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Aliases for MIR224 Gene

Subcategory (RNA class) for MIR224 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR224 Gene

  • MicroRNA 224 2 3
  • GABRE 4 5
  • Gamma-Aminobutyric Acid Type A Receptor Epsilon Subunit 5
  • GABA(A) Receptor Subunit Epsilon 4
  • Hsa-Mir-224 3
  • MiRNA224 3
  • MIRN224 3

External Ids for MIR224 Gene

Previous HGNC Symbols for MIR224 Gene

  • MIRN224

Previous GeneCards Identifiers for MIR224 Gene

  • GC0XM150877
  • GC0XM151127

Summaries for MIR224 Gene

Entrez Gene Summary for MIR224 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR224 Gene

MIR224 (MicroRNA 224) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer. An important paralog of this gene is GABRG3.

UniProtKB/Swiss-Prot for MIR224 Gene

  • GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR224 Gene

Genomics for MIR224 Gene

Regulatory Elements for MIR224 Gene

Enhancers for MIR224 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF151971 0.7 ENCODE 0.8 +0.9 857 4.2 TBP RFX5 SCRT2 CREM MCM3 SP3 MIER1 SMAD5 SMARCB1 POLR2H GABRE ZNF185 MIR452 MIR224 GC0XM151964
GH0XF151970 0.2 ENCODE 0.8 +3.7 3730 1.6 ELF3 ARID4B RAD21 RARA RFX5 RCOR1 CREM THAP11 HMG20B MCM3 MIR452 MIR224 GC0XM151964
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR224 on UCSC Golden Path with GeneCards custom track

Promoters for MIR224 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000261864 880 3201 TBP RFX5 SCRT2 SP3 MIER1 SMAD5 SMARCB1 POLR2H TFDP1 KLF16

Genomic Location for MIR224 Gene

Chromosome:
X
Start:
151,953,124 bp from pter
End:
151,974,680 bp from pter
Size:
21,557 bases
Orientation:
Minus strand

Genomic View for MIR224 Gene

Genes around MIR224 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR224 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR224 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR224 Gene

Proteins for MIR224 Gene

  • Protein details for MIR224 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P78334-GBRE_HUMAN
    Recommended name:
    Gamma-aminobutyric acid receptor subunit epsilon
    Protein Accession:
    P78334
    Secondary Accessions:
    • E7ET93
    • O15345
    • O15346
    • Q6PCD2
    • Q99520

    Protein attributes for MIR224 Gene

    Size:
    506 amino acids
    Molecular mass:
    57972 Da
    Quaternary structure:
    • Generally pentameric. Associates with alpha and beta subunits.
    • Generally pentameric. Associates with alpha and beta subunits.
    • Generally pentameric. Associates with alpha and beta subunits.

    Alternative splice isoforms for MIR224 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MIR224 Gene

Post-translational modifications for MIR224 Gene

  • Glycosylation at Asn 134 and Asn 252
  • Modification sites at PhosphoSitePlus

Other Protein References for MIR224 Gene

No data available for DME Specific Peptides for MIR224 Gene

Domains & Families for MIR224 Gene

Gene Families for MIR224 Gene

Graphical View of Domain Structure for InterPro Entry

P78334

UniProtKB/Swiss-Prot:

GBRE_HUMAN :
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRE sub-subfamily.
Family:
  • Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRE sub-subfamily.
genes like me logo Genes that share domains with MIR224: view

No data available for Suggested Antigen Peptide Sequences for MIR224 Gene

Function for MIR224 Gene

Molecular function for MIR224 Gene

UniProtKB/Swiss-Prot Function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Gene Ontology (GO) - Molecular Function for MIR224 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005230 extracellular ligand-gated ion channel activity IEA --
GO:0005254 chloride channel activity IEA --
GO:0022851 GABA-gated chloride ion channel activity IDA --
genes like me logo Genes that share ontologies with MIR224: view

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR224 Gene

Localization for MIR224 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MIR224 Gene

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for MIR224 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
GO:0034707 chloride channel complex IEA --
genes like me logo Genes that share ontologies with MIR224: view

No data available for Subcellular locations from COMPARTMENTS for MIR224 Gene

Pathways & Interactions for MIR224 Gene

SuperPathways for MIR224 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR224: view

Pathways by source for MIR224 Gene

1 KEGG pathway for MIR224 Gene

Gene Ontology (GO) - Biological Process for MIR224 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006821 chloride transport IEA --
GO:0007165 signal transduction IEA --
GO:0034220 ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with MIR224: view

No data available for SIGNOR curated interactions for MIR224 Gene

Transcripts for MIR224 Gene

mRNA/cDNA for MIR224 Gene

(14) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR224 Gene

No ASD Table

Relevant External Links for MIR224 Gene

GeneLoc Exon Structure for
MIR224
ECgene alternative splicing isoforms for
MIR224

Expression for MIR224 Gene

mRNA expression in normal human tissues for MIR224 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR224 Gene:

MIR224

mRNA Expression by UniProt/SwissProt for MIR224 Gene:

P78334-GBRE_HUMAN
Tissue specificity: Expressed in many tissues. Highest levels of expression in adult heart and placenta.
genes like me logo Genes that share expression patterns with MIR224: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MIR224 Gene

Orthologs for MIR224 Gene

This gene was present in the common ancestor of animals.

Orthologs for MIR224 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GABRE 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GABRE 35
  • 79 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GABRE 35
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 54 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 47 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gabre 35
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves GABRG4 35
  • 48 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 45 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CABZ01113152.1 35
  • 20 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8916 35
  • 24 (a)
ManyToMany
Grd 35
  • 22 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea lgc-37 35
  • 29 (a)
ManyToMany
lgc-36 35
  • 22 (a)
ManyToMany
Species where no ortholog for MIR224 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MIR224 Gene

ENSEMBL:
Gene Tree for MIR224 (if available)
TreeFam:
Gene Tree for MIR224 (if available)

Paralogs for MIR224 Gene

Paralogs for MIR224 Gene

genes like me logo Genes that share paralogs with MIR224: view

Variants for MIR224 Gene

Sequence variations from dbSNP and Humsavar for MIR224 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs112308208 -- 151,958,907(+) CTTTC(C/T)CTCAT intron-variant, upstream-variant-2KB
rs112761881 -- 151,958,990(+) TCTCA(C/T)GACAA intron-variant, upstream-variant-2KB
rs138020133 -- 151,959,927(+) ATTTC(A/C)AGCTT upstream-variant-2KB, reference, synonymous-codon
rs141042152 -- 151,958,886(+) CTCTA(A/G)CCACA intron-variant, upstream-variant-2KB
rs142862047 -- 151,958,217(+) AGCCA(C/T)CAGTG intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR224 Gene

Variant ID Type Subtype PubMed ID
nsv510867 CNV deletion 20534489

Relevant External Links for MIR224 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR224

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR224 Gene

Disorders for MIR224 Gene

Relevant External Links for MIR224

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR224

No disorders were found for MIR224 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR224 Gene

Publications for MIR224 Gene

  1. MicroRNA-224 sustains Wnt/I^-catenin signaling and promotes aggressive phenotype of colorectal cancer. (PMID: 26822534) Li T. … Liao W. (J. Exp. Clin. Cancer Res. 2016) 3 64
  2. Fecal miR-29a and miR-224 as the noninvasive biomarkers for colorectal cancer. (PMID: 26756616) Zhu Y. … Sun J. (Cancer Biomark 2016) 3 64
  3. Increased fucosylation has a pivotal role in multidrug resistance of breast cancer cells through miR-224-3p targeting FUT4. (PMID: 26701615) Feng X. … Jia L. (Gene 2016) 3 64
  4. Dysregulated microRNA-224/apelin axis associated with aggressive progression and poor prognosis in patients with prostate cancer. (PMID: 25532941) Wan Y. … Zhong W.D. (Hum. Pathol. 2015) 3 64
  5. MicroRNA-224 targets ERG2 and contributes to malignant progressions of meningioma. (PMID: 25783051) Wang M. … Liang C. (Biochem. Biophys. Res. Commun. 2015) 3 64

Products for MIR224 Gene

Sources for MIR224 Gene

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