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Aliases for MIR23A Gene

Subcategory (RNA class) for MIR23A Gene

miRNA

Quality Score for this RNA gene is

14.2

Aliases for MIR23A Gene

  • MicroRNA 23a 2 3 5
  • Hsa-Mir-23a 3
  • MiRNA23A 3
  • Mir-23a 3
  • MIRN23A 3

External Ids for MIR23A Gene

Previous HGNC Symbols for MIR23A Gene

  • MIRN23A

Previous GeneCards Identifiers for MIR23A Gene

  • GC19M013847
  • GC19M013853
  • GC19M013950
  • GC19M013953
  • GC19M013958
  • GC19M013968
  • GC19M013862
  • GC19M013867
  • GC19M013872
  • GC19M013878

Summaries for MIR23A Gene

Entrez Gene Summary for MIR23A Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR23A Gene

MIR23A (MicroRNA 23a) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cardiomyocyte hypertrophy and MicroRNAs in cancer.

fRNAdb sequence ontologies for MIR23A Gene - the ORGUL cluster for this gene includes several descriptions:

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

  • pre_miRNA: The 60-70 nucleotide region remain after Drosha processing of the primary transcript, that folds back upon itself to form a hairpin sructure.

View fRNAdb secondary structures for MIR23A

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR23A Gene

Genomics for MIR23A Gene

Regulatory Elements for MIR23A Gene

Enhancers for MIR23A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F013793 1.2 ENCODE 12.6 +40.8 40812 5.5 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 MIR24-2 C19orf53 MRI1 MIR23A MIR27A ITGB1P1 FARSA ENSG00000267582 ZSWIM4
GH19F013787 0.9 ENCODE 12.6 +47.6 47599 4.0 FEZF1 ZNF48 ZNF121 SCRT2 SP5 CEBPB PPARG NR2F2 ZSCAN16 ETV4 C19orf53 MIR23A MIR24-2 MIR27A MRI1 MIR1199 ENSG00000280221
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR23A on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR23A Gene

Chromosome:
19
Start:
13,836,587 bp from pter
End:
13,836,659 bp from pter
Size:
73 bases
Orientation:
Minus strand

Genomic View for MIR23A Gene

Genes around MIR23A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR23A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR23A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR23A Gene

ORGUL Member Location for MIR23A Gene

ORGUL Member Location for MIR23A gene

Proteins for MIR23A Gene

Post-translational modifications for MIR23A Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR23A Gene

Domains & Families for MIR23A Gene

Gene Families for MIR23A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR23A: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR23A Gene

Function for MIR23A Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR23A Gene

Localization for MIR23A Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR23A Gene

Pathways & Interactions for MIR23A Gene

genes like me logo Genes that share pathways with MIR23A: view

Pathways by source for MIR23A Gene

2 BioSystems pathways for MIR23A Gene
1 KEGG pathway for MIR23A Gene

Interacting Proteins for MIR23A Gene

Gene Ontology (GO) - Biological Process for MIR23A Gene

None

No data available for SIGNOR curated interactions for MIR23A Gene

Transcripts for MIR23A Gene

fRNAdb Secondary structures for MIR23A Gene

  • AF480558

mRNA/cDNA for MIR23A Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR23A Gene

No ASD Table

Relevant External Links for MIR23A Gene

GeneLoc Exon Structure for
MIR23A
ECgene alternative splicing isoforms for
MIR23A

Expression for MIR23A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR23A Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR23A Gene:

MIR23A
genes like me logo Genes that share expression patterns with MIR23A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR23A Gene

Orthologs for MIR23A Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR23A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-23a 35
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-23a 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-23a 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir23a 35
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-23a 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-23a 35 35
  • 69 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia aca-mir-23a 35
  • 72 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-23a-3 35
  • 60 (a)
OneToMany
dre-mir-23a-1 35
  • 56 (a)
OneToMany
dre-mir-23a-4 35 35
  • 47 (a)
OneToMany
Species where no ortholog for MIR23A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR23A Gene

ENSEMBL:
Gene Tree for MIR23A (if available)
TreeFam:
Gene Tree for MIR23A (if available)

Paralogs for MIR23A Gene

No data available for Paralogs for MIR23A Gene

Variants for MIR23A Gene

Sequence variations from dbSNP and Humsavar for MIR23A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10422126 -- 13,837,498(+) CTCAC(A/G)CCTGT upstream-variant-2KB
rs10423627 -- 13,836,955(+) CCTCA(C/T)TGAGC upstream-variant-2KB
rs111251582 -- 13,837,836(+) AGGCT(A/G)GAGTG upstream-variant-2KB
rs114246707 -- 13,838,207(+) CACAG(A/T)GTCTG upstream-variant-2KB
rs115255566 -- 13,837,535(+) CAGGA(A/G)AGTCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR23A Gene

Variant ID Type Subtype PubMed ID
nsv833757 CNV loss 17160897
nsv953979 CNV deletion 24416366

Relevant External Links for MIR23A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR23A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR23A Gene

Disorders for MIR23A Gene

Relevant External Links for MIR23A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR23A

No disorders were found for MIR23A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR23A Gene

Publications for MIR23A Gene

  1. Methylation Status of SP1 Sites within miR-23a-27a-24-2 Promoter Region Influences Laryngeal Cancer Cell Proliferation and Apoptosis. (PMID: 27099864) Wang Y. … Fu W.N. (Biomed Res Int 2016) 3 64
  2. microRNA-23a inhibits osteogenic differentiation of human bone marrow-derived mesenchymal stem cells by targeting LRP5. (PMID: 26774446) Li T. … Weng X. (Int. J. Biochem. Cell Biol. 2016) 3 64
  3. Breast tissue-based microRNA panel highlights microRNA-23a and selected target genes as putative biomarkers for breast cancer. (PMID: 25445205) Eissa S. … Shehata H.H. (Transl Res 2015) 3 64
  4. MAPK and JAK/STAT pathways targeted by miR-23a and miR-23b in prostate cancer: computational and in vitro approaches. (PMID: 25604141) Aghaee-Bakhtiari S.H. … Soleimani M. (Tumour Biol. 2015) 3 64
  5. microRNAs: Modulators of the underlying pathophysiology of sarcopenia? (PMID: 26342566) Brown D.M. … Goljanek-Whysall K. (Ageing Res. Rev. 2015) 3 64

Products for MIR23A Gene

Sources for MIR23A Gene

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