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Aliases for MIR221 Gene

Subcategory (RNA class) for MIR221 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR221 Gene

  • MicroRNA 221 2 3 5
  • Hsa-Mir-221 3
  • MiRNA221 3
  • Mir-221 3
  • MIRN221 3

External Ids for MIR221 Gene

Previous HGNC Symbols for MIR221 Gene

  • MIRN221

Previous GeneCards Identifiers for MIR221 Gene

  • GC0XM045492
  • GC0XM045605

Summaries for MIR221 Gene

Entrez Gene Summary for MIR221 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR221 Gene

MIR221 (MicroRNA 221) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR221 include Benign Metastasizing Leiomyoma. Among its related pathways are miRs in Muscle Cell Differentiation and MicroRNAs in cancer.

Additional gene information for MIR221 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR221 Gene

Genomics for MIR221 Gene

Regulatory Elements for MIR221 Gene

Enhancers for MIR221 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH045707 1.5 FANTOM5 Ensembl ENCODE dbSUPER 13.4 +33.6 33604 9.6 JUN NR2F1 JUNB BATF RELA GATA3 JUND POLR2A IKZF1 EED MIR222 MIR221 GC0XM045719 KRT8P14
GH0XH045719 0.2 dbSUPER 13.7 +26.2 26169 1.3 MIR222 MIR221 GC0XM045719 GC0XM044696
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR221 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR221 Gene

Genomic Locations for MIR221 Gene
chrX:45,746,157-45,746,266
(GRCh38/hg38)
Size:
110 bases
Orientation:
Minus strand
chrX:45,605,585-45,605,694
(GRCh37/hg19)

Genomic View for MIR221 Gene

Genes around MIR221 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR221 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR221 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR221 Gene

Proteins for MIR221 Gene

Post-translational modifications for MIR221 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR221 Gene

Domains & Families for MIR221 Gene

Gene Families for MIR221 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR221: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR221 Gene

Function for MIR221 Gene

Gene Ontology (GO) - Molecular Function for MIR221 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IMP 20813046
genes like me logo Genes that share ontologies with MIR221: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR221 Gene

Localization for MIR221 Gene

Gene Ontology (GO) - Cellular Components for MIR221 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 NOT extracellular space IDA 18766170
genes like me logo Genes that share ontologies with MIR221: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR221 Gene

Pathways & Interactions for MIR221 Gene

genes like me logo Genes that share pathways with MIR221: view

Interacting Proteins for MIR221 Gene

Gene Ontology (GO) - Biological Process for MIR221 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IDA 23333386
GO:0010634 positive regulation of epithelial cell migration IGI 21673316
GO:0010718 positive regulation of epithelial to mesenchymal transition IGI 21673316
GO:0034115 negative regulation of heterotypic cell-cell adhesion IDA 20110463
GO:0035195 gene silencing by miRNA IMP 18246122
genes like me logo Genes that share ontologies with MIR221: view

No data available for SIGNOR curated interactions for MIR221 Gene

Drugs & Compounds for MIR221 Gene

No Compound Related Data Available

Transcripts for MIR221 Gene

mRNA/cDNA for MIR221 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR221 Gene

No ASD Table

Relevant External Links for MIR221 Gene

GeneLoc Exon Structure for
MIR221
ECgene alternative splicing isoforms for
MIR221

Expression for MIR221 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR221 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR221 Gene:

MIR221
genes like me logo Genes that share expression patterns with MIR221: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR221 Gene

Orthologs for MIR221 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR221 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-221 34
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir221 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-221 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-221 34
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-221 34
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-221 34
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-221 34
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-221 34
  • 89 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-221 34
  • 78 (a)
OneToOne
Species where no ortholog for MIR221 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR221 Gene

ENSEMBL:
Gene Tree for MIR221 (if available)
TreeFam:
Gene Tree for MIR221 (if available)

Paralogs for MIR221 Gene

No data available for Paralogs for MIR221 Gene

Variants for MIR221 Gene

Sequence variations from dbSNP and Humsavar for MIR221 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1007713125 -- 45,745,727(+) ATAAC(A/G)GTTAC downstream-variant-500B
rs1011632523 -- 45,746,846(+) CCTCT(C/G)TCTCT downstream-variant-500B, upstream-variant-2KB
rs1019553546 -- 45,745,793(+) AGAAG(A/T)CAAAA downstream-variant-500B
rs1022889488 -- 45,746,858(+) TCTCT(C/G)TCTCT downstream-variant-500B, upstream-variant-2KB
rs1026785163 -- 45,747,513(+) CTTGG(A/G)GCATT upstream-variant-2KB

Relevant External Links for MIR221 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR221

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR221 Gene

Disorders for MIR221 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR221 Gene - From: GeneCards

Disorder Aliases PubMed IDs
benign metastasizing leiomyoma
  • benign metastasizing leiomyoma of uterus
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR221

Genetic Association Database (GAD)
MIR221
Human Genome Epidemiology (HuGE) Navigator
MIR221
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR221
genes like me logo Genes that share disorders with MIR221: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR221 Gene

Publications for MIR221 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 45 60
  2. A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias. (PMID: 19464057) Kreil S … Chase A (Leukemia research 2009) 3 45 60
  3. MicroRNA-221 regulates high glucose-induced endothelial dysfunction. (PMID: 19351599) Li Y … Geng YJ (Biochemical and biophysical research communications 2009) 3 22 60
  4. Predictive Effects of Circulating miR-221, miR-130a and miR-155 for Coronary Heart Disease: A Multi-Ethnic Study in China. (PMID: 28628920) Jia QW … Jia EZ (Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017) 3 60
  5. miR-221 and miR-222 synergistically regulate hepatocyte growth factor activator inhibitor type 1 to promote cell proliferation and migration in gastric cancer. (PMID: 28618968) Ning T … Ba Y (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017) 3 60

Products for MIR221 Gene

Sources for MIR221 Gene

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