paralogs for MIR23A Gene

No data available for Paralogs for MIR23A Gene

Variants for MIR23A Gene

Sequence variations from dbSNP and Humsavar for MIR23A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000538048 -- 13,837,030(+) AAGTG(A/G)TCTCA upstream-variant-2KB
rs1001463246 -- 13,838,118(+) GCCAT(C/G)TTGCC upstream-variant-2KB
rs1001573587 -- 13,837,391(+) GTAAG(C/T)GCCCA upstream-variant-2KB
rs1001978328 -- 13,838,043(+) TCGGC(A/T)TTCCA upstream-variant-2KB
rs1003195008 -- 13,837,157(+) ATGCC(A/G)GCAGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR23A Gene

Variant ID Type Subtype PubMed ID
nsv833757 CNV loss 17160897
nsv953979 CNV deletion 24416366

Relevant External Links for MIR23A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR23A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR23A Gene

Disorders for MIR23A Gene

Relevant External Links for MIR23A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR23A

No disorders were found for MIR23A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR23A Gene

Publications for MIR23A Gene

  1. MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells. (PMID: 27737950) Grieco FA … Eizirik DL (Diabetes 2017) 3 60
  2. Analysis of Circulating miR-1, miR-23a, and miR-26a in Atrial Fibrillation Patients Undergoing Coronary Bypass Artery Grafting Surgery. (PMID: 28422282) Feldman A … Farsky P (Annals of human genetics 2017) 3 60
  3. Circulatory microRNA 23a and microRNA 23b and polycystic ovary syndrome (PCOS): the effects of body mass index and sex hormones in an Eastern Han Chinese population. (PMID: 28193283) Xiong W … Feng Y (Journal of ovarian research 2017) 3 60
  4. Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis. (PMID: 28159509) Beltrami C … Emanueli C (Molecular therapy : the journal of the American Society of Gene Therapy 2017) 3 60
  5. MiR-23a inhibited IL-17-mediated proinflammatory mediators expression via targeting IKKα in articular chondrocytes. (PMID: 27936459) Hu J … Fan W (International immunopharmacology 2017) 3 60

Products for MIR23A Gene

Sources for MIR23A Gene

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