Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR221 Gene

Subcategory (RNA class) for MIR221 Gene


Quality Score for this RNA gene is


Aliases for MIR221 Gene

  • MicroRNA 221 2 3 5
  • Hsa-Mir-221 3
  • MiRNA221 3
  • Mir-221 3
  • MIRN221 3

External Ids for MIR221 Gene

Previous HGNC Symbols for MIR221 Gene

  • MIRN221

Previous GeneCards Identifiers for MIR221 Gene

  • GC0XM045492
  • GC0XM045605

Summaries for MIR221 Gene

Entrez Gene Summary for MIR221 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR221 Gene

MIR221 (MicroRNA 221) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR221 include Benign Metastasizing Leiomyoma. Among its related pathways are miRs in Muscle Cell Differentiation and Hematopoietic Stem Cell Differentiation.

Additional gene information for MIR221 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR221 Gene

Genomics for MIR221 Gene

GeneHancer (GH) Regulatory Elements for MIR221 Gene

Promoters and enhancers for MIR221 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI045745 Enhancer 0.4 dbSUPER 550.8 +0.2 230 0.8 CREB1 ATF7 ATF2 GC0XM045749 GC0XP045745 MIR221 MIR222 GC0XM045748 MIR222HG
GH0XI045707 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 13.5 +33.6 33604 9.6 SRF JUN NR2F1 JUNB BATF RELA JUND GATA3 POLR2A IKZF1 MIR221 MIR222 GC0XM045719 GC0XM044696 KRT8P14
GH0XI045719 Enhancer 0.2 dbSUPER 13.7 +26.2 26169 1.3 GC0XM045719 MIR221 MIR222 GC0XM044696
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MIR221 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MIR221 Gene

Genomic Locations for MIR221 Gene
110 bases
Minus strand

Genomic View for MIR221 Gene

Genes around MIR221 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR221 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR221 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR221 Gene

Proteins for MIR221 Gene

Post-translational modifications for MIR221 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR221 Gene

Domains & Families for MIR221 Gene

Gene Families for MIR221 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR221: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR221 Gene

Function for MIR221 Gene

Gene Ontology (GO) - Molecular Function for MIR221 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903231 mRNA binding involved in posttranscriptional gene silencing IMP 20813046
genes like me logo Genes that share ontologies with MIR221: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR221 Gene

Localization for MIR221 Gene

Gene Ontology (GO) - Cellular Components for MIR221 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 26646931
genes like me logo Genes that share ontologies with MIR221: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for MIR221 Gene

Pathways & Interactions for MIR221 Gene

genes like me logo Genes that share pathways with MIR221: view

Interacting Proteins for MIR221 Gene

Gene Ontology (GO) - Biological Process for MIR221 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IDA 23333386
GO:0009749 response to glucose IMP 19351599
GO:0010634 positive regulation of epithelial cell migration IGI 21673316
GO:0010718 positive regulation of epithelial to mesenchymal transition IGI 21673316
GO:0034115 negative regulation of heterotypic cell-cell adhesion IDA 20110463
genes like me logo Genes that share ontologies with MIR221: view

No data available for SIGNOR curated interactions for MIR221 Gene

Drugs & Compounds for MIR221 Gene

No Compound Related Data Available

Transcripts for MIR221 Gene

mRNA/cDNA for MIR221 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR221 Gene

No ASD Table

Relevant External Links for MIR221 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR221 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR221 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR221 Gene:

genes like me logo Genes that share expression patterns with MIR221: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR221 Gene

Orthologs for MIR221 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR221 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-221 34
  • 100 (a)
(Mus musculus)
Mammalia Mir221 34
  • 99 (a)
(Canis familiaris)
Mammalia cfa-mir-221 34
  • 97 (a)
(Bos Taurus)
Mammalia bta-mir-221 34
  • 93 (a)
(Monodelphis domestica)
Mammalia mdo-mir-221 34
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-221 34
  • 91 (a)
(Gallus gallus)
Aves gga-mir-221 34
  • 91 (a)
(Anolis carolinensis)
Reptilia aca-mir-221 34
  • 89 (a)
(Danio rerio)
Actinopterygii dre-mir-221 34
  • 78 (a)
Species where no ortholog for MIR221 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR221 Gene

Gene Tree for MIR221 (if available)
Gene Tree for MIR221 (if available)

Paralogs for MIR221 Gene

No data available for Paralogs for MIR221 Gene

Variants for MIR221 Gene

Sequence variations from dbSNP and Humsavar for MIR221 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1007713125 -- 45,745,727(-) A/G downstream_transcript_variant
rs1011632523 -- 45,746,846(-) C/G upstream_transcript_variant
rs1019553546 -- 45,745,793(-) A/T downstream_transcript_variant
rs1022889488 -- 45,746,858(-) C/G upstream_transcript_variant
rs1026785163 -- 45,747,513(-) A/G upstream_transcript_variant

Additional Variant Information for MIR221 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR221 Gene

Disorders for MIR221 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR221 Gene - From: GeneCards

Disorder Aliases PubMed IDs
benign metastasizing leiomyoma
  • benign metastasizing leiomyoma of uterus
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for MIR221

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MIR221: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR221 Gene

Publications for MIR221 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J … Zhao H (BMC cancer 2010) 3 44 58
  2. MicroRNA-221 regulates high glucose-induced endothelial dysfunction. (PMID: 19351599) Li Y … Geng YJ (Biochemical and biophysical research communications 2009) 3 22 58
  3. A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias. (PMID: 19464057) Kreil S … Chase A (Leukemia research 2009) 3 44 58
  4. MicroRNA-221-3p Regulates Angiopoietin-Like 8 (ANGPTL8) Expression in Adipocytes. (PMID: 28938482) Mysore R … Haridas PAN (The Journal of clinical endocrinology and metabolism 2017) 3 58
  5. Androgen receptor-mediated downregulation of microRNA-221 and -222 in castration-resistant prostate cancer. (PMID: 28886115) Gui B … Jia L (PloS one 2017) 3 58

Products for MIR221 Gene

Sources for MIR221 Gene

Loading form....