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Aliases for MIR222 Gene

Subcategory (RNA class) for MIR222 Gene


Quality Score for this RNA gene is


Aliases for MIR222 Gene

  • MicroRNA 222 2 3 5
  • Hsa-Mir-222 3
  • MiRNA222 3
  • Mir-222 3
  • MIRN222 3

External Ids for MIR222 Gene

Previous HGNC Symbols for MIR222 Gene

  • MIRN222

Previous GeneCards Identifiers for MIR222 Gene

  • GC0XM045493
  • GC0XM045606

Summaries for MIR222 Gene

Entrez Gene Summary for MIR222 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR222 Gene

MIR222 (MicroRNA 222) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are miRs in Muscle Cell Differentiation and miRNAs involved in DNA damage response.

Additional gene information for MIR222 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR222 Gene

Genomics for MIR222 Gene

GeneHancer (GH) Regulatory Elements for MIR222 Gene

Promoters and enhancers for MIR222 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI045745 Enhancer 0.4 dbSUPER 550.8 +1.1 1088 0.8 CREB1 ATF7 ATF2 GC0XM045748 GC0XM045749 GC0XP045745 MIR221 MIR222 MIR222HG
GH0XI045707 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 13.5 +34.5 34462 9.6 SRF JUN NR2F1 JUNB BATF RELA JUND GATA3 POLR2A IKZF1 MIR221 MIR222 GC0XM045719 GC0XM044696 KRT8P14
GH0XI045719 Enhancer 0.2 dbSUPER 13.7 +27.0 27027 1.3 GC0XM045719 MIR221 MIR222 GC0XM044696
GH0XI045746 Enhancer 1 Ensembl ENCODE dbSUPER 0.8 -3.7 -3701 8.2 CTCF RAD21 POLR2A IKZF1 SMC3 ATF7 ETV6 IKZF2 SPI1 MIR222 GC0XM045749 GC0XM045761 MIR222HG
GH0XI045755 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 0.4 -12.8 -12815 8.9 PKNOX1 FOXA2 MZF1 BMI1 FEZF1 BATF IRF4 ATF7 ETV6 FOS GC0XM045761 GC0XM045749 MIR222 MIR222HG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR222 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR222 Gene

Genomic Locations for MIR222 Gene
110 bases
Minus strand

Genomic View for MIR222 Gene

Genes around MIR222 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR222 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR222 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR222 Gene

Proteins for MIR222 Gene

Post-translational modifications for MIR222 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR222 Gene

Domains & Families for MIR222 Gene

Gene Families for MIR222 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR222: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR222 Gene

Function for MIR222 Gene

Gene Ontology (GO) - Molecular Function for MIR222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IMP 20103675
genes like me logo Genes that share ontologies with MIR222: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR222 Gene

Localization for MIR222 Gene

Gene Ontology (GO) - Cellular Components for MIR222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR222: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR222 Gene

Pathways & Interactions for MIR222 Gene

genes like me logo Genes that share pathways with MIR222: view

Pathways by source for MIR222 Gene

Interacting Proteins for MIR222 Gene

Gene Ontology (GO) - Biological Process for MIR222 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010634 positive regulation of epithelial cell migration IGI 21673316
GO:0010718 positive regulation of epithelial to mesenchymal transition IGI 21673316
GO:0016525 negative regulation of angiogenesis IDA 20489169
GO:0035195 gene silencing by miRNA IMP 18246122
GO:0035278 miRNA mediated inhibition of translation IDA 19962668
genes like me logo Genes that share ontologies with MIR222: view

No data available for SIGNOR curated interactions for MIR222 Gene

Drugs & Compounds for MIR222 Gene

No Compound Related Data Available

Transcripts for MIR222 Gene

mRNA/cDNA for MIR222 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR222 Gene

No ASD Table

Relevant External Links for MIR222 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR222 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR222 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR222 Gene:

genes like me logo Genes that share expression patterns with MIR222: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR222 Gene

Orthologs for MIR222 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR222 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-222 34
  • 100 (a)
(Canis familiaris)
Mammalia cfa-mir-222 34
  • 98 (a)
(Bos Taurus)
Mammalia bta-mir-222 34
  • 96 (a)
(Mus musculus)
Mammalia Mir222 34
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-222a 34
  • 75 (a)
(Gallus gallus)
Aves gga-mir-222a 34
  • 81 (a)
(Anolis carolinensis)
Reptilia aca-mir-222 34
  • 74 (a)
(Danio rerio)
Actinopterygii CU550700.1 34
  • 71 (a)
Species where no ortholog for MIR222 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR222 Gene

Gene Tree for MIR222 (if available)
Gene Tree for MIR222 (if available)

Paralogs for MIR222 Gene

No data available for Paralogs for MIR222 Gene

Variants for MIR222 Gene

Sequence variations from dbSNP and Humsavar for MIR222 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1006826788 -- 45,748,601(-) T/C upstream_transcript_variant
rs1011632523 -- 45,746,846(-) C/G downstream_transcript_variant
rs1021933533 -- 45,748,883(-) C/T upstream_transcript_variant
rs1022889488 -- 45,746,858(-) C/G downstream_transcript_variant
rs1026785163 -- 45,747,513(-) A/G upstream_transcript_variant

Additional Variant Information for MIR222 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR222 Gene

Disorders for MIR222 Gene

Additional Disease Information for MIR222

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MIR222 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR222 Gene

Publications for MIR222 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 44 58
  2. A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias. (PMID: 19464057) Kreil S … Chase A (Leukemia research 2009) 3 44 58
  3. The GAS5/miR-222 Axis Regulates Proliferation of Gastric Cancer Cells Through the PTEN/Akt/mTOR Pathway. (PMID: 29098549) Li Y … Lu H (Digestive diseases and sciences 2017) 3 58
  4. Naturally existing isoforms of miR-222 have distinct functions. (PMID: 28981911) Yu F … Bracken CP (Nucleic acids research 2017) 3 58
  5. Changes in the cellular microRNA profile by the intracellular expression of HIV-1 Tat regulator: A potential mechanism for resistance to apoptosis and impaired proliferation in HIV-1 infected CD4+ T cells. (PMID: 28968466) Sánchez-Del Cojo M … Coiras M (PloS one 2017) 3 58

Products for MIR222 Gene

Sources for MIR222 Gene

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