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Aliases for MIR223 Gene

Subcategory (RNA class) for MIR223 Gene


Quality Score for this RNA gene is


Aliases for MIR223 Gene

  • MicroRNA 223 2 3
  • MIRN223 3 6
  • Hsa-Mir-223 3
  • MiRNA223 3
  • Mir-223 3

External Ids for MIR223 Gene

ORGUL Members for MIR223 Gene

Previous HGNC Symbols for MIR223 Gene

  • MIRN223

Previous GeneCards Identifiers for MIR223 Gene

  • GC0XP065156
  • GC0XP065238

Summaries for MIR223 Gene

Entrez Gene Summary for MIR223 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR223 Gene

MIR223 (MicroRNA 223) is an RNA Gene, and is affiliated with the undefined RNA class. Diseases associated with MIR223 include b-cell lymphomas and diffuse large b-cell lymphoma. Among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR223 Gene

Genomics for MIR223 Gene

Genomic Location for MIR223 Gene

66,018,870 bp from pter
66,018,979 bp from pter
110 bases
Plus strand

Genomic View for MIR223 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR223 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR223 Gene

No data available for Regulatory Elements for MIR223 Gene

Proteins for MIR223 Gene

Post-translational modifications for MIR223 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR223 Gene

Domains for MIR223 Gene

Gene Families for MIR223 Gene

  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR223: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR223 Gene

Function for MIR223 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR223 Gene

Localization for MIR223 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR223 Gene

Pathways for MIR223 Gene

genes like me logo Genes that share pathways with MIR223: view

Pathways by source for MIR223 Gene

1 BioSystems pathway for MIR223 Gene
1 KEGG pathway for MIR223 Gene

Interacting Proteins for MIR223 Gene

Gene Ontology (GO) - Biological Process for MIR223 Gene


Transcripts for MIR223 Gene

mRNA/cDNA for MIR223 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIR223

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR223 Gene

No ASD Table

Relevant External Links for MIR223 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR223 Gene

mRNA expression in normal human tissues for MIR223 Gene

mRNA differential expression in normal tissues according to GTEx for MIR223 Gene

This gene is overexpressed in Whole Blood (49.2).
genes like me logo Genes that share expressions with MIR223: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for MIR223 Gene

Orthologs for MIR223 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR223 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia bta-mir-223 36
  • 93 (a)
(Canis familiaris)
Mammalia cfa-mir-223 36
  • 97 (a)
(Monodelphis domestica)
Mammalia mdo-mir-223 36
  • 86 (a)
(Mus musculus)
Mammalia Mir223 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 75 (a)
oan-mir-223 36
  • 73 (a)
(Pan troglodytes)
Mammalia ptr-mir-223 36
  • 100 (a)
(Gallus gallus)
Aves gga-mir-223 36
  • 87 (a)
(Danio rerio)
Actinopterygii dre-mir-223 36
  • 62 (a)
Species with no ortholog for MIR223:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR223 Gene

Gene Tree for MIR223 (if available)
Gene Tree for MIR223 (if available)

Paralogs for MIR223 Gene

No data available for Paralogs for MIR223 Gene

Variants for MIR223 Gene

Sequence variations from dbSNP and Humsavar for MIR223 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs3747360 -- 66,019,016(-) CTGGC(A/C)GTCCA downstream-variant-500B
rs3848900 -- 66,018,169(-) TGATT(C/T)AGCAG upstream-variant-2KB
rs6624834 -- 66,018,575(+) GCATA(A/G)AGGAA upstream-variant-2KB
rs10552143 -- 66,019,418(+) TCCAC(-/AT)GTCTT downstream-variant-500B
rs16989865 -- 66,018,207(+) GGTCA(C/T)ACAAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR223 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354
nsv6933 CNV Insertion 18451855

Relevant External Links for MIR223 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MIR223 Gene

Disorders for MIR223 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MIR223 Gene in MalaCards »

(3) Diseases for MIR223 Gene including...

Relevant External Links for MIR223

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MIR223: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MIR223 Gene

Publications for MIR223 Gene

  1. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J. … Zhao H. (Int. J. Cancer 2009) 3 48
  2. MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1. (PMID: 18555017) Wong Q.W. … Wong N. (Gastroenterology 2008) 3 23
  3. Vertebrate microRNA genes. (PMID: 12624257) Lim L.P. … Bartel D.P. (Science 2003) 3
  4. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3
  5. A mammalian microRNA expression atlas based on small RNA library sequencing. (PMID: 17604727) Landgraf P. … Tuschl T. (Cell 2007) 3

Products for MIR223 Gene

Sources for MIR223 Gene

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