Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR223 Gene

Subcategory (RNA class) for MIR223 Gene

undefined

Quality Score for this RNA gene is

3

Aliases for MIR223 Gene

  • MicroRNA 223 2 3 5
  • Hsa-Mir-223 3
  • MiRNA223 3
  • Mir-223 3
  • MIRN223 3

External Ids for MIR223 Gene

ORGUL Members for MIR223 Gene

Previous HGNC Symbols for MIR223 Gene

  • MIRN223

Previous GeneCards Identifiers for MIR223 Gene

  • GC0XP065156
  • GC0XP065238

Summaries for MIR223 Gene

Entrez Gene Summary for MIR223 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR223 Gene

MIR223 (MicroRNA 223) is an RNA Gene, and is affiliated with the undefined RNA class. Diseases associated with MIR223 include Primary Biliary Cholangitis. Among its related pathways are MicroRNAs in cancer.

Additional gene information for MIR223 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR223 Gene

Genomics for MIR223 Gene

GeneHancer (GH) Regulatory Elements for MIR223 Gene

Promoters and enhancers for MIR223 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI065985 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 13.3 -31.9 -31891 2.6 PKNOX1 IRF4 RAD21 ZBTB40 RFX5 ZNF766 ARID2 BCLAF1 RUNX3 ZNF654 MIR223 MSN ENSG00000237311 LOC100288788 GC0XM065963 GC0XM065545
GH0XI065693 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -320.9 -320901 8 HDGF HDAC1 PKNOX1 BMI1 IRF4 ZBTB40 TCF12 ATF7 ETV6 BCLAF1 MSN MIR223 GC0XM065725 GC0XM065726 GC0XM065596 GC0XM065545
GH0XI066045 Enhancer 1.3 FANTOM5 Ensembl ENCODE 13 +27.9 27949 2.6 PKNOX1 BMI1 BATF IRF4 EGR1 ZNF207 ATF7 ETV6 BCLAF1 IKZF2 MIR223 MSN LOC392485 VSIG4 GC0XM065963 GC0XM065545
GH0XI065719 Enhancer 1.2 Ensembl ENCODE dbSUPER 12.2 -296.9 -296903 5.6 HDGF ATF1 INSM2 MZF1 FEZF1 BATF IRF4 ETV6 ATF7 IKZF2 MIR223 GC0XM065725 GC0XM065726 GC0XM065596 MSN GC0XM065545
GH0XI065684 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.7 -330.3 -330269 7.6 FOXA2 PKNOX1 MAX EBF1 RAD21 POLR2A HNF4G PRDM10 IKZF2 BCLAF1 MSN MIR223 GC0XM065725 GC0XM065726 GC0XM065596 GC0XM065545
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR223 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR223 Gene

Genomic Locations for MIR223 Gene
chrX:66,018,870-66,018,979
(GRCh38/hg38)
Size:
110 bases
Orientation:
Plus strand
chrX:65,238,712-65,238,821
(GRCh37/hg19)

Genomic View for MIR223 Gene

Genes around MIR223 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR223 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR223 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR223 Gene

Proteins for MIR223 Gene

Post-translational modifications for MIR223 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR223 Gene

Domains & Families for MIR223 Gene

Gene Families for MIR223 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR223: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR223 Gene

Function for MIR223 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR223 Gene

Localization for MIR223 Gene

Gene Ontology (GO) - Cellular Components for MIR223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with MIR223: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR223 Gene

Pathways & Interactions for MIR223 Gene

SuperPathways for MIR223 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR223: view

Pathways by source for MIR223 Gene

1 KEGG pathway for MIR223 Gene

Interacting Proteins for MIR223 Gene

Gene Ontology (GO) - Biological Process for MIR223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010628 positive regulation of gene expression IDA 20080987
GO:0046326 positive regulation of glucose import IDA 20080987
GO:1903078 positive regulation of protein localization to plasma membrane IDA 20080987
genes like me logo Genes that share ontologies with MIR223: view

No data available for SIGNOR curated interactions for MIR223 Gene

Drugs & Compounds for MIR223 Gene

No Compound Related Data Available

Transcripts for MIR223 Gene

mRNA/cDNA for MIR223 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR223 Gene

No ASD Table

Relevant External Links for MIR223 Gene

GeneLoc Exon Structure for
MIR223
ECgene alternative splicing isoforms for
MIR223

Expression for MIR223 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR223 Gene

mRNA differential expression in normal tissues according to GTEx for MIR223 Gene

This gene is overexpressed in Whole Blood (x49.2).

NURSA nuclear receptor signaling pathways regulating expression of MIR223 Gene:

MIR223
genes like me logo Genes that share expression patterns with MIR223: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR223 Gene

Orthologs for MIR223 Gene

Evolution for MIR223 Gene

ENSEMBL:
Gene Tree for MIR223 (if available)
TreeFam:
Gene Tree for MIR223 (if available)

No data available for Orthologs for MIR223 Gene

Paralogs for MIR223 Gene

No data available for Paralogs for MIR223 Gene

Variants for MIR223 Gene

Sequence variations from dbSNP and Humsavar for MIR223 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000544380 -- 66,016,919(+) G/A upstream_transcript_variant
rs1001510722 -- 66,018,619(+) C/T upstream_transcript_variant
rs1004013580 -- 66,017,886(+) C/A upstream_transcript_variant
rs1004385637 -- 66,017,486(+) T/C upstream_transcript_variant
rs1004585345 -- 66,019,379(+) A/C downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MIR223 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER inversion 17803354
esv3576919 CNV gain 25503493
nsv6933 CNV insertion 18451855

Additional Variant Information for MIR223 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR223

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR223 Gene

Disorders for MIR223 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR223 Gene - From: GeneCards

Disorder Aliases PubMed IDs
primary biliary cholangitis
  • pbc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR223

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR223: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR223 Gene

Publications for MIR223 Gene

  1. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 44 58
  2. MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1. (PMID: 18555017) Wong QW … Wong N (Gastroenterology 2008) 3 22 58
  3. miR-223 and Stathmin-1 Expression in Non-tumor Liver Tissue of Patients with Hepatocellular Carcinoma. (PMID: 28982915) Imura S … Shimada M (Anticancer research 2017) 3 58
  4. MicroRNA-223 and microRNA-21 in peripheral blood B cells associated with progression of primary biliary cholangitis patients. (PMID: 28886078) Wang X … Jin Q (PloS one 2017) 3 58
  5. MicroRNA-223-3p Regulates Ovarian Cancer Cell Proliferation and Invasion by Targeting SOX11 Expression. (PMID: 28587313) Fang G … Yang M (International journal of molecular sciences 2017) 3 58

Products for MIR223 Gene

Sources for MIR223 Gene

Content
Loading form....