Aliases for MIR221 Gene
Subcategory (RNA class) for MIR221 Gene
Quality Score for this RNA gene is
External Ids for MIR221 Gene
- HGNC: 31601
- Entrez Gene: 407006
- Ensembl: ENSG00000207870
- OMIM: 300568
- miRBase: hsa-mir-221
ORGUL Members for MIR221 Gene
Previous HGNC Symbols for MIR221 Gene
- MIRN221
Previous GeneCards Identifiers for MIR221 Gene
- GC0XM045492
- GC0XM045605
Summaries for MIR221 Gene
-
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
GeneCards Summary for MIR221 Gene
MIR221 (MicroRNA 221) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR221 include Benign Metastasizing Leiomyoma. Among its related pathways are miRs in Muscle Cell Differentiation and Hematopoietic Stem Cell Differentiation.
Additional gene information for MIR221 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR221 Gene
Genomics for MIR221 Gene
GeneHancer (GH) Regulatory Elements for MIR221 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH0XI045745 | Enhancer | 0.4 | dbSUPER | 550.8 | +0.2 | 230 | 0.8 | CREB1 ATF7 ATF2 | GC0XM045749 GC0XP045745 MIR221 MIR222 GC0XM045748 MIR222HG | |
GH0XI045707 | Enhancer | 1.3 | FANTOM5 Ensembl ENCODE dbSUPER | 13.5 | +33.6 | 33604 | 9.6 | SRF JUN NR2F1 JUNB BATF RELA JUND GATA3 POLR2A IKZF1 | MIR221 MIR222 GC0XM045719 GC0XM044696 KRT8P14 | |
GH0XI045719 | Enhancer | 0.2 | dbSUPER | 13.7 | +26.2 | 26169 | 1.3 | GC0XM045719 MIR221 MIR222 GC0XM044696 |
Regulatory Element Products
Genomic Locations for MIR221 Gene
- chrX:45,746,157-45,746,266
- (GRCh38/hg38)
- Size:
- 110 bases
- Orientation:
- Minus strand
- chrX:45,605,585-45,605,694
- (GRCh37/hg19)
Genomic View for MIR221 Gene
- Cytogenetic band:
-
- Xp11.3 by Ensembl
- Xp11.3 by Entrez Gene
- Xp11.3 by HGNC


RefSeq DNA sequence for MIR221 Gene
Proteins for MIR221 Gene
Post-translational modifications for MIR221 Gene
Antibody Products
- Search GeneTex for Antibodies for MIR221
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for MIR221
- Origene Custom Protein Services for MIR221
- Search GeneTex for Proteins for MIR221
No data available for DME Specific Peptides for MIR221 Gene
Domains & Families for MIR221 Gene
Gene Families for MIR221 Gene
- HGNC:
Graphical View of Domain Structure for InterPro Entry
No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR221 Gene
Function for MIR221 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:1903231 | mRNA binding involved in posttranscriptional gene silencing | IMP | 20813046 |
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR221
-
- Search ViGene Biosciences for MIR221
CRISPR Products
- Browse CRISPR knockouts for MIR221
- Applied Biological Materials CRISPR for MIR221
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR221
Clone Products
- GenScript: Custom all cDNA clones Services for MIR221
- VectorBuilder custom plasmid, inducible vectors for MIR221
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR221
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR221
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR221 Gene
Localization for MIR221 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005615 | extracellular space | IDA | 26646931 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR221 Gene
Pathways & Interactions for MIR221 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | MicroRNAs in cancer | ||
2 | Cell Differentiation - Index | ||
3 | Hematopoietic Stem Cell Differentiation | ||
4 | DNA Damage Response | ||
5 | miRNAs involved in DNA damage response |
Pathways by source for MIR221 Gene
1 KEGG pathway for MIR221 Gene
Interacting Proteins for MIR221 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008285 | negative regulation of cell proliferation | IDA | 23333386 |
GO:0009749 | response to glucose | IMP | 19351599 |
GO:0010634 | positive regulation of epithelial cell migration | IGI | 21673316 |
GO:0010718 | positive regulation of epithelial to mesenchymal transition | IGI | 21673316 |
GO:0034115 | negative regulation of heterotypic cell-cell adhesion | IDA | 20110463 |
No data available for SIGNOR curated interactions for MIR221 Gene
Transcripts for MIR221 Gene
mRNA/cDNA for MIR221 Gene
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
- Browse CRISPR knockouts for MIR221
- Applied Biological Materials CRISPR for MIR221
-
Vectors and viruses for KO, Activation, Repression, and more
Inhibitory RNA Products
- Search ViGene Biosciences for MIR221
Clone Products
- GenScript: Custom all cDNA clones Services for MIR221
- VectorBuilder custom plasmid, inducible vectors for MIR221
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR221
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for MIR221
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for MIR221 Gene
NURSA nuclear receptor signaling pathways regulating expression of MIR221 Gene:
MIR221Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR221 Gene
Orthologs for MIR221 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | ptr-mir-221 34 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Mir221 34 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | cfa-mir-221 34 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | bta-mir-221 34 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | mdo-mir-221 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | oan-mir-221 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | gga-mir-221 34 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | aca-mir-221 34 |
|
OneToOne | |
zebrafish (Danio rerio) |
Actinopterygii | dre-mir-221 34 |
|
OneToOne |
- Species where no ortholog for MIR221 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for MIR221 Gene
No data available for Paralogs for MIR221 Gene
Variants for MIR221 Gene
SNP ID | Clin | Chr 0X pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1007713125 | -- | 45,745,727(-) | A/G | downstream_transcript_variant | |
rs1011632523 | -- | 45,746,846(-) | C/G | upstream_transcript_variant | |
rs1019553546 | -- | 45,745,793(-) | A/T | downstream_transcript_variant | |
rs1022889488 | -- | 45,746,858(-) | C/G | upstream_transcript_variant | |
rs1026785163 | -- | 45,747,513(-) | A/G | upstream_transcript_variant |
Additional Variant Information for MIR221 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MIR221
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR221 Gene
Disorders for MIR221 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
benign metastasizing leiomyoma |
|
|
Additional Disease Information for MIR221
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for MIR221 Gene
Publications for MIR221 Gene
- Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 44 58
- MicroRNA-221 regulates high glucose-induced endothelial dysfunction. (PMID: 19351599) Li Y … Geng YJ (Biochemical and biophysical research communications 2009) 3 22 58
- A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias. (PMID: 19464057) Kreil S … Chase A (Leukemia research 2009) 3 44 58
- MicroRNA-221-3p Regulates Angiopoietin-Like 8 (ANGPTL8) Expression in Adipocytes. (PMID: 28938482) Mysore R … Haridas PAN (The Journal of clinical endocrinology and metabolism 2017) 3 58
- Androgen receptor-mediated downregulation of microRNA-221 and -222 in castration-resistant prostate cancer. (PMID: 28886115) Gui B … Jia L (PloS one 2017) 3 58
Products for MIR221 Gene
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- Cyagen custom Knockout/knockin (KOKI) mouse models for MIR221
- VectorBuilder custom plasmid, inducible vectors for MIR221
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MIR221
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for MIR221
- Search GeneTex for Proteins for MIR221
Sources for MIR221 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
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- (125) NCBI Bookshelf
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- (133) ENCODE
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- (139) VectorBuilder
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- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew