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Aliases for MIR224 Gene

Subcategory (RNA class) for MIR224 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR224 Gene

  • MicroRNA 224 2 3 5
  • Hsa-Mir-224 3
  • MiRNA224 3
  • MIRN224 3

External Ids for MIR224 Gene

Previous HGNC Symbols for MIR224 Gene

  • MIRN224

Previous GeneCards Identifiers for MIR224 Gene

  • GC0XM150877
  • GC0XM151127

Summaries for MIR224 Gene

Entrez Gene Summary for MIR224 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR224 Gene

MIR224 (MicroRNA 224) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR224 Gene

Genomics for MIR224 Gene

Genomic Location for MIR224 Gene

Chromosome:
X
Start:
151,958,578 bp from pter
End:
151,958,658 bp from pter
Size:
81 bases
Orientation:
Minus strand

Genomic View for MIR224 Gene

Genes around MIR224 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR224 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR224 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR224 Gene

No data available for Regulatory Elements for MIR224 Gene

Proteins for MIR224 Gene

Post-translational modifications for MIR224 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR224 Gene

Domains & Families for MIR224 Gene

Gene Families for MIR224 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR224: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR224 Gene

Function for MIR224 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR224 Gene

Localization for MIR224 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR224 Gene

Pathways & Interactions for MIR224 Gene

SuperPathways for MIR224 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR224: view

Pathways by source for MIR224 Gene

1 KEGG pathway for MIR224 Gene

Interacting Proteins for MIR224 Gene

Gene Ontology (GO) - Biological Process for MIR224 Gene

None

No data available for SIGNOR curated interactions for MIR224 Gene

Drugs & Compounds for MIR224 Gene

No Compound Related Data Available

Transcripts for MIR224 Gene

mRNA/cDNA for MIR224 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR224 Gene

No ASD Table

Relevant External Links for MIR224 Gene

GeneLoc Exon Structure for
MIR224
ECgene alternative splicing isoforms for
MIR224

Expression for MIR224 Gene

mRNA expression in normal human tissues for MIR224 Gene

genes like me logo Genes that share expression patterns with MIR224: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR224 Gene

Orthologs for MIR224 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MIR224 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-224 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-224 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir224 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-224 36
  • 100 (a)
OneToOne
Species with no ortholog for MIR224:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MIR224 Gene

ENSEMBL:
Gene Tree for MIR224 (if available)
TreeFam:
Gene Tree for MIR224 (if available)

Paralogs for MIR224 Gene

No data available for Paralogs for MIR224 Gene

Variants for MIR224 Gene

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Relevant External Links for MIR224 Gene

Disorders for MIR224 Gene

Relevant External Links for MIR224

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR224

No disorders were found for MIR224 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR224 Gene

Publications for MIR224 Gene

  1. MicroRNA-224 promotes tumor progression in nonsmall cell lung cancer. (PMID: 26187928) Cui R. … Croce C.M. (Proc. Natl. Acad. Sci. U.S.A. 2015) 3 67
  2. miR-224 overexpression is a strong and independent prognosticator of short-term relapse and poor overall survival in colorectal adenocarcinoma. (PMID: 25420464) Adamopoulos P.G. … Scorilas A. (Int. J. Oncol. 2015) 3
  3. Dysregulated microRNA-224/apelin axis associated with aggressive progression and poor prognosis in patients with prostate cancer. (PMID: 25532941) Wan Y. … Zhong W.D. (Hum. Pathol. 2015) 3
  4. MicroRNA-224 targets ERG2 and contributes to malignant progressions of meningioma. (PMID: 25783051) Wang M. … Liang C. (Biochem. Biophys. Res. Commun. 2015) 3
  5. Uncovering the clinical utility of miR-143, miR-145 and miR-224 for predicting the survival of bladder cancer patients following treatment. (PMID: 25804644) Avgeris M. … Scorilas A. (Carcinogenesis 2015) 3

Products for MIR224 Gene

Sources for MIR224 Gene

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