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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MIR221 Gene

RNA gene GIFtS: 26
GCID: GC0XM045605

MicroRNA 221

(Previous symbol: MIRN221)

34 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Subcategory (RNA class): miRNA

Quality score for this RNA gene is 3

Aliases
MicroRNA 221¹ ²
MIRN221¹ ² ⁵
mir-221² ⁹
miRNA221²

External Ids:	HGNC: 31601¹	Entrez Gene: 407006²	Ensembl: ENSG00000207870⁷	OMIM: 300568⁵

ORGUL members:
	miRBase: MI0000298

Export aliases for MIR221 gene to outside databases

Previous GC identifer: GC0XM045492

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MIR221 Gene:

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene

expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed

by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either

protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an

approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer

ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated

into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the

miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq

represents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)

GeneCards Summary for MIR221 Gene:

MIR221 (microRNA 221) is an RNA gene, and is affiliated with the miRNA class. Diseases associated with MIR221 include noma, and benign metastasizing leiomyoma.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for MIR221
Other transcription factors

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MIR221

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.3 Ensembl cytogenetic band: Xp11.3 HGNC cytogenetic band: Xp11.3

MIR221 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIR221 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM045605: view genomic region (via miRBase) (about GC identifiers)

Start:	45,605,585 bp from pter	End:	45,605,694 bp from pter
Size:	110 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB: --

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

HGNC Gene Families:

MIR: ncRNAs / Micro RNAs

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for MIR221 About

See pathways by source

SuperPath

Contained pathways About

miRNAs involved in DDR

miRNAs involved in DDR

MicroRNAs in cancer

MicroRNAs in cancer

miRs in Muscle Cell Differentiation

miRs in Muscle Cell Differentiation

Pathways by source See SuperPaths
Show all pathways

2 BioSystems Pathways for MIR221

	miRNAs involved in DDR
	miRs in Muscle Cell Differentiation

1 Kegg Pathway (Kegg details for MIR221):

MicroRNAs in cancer

MIR221 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MIR221

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

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Search CenterWatch for drugs/clinical trials and news about MIR221

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000385135(miRNA)

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GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

Expression evidence for MIR221:none

MIR221 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

SABiosciences Custom PCR Arrays for MIR221

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MIR221 gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	gga-mir-221⁶	gga-mir-221	91(a)	1 ↔ 1	1(109977681-109977779) ENSGALG00000018247
lizard (Anolis carolinensis)	Reptilia	aca-mir-221⁶	aca-mir-221	89(a)	1 ↔ 1	3(135996372-135996468)
zebrafish (Danio rerio)	Actinopterygii	dre-mir-221⁶ CU550700.2⁶	--	78(a) 69(a)	1 ↔ many 1 ↔ many	9(34892129-34892221) ENSDARG00000091272 6(59627903-59627976) ENSDARG00000081645

Species with no ortholog for MIR221

ENSEMBL Gene Tree for MIR221 (if available)
TreeFam Gene Tree for MIR221 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7050391^1,2	C	--	45605273(+)	`GGGTGC/TTATGC`	1	--	ds500¹		0	--	--	--	--
rs181300453^1,2		--	45605440(+)	`TCGTAC/TTGAAA`	1	--	ds500¹		0	--	--	--	--
rs185905117^1,2		--	45605523(+)	`GTTTAC/TACCTC`	1	--	ds500¹		0	--	--	--	--
rs191213444^1,2	C	--	45605777(+)	`TTCTAA/CCACAA`	1	--	us2k¹		0	--	--	--	--
rs182584022^1,2		--	45605837(+)	`AAAATG/TTCCTT`	1	--	us2k¹		0	--	--	--	--
rs57042952^1,2	C	--	45606303(+)	`TCTCT-/CTC/CTC TCTCTCTCTTTGTG`	1	--	us2k¹		0	--	--	--	--
rs72631825^1,2	F	--	45606471(-)	`CTTTCG/ATAATC`	1	--	us2k¹		1		MN	162
rs187612279^1,2	C	--	45606472(+)	`ATTACA/GAAAGA`	1	--	us2k¹		0	--	--	--	--
rs191727254^1,2	C	--	45606504(+)	`AGCCAA/TTGAGG`	1	--	us2k¹		0	--	--	--	--
rs113054794^1,2	--	--	45605666(+)	`TATGCC/AAGGTT`	1	--	nc-transcript-variant		1		CSA	2

HapMap Linkage Disequilibrium report for MIR221 (45605585 - 45605694 bp)

Structural Variations
Database of Genomic Variants (DGV) variations for MIR221: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MIR221 for disorders           About GeneDecksing

OMIM gene information: 300568    OMIM disorders: --

20/34 diseases for MIR221 (see all 34):    About MalaCards

noma benign metastasizing leiomyoma papillary thyroid carcinoma acute lymphocytic leukemia

rhabdoid tumor gastrointestinal stromal tumor papillary carcinoma leiomyoma

hairy cell leukemia myelodysplastic syndromes lupus nephritis cervical cancer

pancreatic ductal adenocarcinoma nephritis glioblastoma lung cancer

thyroiditis cervicitis hepatocellular carcinoma colorectal cancer

Genetic Association Database (GAD): MIR221
Human Genome Epidemiology (HuGE) Navigator: MIR221 (2 documents)

Export disorders for MIR221 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for MIR221 gene, integrated from 9 sources (see all 102):
(articles sorted by number of sources associating them with MIR221)

Utopia: connect your pdf to the dynamic
world of online information

Novel genetic variants in miR-191 gene and familial o varian cancer. (PubMed id 20167074)^{1, 4} Shen J....Zhao H. (2010)
A high-throughput candidate gene mutation screen in l ymphoproliferative and myeloproliferative neoplasias. (PubMed id 19464057)^{1, 4} Kreil S....Chase A. (2009)
MicroRNA-221 regulates high glucose-induced endothelial dysfunction. (PubMed id 19351599)^{1, 9} Li Y....Geng Y.J. (2009)
miRNA expression profiles of oral squamous cell carcin omas. (PubMed id 23564792)¹ Gombos K....Olasz L. (2013)
Increased expression of microRNA-221 inhibits PAK1 in endothelial progenitor cells and impairs its function via c-Raf/MEK/ERK pathway. (PubMed id 23333386)¹ Zhang X....Lv Z. (2013)
Aberrant expression of microRNAs in T cells from patie nts with ankylosing spondylitis contributes to the immunopathogenesis. (PubMed id 23607629)¹ Lai N.S....Lu M.C. (2013)
Increased miR-221 expression in hepatocellular carcino ma tissues and its role in enhancing cell growth and inhibiting apoptosis in vit ro. (PubMed id 23320393)¹ Rong M....Dang Y. (2013)
The abrogation of the HOXB7/PBX2 complex induces apopt osis in melanoma through the miR-221&222-c-FOS pathway. (PubMed id 23400877)¹ Errico M.C....Care A. (2013)
miR-21, miR-221 and miR-222 expression and prostate ca ncer recurrence among obese and non-obese cases. (PubMed id 23353719)¹ Amankwah E.K....Park J.Y. (2013)
Plasma microRNAs serve as novel potential biomarkers f or early detection of gastric cancer. (PubMed id 23307259)¹ Cai H....Zhang Y.M. (2013)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 407006	HGNC: 31601	Ensembl:ENSG00000207870	miRBase: hsa-mir-221	euGenes: HUgn407006
ECgene: MIR221	Kegg: 407006	H-InvDB: MIR221

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for MIR221	Pharmacogenomics, SNPs, Pathways

Intellectual Property for MIR221 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for MIR221 gene:
Search GeneIP for patents involving MIR221

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Functionfor MIR221 gene

Pathways & Interactionsfor MIR221 gene

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for MIR221 gene

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for MIR221 gene

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for MIR221 gene

Proteins
for MIR221 gene

Protein Domains /
Families
for MIR221 gene

Function
for MIR221 gene

Pathways & Interactions
for MIR221 gene

Drugs & Compounds
for MIR221 gene

Transcripts
for MIR221 gene

Expression
for MIR221 gene

Orthologs
for MIR221 gene

Paralogs
for MIR221 gene

Genomic Variants
for MIR221 gene

Disorders / Diseases
for MIR221 gene

Publications
for MIR221 gene

Intellectual Property
for MIR221 gene

Products
for MIR221 gene