Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR223 Gene

Subcategory (RNA class) for MIR223 Gene


Quality Score for this RNA gene is


Aliases for MIR223 Gene

  • MicroRNA 223 2 3 5
  • Hsa-Mir-223 3
  • MiRNA223 3
  • Mir-223 3
  • MIRN223 3

External Ids for MIR223 Gene

ORGUL Members for MIR223 Gene

Previous HGNC Symbols for MIR223 Gene

  • MIRN223

Previous GeneCards Identifiers for MIR223 Gene

  • GC0XP065156
  • GC0XP065238

Summaries for MIR223 Gene

Entrez Gene Summary for MIR223 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR223 Gene

MIR223 (MicroRNA 223) is an RNA Gene, and is affiliated with the undefined RNA class. Among its related pathways are MicroRNAs in cancer.

Additional gene information for MIR223 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR223 Gene

Genomics for MIR223 Gene

Regulatory Elements for MIR223 Gene

Enhancers for MIR223 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH065693 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -320.9 -320901 8 HDGF PKNOX1 BMI1 TCF12 ELK1 ATF7 ETV6 RUNX3 CREM IKZF2 MSN MIR223 GC0XM065725 GC0XM065726 GC0XM065596
GH0XH065985 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13.2 -31.9 -31891 2.6 CTCF PKNOX1 LEF1 ETV1 MAX RAD21 RFX5 CC2D1A ZNF766 EED MIR223 MSN ENSG00000237311 LOC100288788
GH0XH066045 1.5 FANTOM5 Ensembl ENCODE 13 +27.9 27949 2.6 PKNOX1 TBL1XR1 SIN3A BMI1 BATF EGR1 ZNF207 ATF7 ETV6 RUNX3 MIR223 MSN LOC392485 VSIG4
GH0XH065719 1.4 Ensembl ENCODE dbSUPER 12.2 -296.9 -296904 5.6 HDGF ATF1 TBL1XR1 INSM2 FEZF1 BATF ETV6 ATF7 RUNX3 CREM MIR223 GC0XM065726 GC0XM065725 GC0XM065596
GH0XH065684 1.2 Ensembl ENCODE dbSUPER 11.7 -330.3 -330270 7.6 FOXA2 PKNOX1 TBL1XR1 MAX EBF1 RAD21 POLR2A HNF4G PRDM10 RUNX3 MSN MIR223 GC0XM065725 GC0XM065726 GC0XM065596
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR223 on UCSC Golden Path with GeneCards custom track

Promoters for MIR223 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000246894 -1970 201 ZNF639 POLR2A SMAD5 GTF2E2 NFRKB MLLT1 SUPT5H

Genomic Locations for MIR223 Gene

Genomic Locations for MIR223 Gene
110 bases
Plus strand

Genomic View for MIR223 Gene

Genes around MIR223 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR223 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR223 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR223 Gene

Proteins for MIR223 Gene

Post-translational modifications for MIR223 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR223 Gene

Domains & Families for MIR223 Gene

Gene Families for MIR223 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR223: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR223 Gene

Function for MIR223 Gene

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR223 Gene

Localization for MIR223 Gene

Gene Ontology (GO) - Cellular Components for MIR223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 18766170
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with MIR223: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR223 Gene

Pathways & Interactions for MIR223 Gene

SuperPathways for MIR223 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR223: view

Pathways by source for MIR223 Gene

1 KEGG pathway for MIR223 Gene

Interacting Proteins for MIR223 Gene

Gene Ontology (GO) - Biological Process for MIR223 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010628 positive regulation of gene expression IDA 20080987
GO:0046326 positive regulation of glucose import IDA 20080987
GO:1903078 positive regulation of protein localization to plasma membrane IDA 20080987
genes like me logo Genes that share ontologies with MIR223: view

No data available for SIGNOR curated interactions for MIR223 Gene

Drugs & Compounds for MIR223 Gene

No Compound Related Data Available

Transcripts for MIR223 Gene

mRNA/cDNA for MIR223 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR223 Gene

No ASD Table

Relevant External Links for MIR223 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR223 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR223 Gene

mRNA differential expression in normal tissues according to GTEx for MIR223 Gene

This gene is overexpressed in Whole Blood (x49.2).

NURSA nuclear receptor signaling pathways regulating expression of MIR223 Gene:

genes like me logo Genes that share expression patterns with MIR223: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR223 Gene

Orthologs for MIR223 Gene

Evolution for MIR223 Gene

Gene Tree for MIR223 (if available)
Gene Tree for MIR223 (if available)

No data available for Orthologs for MIR223 Gene

Paralogs for MIR223 Gene

No data available for Paralogs for MIR223 Gene

Variants for MIR223 Gene

Sequence variations from dbSNP and Humsavar for MIR223 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000544380 -- 66,016,919(+) CTGGA(A/G)GTGAA upstream-variant-2KB
rs1001510722 -- 66,018,619(+) AGCTA(C/T)AGGAC upstream-variant-2KB
rs1004013580 -- 66,017,886(+) GTCTT(A/C)CCTTT upstream-variant-2KB
rs1004385637 -- 66,017,486(+) AAGAA(C/T)AGAGC upstream-variant-2KB
rs1004585345 -- 66,019,379(+) CTTCT(A/C)AACAC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR223 Gene

Variant ID Type Subtype PubMed ID
nsv6933 CNV insertion 18451855
esv3576919 CNV gain 25503493
esv1584074 OTHER inversion 17803354

Relevant External Links for MIR223 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR223 Gene

Disorders for MIR223 Gene

Relevant External Links for MIR223

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR223 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR223 Gene

Publications for MIR223 Gene

  1. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J … Zhao H (International journal of cancer 2009) 3 45 60
  2. MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1. (PMID: 18555017) Wong QW … Wong N (Gastroenterology 2008) 3 22 60
  3. MicroRNA-223 ameliorates alcoholic liver injury by inhibiting the IL-6-p47phox-oxidative stress pathway in neutrophils. (PMID: 27679493) Li M … Gao B (Gut 2017) 3 60
  4. MiR-223 modulates hepatocellular carcinoma cell proliferation through promoting apoptosis via the Rab1-mediated mTOR activation. (PMID: 27998765) Dong Z … Lu Y (Biochemical and biophysical research communications 2017) 3 60
  5. miR‑223‑3p regulates cell growth and apoptosis via FBXW7 suggesting an oncogenic role in human testicular germ cell tumors. (PMID: 28000896) Liu J … Lui WO (International journal of oncology 2017) 3 60

Products for MIR223 Gene

Sources for MIR223 Gene

Loading form....