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Aliases for MIR221 Gene

Subcategory (RNA class) for MIR221 Gene


Quality Score for this RNA gene is


Aliases for MIR221 Gene

  • MicroRNA 221 2 3 5
  • Hsa-Mir-221 3
  • MiRNA221 3
  • Mir-221 3
  • MIRN221 3

External Ids for MIR221 Gene

Previous HGNC Symbols for MIR221 Gene

  • MIRN221

Previous GeneCards Identifiers for MIR221 Gene

  • GC0XM045492
  • GC0XM045605

Summaries for MIR221 Gene

Entrez Gene Summary for MIR221 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR221 Gene

MIR221 (MicroRNA 221) is an RNA Gene, and is affiliated with the miRNA class. Diseases associated with MIR221 include Benign Metastasizing Leiomyoma. Among its related pathways are miRs in Muscle Cell Differentiation and MicroRNAs in cancer.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR221 Gene

Genomics for MIR221 Gene

Regulatory Elements for MIR221 Gene

Enhancers for MIR221 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF045707 1.3 FANTOM5 Ensembl ENCODE 13.4 +33.6 33604 9.6 SRF JUN BHLHE40 JUNB RAD21 RELA JUND POLR2A IKZF1 ETV6 MIR221 MIR222 GC0XM045719 KRT8P14
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR221 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR221 Gene

45,746,157 bp from pter
45,746,266 bp from pter
110 bases
Minus strand

Genomic View for MIR221 Gene

Genes around MIR221 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR221 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR221 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR221 Gene

Proteins for MIR221 Gene

Post-translational modifications for MIR221 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR221 Gene

Domains & Families for MIR221 Gene

Gene Families for MIR221 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR221: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR221 Gene

Function for MIR221 Gene

Animal Model Products

miRNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR221 Gene

Localization for MIR221 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR221 Gene

Pathways & Interactions for MIR221 Gene

genes like me logo Genes that share pathways with MIR221: view

Pathways by source for MIR221 Gene

Interacting Proteins for MIR221 Gene

Gene Ontology (GO) - Biological Process for MIR221 Gene


No data available for SIGNOR curated interactions for MIR221 Gene

Transcripts for MIR221 Gene

mRNA/cDNA for MIR221 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR221 Gene

No ASD Table

Relevant External Links for MIR221 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MIR221 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR221 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR221 Gene:

genes like me logo Genes that share expression patterns with MIR221: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR221 Gene

Orthologs for MIR221 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR221 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ptr-mir-221 35
  • 100 (a)
(Mus musculus)
Mammalia Mir221 35
  • 99 (a)
(Canis familiaris)
Mammalia cfa-mir-221 35
  • 97 (a)
(Bos Taurus)
Mammalia bta-mir-221 35
  • 93 (a)
(Monodelphis domestica)
Mammalia mdo-mir-221 35
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia oan-mir-221 35
  • 91 (a)
(Gallus gallus)
Aves gga-mir-221 35
  • 91 (a)
(Anolis carolinensis)
Reptilia aca-mir-221 35
  • 89 (a)
(Danio rerio)
Actinopterygii dre-mir-221 35
  • 78 (a)
Species where no ortholog for MIR221 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR221 Gene

Gene Tree for MIR221 (if available)
Gene Tree for MIR221 (if available)

Paralogs for MIR221 Gene

No data available for Paralogs for MIR221 Gene

Variants for MIR221 Gene

Sequence variations from dbSNP and Humsavar for MIR221 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs113054794 -- 45,746,238(+) TATGC(A/C)AGGTT nc-transcript-variant
rs113547497 -- 45,747,153(+) GAGGG(A/G)CTCTG upstream-variant-2KB
rs11797826 -- 45,746,925(+) gtgtg(A/T)gtgtg downstream-variant-500B, upstream-variant-2KB
rs12841848 -- 45,746,923(+) gtgtg(A/T)gtgtg downstream-variant-500B, upstream-variant-2KB
rs12841866 -- 45,746,935(+) gtgtg(A/T)gtgtg downstream-variant-500B, upstream-variant-2KB

Relevant External Links for MIR221 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MIR221 Gene

Disorders for MIR221 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MIR221 Gene - From: GeneCards

Disorder Aliases PubMed IDs
benign metastasizing leiomyoma
  • benign metastasizing leiomyoma of uterus
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MIR221

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MIR221: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MIR221 Gene

Publications for MIR221 Gene

  1. Novel genetic variants in miR-191 gene and familial ovarian cancer. (PMID: 20167074) Shen J. … Zhao H. (BMC Cancer 2010) 3 46 64
  2. MicroRNA-221 regulates high glucose-induced endothelial dysfunction. (PMID: 19351599) Li Y. … Geng Y.J. (Biochem. Biophys. Res. Commun. 2009) 3 22 64
  3. A high-throughput candidate gene mutation screen in lymphoproliferative and myeloproliferative neoplasias. (PMID: 19464057) Kreil S. … Chase A. (Leuk. Res. 2009) 3 46 64
  4. MiR-221 promotes stemness of breast cancer cells by targeting DNMT3b. (PMID: 26556862) Roscigno G. … Condorelli G. (Oncotarget 2016) 3 64
  5. Influenza A Virus-Induced Expression of a GalNAc Transferase, GALNT3, via MicroRNAs Is Required for Enhanced Viral Replication. (PMID: 26637460) Nakamura S. … Tomonaga K. (J. Virol. 2016) 3 64

Products for MIR221 Gene

Sources for MIR221 Gene

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