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Aliases for MIR219A2 Gene

Subcategory (RNA class) for MIR219A2 Gene

miRNA

Quality Score for this RNA gene is

3

Aliases for MIR219A2 Gene

  • MicroRNA 219a-2 2 3 5
  • MicroRNA 219-2 2 3
  • Hsa-Mir-219a-2 3
  • Hsa-Mir-219-2 3
  • Mir-219a-2 3
  • MIRN219-2 3
  • MIR219-2 3

External Ids for MIR219A2 Gene

Previous HGNC Symbols for MIR219A2 Gene

  • MIRN219-2
  • MIR219-2

Previous GeneCards Identifiers for MIR219A2 Gene

  • GC09M131156

Summaries for MIR219A2 Gene

Entrez Gene Summary for MIR219A2 Gene

  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

GeneCards Summary for MIR219A2 Gene

MIR219A2 (MicroRNA 219a-2) is an RNA Gene, and is affiliated with the miRNA class. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins..

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MIR219A2 Gene

Genomics for MIR219A2 Gene

Regulatory Elements for MIR219A2 Gene

Enhancers for MIR219A2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F128393 0.5 ENCODE 0.8 +0.1 124 0.1 SUZ12 TEAD4 EZH2 MIR219A2 GC09M128394
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MIR219A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MIR219A2 Gene

Chromosome:
9
Start:
128,392,007 bp from pter
End:
128,393,510 bp from pter
Size:
1,504 bases
Orientation:
Minus strand

Genomic View for MIR219A2 Gene

Genes around MIR219A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MIR219A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MIR219A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MIR219A2 Gene

Proteins for MIR219A2 Gene

Post-translational modifications for MIR219A2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MIR219A2 Gene

Domains & Families for MIR219A2 Gene

Gene Families for MIR219A2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MIR219A2: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MIR219A2 Gene

Function for MIR219A2 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MIR219A2 Gene

Localization for MIR219A2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MIR219A2 Gene

Pathways & Interactions for MIR219A2 Gene

genes like me logo Genes that share pathways with MIR219A2: view

Pathways by source for MIR219A2 Gene

1 BioSystems pathway for MIR219A2 Gene

Interacting Proteins for MIR219A2 Gene

Gene Ontology (GO) - Biological Process for MIR219A2 Gene

None

No data available for SIGNOR curated interactions for MIR219A2 Gene

Transcripts for MIR219A2 Gene

mRNA/cDNA for MIR219A2 Gene

(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MIR219A2 Gene

No ASD Table

Relevant External Links for MIR219A2 Gene

GeneLoc Exon Structure for
MIR219A2
ECgene alternative splicing isoforms for
MIR219A2

Expression for MIR219A2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MIR219A2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MIR219A2 Gene:

MIR219A2
genes like me logo Genes that share expression patterns with MIR219A2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MIR219A2 Gene

Orthologs for MIR219A2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MIR219A2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ptr-mir-219-2 35
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mir219-2 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-219 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia cfa-mir-219-2 35
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia mdo-mir-219-1 35
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-219 35
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dre-mir-219-1 35
  • 68 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea csa-mir-219 35
  • 45 (a)
OneToMany
Species where no ortholog for MIR219A2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MIR219A2 Gene

ENSEMBL:
Gene Tree for MIR219A2 (if available)
TreeFam:
Gene Tree for MIR219A2 (if available)

Paralogs for MIR219A2 Gene

No data available for Paralogs for MIR219A2 Gene

Variants for MIR219A2 Gene

Sequence variations from dbSNP and Humsavar for MIR219A2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs113765234 -- 128,392,358(+) CGCCG(C/G)TGCGT downstream-variant-500B, upstream-variant-2KB
rs146160928 -- 128,392,187(+) TGGTT(G/T)GTTTG downstream-variant-500B, upstream-variant-2KB
rs180719689 -- 128,394,561(+) GAAAC(A/G)GGTCC upstream-variant-2KB
rs183878334 -- 128,394,195(+) CAGGA(A/G)AGCAG upstream-variant-2KB
rs184253244 -- 128,392,578(+) TCGCC(C/T)GCGCT downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MIR219A2 Gene

Variant ID Type Subtype PubMed ID
nsv831728 CNV loss 17160897

Relevant External Links for MIR219A2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MIR219A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for MIR219A2 Gene

Disorders for MIR219A2 Gene

Relevant External Links for MIR219A2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MIR219A2

No disorders were found for MIR219A2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MIR219A2 Gene

Publications for MIR219A2 Gene

  1. The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model. (PMID: 26965827) Murai K. … Shi Y. (Nat Commun 2016) 3 64
  2. MicroRNA-219-2-3p functions as a tumor suppressor in gastric cancer and is regulated by DNA methylation. (PMID: 23637748) Lei H. … Li Y. (PLoS ONE 2013) 3 64
  3. Self-limited versus delayed resolution of acute inflammation: temporal regulation of pro-resolving mediators and microRNA. (PMID: 22957142) Fredman G. … Serhan C.N. (Sci Rep 2012) 3 64
  4. miRBase: integrating microRNA annotation and deep-sequencing data. (PMID: 21037258) Kozomara A. … Griffiths-Jones S. (Nucleic Acids Res. 2011) 3 64
  5. MicroRNAs and deletion of the derivative chromosome 9 in chronic myeloid leukemia. (PMID: 18548097) Chaubey A. … Aguiar R.C. (Leukemia 2009) 3 64

Products for MIR219A2 Gene

Sources for MIR219A2 Gene

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