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Aliases for MIR222 Gene

Subcategory (RNA class) for MIR222 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR222 Gene

  • MicroRNA 222 2 3 5
  • Hsa-Mir-222 3
  • MiRNA222 3
  • Mir-222 3
  • MIRN222 3

External Ids for MIR222 Gene

Previous HGNC Symbols for MIR222 Gene

  • MIRN222

Previous GeneCards Identifiers for MIR222 Gene

  • GC0XM045493
  • GC0XM045606

Summaries for MIR222 Gene

Entrez Gene Summary for MIR222 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR222 Gene

MIR222 (MicroRNA 222) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR222 Gene

Genomics for MIR222 Gene

Regulatory Elements for MIR222 Gene

Enhancers for MIR222 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MIR222 on UCSC Golden Path with GeneCards custom track

Promoters for MIR222 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MIR222 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR222 Gene

Chromosome:
X
Start:
45,747,015 bp from pter
End:
45,747,126 bp from pter
Size:
112 bases
Orientation:
Minus strand

Genomic View for MIR222 Gene

Genes around MIR222 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR222 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR222 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR222 Gene

Proteins for MIR222 Gene

Post-translational modifications for MIR222 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR222 Gene

Domains & Families for MIR222 Gene

Gene Families for MIR222 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR222: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR222 Gene

Function for MIR222 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR222 Gene

Localization for MIR222 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR222 Gene

Pathways & Interactions for MIR222 Gene

genes like me logo Genes that share pathways with MIR222: view

Pathways by source for MIR222 Gene

2 BioSystems pathways for MIR222 Gene
1 KEGG pathway for MIR222 Gene

Interacting Proteins for MIR222 Gene

Gene Ontology (GO) - Biological Process for MIR222 Gene

None

No data available for SIGNOR curated interactions for MIR222 Gene

Drugs & Compounds for MIR222 Gene

No Compound Related Data Available

Transcripts for MIR222 Gene

mRNA/cDNA for MIR222 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR222 Gene

No ASD Table

Relevant External Links for MIR222 Gene

GeneLoc Exon Structure for
MIR222
ECgene alternative splicing isoforms for
MIR222

Expression for MIR222 Gene

mRNA expression in normal human tissues for MIR222 Gene

genes like me logo Genes that share expression patterns with MIR222: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MIR222 Gene

Orthologs for MIR222 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR222 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-222 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-222 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir222 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-222a 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-222 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-222a 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-222 36
  • 74 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CU550700.1 36
  • 71 (a)
OneToOne
Species with no ortholog for MIR222:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR222 Gene

ENSEMBL:
Gene Tree for MIR222 (if available)
TreeFam:
Gene Tree for MIR222 (if available)

Paralogs for MIR222 Gene

No data available for Paralogs for MIR222 Gene

Variants for MIR222 Gene

Sequence variations from dbSNP and Humsavar for MIR222 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs989624 -- 45,749,091(-) TTAAA(C/T)TTAAA upstream-variant-2KB
rs180729610 -- 45,748,978(+) ATTAT(C/T)TTTTA upstream-variant-2KB
rs186045791 -- 45,749,121(+) AAAAT(C/T)TGTAA upstream-variant-2KB
rs186307019 -- 45,748,671(+) CAGGG(A/G)TTTTT upstream-variant-2KB
rs189605238 -- 45,748,879(+) TAAAA(C/T)TAACT upstream-variant-2KB

Relevant External Links for MIR222 Gene

HapMap Linkage Disequilibrium report
MIR222

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR222 Gene

Disorders for MIR222 Gene

Relevant External Links for MIR222

Genetic Association Database (GAD)
MIR222
Human Genome Epidemiology (HuGE) Navigator
MIR222
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR222

No disorders were found for MIR222 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR222 Gene

Publications for MIR222 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 48 67
  2. Papillary thyroid cancer-derived exosomes contain miRNA-146b and miRNA-222. (PMID: 25819770) Lee J.C. … Sidhu S. (J. Surg. Res. 2015) 3
  3. HMGB1-Induced Cross Talk between PTEN and miRs 221/222 in Thyroid Cancer. (PMID: 26106610) Mardente S. … Zicari A. (Biomed Res Int 2015) 3
  4. Targeting the miR-221-222/PUMA/BAK/BAX Pathway Abrogates Dexamethasone Resistance in Multiple Myeloma. (PMID: 26249174) Zhao J.J. … Carrasco R.D. (Cancer Res. 2015) 3
  5. MiR-221/222 promote human glioma cell invasion and angiogenesis by targeting TIMP2. (PMID: 25731730) Yang F. … Wang T. (Tumour Biol. 2015) 3

Products for MIR222 Gene

Sources for MIR222 Gene

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