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Aliases for MIR22 Gene

Subcategory (RNA class) for MIR22 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR22 Gene

  • MicroRNA 22 2 3
  • MIR22 Host Gene 5
  • Hsa-Mir-22 3
  • MIR22HG 5
  • MiR-22 3
  • MIRN22 3

External Ids for MIR22 Gene

Previous HGNC Symbols for MIR22 Gene

  • MIRN22

Previous GeneCards Identifiers for MIR22 Gene

  • GC17M001571
  • GC17M001617
  • GC17M001619
  • GC17M001624

Summaries for MIR22 Gene

Entrez Gene Summary for MIR22 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR22 Gene

MIR22 (MicroRNA 22) is an RNA Gene, and is affiliated with the miRNA class.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR22 Gene

Genomics for MIR22 Gene

Regulatory Elements for MIR22 Gene

Enhancers for MIR22 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F001648 0.7 ENCODE 11.9 +67.5 67544 3.8 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 ZNF207 SMYD4 RPA1 METTL16 RILP TLCD2 WDR81 MIR22 MIR22HG PITPNA SMG6
GH17F001860 0.2 ENCODE 11.8 -144.3 -144251 1.5 KLF1 BHLHE40 RAD21 YY1 NR2F2 ZNF121 POLR2A ZBTB33 FOXP2 SMYD4 RPA1 MIR22 MIR22HG WDR81 SERPINF2 DPH1 RTN4RL1 LOC642502 GC17P001886
GH17F001865 0.6 ENCODE 11.8 -148.5 -148478 0.1 CTCF ZNF654 ZNF143 SMC3 TRIM22 RAD21 RPA1 SMYD4 MIR22 MIR22HG WDR81 DPH1 LOC642502 GC17P001886
GH17F001785 1.2 Ensembl ENCODE 11.7 -70.2 -70210 3.4 GTF2F1 TBP JUN MAX SIN3A ZIC2 HIC1 ZNF121 ZNF366 SMARCC2 SMYD4 SMG6 SERPINF1 SERPINF2 RPA1 WDR81 MIR22 MIR22HG TLCD2 ENSG00000263345
GH17F001781 0.6 Ensembl ENCODE 11.7 -66.2 -66185 3.0 HDAC1 PKNOX1 ATF1 ARID4B SIN3A ZBTB40 RAD21 ZNF121 ZNF335 SLC30A9 SMYD4 SERPINF1 SERPINF2 RPA1 WDR81 MIR22 MIR22HG TLCD2 PIR53033
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MIR22 on UCSC Golden Path with GeneCards custom track

Promoters for MIR22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001533658 1074 3801 MLX CREB3L1 ZFP64 YBX1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC

Genomic Location for MIR22 Gene

Chromosome:
17
Start:
1,711,493 bp from pter
End:
1,717,174 bp from pter
Size:
5,682 bases
Orientation:
Minus strand

Genomic View for MIR22 Gene

Genes around MIR22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR22 Gene

Proteins for MIR22 Gene

Post-translational modifications for MIR22 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR22 Gene

Domains & Families for MIR22 Gene

Gene Families for MIR22 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR22: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR22 Gene

Function for MIR22 Gene

Animal Model Products

miRNA Products

Clone Products

  • Addgene plasmids for MIR22

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR22 Gene

Localization for MIR22 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR22 Gene

Pathways & Interactions for MIR22 Gene

SuperPathways for MIR22 Gene

No Data Available

Interacting Proteins for MIR22 Gene

Gene Ontology (GO) - Biological Process for MIR22 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MIR22 Gene

Transcripts for MIR22 Gene

mRNA/cDNA for MIR22 Gene

(20) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Clone Products

  • Addgene plasmids for MIR22

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MIR22 Gene

No ASD Table

Relevant External Links for MIR22 Gene

GeneLoc Exon Structure for
MIR22
ECgene alternative splicing isoforms for
MIR22

Expression for MIR22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR22 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR22 Gene:

MIR22
genes like me logo Genes that share expression patterns with MIR22: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR22 Gene

Orthologs for MIR22 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR22 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia bta-mir-22 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-22 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir22 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-22 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-22 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-22 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves gga-mir-22 35
  • 75 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-22a 35
  • 81 (a)
OneToMany
CU442763.1 35
  • 72 (a)
OneToMany
dre-mir-22b 35
  • 68 (a)
OneToMany
Species where no ortholog for MIR22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR22 Gene

ENSEMBL:
Gene Tree for MIR22 (if available)
TreeFam:
Gene Tree for MIR22 (if available)

Paralogs for MIR22 Gene

No data available for Paralogs for MIR22 Gene

Variants for MIR22 Gene

Sequence variations from dbSNP and Humsavar for MIR22 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1075485 -- 1,715,954(-) AGCTA(C/T)GAGGA intron-variant, upstream-variant-2KB
rs11078596 -- 1,714,968(+) ATACT(C/T)AGAGG intron-variant, upstream-variant-2KB
rs11078597 -- 1,715,069(+) ACCAG(C/T)CCAAC intron-variant, upstream-variant-2KB
rs111505806 -- 1,714,635(+) GGTAT(A/G)GGCAG intron-variant, upstream-variant-2KB
rs111969187 -- 1,713,806(+) CCCAA(A/G)ACGTA nc-transcript-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MIR22 Gene

Variant ID Type Subtype PubMed ID
nsv470568 CNV loss 18288195
nsv516886 CNV loss 19592680
nsv833335 CNV gain+loss 17160897
nsv9490 CNV loss 18304495

Relevant External Links for MIR22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR22 Gene

Disorders for MIR22 Gene

Relevant External Links for MIR22

Human Genome Epidemiology (HuGE) Navigator
MIR22
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR22

No disorders were found for MIR22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR22 Gene

Publications for MIR22 Gene

  1. MicroRNA-22 functions as a tumor suppressor by targeting SIRT1 in renal cell carcinoma. (PMID: 26499759) Zhang S. … Wang J. (Oncol. Rep. 2016) 3 64
  2. MiR-22-silenced cyclin A expression in colon and liver cancer cells is regulated by bile acid receptor. (PMID: 25596928) Yang F. … Wan Y.J. (J. Biol. Chem. 2015) 3 64
  3. MicroRNA-22 Suppresses DNA Repair and Promotes Genomic Instability through Targeting of MDC1. (PMID: 25627978) Lee J.H. … You H.J. (Cancer Res. 2015) 3 64
  4. miR-22 and miR-29a Are Members of the Androgen Receptor Cistrome Modulating LAMC1 and Mcl-1 in Prostate Cancer. (PMID: 26052614) Pasqualini L. … Klocker H. (Mol. Endocrinol. 2015) 3 64
  5. Extracellular Uridine Triphosphate and Adenosine Triphosphate Attenuate Endothelial Inflammation through miR-22-Mediated ICAM-1 Inhibition. (PMID: 26088024) GidlAPf O. … Erlinge D. (J. Vasc. Res. 2015) 3 64

Products for MIR22 Gene

Sources for MIR22 Gene

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