MIR221 Gene

Aliases
for MIR221 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifer: GC0XM045492

Summaries
for MIR221 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for MIR221 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Browse SwitchGear Promoter luciferase reporter plasmids

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIR221

MIR221 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM045605:  view genomic region (via miRBase)     (about GC identifiers)

Proteins
for MIR221 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Domains /
Families
for MIR221 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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Function
for MIR221 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Localization
for MIR221 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Pathways & Interactions
for MIR221 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Drugs & Compounds
for MIR221 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for MIR221 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for MIR221 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for MIR221:none

See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

Primer Products:		Browse OriGene qPCR
		Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat MIR221
		Search QuantiTect SYBR Green Assays in human, mouse, rat MIR221
		QuantiFast Probe-based Assays in human, mouse, rat MIR221

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MIR221

Orthologs
for MIR221 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for MIR221 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Genomic Variants
for MIR221 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MIR221 (see all 16)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs70503911,2	C	--	45605273(+)	GGGTGC/TTATGC	1	--	ds5001		0	--	--	--	--
rs1813004531,2		--	45605440(+)	TCGTAC/TTGAAA	1	--	ds5001		0	--	--	--	--
rs1859051171,2		--	45605523(+)	GTTTAC/TACCTC	1	--	ds5001		0	--	--	--	--
rs1912134441,2	C	--	45605777(+)	TTCTAA/CCACAA	1	--	us2k1		0	--	--	--	--
rs1825840221,2		--	45605837(+)	AAAATG/TTCCTT	1	--	us2k1		0	--	--	--	--
rs570429521,2	C	--	45606303(+)	TCTCT-/CTC/CTC TCTCTCTCTTTGTG	1	--	us2k1		0	--	--	--	--
rs726318251,2	F	--	45606471(-)	CTTTCG/ATAATC	1	--	us2k1		1		MN	162
rs1876122791,2	C	--	45606472(+)	ATTACA/GAAAGA	1	--	us2k1		0	--	--	--	--
rs1917272541,2	C	--	45606504(+)	AGCCAA/TTGAGG	1	--	us2k1		0	--	--	--	--
rs1130547941,2	--	--	45605666(+)	TATGCC/AAGGTT	1	--	nc-transcript-variant		1		CSA	2

HapMap Linkage Disequilibrium report for MIR221 (45605585 - 45605694 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for MIR221: --

Site Specific Mutation Identification with PCR Assays

Search QIAGEN SeqTarget long-range PCR primers for resequencing MIR221

DNA2.0 Custom Variant and Variant Library Synthesis for MIR221

Disorders / Diseases
for MIR221 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for MIR221 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MIR221 gene, integrated from 10 sources (see all 116): (articles sorted by number of sources associating them with MIR221)

Utopia: connect your pdf to the dynamic world of online information

1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PubMed id 20167074)^{1, 4} Shen J....Zhao H. (BMC Cancer 2010)
2. A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias. (PubMed id 19464057)^{1, 4} Kreil S....Chase A. (Leuk. Res. 2009)
3. MicroRNA-221 regulates high glucose-induced endothelial dysfunction. (PubMed id 19351599)^{1, 9} Li Y....Geng Y.J. (Biochem. Biophys. Res. Commun. 2009)
4. MicroRNA-221 promotes colorectal cancer cell invasion and metastasis by targeting RECK. (PubMed id 24269686)¹ Qin J. and Luo M. (FEBS Lett. 2014)
5. Prognostic significance of serum microRNA-221 expression in human epithelial ovarian cancer. (PubMed id 23569131)¹ Hong F....Zhu L. (J. Int. Med. Res. 2013)
6. miRNA expression profiles of oral squamous cell carcinomas. (PubMed id 23564792)¹ Gombos K....Olasz L. (Anticancer Res. 2013)
7. Overexpression of primary microRNA 221/222 in acute myeloid leukemia. (PubMed id 23895238)¹ Rommer A....Wieser R. (BMC Cancer 2013)
8. Increased expression of microRNA-221 inhibits PAK1 in endothelial progenitor cells and impairs its function via c-Raf/MEK/ERK pathway. (PubMed id 23333386)¹ Zhang X....Lv Z. (Biochem. Biophys. Res. Commun. 2013)
9. Aberrant expression of microRNAs in T cells from patients with ankylosing spondylitis contributes to the immunopathogenesis. (PubMed id 23607629)¹ Lai N.S....Lu M.C. (Clin. Exp. Immunol. 2013)
10. MiR-221/-222 differentiate prognostic groups in advanced breast cancers and influence cell invasion. (PubMed id 24129242)¹ Falkenberg N....Aubele M. (Br. J. Cancer 2013)

External Searches for MIR221 gene

Genome Databases showing MIR221 gene

Other Databases showing MIR221 gene

Specialized Databases showing MIR221 gene

Products
for MIR221 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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