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Aliases for MIR2277 Gene

Subcategory (RNA class) for MIR2277 Gene

miRNA

Quality Score for this RNA gene is

8

Aliases for MIR2277 Gene

  • MicroRNA 2277 2 3 5
  • Hsa-Mir-2277 3
  • Mir-2277 3

External Ids for MIR2277 Gene

Previous GeneCards Identifiers for MIR2277 Gene

  • GC00U926188
  • GC05M092953

Summaries for MIR2277 Gene

Entrez Gene Summary for MIR2277 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR2277 Gene

MIR2277 (MicroRNA 2277) is an RNA Gene, and is affiliated with the miRNA class.

Additional gene information for MIR2277 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR2277 Gene

Genomics for MIR2277 Gene

Regulatory Elements for MIR2277 Gene

Enhancers for MIR2277 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H093571 2.1 Ensembl ENCODE dbSUPER 10.8 +47.0 46989 3 SUZ12 MAX HDAC2 MBD1 CTBP2 FOXP2 PRDM1 EZH2 MIR2277 NR2F1 PIR38533
GH05H093576 1.8 FANTOM5 ENCODE dbSUPER 11.7 +39.2 39173 10 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF302 NPM1P27 POU5F2 NR2F1-AS1 MIR2277 ENSG00000272406 FAM172A ENSG00000251023 NR2F1 PIR38533
GH05H093563 1.2 Ensembl ENCODE dbSUPER 11.2 +56.2 56200 2 ZNF362 JUN JUNB ZNF384 BATF RELA JUND POLR2A FOS ATF7 NR2F1-AS1 MIR2277 NR2F1 PIR38533
GH05H093586 1.1 Ensembl ENCODE dbSUPER 11.7 +32.5 32518 2 ZNF202 SUZ12 PRDM10 ZNF384 RUNX3 EZH2 NPM1P27 MIR2277 NR2F1-AS1 GC05P093594
GH05H093589 0.6 Ensembl dbSUPER 11.7 +30.8 30788 0 PRDM10 MIR2277 NR2F1-AS1 GC05P093594
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR2277 on UCSC Golden Path with GeneCards custom track

Promoters for MIR2277 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000184061 -412 1600 PKNOX1 ARID4B SIN3A FEZF1 ZNF2 GLIS2 ZNF143 KLF7 RUNX3 DEK

Genomic Location for MIR2277 Gene

Chromosome:
5
Start:
93,620,696 bp from pter
End:
93,620,788 bp from pter
Size:
93 bases
Orientation:
Minus strand

Genomic View for MIR2277 Gene

Genes around MIR2277 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR2277 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR2277 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR2277 Gene

ORGUL Member Location for MIR2277 Gene

ORGUL Member Location for MIR2277 gene

Proteins for MIR2277 Gene

Post-translational modifications for MIR2277 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR2277 Gene

Domains & Families for MIR2277 Gene

Gene Families for MIR2277 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR2277: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR2277 Gene

Function for MIR2277 Gene

Animal Model Products

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR2277
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR2277 Gene

Localization for MIR2277 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MIR2277 Gene

Pathways & Interactions for MIR2277 Gene

SuperPathways for MIR2277 Gene

No Data Available

Interacting Proteins for MIR2277 Gene

Gene Ontology (GO) - Biological Process for MIR2277 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR2277 Gene

Drugs & Compounds for MIR2277 Gene

No Compound Related Data Available

Transcripts for MIR2277 Gene

mRNA/cDNA for MIR2277 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Clone Products

  • Applied Biological Materials Clones for MIR2277
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MIR2277 Gene

No ASD Table

Relevant External Links for MIR2277 Gene

GeneLoc Exon Structure for
MIR2277
ECgene alternative splicing isoforms for
MIR2277

Expression for MIR2277 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR2277 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR2277 Gene:

MIR2277
genes like me logo Genes that share expression patterns with MIR2277: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR2277 Gene

Orthologs for MIR2277 Gene

Evolution for MIR2277 Gene

ENSEMBL:
Gene Tree for MIR2277 (if available)
TreeFam:
Gene Tree for MIR2277 (if available)

No data available for Orthologs for MIR2277 Gene

Paralogs for MIR2277 Gene

No data available for Paralogs for MIR2277 Gene

Variants for MIR2277 Gene

Sequence variations from dbSNP and Humsavar for MIR2277 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000264633 -- 93,621,621(+) CGTGC(A/G)GGATC intron-variant, upstream-variant-2KB
rs1000457580 -- 93,621,930(+) TTCAA(C/T)TTAGA intron-variant, upstream-variant-2KB
rs1001478271 -- 93,622,248(+) TGAAA(A/T)CTCTT intron-variant, upstream-variant-2KB
rs1001663668 -- 93,621,541(+) GGCGG(G/T)AAGGG intron-variant, upstream-variant-2KB
rs1002096241 -- 93,621,190(+) AGGGC(A/G)GCGAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR2277 Gene

Variant ID Type Subtype PubMed ID
dgv954n67 CNV gain 20364138
nsv830404 CNV loss 17160897

Relevant External Links for MIR2277 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR2277

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR2277 Gene

Disorders for MIR2277 Gene

Relevant External Links for MIR2277

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR2277

No disorders were found for MIR2277 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR2277 Gene

Publications for MIR2277 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A … Griffiths-Jones S (Nucleic acids research 2011) 3 60
  2. Discovery of novel microRNAs in female reproductive tract using next generation sequencing. (PMID: 20224791) Creighton CJ … Gunaratne PH (PloS one 2010) 3 60
  3. Identification and analysis of miRNAs in human breast cancer and teratoma samples using deep sequencing. (PMID: 19508715) Nygaard S … Litman T (BMC medical genomics 2009) 3 60
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S … Enright AJ (Nucleic acids research 2006) 3 60

Products for MIR2277 Gene

Sources for MIR2277 Gene

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