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Aliases for MIR221 Gene

Subcategory (RNA class) for MIR221 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR221 Gene

  • MicroRNA 221 2 3
  • MIRN221 3 6
  • Hsa-Mir-221 3
  • MiRNA221 3
  • Mir-221 3

External Ids for MIR221 Gene

Previous Symbols for MIR221 Gene

  • MIRN221

Summaries for MIR221 Gene

Entrez Gene Summary for MIR221 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR221 Gene

MIR221 (MicroRNA 221) is a RNA Gene, and belongs to miRNA RNA class. Diseases associated with MIR221 include benign metastasizing leiomyoma and myelodysplastic syndrome. Among its related pathways are MicroRNAs in cancer and miRNAs involved in DDR.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR221 Gene

Genomics for MIR221 Gene

Genomic Location for MIR221 Gene

Start:
45,746,157 bp from pter
End:
45,746,266 bp from pter
Size:
110 bases
Orientation:
Minus strand

Genomic View for MIR221 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR221 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR221 Gene

No data available for Regulatory Elements for MIR221 Gene

Proteins for MIR221 Gene

Post-translational modifications for MIR221 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR221 Gene

Domains for MIR221 Gene

Gene Families for MIR221 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs
genes like me logo Genes that share domains with MIR221: view

No data available for Protein Domains and UniProtKB/Swiss-Prot for MIR221 Gene

Function for MIR221 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR221 Gene

Localization for MIR221 Gene

No data available for Gene Ontology (GO) - Cellular Components for MIR221 Gene

Pathways for MIR221 Gene

genes like me logo Genes that share pathways with MIR221: view

Pathways by source for MIR221 Gene

2 BioSystems pathways for MIR221 Gene
1 KEGG pathway for MIR221 Gene

Interacting Proteins for MIR221 Gene

Gene Ontology (GO) - Biological Process for MIR221 Gene

None

Transcripts for MIR221 Gene

mRNA/cDNA for MIR221 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR221 Gene

No ASD Table

Relevant External Links for MIR221 Gene

GeneLoc Exon Structure for
MIR221
ECgene alternative splicing isoforms for
MIR221

Expression for MIR221 Gene

mRNA expression in normal human tissues for MIR221 Gene

genes like me logo Genes that share expressions with MIR221: view

Orthologs for MIR221 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR221 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-221 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-221 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-221 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir221 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-221 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-221 37
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-221 37
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-221 37
  • 89 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-221 37
  • 78 (a)
OneToOne
Species with no ortholog for MIR221:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR221 Gene

ENSEMBL:
Gene Tree for MIR221 (if available)
TreeFam:
Gene Tree for MIR221 (if available)

Paralogs for MIR221 Gene

No data available for Paralogs for MIR221 Gene

Variants for MIR221 Gene

Sequence variations from dbSNP and Humsavar for MIR221 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs7050391 -- 45,745,845(+) GGGTG(C/T)TATGC downstream-variant-500B
rs113054794 -- 45,746,238(+) TATGC(A/C)AGGTT nc-transcript-variant
rs181300453 -- 45,746,012(+) TCGTA(C/T)TGAAA downstream-variant-500B
rs182584022 -- 45,746,409(+) AAAAT(G/T)TCCTT upstream-variant-2KB
rs185905117 -- 45,746,095(+) GTTTA(C/T)ACCTC downstream-variant-500B

Relevant External Links for MIR221 Gene

HapMap Linkage Disequilibrium report
MIR221

No data available for Structural Variations from Database of Genomic Variants (DGV) for MIR221 Gene

Disorders for MIR221 Gene

Relevant External Links for MIR221

Genetic Association Database (GAD)
MIR221
Human Genome Epidemiology (HuGE) Navigator
MIR221
genes like me logo Genes that share disorders with MIR221: view

No data available for UniProtKB/Swiss-Prot for MIR221 Gene

Publications for MIR221 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 49
  2. MicroRNA-221 regulates high glucose-induced endothelial dysfunction. (PMID: 19351599) Li Y. … Geng Y.J. (Biochem. Biophys. Res. Commun. 2009) 3 23
  3. A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias. (PMID: 19464057) Kreil S. … Chase A. (Leuk. Res. 2009) 3 49
  4. Expression of microRNA-221 is progressively reduced in aggressive prostate cancer and metastasis and predicts clinical recurrence. (PMID: 19585579) Spahn M. … Kneitz B. (Int. J. Cancer 2010) 3
  5. Significant inverse correlation of microRNA-150/MYB and microRNA-222/p27 in myelodysplastic syndrome. (PMID: 19615744) Hussein K. … Bock O. (Leuk. Res. 2010) 3

Products for MIR221 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR221
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR221
    • Block miRNA regulation of MIR221 using miScript Target Protectors

    Sources for MIR221 Gene

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