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Aliases for MIR223 Gene

Subcategory (RNA class) for MIR223 Gene

undefined

Quality Score for this RNA gene is

3

Aliases for MIR223 Gene

  • MicroRNA 223 2 3 5
  • Hsa-Mir-223 3
  • MiRNA223 3
  • Mir-223 3
  • MIRN223 3

External Ids for MIR223 Gene

ORGUL Members for MIR223 Gene

Previous HGNC Symbols for MIR223 Gene

  • MIRN223

Previous GeneCards Identifiers for MIR223 Gene

  • GC0XP065156
  • GC0XP065238

Summaries for MIR223 Gene

Entrez Gene Summary for MIR223 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR223 Gene

MIR223 (MicroRNA 223) is an RNA Gene, and is affiliated with the undefined RNA class. Diseases associated with MIR223 include Familial Breast Cancer. Among its related pathways are miRNAs involved in DDR and MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR223 Gene

Genomics for MIR223 Gene

Regulatory Elements for MIR223 Gene

Enhancers for MIR223 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MIR223 on UCSC Golden Path with GeneCards custom track

Promoters for MIR223 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR223 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR223 Gene

Chromosome:
X
Start:
66,018,870 bp from pter
End:
66,018,979 bp from pter
Size:
110 bases
Orientation:
Plus strand

Genomic View for MIR223 Gene

Genes around MIR223 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR223 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR223 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR223 Gene

Proteins for MIR223 Gene

Post-translational modifications for MIR223 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR223 Gene

Domains & Families for MIR223 Gene

Gene Families for MIR223 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR223: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR223 Gene

Function for MIR223 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR223 Gene

Localization for MIR223 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR223 Gene

Pathways & Interactions for MIR223 Gene

genes like me logo Genes that share pathways with MIR223: view

Pathways by source for MIR223 Gene

1 BioSystems pathway for MIR223 Gene
1 KEGG pathway for MIR223 Gene

Interacting Proteins for MIR223 Gene

Gene Ontology (GO) - Biological Process for MIR223 Gene

None

No data available for SIGNOR curated interactions for MIR223 Gene

Drugs & Compounds for MIR223 Gene

No Compound Related Data Available

Transcripts for MIR223 Gene

mRNA/cDNA for MIR223 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR223 Gene

No ASD Table

Relevant External Links for MIR223 Gene

GeneLoc Exon Structure for
MIR223
ECgene alternative splicing isoforms for
MIR223

Expression for MIR223 Gene

mRNA expression in normal human tissues for MIR223 Gene

mRNA differential expression in normal tissues according to GTEx for MIR223 Gene

This gene is overexpressed in Whole Blood (x49.2).
genes like me logo Genes that share expression patterns with MIR223: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR223 Gene

Orthologs for MIR223 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR223 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-223 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-223 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-223 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir223 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 75 (a)
OneToMany
oan-mir-223 36
  • 73 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-223 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-223 36
  • 87 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-223 36
  • 62 (a)
OneToOne
Species with no ortholog for MIR223:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR223 Gene

ENSEMBL:
Gene Tree for MIR223 (if available)
TreeFam:
Gene Tree for MIR223 (if available)

Paralogs for MIR223 Gene

No data available for Paralogs for MIR223 Gene

Variants for MIR223 Gene

Sequence variations from dbSNP and Humsavar for MIR223 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747839050 -- 66,017,433(+) GACTG(C/T)CAGAA upstream-variant-2KB
rs748820834 -- 66,019,000(+) GATGG(A/G)ATATG downstream-variant-500B
rs749793262 -- 66,018,775(+) TCCCC(A/G)GGGCT upstream-variant-2KB
rs749803299 -- 66,019,171(+) ACCAT(G/T)AGAGT downstream-variant-500B
rs750434671 -- 66,017,980(+) ATTGT(A/G)TAAAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR223 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354
nsv6933 CNV Insertion 18451855

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Variation tolerance and Relevant External Links for MIR223 Gene

Disorders for MIR223 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR223 Gene - From: GeneCards

Disorder Aliases PubMed IDs
familial breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR223

Genetic Association Database (GAD)
MIR223
Human Genome Epidemiology (HuGE) Navigator
MIR223
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR223
genes like me logo Genes that share disorders with MIR223: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR223 Gene

Publications for MIR223 Gene

  1. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J. … Zhao H. (Int. J. Cancer 2009) 3 48 67
  2. MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1. (PMID: 18555017) Wong Q.W. … Wong N. (Gastroenterology 2008) 3 23
  3. The sensitivity of gastric cancer to trastuzumab is regulated by the miR-223/FBXW7 pathway. (PMID: 25159729) Eto K. … Baba H. (Int. J. Cancer 2015) 3
  4. MicroRNA -143 and -223 in obesity. (PMID: 25637573) Kilic I.D. … BostancA+ H.E. (Gene 2015) 3
  5. Role of serum miRNAs in the prediction of ovarian hyperstimulation syndrome in polycystic ovarian syndrome patients. (PMID: 25662703) Zhao C. … Ling X. (Cell. Physiol. Biochem. 2015) 3

Products for MIR223 Gene

Sources for MIR223 Gene

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