Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MIR22 Gene

Subcategory (RNA class) for MIR22 Gene

miRNA

Quality Score for this RNA gene is

8.2

Aliases for MIR22 Gene

  • MicroRNA 22 2 3
  • MIRN22 3 6
  • Hsa-Mir-22 3
  • MiR-22 3

External Ids for MIR22 Gene

Previous HGNC Symbols for MIR22 Gene

  • MIRN22

Previous GeneCards Identifiers for MIR22 Gene

  • GC17M001571
  • GC17M001617
  • GC17M001619
  • GC17M001624

Summaries for MIR22 Gene

Entrez Gene Summary for MIR22 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR22 Gene

MIR22 (MicroRNA 22) is an RNA Gene, and is affiliated with the miRNA class.

fRNAdb sequence ontologies for MIR22 Gene

  • nc_conserved_region: Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for MIR22

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary and piRNA Summary for MIR22 Gene

Genomics for MIR22 Gene

Genomic Location for MIR22 Gene

Start:
1,713,895 bp from pter
End:
1,714,005 bp from pter
Size:
111 bases
Orientation:
Minus strand

Genomic View for MIR22 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MIR22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR22 Gene

ORGUL Member Location for MIR22 Gene

ORGUL Member Location for MIR22 gene

No data available for Regulatory Elements for MIR22 Gene

Proteins for MIR22 Gene

Post-translational modifications for MIR22 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR22 Gene

Domains for MIR22 Gene

Gene Families for MIR22 Gene

HGNC:
  • MIR :ncRNAs / Micro RNAs

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR22: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR22 Gene

Function for MIR22 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MIR22 Gene

Localization for MIR22 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR22 Gene

Pathways for MIR22 Gene

SuperPathways for MIR22 Gene

No Data Available

Interacting Proteins for MIR22 Gene

Gene Ontology (GO) - Biological Process for MIR22 Gene

None

No data available for Pathways by source for MIR22 Gene

Transcripts for MIR22 Gene

fRNAdb Secondary structures for MIR22 Gene

  • FR130692

mRNA/cDNA for MIR22 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MIR22

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR22 Gene

No ASD Table

Relevant External Links for MIR22 Gene

GeneLoc Exon Structure for
MIR22
ECgene alternative splicing isoforms for
MIR22

Expression for MIR22 Gene

mRNA expression in normal human tissues for MIR22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

genes like me logo Genes that share expressions with MIR22: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for MIR22 Gene

Orthologs for MIR22 Gene

Evolution for MIR22 Gene

ENSEMBL:
Gene Tree for MIR22 (if available)
TreeFam:
Gene Tree for MIR22 (if available)

No data available for Orthologs for MIR22 Gene

Paralogs for MIR22 Gene

No data available for Paralogs for MIR22 Gene

Variants for MIR22 Gene

Structural Variations from Database of Genomic Variants (DGV) for MIR22 Gene

Variant ID Type Subtype PubMed ID
nsv907502 CNV Loss 21882294
nsv907511 CNV Loss 21882294
nsv907515 CNV Loss 21882294
nsv9490 CNV Loss 18304495
nsv470568 CNV Loss 18288195
nsv516886 CNV Loss 19592680
dgv3033n71 CNV Loss 21882294
nsv833335 CNV Gain+Loss 17160897

Relevant External Links for MIR22 Gene

HapMap Linkage Disequilibrium report
MIR22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for MIR22 Gene

Disorders for MIR22 Gene

Relevant External Links for MIR22

Human Genome Epidemiology (HuGE) Navigator
MIR22
genes like me logo Genes that share disorders with MIR22: view

No data available for UniProtKB/Swiss-Prot for MIR22 Gene

Publications for MIR22 Gene

  1. Identification of novel genes coding for small expressed RNAs. (PMID: 11679670) Lagos-Quintana M. … Tuschl T. (Science 2001) 3
  2. miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. (PMID: 11914277) Mourelatos Z. … Dreyfuss G. (Genes Dev. 2002) 3
  3. Reduced accumulation of specific microRNAs in colorectal neoplasia. (PMID: 14573789) Michael M.Z. … James R.J. (Mol. Cancer Res. 2003) 3
  4. Identification of human fetal liver miRNAs by a novel method. (PMID: 15978578) Fu H. … Zheng X. (FEBS Lett. 2005) 3
  5. miRBase: microRNA sequences, targets and gene nomenclature. (PMID: 16381832) Griffiths-Jones S. … Enright A.J. (Nucleic Acids Res. 2006) 3

Products for MIR22 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate MIR22
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MIR22
    • Block miRNA regulation of MIR22 using miScript Target Protectors

    Sources for MIR22 Gene

    Back to Top

    Content