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Aliases for MIR224 Gene

Subcategory (RNA class) for MIR224 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR224 Gene

  • MicroRNA 224 2 3 5
  • Hsa-Mir-224 3
  • MiRNA224 3
  • MIRN224 3

External Ids for MIR224 Gene

Previous HGNC Symbols for MIR224 Gene

  • MIRN224

Previous GeneCards Identifiers for MIR224 Gene

  • GC0XM150877
  • GC0XM151127

Summaries for MIR224 Gene

Entrez Gene Summary for MIR224 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR224 Gene

MIR224 (MicroRNA 224) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR224 Gene

Genomics for MIR224 Gene

Regulatory Elements for MIR224 Gene

Enhancers for MIR224 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG151981 1.2 Ensembl ENCODE 12.4 -25.6 -25643 6.4 FOXA2 ZNF766 GATA2 FOS REST ZNF592 MBD2 SMARCA4 PBX2 ETV4 MIR224 MAGEA4 LOC105373368 GABRE GC0XM152046
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR224 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR224 Gene

Chromosome:
X
Start:
151,958,578 bp from pter
End:
151,958,658 bp from pter
Size:
81 bases
Orientation:
Minus strand

Genomic View for MIR224 Gene

Genes around MIR224 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR224 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR224 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR224 Gene

Proteins for MIR224 Gene

Post-translational modifications for MIR224 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR224 Gene

Domains & Families for MIR224 Gene

Gene Families for MIR224 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR224: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR224 Gene

Function for MIR224 Gene

Animal Model Products

miRNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR224 Gene

Localization for MIR224 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR224 Gene

Pathways & Interactions for MIR224 Gene

SuperPathways for MIR224 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR224: view

Pathways by source for MIR224 Gene

1 KEGG pathway for MIR224 Gene

Interacting Proteins for MIR224 Gene

Gene Ontology (GO) - Biological Process for MIR224 Gene

None

No data available for SIGNOR curated interactions for MIR224 Gene

Drugs & Compounds for MIR224 Gene

No Compound Related Data Available

Transcripts for MIR224 Gene

mRNA/cDNA for MIR224 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR224 Gene

No ASD Table

Relevant External Links for MIR224 Gene

GeneLoc Exon Structure for
MIR224
ECgene alternative splicing isoforms for
MIR224

Expression for MIR224 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR224 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR224 Gene:

MIR224
genes like me logo Genes that share expression patterns with MIR224: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR224 Gene

Orthologs for MIR224 Gene

Evolution for MIR224 Gene

ENSEMBL:
Gene Tree for MIR224 (if available)
TreeFam:
Gene Tree for MIR224 (if available)

No data available for Orthologs for MIR224 Gene

Paralogs for MIR224 Gene

No data available for Paralogs for MIR224 Gene

Variants for MIR224 Gene

Sequence variations from dbSNP and Humsavar for MIR224 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1002349623 -- 151,958,984(+) GATGC(C/T)TCTCA intron-variant, upstream-variant-2KB
rs1002401779 -- 151,958,398(+) CCCAA(A/C)TGGAA intron-variant, downstream-variant-500B
rs1006712303 -- 151,958,081(+) GTGGA(A/G)CTTCC intron-variant, downstream-variant-500B
rs1010099404 -- 151,960,635(+) CCTAG(A/G)TGACC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1012489166 -- 151,959,304(+) AATCT(G/T)TGCTT intron-variant, downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR224 Gene

Variant ID Type Subtype PubMed ID
nsv510867 CNV deletion 20534489

Relevant External Links for MIR224 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR224

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR224 Gene

Disorders for MIR224 Gene

Relevant External Links for MIR224

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR224

No disorders were found for MIR224 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR224 Gene

Publications for MIR224 Gene

  1. Long non-coding RNA FTH1P3 facilitates oral squamous cell carcinoma progression by acting as a molecular sponge of miR-224-5p to modulate fizzled 5 expression. (PMID: 28093311) Zhang C.Z. (Gene 2017) 3 64
  2. Prognostic Significance of MiRNA in Patients with Diffuse Large B-Cell Lymphoma: a Meta-Analysis. (PMID: 27771712) Zheng Z. … Jiang J. (Cell. Physiol. Biochem. 2016) 3 64
  3. MicroRNA-224 aggrevates tumor growth and progression by targeting mTOR in gastric cancer. (PMID: 27315344) Zhang Y. … Zhang B. (Int. J. Oncol. 2016) 3 64
  4. The MicroRNA-224 Inhibitor Prevents Neuronal Apoptosis via Targeting Spastic Paraplegia 7 After Cerebral Ischemia. (PMID: 27165196) Fu F. … Qian C. (J. Mol. Neurosci. 2016) 3 64
  5. MicroRNA-224 sustains Wnt/I^-catenin signaling and promotes aggressive phenotype of colorectal cancer. (PMID: 26822534) Li T. … Liao W. (J. Exp. Clin. Cancer Res. 2016) 3 64

Products for MIR224 Gene

Sources for MIR224 Gene

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