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Aliases for MIR223 Gene

Subcategory (RNA class) for MIR223 Gene


Quality Score for this RNA gene is


Aliases for MIR223 Gene

  • MicroRNA 223 2 3 5
  • Hsa-Mir-223 3
  • MiRNA223 3
  • Mir-223 3
  • MIRN223 3

External Ids for MIR223 Gene

Previous HGNC Symbols for MIR223 Gene

  • MIRN223

Previous GeneCards Identifiers for MIR223 Gene

  • GC0XP065156
  • GC0XP065238

Summaries for MIR223 Gene

Entrez Gene Summary for MIR223 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR223 Gene

MIR223 (MicroRNA 223) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR223 Gene

Genomics for MIR223 Gene

Regulatory Elements for MIR223 Gene

Enhancers for MIR223 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF066045 1.5 FANTOM5 Ensembl ENCODE 13 +31.5 31507 2.9 PKNOX1 CBX3 TBL1XR1 BMI1 EGR1 CBX5 ETV6 RCOR1 CREM CBFB MIR223 MSN LOC392485 VSIG4
GH0XF065684 1.6 FANTOM5 Ensembl ENCODE 11.9 -319.2 -319157 23.8 HDGF TBL1XR1 ZNF133 BMI1 RAD21 YY1 GLIS2 ELK1 SCRT2 ETV6 MSN MIR223 CCT4P2 GC0XM065725 GC0XM065726 GC0XM065596
GH0XF065985 1.3 FANTOM5 Ensembl ENCODE 13.2 -28.3 -28312 2.9 CTCF RFX1 PKNOX1 ZNF654 MTA2 WRNIP1 ETV1 MAX TRIM22 REST MIR223 MSN ENSG00000237311 LOC100288788
GH0XF065719 1.1 Ensembl ENCODE 12.2 -293.5 -293495 5.6 HDGF ATF1 TBL1XR1 INSM2 FEZF1 YY1 ETV6 CREM ZNF280D JUNB MIR223 LOC100288788 GC0XM065725 GC0XM065726 GC0XM065596
GH0XF065932 0.9 ENCODE 11.4 -82.4 -82418 2.1 CBX3 PKNOX1 INSM2 KLF17 RAD21 CHAMP1 RCOR1 FOS SMARCA5 SMARCC1 LOC100288788 MIR223 GC0XM065956 LOC100130724
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR223 on UCSC Golden Path with GeneCards custom track

Promoters for MIR223 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MIR223 Gene

66,015,461 bp from pter
66,020,422 bp from pter
4,962 bases
Plus strand

Genomic View for MIR223 Gene

Genes around MIR223 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR223 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR223 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR223 Gene

Proteins for MIR223 Gene

Post-translational modifications for MIR223 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR223 Gene

Domains & Families for MIR223 Gene

Gene Families for MIR223 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR223: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR223 Gene

Function for MIR223 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR223 Gene

Localization for MIR223 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR223 Gene

Pathways & Interactions for MIR223 Gene

SuperPathways for MIR223 Gene

SuperPathway Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with MIR223: view

Pathways by source for MIR223 Gene

1 KEGG pathway for MIR223 Gene

Interacting Proteins for MIR223 Gene

Gene Ontology (GO) - Biological Process for MIR223 Gene


No data available for SIGNOR curated interactions for MIR223 Gene

Transcripts for MIR223 Gene

mRNA/cDNA for MIR223 Gene

(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR223 Gene

No ASD Table

Relevant External Links for MIR223 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR223 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR223 Gene

mRNA differential expression in normal tissues according to GTEx for MIR223 Gene

This gene is overexpressed in Whole Blood (x49.2).

NURSA nuclear receptor signaling pathways regulating expression of MIR223 Gene:

genes like me logo Genes that share expression patterns with MIR223: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR223 Gene

Orthologs for MIR223 Gene

Evolution for MIR223 Gene

Gene Tree for MIR223 (if available)
Gene Tree for MIR223 (if available)

No data available for Orthologs for MIR223 Gene

Paralogs for MIR223 Gene

No data available for Paralogs for MIR223 Gene

Variants for MIR223 Gene

Sequence variations from dbSNP and Humsavar for MIR223 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs10552143 -- 66,019,418(+) TCCAC(-/AT)GTCTT downstream-variant-500B
rs111394789 -- 66,018,272(+) GCATT(A/T)TCTCC upstream-variant-2KB
rs111776283 -- 66,018,265(+) TTTAC(A/C)TGCAT upstream-variant-2KB
rs139641330 -- 66,016,962(+) ACACC(A/T)CCAGC upstream-variant-2KB
rs139894104 -- 66,017,985(+) ATAAA(C/G)TTTAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR223 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER inversion 17803354
esv3576919 CNV gain 25503493
nsv6933 CNV insertion 18451855

Relevant External Links for MIR223 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR223 Gene

Disorders for MIR223 Gene

Relevant External Links for MIR223

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MIR223 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR223 Gene

Publications for MIR223 Gene

  1. Novel genetic variants in microRNA genes and familial breast cancer. (PMID: 19048628) Shen J. … Zhao H. (Int. J. Cancer 2009) 3 46 64
  2. MicroRNA-223 is commonly repressed in hepatocellular carcinoma and potentiates expression of Stathmin1. (PMID: 18555017) Wong Q.W. … Wong N. (Gastroenterology 2008) 3 22 64
  3. miR-223 reverses the resistance of EGFR-TKIs through IGF1R/PI3K/Akt signaling pathway. (PMID: 26936292) Han J. … Chen Z. (Int. J. Oncol. 2016) 3 64
  4. Association of tumor and plasma microRNA expression with tumor monosomy-3 in patients with uveal melanoma. (PMID: 27453764) Triozzi P.L. … Singh A.D. (Clin Epigenetics 2016) 3 64
  5. Circulating MicroRNA223 is a New Biomarker for Inflammatory Bowel Disease. (PMID: 26844512) Wang H. … Chen M. (Medicine (Baltimore) 2016) 3 64

Products for MIR223 Gene

Sources for MIR223 Gene

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