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MIR22 Gene

RNA gene   GIFtS: 22
GCID: GC17M001624

MicroRNA 22


(Previous symbol: MIRN22)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Subcategory (RNA class): antisense

Quality score for this RNA gene is 3

Aliases
MicroRNA 221 2
MIRN221 2 5
hsa-mir-222
miR-222
mir-229

External Ids:    HGNC: 315991   Entrez Gene: 4070042   Ensembl: ENSG000001865947   OMIM: 6120775   
ORGUL members:         

Export aliases for MIR22 gene to outside databases

Previous GC identifers: GC17M001571 GC17M001617 GC17M001619


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MIR22 Gene:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of
gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are
transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can
be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme
to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the
cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The
mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through
imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of
the target mRNA. The RefSeq represents the predicted microRNA stem-loop. (provided by RefSeq, Sep 2009)

GeneCards Summary for MIR22 Gene:
MIR22 (microRNA 22) is an RNA gene, and is affiliated with the antisense RNA class. Diseases associated with MIR22 include hairy cell leukemia, and panic disorder.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for MIR22
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for MIR22

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MIR22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.3   Ensembl cytogenetic band:  17p13.3   HGNC cytogenetic band: 17p13.3

MIR22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MIR22 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M001624:  view genomic region (via miRBase)     (about GC identifiers)

Start:
1,614,805 bp from pter      End:
1,620,468 bp from pter
Size:
5,664 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for MIR22

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
MIR: ncRNAs / Micro RNAs

  --

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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  --

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MIR22
Interactions:

    Search GeneGlobe Interaction Network for MIR22

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MIR22



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
ENST00000334146(lincRNA)(uc002ftf.3) ENST00000574306(lincRNA)(uc002ftg.3 uc021tni.1 uc021tnj.1)
ENST00000576749(lincRNA) ENST00000570416(lincRNA) ENST00000571595(lincRNA) ENST00000571091(lincRNA) ENST00000573127(lincRNA)
ENST00000576489(lincRNA) ENST00000575626(lincRNA) ENST00000608245(lincRNA) ENST00000609398(lincRNA) ENST00000610106(lincRNA)
ENST00000609990(lincRNA) ENST00000608198(lincRNA) ENST00000609442(lincRNA) ENST00000608913(lincRNA) ENST00000573075(lincRNA)
ENST00000574016(lincRNA)
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GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for MIR22    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4
SP1:                                -     -         
SP2:                                                
SP3:                    -                           


ECgene alternative splicing isoforms for MIR22

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for MIR22:none

MIR22 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
MIR22 Expression
About this image


MIR22 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 2) fully expand
 
 Umbilical Cord (Extraembryonic Tissues)
         Umbilical cord blood-derived endothelial progenitor cells
 
 Endothelium (Cardiovascular System)
         Umbilical cord blood-derived endothelial progenitor cells
MIR22 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
    Custom PCR Arrays for MIR22
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for MIR22 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves gga-mir-226
gga-mir-22
75(a)
1 ↔ 1
19(5377511-5377610) ENSGALG00000024507
zebrafish
(Danio rerio)
Actinopterygii dre-mir-22a6
CU442763.16
(see all 3)
--
81(a)
72(a)
(see all 3)
many → 1
many → 1
(see all 3)
15(24261942-24262027) ENSDARG00000083597
21(38102084-38102169) ENSDARG00000082168
        Species with no ortholog for MIR22

ENSEMBL Gene Tree for MIR22 (if available)
TreeFam Gene Tree for MIR22 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Structural Variations
     Database of Genomic Variants (DGV) 8 variations for MIR22:    About this table    
Variant IDTypeSubtypePubMed ID
dgv3033n71CNV Loss21882294
nsv907515CNV Loss21882294
nsv516886CNV Loss19592680
nsv907511CNV Loss21882294
nsv907502CNV Loss21882294
nsv9490CNV Loss18304495
nsv470568CNV Loss18288195
nsv833335CNV Gain+Loss17160897

Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing MIR22
DNA2.0 Custom Variant and Variant Library Synthesis for MIR22

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 612077    OMIM disorders: --

16 diseases for MIR22:    
About MalaCards
hairy cell leukemia    panic disorder    hypoxia    t-cell leukemia
cervical cancer    lung cancer    cervicitis    endometriosis
huntington's disease    ovarian cancer    hepatocellular carcinoma    leukemia
breast cancer    colorectal cancer    hepatitis    neuronitis


MIR22 for disorders           About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: MIR22 (1 document)

Export disorders for MIR22 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MIR22 gene, integrated from 10 sources (see all 46):
(articles sorted by number of sources associating them with MIR22)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Circulating miR-22, miR-24 and miR-34a as novel predictive biomarkers to pemetrexed-based chemotherapy in advanced non-small cell lung cancer. (PubMed id 23794259)1 Franchina T....Adamo V. (J. Cell. Physiol. 2014)
  2. A novel p53/microRNA-22/Cyr61 axis in synovial cells regulates inflammation in rheumatoid arthritis. (PubMed id 24449575)1 Lin J....Li N. (amp 2014)
  3. Increased miRNA-22 expression sensitizes esophageal squamous cell carcinoma to irradiation. (PubMed id 23188185)1 Wang X.C....Fan F.Y. (J. Radiat. Res. 2013)
  4. Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of neuronal phenotypes. (PubMed id 23516279)1 JoviA8iA8 A....Luthi-Carter R. (J. Neurosci. 2013)
  5. MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling. (PubMed id 23830207)1 Song S.J....Pandolfi P.P. (Cell 2013)
  6. Reduced expression of miR-22 in gastric cancer is related to clinicopathologic characteristics or patient prognosis. (PubMed id 23786758)1 Wang W....Gao X. (Diagn Pathol 2013)
  7. miR-22 is down-regulated in gastric cancer, and its overexpression inhibits cell migration and invasion via targeting transcription factor Sp1. (PubMed id 23529765)1 Guo M.M....Liao C.G. (Med. Oncol. 2013)
  8. MicroRNA-22 (miR-22) overexpression is neuroprotective via general anti-apoptotic effects and may also target specific Huntington's disease-related mechanisms. (PubMed id 23349832)1 Jovicic A....Luthi-Carter R. (PLoS ONE 2013)
  9. Plasma miR-17-5p, miR-20a and miR-22 are down-regulated in women with endometriosis. (PubMed id 23203215)1 Jia S.Z....Leng J. (Hum. Reprod. 2013)
  10. Common variation neighbouring micro-RNA 22 is associated with increased left ventricular mass. (PubMed id 23372812)1 Harper A.R....Keavney B.D. (PLoS ONE 2013)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 407004 HGNC: 31599 Ensembl:ENSG00000186594 miRBase: hsa-mir-22 euGenes: HUgn407004
ECgene: MIR22 H-InvDB: MIR22

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MIR22 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MIR22 gene:
Search GeneIP for patents involving MIR22

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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