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Aliases for MIR2277 Gene

Subcategory (RNA class) for MIR2277 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR2277 Gene

  • MicroRNA 2277 2 3
  • FAM172A 4 5
  • Family With Sequence Similarity 172 Member A 5
  • Hsa-Mir-2277 3
  • Mir-2277 3
  • C5orf21 4

External Ids for MIR2277 Gene

Previous GeneCards Identifiers for MIR2277 Gene

  • GC00U926188
  • GC05M092953

Summaries for MIR2277 Gene

Entrez Gene Summary for MIR2277 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR2277 Gene

MIR2277 (MicroRNA 2277) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR2277 Gene

Genomics for MIR2277 Gene

Regulatory Elements for MIR2277 Gene

Enhancers for MIR2277 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F093597 1.3 FANTOM5 Ensembl ENCODE 11.7 +510.6 510634 7.2 PKNOX1 FEZF1 GLIS2 KLF7 ZNF263 SP3 TSHZ1 ZNF488 REST ZNF623 ENSG00000272406 POU5F2 NPM1P27 MIR2277 NR2F1 ENSG00000278905
GH05F093591 0.4 Ensembl 11.5 +519.8 519799 0.2 ATF1 MLX ARID4B DMAP1 ZNF48 FOS JUNB MIER2 PPARG KAT8 MIR2277 GC05P093594 NR2F1-AS1
GH05F093586 0.9 Ensembl ENCODE 11.5 +523.0 523031 3.5 ZNF202 RNF2 SUZ12 CBX2 ZNF384 ZIC2 RAD21 ZKSCAN1 CBX8 PRDM10 NPM1P27 MIR2277 NR2F1-AS1 GC05P093594
GH05F093592 0.2 Ensembl 11.5 +520.2 520199 0.2 PKNOX1 ATF1 ARID4B DMAP1 ZNF48 RARA GATA4 MIXL1 HMG20B MIER2 MIR2277 GC05P093594 NR2F1-AS1
GH05F093576 1 FANTOM5 ENCODE 11.5 +530.1 530084 10.1 PKNOX1 MLX ARID4B SIN3A FEZF1 ZNF2 ZNF302 ZNF416 ZNF143 ZNF548 NPM1P27 ENSG00000272406 POU5F2 MIR2277 NR2F1-AS1 ENSG00000251023 NR2F1 PIR38533
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR2277 on UCSC Golden Path with GeneCards custom track

Promoters for MIR2277 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001411869 399 2201 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 ZNF143 KLF13 ZNF263

Genomic Location for MIR2277 Gene

Chromosome:
5
Start:
93,618,069 bp from pter
End:
94,111,699 bp from pter
Size:
493,631 bases
Orientation:
Minus strand

Genomic View for MIR2277 Gene

Genes around MIR2277 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR2277 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR2277 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR2277 Gene

Proteins for MIR2277 Gene

  • Protein details for MIR2277 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUF8-F172A_HUMAN
    Recommended name:
    Protein FAM172A
    Protein Accession:
    Q8WUF8
    Secondary Accessions:
    • B2R7C6
    • B4DJ14
    • B4DLG5
    • Q9H0U8

    Protein attributes for MIR2277 Gene

    Size:
    416 amino acids
    Molecular mass:
    47972 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MIR2277 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR2277 Gene

Post-translational modifications for MIR2277 Gene

  • Ubiquitination at Lys 35 and Lys 333
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR2277 Gene

No data available for DME Specific Peptides for MIR2277 Gene

Domains & Families for MIR2277 Gene

Gene Families for MIR2277 Gene

Protein Domains for MIR2277 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8WUF8

UniProtKB/Swiss-Prot:

F172A_HUMAN :
  • Belongs to the UPF0528 family.
Family:
  • Belongs to the UPF0528 family.
genes like me logo Genes that share domains with MIR2277: view

No data available for Suggested Antigen Peptide Sequences for MIR2277 Gene

Function for MIR2277 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR2277 Gene

Localization for MIR2277 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR2277 Gene

Gene Ontology (GO) - Cellular Components for MIR2277 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
genes like me logo Genes that share ontologies with MIR2277: view

No data available for Subcellular locations from COMPARTMENTS for MIR2277 Gene

Pathways & Interactions for MIR2277 Gene

SuperPathways for MIR2277 Gene

No Data Available

Interacting Proteins for MIR2277 Gene

Gene Ontology (GO) - Biological Process for MIR2277 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR2277 Gene

Transcripts for MIR2277 Gene

mRNA/cDNA for MIR2277 Gene

(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR2277 Gene

No ASD Table

Relevant External Links for MIR2277 Gene

GeneLoc Exon Structure for
MIR2277
ECgene alternative splicing isoforms for
MIR2277

Expression for MIR2277 Gene

mRNA expression in normal human tissues for MIR2277 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR2277 Gene:

MIR2277
genes like me logo Genes that share expression patterns with MIR2277: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR2277 Gene

Orthologs for MIR2277 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR2277 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM172A 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FAM172A 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fam172a 35
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FAM172A 35
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM172A 35
  • 88 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FAM172A 35
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM172A 35
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM172A 35
  • 86 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fam172a 35
  • 73 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10038 35
  • 37 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y75B8A.31 35
  • 34 (a)
OneToOne
Species where no ortholog for MIR2277 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR2277 Gene

ENSEMBL:
Gene Tree for MIR2277 (if available)
TreeFam:
Gene Tree for MIR2277 (if available)

Paralogs for MIR2277 Gene

Pseudogenes.org Pseudogenes for MIR2277 Gene

genes like me logo Genes that share paralogs with MIR2277: view

No data available for Paralogs for MIR2277 Gene

Variants for MIR2277 Gene

Sequence variations from dbSNP and Humsavar for MIR2277 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs111409602 -- 93,620,703(+) GCTTC(A/G)CCGGC nc-transcript-variant, utr-variant-3-prime
rs113403066 -- 93,620,924(+) ACACA(-/CA)AGCAG nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs113720721 -- 93,620,921(+) TCGAC(-/G/GAC)ACAAG nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs114209248 -- 93,620,446(+) AAATC(A/G)GCTTT nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs115622747 -- 93,622,620(+) TTCTC(G/T)CTATC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR2277 Gene

Variant ID Type Subtype PubMed ID
dgv954n67 CNV gain 20364138
nsv830404 CNV loss 17160897

Relevant External Links for MIR2277 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR2277

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR2277 Gene

Disorders for MIR2277 Gene

Relevant External Links for MIR2277

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR2277

No disorders were found for MIR2277 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR2277 Gene

Publications for MIR2277 Gene

  1. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  2. Discovery of novel microRNAs in female reproductive tract using next generation sequencing. (PMID: 20224791) Creighton C.J. … Gunaratne P.H. (PLoS ONE 2010) 3 64
  3. Identification and analysis of miRNAs in human breast cancer and teratoma samples using deep sequencing. (PMID: 19508715) Nygaard S. … Litman T. (BMC Med Genomics 2009) 3 64
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for MIR2277 Gene

Sources for MIR2277 Gene

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