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Aliases for MIR2278 Gene

Subcategory (RNA class) for MIR2278 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR2278 Gene

  • MicroRNA 2278 2 3 5
  • Hsa-Mir-2278 3
  • Mir-2278 3

External Ids for MIR2278 Gene

Previous GeneCards Identifiers for MIR2278 Gene

  • GC00U930250
  • GC09U901331
  • GC09P097572
  • GC09P067180

Summaries for MIR2278 Gene

Entrez Gene Summary for MIR2278 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR2278 Gene

MIR2278 (MicroRNA 2278) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR2278 Gene

Genomics for MIR2278 Gene

Regulatory Elements for MIR2278 Gene

Enhancers for MIR2278 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F094911 1.7 FANTOM5 Ensembl ENCODE 11.1 +110.8 110840 19.6 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF548 FOS DEK ZHX2 MIR2278 ENSG00000271155 LOC100132077 FBP1 ZNF169 FANCC C9orf3 LOC101928119 ENSG00000236095
GH09F094935 1.6 FANTOM5 Ensembl ENCODE 10.4 +127.4 127396 3.1 HDAC1 PKNOX1 ATF1 ARNT PTRF RARA ZNF335 RCOR1 FOS JUNB MIR2278 FBP1 LOC101928119 ENSG00000236095
GH09F094899 1.1 Ensembl ENCODE 12.3 +92.4 92391 5.7 TBP ZNF133 RAD21 RARA YY1 RCOR1 FOS CREM MIXL1 CEBPB MIR2278 FBP1 ZNF169 ENSG00000236095 LOC101928119
GH09F094906 1 Ensembl ENCODE 12.3 +98.6 98639 4.0 JUN ARID4B CHD1 NR3C1 ZNF644 ATF2 RARA SREBF1 JUND SMARCA4 MIR2278 LOC101928119 FBP1 FANCC ENSG00000236095
GH09F094885 1 Ensembl ENCODE 11.7 +76.0 75954 1.8 ELF3 SAP130 BHLHE40 TEAD4 RAD21 TEAD3 ARID1B ZNF316 JUND RCOR2 MIR2278 ENSG00000236095 ENSG00000230815
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR2278 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR2278 Gene

Chromosome:
9
Start:
94,809,962 bp from pter
End:
94,810,057 bp from pter
Size:
96 bases
Orientation:
Plus strand

Genomic View for MIR2278 Gene

Genes around MIR2278 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR2278 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR2278 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR2278 Gene

Proteins for MIR2278 Gene

Post-translational modifications for MIR2278 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR2278 Gene

Domains & Families for MIR2278 Gene

Gene Families for MIR2278 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR2278: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR2278 Gene

Function for MIR2278 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR2278 Gene

Localization for MIR2278 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR2278 Gene

Pathways & Interactions for MIR2278 Gene

SuperPathways for MIR2278 Gene

No Data Available

Interacting Proteins for MIR2278 Gene

Gene Ontology (GO) - Biological Process for MIR2278 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR2278 Gene

Transcripts for MIR2278 Gene

mRNA/cDNA for MIR2278 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR2278 Gene

No ASD Table

Relevant External Links for MIR2278 Gene

GeneLoc Exon Structure for
MIR2278
ECgene alternative splicing isoforms for
MIR2278

Expression for MIR2278 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR2278 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR2278 Gene:

MIR2278
genes like me logo Genes that share expression patterns with MIR2278: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR2278 Gene

Orthologs for MIR2278 Gene

Evolution for MIR2278 Gene

ENSEMBL:
Gene Tree for MIR2278 (if available)
TreeFam:
Gene Tree for MIR2278 (if available)

No data available for Orthologs for MIR2278 Gene

Paralogs for MIR2278 Gene

No data available for Paralogs for MIR2278 Gene

Variants for MIR2278 Gene

Sequence variations from dbSNP and Humsavar for MIR2278 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs113399680 -- 94,810,514(+) TTCAC(A/C)ATGTT intron-variant, downstream-variant-500B
rs113785239 -- 94,808,066(+) GAGAC(A/G)GAGTC intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs114082139 -- 94,808,150(+) CAGTT(A/C)TGCCT intron-variant, downstream-variant-500B, upstream-variant-2KB
rs115476220 -- 94,809,910(+) AGTGA(A/G)TTGAG intron-variant, upstream-variant-2KB
rs118121535 -- 94,810,114(+) AGAAA(A/G)CTCCC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR2278 Gene

Variant ID Type Subtype PubMed ID
nsv1147999 OTHER inversion 26484159
esv3621113 CNV gain 21293372

Relevant External Links for MIR2278 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR2278

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR2278 Gene

Disorders for MIR2278 Gene

Relevant External Links for MIR2278

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR2278

No disorders were found for MIR2278 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR2278 Gene

Publications for MIR2278 Gene

  1. Revealing genome-wide mRNA and microRNA expression patterns in leukemic cells highlighted "hsa-miR-2278" as a tumor suppressor for regain of chemotherapeutic imatinib response due to targeting STAT5A. (PMID: 25953263) Kaymaz B.T. … Can B.K. (Tumour Biol. 2015) 3 64
  2. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  3. Identification and analysis of miRNAs in human breast cancer and teratoma samples using deep sequencing. (PMID: 19508715) Nygaard S. … Litman T. (BMC Med Genomics 2009) 3 64
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64

Products for MIR2278 Gene

Sources for MIR2278 Gene

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