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Aliases for MIR22 Gene

Subcategory (RNA class) for MIR22 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR22 Gene

  • MicroRNA 22 2 3 5
  • Hsa-Mir-22 3
  • MiR-22 3
  • MIRN22 3

External Ids for MIR22 Gene

Previous HGNC Symbols for MIR22 Gene

  • MIRN22

Previous GeneCards Identifiers for MIR22 Gene

  • GC17M001571
  • GC17M001617
  • GC17M001619
  • GC17M001624

Summaries for MIR22 Gene

Entrez Gene Summary for MIR22 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR22 Gene

MIR22 (MicroRNA 22) is an RNA Gene, and is affiliated with the miRNA class.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR22 Gene

Genomics for MIR22 Gene

Regulatory Elements for MIR22 Gene

Enhancers for MIR22 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G001782 1.5 Ensembl ENCODE dbSUPER 11.7 -69.3 -69345 3.1 HDGF FOXA2 PKNOX1 ATF1 ARID4B SIN3A YY1 ZNF121 SLC30A9 ZNF143 SMYD4 SERPINF1 SERPINF2 RPA1 MIR22 MIR22HG WDR81 TLCD2 PIR53033
GH17G001648 1.4 ENCODE dbSUPER 11.9 +64.4 64357 3.8 HDGF FOXA2 PKNOX1 CREB3L1 AGO1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 SMYD4 RPA1 METTL16 RILP TLCD2 MIR22 MIR22HG WDR81 PITPNA SMG6
GH17G001785 1.3 Ensembl ENCODE dbSUPER 11.7 -73.4 -73397 3.4 GTF2F1 TBP JUN MAX SIN3A ZIC2 FOSL1 ZNF121 HIC1 GATA2 SMYD4 SMG6 SERPINF1 SERPINF2 RPA1 MIR22 MIR22HG WDR81 TLCD2 ENSG00000263345
GH17G001778 1.2 Ensembl ENCODE dbSUPER 11.6 -65.7 -65691 2.3 HDGF PKNOX1 NRF1 ZNF76 OSR2 PRDM6 SCRT2 GLIS1 FOXP2 WT1 SMYD4 SERPINF2 TLCD2 MIR22HG WDR81 MIR22 RPA1 SERPINF1 PIR54968 PIR53033
GH17G001781 1.1 dbSUPER 11.6 -67.4 -67385 0.4 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 SMYD4 RPA1 TSR1 SERPINF2 METTL16 TLCD2 MIR22HG WDR81 MIR22 SERPINF1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR22 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR22 Gene

Chromosome:
17
Start:
1,713,903 bp from pter
End:
1,713,987 bp from pter
Size:
85 bases
Orientation:
Minus strand

Genomic View for MIR22 Gene

Genes around MIR22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR22 Gene

Proteins for MIR22 Gene

Post-translational modifications for MIR22 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR22 Gene

Domains & Families for MIR22 Gene

Gene Families for MIR22 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR22: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR22 Gene

Function for MIR22 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR22 Gene

Localization for MIR22 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR22 Gene

Pathways & Interactions for MIR22 Gene

SuperPathways for MIR22 Gene

No Data Available

Interacting Proteins for MIR22 Gene

Gene Ontology (GO) - Biological Process for MIR22 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR22 Gene

Drugs & Compounds for MIR22 Gene

No Compound Related Data Available

Transcripts for MIR22 Gene

mRNA/cDNA for MIR22 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

  • Addgene plasmids for MIR22

Alternative Splicing Database (ASD) splice patterns (SP) for MIR22 Gene

No ASD Table

Relevant External Links for MIR22 Gene

GeneLoc Exon Structure for
MIR22
ECgene alternative splicing isoforms for
MIR22

Expression for MIR22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MIR22 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR22 Gene:

MIR22
genes like me logo Genes that share expression patterns with MIR22: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MIR22 Gene

Orthologs for MIR22 Gene

Evolution for MIR22 Gene

ENSEMBL:
Gene Tree for MIR22 (if available)
TreeFam:
Gene Tree for MIR22 (if available)

No data available for Orthologs for MIR22 Gene

Paralogs for MIR22 Gene

No data available for Paralogs for MIR22 Gene

Variants for MIR22 Gene

Sequence variations from dbSNP and Humsavar for MIR22 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000631440 -- 1,715,013(+) AATTC(C/T)GAAAC intron-variant, upstream-variant-2KB
rs1004524399 -- 1,715,678(+) CTGGA(A/G)AGAAC intron-variant, upstream-variant-2KB
rs1004567424 -- 1,714,557(+) CTGGA(C/G)AGGAG intron-variant, upstream-variant-2KB
rs1004598705 -- 1,714,260(+) TCACC(C/T)TCCCC intron-variant, upstream-variant-2KB
rs1006244144 -- 1,714,352(+) ACGCA(A/G)GTACT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR22 Gene

Variant ID Type Subtype PubMed ID
nsv470568 CNV loss 18288195
nsv516886 CNV loss 19592680
nsv833335 CNV gain+loss 17160897
nsv9490 CNV loss 18304495

Relevant External Links for MIR22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR22 Gene

Disorders for MIR22 Gene

Relevant External Links for MIR22

Human Genome Epidemiology (HuGE) Navigator
MIR22
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR22

No disorders were found for MIR22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR22 Gene

Publications for MIR22 Gene

  1. The predicted target gene validation, function, and prognosis studies of miRNA-22 in colorectal cancer tissue. (PMID: 28347238) Li B. … Zhang H. (Tumour Biol. 2017) 3 64
  2. miR-22 contributes to endosulfan-induced endothelial dysfunction by targeting SRF in HUVECs. (PMID: 28161397) Xu D. … Sun Y. (Toxicol. Lett. 2017) 3 64
  3. Molecular mechanisms and clinical applications of miR-22 in regulating malignant progression in human cancer (Review). (PMID: 28000852) Wang J. … Tang J. (Int. J. Oncol. 2017) 3 64
  4. FosB regulates expression of miR-22 during PMA induced differentiation of K562A cells to megakaryocytes. (PMID: 27889568) Ahmad H.M. … Bhattacharya A. (Biochimie 2017) 3 64
  5. miR-22 inhibits the proliferation, motility, and invasion of human glioblastoma cells by directly targeting SIRT1. (PMID: 26662303) Chen H. … Dai D. (Tumour Biol. 2016) 3 64

Products for MIR22 Gene

Sources for MIR22 Gene

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