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Aliases for MIR223 Gene

Subcategory (RNA class) for MIR223 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR223 Gene

  • MicroRNA 223 2 3 5
  • Hsa-Mir-223 3
  • MiRNA223 3
  • Mir-223 3
  • MIRN223 3

External Ids for MIR223 Gene

Previous HGNC Symbols for MIR223 Gene

  • MIRN223

Previous GeneCards Identifiers for MIR223 Gene

  • GC0XP065156
  • GC0XP065238

Summaries for MIR223 Gene

Entrez Gene Summary for MIR223 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR223 Gene

MIR223 (MicroRNA 223) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR223 Gene

Genomics for MIR223 Gene

Regulatory Elements for MIR223 Gene

Enhancers for MIR223 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF065985 1.2 FANTOM5 Ensembl ENCODE 13.2 -28.3 -28312 2.9 CTCF RFX1 PKNOX1 ZNF654 MTA2 WRNIP1 ETV1 MAX TRIM22 REST MIR223 MSN ENSG00000237311 LOC100288788
GH0XF066045 1.2 FANTOM5 Ensembl ENCODE 13 +31.5 31507 2.9 PKNOX1 CBX3 TBL1XR1 BMI1 EGR1 CBX5 ETV6 RCOR1 CREM CBFB MIR223 MSN VSIG4 LOC392485
GH0XF066049 0.2 Ensembl 13 +35.0 35028 1.0 ZNF175 HMBOX1 CEBPB MIR223 LOC392485 VSIG4
GH0XF065990 0.7 Ensembl 12.9 -24.6 -24561 0.2 NCOR1 IKZF1 KDM1A MIR223 ENSG00000237311 LOC100288788
GH0XF065719 1.2 Ensembl ENCODE 12.2 -293.5 -293495 5.6 HDGF ATF1 TBL1XR1 INSM2 FEZF1 YY1 ETV6 CREM ZNF280D JUNB MIR223 LOC100288788 GC0XM065725 GC0XM065726 GC0XM065596
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR223 on UCSC Golden Path with GeneCards custom track

Promoters for MIR223 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001917457 1239 2601 ATF1 ARNT ELK1 GATA2 KDM4B JUNB NCOA1 MBD2 SMARCA4 NBN

Genomic Location for MIR223 Gene

Chromosome:
X
Start:
66,015,461 bp from pter
End:
66,020,422 bp from pter
Size:
4,962 bases
Orientation:
Plus strand

Genomic View for MIR223 Gene

Genes around MIR223 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR223 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR223 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR223 Gene

Proteins for MIR223 Gene

Post-translational modifications for MIR223 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR223 Gene

Domains & Families for MIR223 Gene

Gene Families for MIR223 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR223: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR223 Gene

Function for MIR223 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR223 Gene

Localization for MIR223 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR223 Gene

Pathways & Interactions for MIR223 Gene

SuperPathways for MIR223 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR223: view

Pathways by source for MIR223 Gene

1 KEGG pathway for MIR223 Gene

Interacting Proteins for MIR223 Gene

Gene Ontology (GO) - Biological Process for MIR223 Gene

None

No data available for SIGNOR curated interactions for MIR223 Gene

Transcripts for MIR223 Gene

mRNA/cDNA for MIR223 Gene

(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR223 Gene

No ASD Table

Relevant External Links for MIR223 Gene

GeneLoc Exon Structure for
MIR223
ECgene alternative splicing isoforms for
MIR223

Expression for MIR223 Gene

mRNA expression in normal human tissues for MIR223 Gene

mRNA differential expression in normal tissues according to GTEx for MIR223 Gene

This gene is overexpressed in Whole Blood (x49.2).

NURSA nuclear receptor signaling pathways regulating expression of MIR223 Gene:

MIR223
genes like me logo Genes that share expression patterns with MIR223: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR223 Gene

Orthologs for MIR223 Gene

Evolution for MIR223 Gene

ENSEMBL:
Gene Tree for MIR223 (if available)
TreeFam:
Gene Tree for MIR223 (if available)

No data available for Orthologs for MIR223 Gene

Paralogs for MIR223 Gene

No data available for Paralogs for MIR223 Gene

Variants for MIR223 Gene

Sequence variations from dbSNP and Humsavar for MIR223 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs10552143 -- 66,019,418(+) TCCAC(-/AT)GTCTT downstream-variant-500B
rs111394789 -- 66,018,272(+) GCATT(A/T)TCTCC upstream-variant-2KB
rs111776283 -- 66,018,265(+) TTTAC(A/C)TGCAT upstream-variant-2KB
rs139641330 -- 66,016,962(+) ACACC(A/T)CCAGC upstream-variant-2KB
rs139894104 -- 66,017,985(+) ATAAA(C/G)TTTAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR223 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER inversion 17803354
esv3576919 CNV gain 25503493
nsv6933 CNV insertion 18451855

Relevant External Links for MIR223 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR223

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR223 Gene

Disorders for MIR223 Gene

Relevant External Links for MIR223

Genetic Association Database (GAD)
MIR223
Human Genome Epidemiology (HuGE) Navigator
MIR223
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR223

No disorders were found for MIR223 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR223 Gene

Publications for MIR223 Gene

  1. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J. … Zhao H. (Int. J. Cancer 2009) 3 46 64
  2. MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1. (PMID: 18555017) Wong Q.W. … Wong N. (Gastroenterology 2008) 3 22 64
  3. Circulating MicroRNA223 is a New Biomarker for Inflammatory Bowel Disease. (PMID: 26844512) Wang H. … Chen M. (Medicine (Baltimore) 2016) 3 64
  4. miR-223 reverses the resistance of EGFR-TKIs through IGF1R/PI3K/Akt signaling pathway. (PMID: 26936292) Han J. … Chen Z. (Int. J. Oncol. 2016) 3 64
  5. Association of tumor and plasma microRNA expression with tumor monosomy-3 in patients with uveal melanoma. (PMID: 27453764) Triozzi P.L. … Singh A.D. (Clin Epigenetics 2016) 3 64

Products for MIR223 Gene

Sources for MIR223 Gene

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