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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MIR22HG Gene

RNA gene   GIFtS: 32
GCID: GC17M001618

MIR22 Host Gene (Non-Protein Coding)

(Previous name: chromosome 17 open reading frame 91)
(Previous symbol: C17orf91)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Subcategory (RNA class): lncRNA

Quality score for this RNA gene is 3

Aliases
MIR22 Host Gene (Non-Protein Coding)1 2
C17orf911 2 3
Chromosome 17 Open Reading Frame 911

External Ids:    HGNC: 282191   Entrez Gene: 849812   Ensembl: ENSG000001865947   UniProtKB: Q0VDD53   
ORGUL members:         
NONCODE14:n408295 n408292 n377677 n408293      

Export aliases for MIR22HG gene to outside databases

Previous GC identifer: GC17M001616


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MIR22HG Gene: 
MIR22HG (MIR22 host gene (non-protein coding)) is an RNA gene, and is affiliated with the lncRNA class. Diseases associated with MIR22HG include gastric cancer.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010718.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for MIR22HG
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for MIR22HG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR22HG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

MIR22HG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIR22HG gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M001618:  view genomic region     (about GC identifiers)

Start:
1,614,798 bp from pter      End:
1,620,468 bp from pter
Size:
5,671 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for MIR22HG

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CQ091_HUMAN, Q0VDD5 (See protein sequence)
Recommended Name: Putative uncharacterized protein encoded by MIR22HG  
Size: 57 amino acids; 6478 Da
Caution: Product of a dubious CDS prediction. May be a non-coding RNA
Secondary accessions: Q0VDD6

Explore the universe of human proteins at neXtProt for MIR22HG: NX_Q0VDD5

MIR22HG Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
LNCRNA: Long non-coding RNAs

ProtoNet protein and cluster: Q0VDD5


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MIR22HG

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MIR22HG (CQ091)

Search CenterWatch for drugs/clinical trials and news about MIR22HG

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MIR22HG gene (2 alternative transcripts): 
NM_001001870.1  NM_032895.2  

Unigene Cluster for MIR22HG:

MIR22 host gene (non-protein coding)
Hs.597755  [show with all ESTs]
Unigene Representative Sequence: BX648321
13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000334146(lincRNA)(uc002ftf.3) ENST00000574306(lincRNA)(uc002ftg.3 uc021tni.1 uc021tnj.1)
ENST00000576749(lincRNA) ENST00000570416(lincRNA) ENST00000571595(lincRNA) ENST00000571091(lincRNA) ENST00000573127(lincRNA)
ENST00000576489(lincRNA) ENST00000575626(lincRNA) ENST00000573075(lincRNA) ENST00000574016(lincRNA) ENST00000577164(lincRNA)
ENST00000362190(lincRNA)(uc021tnl.1)
miRNA
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Inhib. RNA
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Additional mRNA sequence: 

AF070569.1 BC007813.2 BC070225.1 BC119720.1 BC119721.1 BX640650.1 BX648321.1 NR_028502.1 
NR_028503.1 NR_028504.1 NR_028505.1 

7 DOTS entries:

DT.455644  DT.100776839  DT.100017602  DT.91826492  DT.120948548  DT.120948593  DT.97842858 

24/156 AceView cDNA sequences (see all 156):

BQ183272 BF589171 CA306554 BQ129198 AW804377 CR591309 AA565303 AI952239 
CA309715 AA434535 CR599859 AW103633 BE710283 AA443422 CA309565 BM126997 
BG482710 BQ030155 BQ029784 AW189498 BE710277 NM_032895 CR615473 AI344594 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for MIR22HG    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4
SP1:                                -     -         
SP2:                                                
SP3:                    -                           


ECgene alternative splicing isoforms for MIR22HG

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for MIR22HG:none

MIR22HG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTATGTGATT
MIR22HG Expression
About this image


Genevestigator expression for MIR22HG

SOURCE GeneReport for Unigene cluster: Hs.597755
    SABiosciences Custom PCR Arrays for MIR22HG
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for MIR22HG gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Mir22hg5 RIKEN cDNA 2210403K04 gene   --   11 (45.91 cM) 75461539 


ENSEMBL Gene Tree for MIR22HG (if available)
TreeFam Gene Tree for MIR22HG (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/16 SNPs in MIR22HG are shown (see all 16)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs617367121,2
C,F--1615755(+) GCTGGC/TTGCCC 4 -- nc-transcript-variantint12Minor allele frequency- T:0.02NS WA 196
rs1493448241,2
--1615830(+) GTGCTC/TTCCAG 4 -- nc-transcript-variantint10--------
rs1858317571,2
--1615882(+) CCTCAC/TCTCTG 4 -- nc-transcript-variantint10--------
rs592824801,2
C,F--1616017(+) TGAGTC/TTATCC 4 -- nc-transcript-variantint13Minor allele frequency- T:0.08WA NA EA 358
rs348535041,2
C,F,H--1616093(+) CCACGG/ATCTAC 4 -- nc-transcript-variantint118Minor allele frequency- A:0.23NS EA NA WA 2342
rs1875358171,2
--1616198(+) TAGCCA/GCTAGG 4 -- nc-transcript-variantint10--------
rs1927919661,2
--1616206(+) AGGTGA/CGAATG 4 -- nc-transcript-variantint10--------
rs1446966431,2
C--1616402(+) CCCACC/TAAGGG 4 -- nc-transcript-variantint10--------
rs1843802871,2
--1616411(+) GGGCTA/GCTGTC 4 -- nc-transcript-variantint10--------
rs620900131,2
C--1616498(+) TCCTCG/ACATTG 4 -- nc-transcript-variantint13Minor allele frequency- A:0.08NA EA 242

HapMap Linkage Disequilibrium report for MIR22HG (1614798 - 1620468 bp)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for MIR22HG:    About this table     
Variant IDTypeSubtypePubMed ID
dgv3033n71CNV Loss21882294
nsv907515CNV Loss21882294
nsv516886CNV Loss19592680
nsv907511CNV Loss21882294
nsv907502CNV Loss21882294
nsv470568CNV Loss18288195
nsv9490CNV Loss18304495
nsv827856CNV Gain20364138
nsv833335CNV Gain+Loss17160897

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for MIR22HG:    About MalaCards
gastric cancer    


MIR22HG for disorders           About GeneDecksing


Export disorders for MIR22HG gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for MIR22HG gene integrated from 9 sources:
(articles sorted by number of sources associating them with MIR22HG)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (1997)
  2. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (1996)
  3. Discovery and fine mapping of serum protein loci throu gh transethnic meta-analysis. (PubMed id 23022100)1 Franceschini N....Morris A.P. (2012)
  4. Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels. (PubMed id 20705733)1 O'Seaghdha C.M....KAPttgen A. (2010)
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  6. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 84981 HGNC: 28219 AceView: MGC14376 Ensembl:ENSG00000186594 euGenes: HUgn84981
ECgene: MIR22HG H-InvDB: MIR22HG

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for MIR22HG Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for MIR22HG gene:
Search GeneIP for patents involving MIR22HG

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.
 Search LifeMap BioReagents cell lines for MIR22HG
 Gene Synthesis
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIR22HG
 SwitchGear 3'UTR luciferase reporter plasmids for MIR22HG
 Browse SwitchGear Promoter luciferase reporter plasmids for MIR22HG
 Search ThermoFisher Antibodies for MIR22HG
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MIR22HG
 inGenious Targeting Laboratory - Custom generated mouse model solutions for MIR22HG
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MIR22HG
Customized:
 lentivirus for stable overexpression of MIR22HG
 lentivirus expression plasmids for stable overexpression of MIR22HG
 adenovirus for overexpression of MIR22HG
 Search LSBio for Antibodies for MIR22HG
Customized transgenic rodents for:
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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